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Volumn 26, Issue 2, 2007, Pages 281-290

Hypoxia: A key regulator of angiogenesis in cancer

Author keywords

Angiogenesis; Cancer; HIF; Hypoxia

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; AVE 0005; AXITINIB; E 7820; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; NITRIC OXIDE; PAZOPANIB; PI 88; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

EID: 34547124062     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-007-9066-y     Document Type: Review
Times cited : (607)

References (78)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. (1971). Tumor angiogenesis: therapeutic implications. New England Journal of Medicine, 285, 1182-1186.
    • (1971) New England Journal of Medicine , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0017171175 scopus 로고
    • Prolonged tumor dormancy by prevention of neovascularization in the vitreous
    • Brem, S., Brem, H., Folkman, J., Finkelstein, D., & Patz, A. (1976). Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Research, 36, 2807-2812.
    • (1976) Cancer Research , vol.36 , pp. 2807-2812
    • Brem, S.1    Brem, H.2    Folkman, J.3    Finkelstein, D.4    Patz, A.5
  • 5
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren, L., O'Reilly, M. S., Folkman, J. (1995). Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Medicine, 1, 149-153.
    • (1995) Nature Medicines , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 6
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet, P. (2000). Mechanisms of angiogenesis and arteriogenesis. Nature Medicine, 6, 389-395.
    • (2000) Nature Medicines , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 7
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers, G., & Benjamin, L. E. (2003). Tumorigenesis and the angiogenic switch. Nature Reviews Cancer, 3, 401-410.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 8
    • 33748940402 scopus 로고    scopus 로고
    • Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch
    • Naumov, G. N., Akslen, L. A., & Folkman, J. (2006). Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch. Cell Cycle, 5, 1779-1787.
    • (2006) Cell Cycle , vol.5 , pp. 1779-1787
    • Naumov, G.N.1    Akslen, L.A.2    Folkman, J.3
  • 9
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989). Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature, 339, 58-61.
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 10
    • 11444250615 scopus 로고    scopus 로고
    • Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors
    • North, S., Moenner, M., & Bikfalvi, A. (2005). Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Letter, 218, 1-14.
    • (2005) Cancer Letter , vol.218 , pp. 1-14
    • North, S.1    Moenner, M.2    Bikfalvi, A.3
  • 11
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin. E. Y., Li, J. F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., et al. (2006). Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Research, 66, 11238-11246.
    • (2006) Cancer Research , vol.66 , pp. 11238-11246
    • Li, E.Y.1    Gnatovskiy, J.F.2    Deng, L.3    Zhu, Y.4    Grzesik, L.5
  • 13
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash, J., Maisonpierre, P. C., Compton. D., Boland, P., Alexander, C. R., Zagzag, D., et al. (1999). Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science, 284, 1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Boland, D.3    Alexander, P.4    Zagzag, C.R.5
  • 14
    • 0035253409 scopus 로고    scopus 로고
    • Angiogenesis: The role of the microenvironment in flipping the switch
    • Giordano, F. J., & Johnson, R. S (2001). Angiogenesis: The role of the microenvironment in flipping the switch. Current Opinion in Genetics & Development, 11, 35-40.
    • (2001) Current Opinion in Genetics & Development , vol.11 , pp. 35-40
    • Giordano, F.J.1    Johnson, R.S.2
  • 15
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza, G. L. (2004). Hydroxylation of HIF-1: Oxygen sensing at the molecular level. Physiology (Bethesda), 19, 176-182.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 17
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., & Fujii-Kuriyama, Y. (1997). A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proceedings of the National Academy of Sciences of the United States of America, 94, 4273-4278.
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 18
    • 0035969508 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    • Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., et al. (2001). Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature, 414, 550-554.
    • (2001) Nature , vol.414 , pp. 550-554
    • Makino, Y.1    Cao, R.2    Svensson, K.3    Bertilsson, G.4    Asman, M.5    Tanaka, H.6
  • 19
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan, H. E., Lo, J., & Johnson, R. S. (1998). HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO Journal, 17, 3005-3015.
    • (1998) EMBO Journal , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 21
    • 2942685341 scopus 로고    scopus 로고
    • Ellis LM: Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation
    • Stoeltzing, O., McCarty, M. F., Wey, J. S., Fan, F., Liu, W., Belcheva, A., et al. (2004) Ellis LM: Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. Journal of the National Cancer Institute, 96, 946-956.
    • (2004) Journal of the National Cancer Institute , vol.96 , pp. 946-956
    • Stoeltzing, O.1    McCarty, M.F.2    Wey, J.S.3    Fan, F.4    Liu, W.5    Belcheva, A.6
  • 22
    • 33745767945 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas
    • Jensen, R. L., Ragel, B. T., Whang, K., & Gillespie, D. (2006). Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. Journal of Neuro-oncology, 78, 233-247.
    • (2006) Journal of Neuro-oncology , vol.78 , pp. 233-247
    • Jensen, R.L.1    Ragel, B.T.2    Whang, K.3    Gillespie, D.4
  • 24
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • Liao, D., Corle, C., Seagroves, T. N., & Johnson, R. S. (2007). Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Research, 67, 563-572.
    • (2007) Cancer Research , vol.67 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 25
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang, N., Wang, L., Esko, J., Giordano, F. J., Huang, Y., Gerber, H. P., et al. (2004). Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell, 6, 485-495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6
  • 26
    • 0035835819 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene
    • Kondo, K., & Kaelin, W. G., Jr. (2001) The von Hippel-Lindau tumor suppressor gene. Experimental Cell Research, 264, 117-125.
    • (2001) Experimental Cell Research , vol.264 , pp. 117-125
    • Kondo, K.1    Kaelin Jr., W.G.2
  • 27
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon, P. C., Hirota, K., & Semenza, G. L. (2001). FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes & Development, 15, 2675-2686.
    • (2001) Genes & Development , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 28
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (1996). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes & Development, 16, 1466-1471.
    • (1996) Genes & Development , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 30
    • 0032725554 scopus 로고    scopus 로고
    • P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard, D. E., Berra, E., Gothie, E., Roux, D., & Pouyssegur, J. (1999). p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. Journal of Biological Chemistry, 274, 32631-32637.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 31
    • 33845403070 scopus 로고    scopus 로고
    • Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha
    • Mylonis, I., Chachami, G., Samiotaki, M., Panayotou, G., Paraskeva, E., Kalousi, A., et al. (2006). Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. Journal of Biological Chemistry, 281, 33095-33106.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 33095-33106
    • Mylonis, I.1    Chachami, G.2    Samiotaki, M.3    Panayotou, G.4    Paraskeva, E.5    Kalousi, A.6
  • 32
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw, R. J., & Cantley, L. C. (2006). Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature, 441, 424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 33
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M. M., et al. (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Research, 60, 1541-1545.
    • (2000) Cancer Research , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6
  • 34
    • 0035477438 scopus 로고    scopus 로고
    • Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
    • Blancher, C., Moore, J. W., Robertson, N., & Harris, A. L. (2001) Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Research, 61, 7349-7355.
    • (2001) Cancer Research , vol.61 , pp. 7349-7355
    • Blancher, C.1    Moore, J.W.2    Robertson, N.3    Harris, A.L.4
  • 37
    • 0033830523 scopus 로고    scopus 로고
    • Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature
    • Grunstein, J., Masbad, J. J., Hickey, R., Giordano, F., & Johnson, R. S. (2000) Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature. Molecular and Cellular Biology, 20, 7282-7291.
    • (2000) Molecular and Cellular Biology , vol.20 , pp. 7282-7291
    • Grunstein, J.1    Masbad, J.J.2    Hickey, R.3    Giordano, F.4    Johnson, R.S.5
  • 38
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., et al. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Molecular and Cellular Biology, 16, 4604-4613.
    • (1996) Molecular and Cellular Biology , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 40
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., et al. (1996). Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature, 380, 439-442.
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3    Dowd, M.4    Lu, L.5    O'Shea, K.S.6
  • 41
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein, J., Roberts, W. G., Mathieu-Costello, O., Hanahan, D., Johnson, R. S. (1999). Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Research, 59, 1592-1598.
    • (1999) Cancer Research , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 43
    • 23844450576 scopus 로고    scopus 로고
    • A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma
    • Das, B., Yeger, H., Tsuchida, R., Torkin, R., Gee, M. F., Thorner, P. S. et al. (2005). A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Research, 65, 7267-7275.
    • (2005) Cancer Research , vol.65 , pp. 7267-7275
    • Das, B.1    Yeger, H.2    Tsuchida, R.3    Torkin, R.4    Gee, M.F.5    Thorner, P.S.6
  • 45
    • 0033975850 scopus 로고    scopus 로고
    • Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
    • Kimura, H., Weisz, A., Kurashima, Y., Hashimoto, K., Ogura, T., D'Acquisto, F., et al. (2000). Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide. Blood, 95, 189-197.
    • (2000) Blood , vol.95 , pp. 189-197
    • Kimura, H.1    Weisz, A.2    Kurashima, Y.3    Hashimoto, K.4    Ogura, T.5    D'Acquisto, F.6
  • 46
    • 0031888729 scopus 로고    scopus 로고
    • Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
    • Palmer, L. A., Semenza, G. L., Stoler, M. H., & Johns, R. A. (1998). Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. American Journal of Physiology, 274, L212-219.
    • (1998) American Journal of Physiology , vol.274
    • Palmer, L.A.1    Semenza, G.L.2    Stoler, M.H.3    Johns, R.A.4
  • 47
    • 0033976342 scopus 로고    scopus 로고
    • Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
    • Jung, F., Palmer, L. A., Zhou, N., & Johns, R. A. (2000). Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circulation Research, 86, 319-325.
    • (2000) Circulation Research , vol.86 , pp. 319-325
    • Jung, F.1    Palmer, L.A.2    Zhou, N.3    Johns, R.A.4
  • 48
    • 0344012597 scopus 로고    scopus 로고
    • Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter
    • Coulet, F., Nadaud, S., Agrapart, M., & Soubrier, F. (2003). Identification of hypoxia-response element in the human endothelial nitric oxide synthase gene promoter. Journal of Biological Chemistry, 278, 46230-46240.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 46230-46240
    • Coulet, F.1    Nadaud, S.2    Agrapart, M.3    Soubrier, F.4
  • 52
    • 33646063560 scopus 로고    scopus 로고
    • Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126
    • Cullis, E. R., Kalber, T. L., Ashton, S. E., Cartwright, J. E., Griffiths, J. R., Ryan, A. J., et al. (2006). Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126. Microvascular Research, 71, 76-84.
    • (2006) Microvascular Research , vol.71 , pp. 76-84
    • Cullis, E.R.1    Kalber, T.L.2    Ashton, S.E.3    Cartwright, J.E.4    Griffiths, J.R.5    Ryan, A.J.6
  • 53
    • 18144413583 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling in tumorigenesis
    • Grose, R., & Dickson, C. (2005). Fibroblast growth factor signaling in tumorigenesis. Cytokine & Growth Factor Reviews, 16, 179-186.
    • (2005) Cytokine & Growth Factor Reviews , vol.16 , pp. 179-186
    • Grose, R.1    Dickson, C.2
  • 54
    • 14944380568 scopus 로고    scopus 로고
    • In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: Involvement of PI-3K/Akt and MEK1/ERK pathways
    • Shi, Y. H., Wang, Y. X., Bingle, L., Gong, L. H., Heng, W. J., Li, Y., et al. (2005). In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways. Journal of Pathology, 205, 530-536.
    • (2005) Journal of Pathology , vol.205 , pp. 530-536
    • Shi, Y.H.1    Wang, Y.X.2    Bingle, L.3    Gong, L.H.4    Heng, W.J.5    Li, Y.6
  • 55
    • 0037228960 scopus 로고    scopus 로고
    • PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    • Pore, N., Liu, S., Haas-Kogan, D. A., O'Rourke, D. M., & Maity, A. (2003). PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Research, 63, 236-241.
    • (2003) Cancer Research , vol.63 , pp. 236-241
    • Pore, N.1    Liu, S.2    Haas-Kogan, D.A.3    O'Rourke, D.M.4    Maity, A.5
  • 56
    • 33645504221 scopus 로고    scopus 로고
    • Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
    • Calvani, M., Rapisarda, A., Uranchimeg, B., Shoemaker. R. H., & Melillo, G. (2006). Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood, 107, 2705-2712.
    • (2006) Blood , vol.107 , pp. 2705-2712
    • Calvani, M.1    Rapisarda, A.2    Uranchimeg, B.3    Melillo, R.H.4
  • 57
    • 0036558290 scopus 로고    scopus 로고
    • Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
    • Li, J., Shworak, N. W., & Simons, M. (2002). Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. Journal of Cell Science, 115, 1951-1959.
    • (2002) Journal of Cell Science , vol.115 , pp. 1951-1959
    • Li, J.1    Shworak, N.W.2    Simons, M.3
  • 58
    • 0037501724 scopus 로고    scopus 로고
    • Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression
    • Brat, D. J., & Mapstone, T. B. (2003). Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression. Annals of Internal Medicine, 138, 659-668.
    • (2003) Annals of Internal Medicine , vol.138 , pp. 659-668
    • Brat, D.J.1    Mapstone, T.B.2
  • 59
    • 0036362221 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence in human tumors: More than just expression?
    • Suppl 4
    • Arteaga, C. L. (2002). Epidermal growth factor receptor dependence in human tumors: more than just expression? Oncologist, 7(Suppl 4), 31-39.
    • (2002) Oncologist , vol.7 , pp. 31-39
    • Arteaga, C.L.1
  • 60
    • 33744903661 scopus 로고    scopus 로고
    • PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib
    • Ueda, S., Basaki, Y., Yoshie, M., Ogawa, K., Sakisaka, S., Kuwano, M., et al. (2006). PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib. Cancer Research, 66, 5346-5353.
    • (2006) Cancer Research , vol.66 , pp. 5346-5353
    • Ueda, S.1    Basaki, Y.2    Yoshie, M.3    Ogawa, K.4    Sakisaka, S.5    Kuwano, M.6
  • 61
    • 33644546368 scopus 로고    scopus 로고
    • Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors
    • Amin, D. N., Hida, K., Bielenberg, D. R., & Klagsbrun, M. (2006). Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. Cancer Research, 66, 2173-2180.
    • (2006) Cancer Research , vol.66 , pp. 2173-2180
    • Amin, D.N.1    Hida, K.2    Bielenberg, D.R.3    Klagsbrun, M.4
  • 62
    • 30944442620 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells
    • Yoshida, D., Kim, K., Noha, M., & Teramoto, A. (2006). Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells. Journal of Neuro-oncology, 76, 13-21.
    • (2006) Journal of Neuro-oncology , vol.76 , pp. 13-21
    • Yoshida, D.1    Kim, K.2    Noha, M.3    Teramoto, A.4
  • 63
    • 33749503264 scopus 로고    scopus 로고
    • KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties
    • Nakamura, K., Taguchi, E., Miura, T., Yamamoto, A., Takahashi, K., Bichat, F., et al. (2006). KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Research, 66, 9134-9142.
    • (2006) Cancer Research , vol.66 , pp. 9134-9142
    • Nakamura, K.1    Taguchi, E.2    Miura, T.3    Yamamoto, A.4    Takahashi, K.5    Bichat, F.6
  • 64
    • 34250017806 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells
    • Lederle, W., Stark, H. J., Skobe, M., Fusenig, N. E., & Mueller, M. M. (2006). Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. American Journal of Pathology, 169, 1767-1783.
    • (2006) American Journal of Pathology , vol.169 , pp. 1767-1783
    • Lederle, W.1    Stark, H.J.2    Skobe, M.3    Fusenig, N.E.4    Mueller, M.M.5
  • 65
    • 12344287138 scopus 로고    scopus 로고
    • Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors
    • Pages, G., & Pouyssegur, J. (2005). Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors. Cardiovascular Research, 65, 564-573.
    • (2005) Cardiovascular Research , vol.65 , pp. 564-573
    • Pages, G.1    Pouyssegur, J.2
  • 66
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang, S., Pettaway, C. A., Uehara, H., Bucana, C. D., & Fidler, I. J. (2001). Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene, 20, 4188-4197.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 67
    • 33846995958 scopus 로고    scopus 로고
    • Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis
    • Schmidt, D., Textor, B., Pein, O. T., Licht, A. H., Andrecht, S., Sator-Schmitt, et al. (2007). Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO Journal, 26, 710-719.
    • (2007) EMBO Journal , vol.26 , pp. 710-719
    • Schmidt, D.1    Textor, B.2    Pein, O.T.3    Licht, A.H.4    Andrecht, S.5    Sator-Schmitt, M.6
  • 68
    • 1642329821 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
    • Mizukami, Y., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., & Chung, D. C. (2004). Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Research, 64, 1765-1772.
    • (2004) Cancer Research , vol.64 , pp. 1765-1772
    • Mizukami, Y.1    Li, J.2    Zhang, X.3    Zimmer, M.A.4    Iliopoulos, O.5    Chung, D.C.6
  • 69
    • 24744438663 scopus 로고    scopus 로고
    • Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
    • Mizukami, Y., Jo, W. S., Duerr, E. M., Gala, M., Li, J., Zhang, X., et al. (2005) Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nature Medicine, 11, 992-997.
    • (2005) Nature Medicines , vol.11 , pp. 992-997
    • Mizukami, Y.1    Jo, W.S.2    Duerr, E.M.3    Gala, M.4    Li, J.5    Zhang, X.6
  • 70
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003). Targeting HIF-1 for cancer therapy. Nature Reviews Cancer, 3, 721-732.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 71
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E. C., Lu N., Selig, M., et al. (1998). Tumor induction of VEGF promoter activity in stromal cells. Cell, 94, 715-725.
    • (1998) Cell , vol.94 , pp. 715-725
    • Fukumura, D.1    Xavier, R.2    Sugiura, T.3    Chen, Y.4    Park, E.C.5    Lu, N.6
  • 72
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw, B., Song, H., Tihan, T., Bosze, J., Ferrara, N., Gerber, H. P., et al. (2003). The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell, 4, 133-146.
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3    Bosze, J.4    Ferrara, N.5    Gerber, H.P.6
  • 73
    • 0033571939 scopus 로고    scopus 로고
    • Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin
    • Zaman, K., Ryu, H., Hall, D., O'Donovan, K., Lin, K. I., Miller M. P., et al. (1999). Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. Journal of Neuroscience, 19, 9821-9830.
    • (1999) Journal of Neuroscience , vol.19 , pp. 9821-9830
    • Zaman, K.1    Ryu, H.2    Hall, D.3    O'Donovan, K.4    Lin, K.I.5    Miller, M.P.6
  • 74
    • 29244485561 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. a target for neuroprotection in the central nervous system
    • Siddiq, A., Ayoub, I. A., Chavez, J. C., Aminova, L., Shah, S., LaManna, J. C., et al. (2005). Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. Journal of Biological Chemistry, 280, 41732-41743.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 41732-41743
    • Siddiq, A.1    Ayoub, I.A.2    Chavez, J.C.3    Aminova, L.4    Shah, S.5    Lamanna, J.C.6
  • 75
    • 34447274187 scopus 로고    scopus 로고
    • Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model
    • Lee, H. J., Kim, K. S., Park, I. H., & Kim, S. U. (2007). Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS ONE 2: e156.
    • (2007) PLoS ONE , vol.2
    • Lee, H.J.1    Kim, K.S.2    Park, I.H.3    Kim, S.U.4
  • 76
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., et al. (2001). Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genetics, 28, 131-138
    • (2001) Nature Genetics , vol.28 , pp. 131-138
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3    Beck, H.4    Nuyens, D.5    Brusselmans, K.6
  • 77
    • 0036853422 scopus 로고    scopus 로고
    • Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells
    • Martinez, P., Esbrit, P., Rodrigo, A., Alvarez-Arroyo, M. V., Martinez, M. E. (2002). Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells. Osteoporosis International, 13, 874-881.
    • (2002) Osteoporosis International , vol.13 , pp. 874-881
    • Martinez, P.1    Esbrit, P.2    Rodrigo, A.3    Alvarez-Arroyo, M.V.4    Martinez, M.E.5
  • 78
    • 27144509839 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: Evidence that angiogenesis participates in alveolarization
    • Thebaud, B., Ladha, F., Michelakis, E. D., Sawicka, M., Thurston, G., Eaton, F., et al. (2005). Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation, 112, 2477-2486.
    • (2005) Circulation , vol.112 , pp. 2477-2486
    • Thebaud, B.1    Ladha, F.2    Michelakis, E.D.3    Sawicka, M.4    Thurston, G.5    Eaton, F.6


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