-
1
-
-
33644905318
-
N-acetylcysteine-passe-partout or much ado about nothing?
-
Aitio M.L. N-acetylcysteine-passe-partout or much ado about nothing?. Br. J. Clin. Pharmacol. 61 (2006) 5-15
-
(2006)
Br. J. Clin. Pharmacol.
, vol.61
, pp. 5-15
-
-
Aitio, M.L.1
-
2
-
-
20044394527
-
Developmental context determines latency of MYC-induced tumorigenesis
-
10.1371/journal.pbio.0020332 Published online September 28, 2004
-
Beer S., Zetterberg A., Ihrie R.A., McTaggart R.A., Yang Q., Bradon N., Arvanitis C., Attardi L.D., Feng S., Ruebner B., et al. Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol. 2 (2004) e332 10.1371/journal.pbio.0020332 Published online September 28, 2004
-
(2004)
PLoS Biol.
, vol.2
-
-
Beer, S.1
Zetterberg, A.2
Ihrie, R.A.3
McTaggart, R.A.4
Yang, Q.5
Bradon, N.6
Arvanitis, C.7
Attardi, L.D.8
Feng, S.9
Ruebner, B.10
-
3
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E., Benizri E., Ginouves A., Volmat V., Roux D., and Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J. 22 (2003) 4082-4090
-
(2003)
EMBO J.
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
5
-
-
24144444133
-
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
-
Brunelle J.K., Bell E.L., Quesada N.M., Vercauteren K., Tiranti V., Zeviani M., Scarpulla R.C., and Chandel N.S. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 1 (2005) 409-414
-
(2005)
Cell Metab.
, vol.1
, pp. 409-414
-
-
Brunelle, J.K.1
Bell, E.L.2
Quesada, N.M.3
Vercauteren, K.4
Tiranti, V.5
Zeviani, M.6
Scarpulla, R.C.7
Chandel, N.S.8
-
7
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou M.A., Ringshausen I., Finch A.J., Swigart L.B., and Evan G.I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443 (2006) 214-217
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
8
-
-
16644389516
-
HIFs, hypoxia, and vascular development
-
Covello K.L., and Simon M.C. HIFs, hypoxia, and vascular development. Curr. Top. Dev. Biol. 62 (2004) 37-54
-
(2004)
Curr. Top. Dev. Biol.
, vol.62
, pp. 37-54
-
-
Covello, K.L.1
Simon, M.C.2
-
10
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan J.D., Bertout J.A., Hu C.J., Diehl J.A., and Simon M.C. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11 (2007) 335-347
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
11
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
Guzy R.D., Hoyos B., Robin E., Chen H., Liu L., Mansfield K.D., Simon M.C., Hammerling U., and Schumacker P.T. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1 (2005) 401-408
-
(2005)
Cell Metab.
, vol.1
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
Chen, H.4
Liu, L.5
Mansfield, K.D.6
Simon, M.C.7
Hammerling, U.8
Schumacker, P.T.9
-
12
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu C.J., Wang L.Y., Chodosh L.A., Keith B., and Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 23 (2003) 9361-9374
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
13
-
-
33744960411
-
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
-
Hummel M., Bentink S., Berger H., Klapper W., Wessendorf S., Barth T.F., Bernd H.W., Cogliatti S.B., Dierlamm J., Feller A.C., et al. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N. Engl. J. Med. 354 (2006) 2419-2430
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2419-2430
-
-
Hummel, M.1
Bentink, S.2
Berger, H.3
Klapper, W.4
Wessendorf, S.5
Barth, T.F.6
Bernd, H.W.7
Cogliatti, S.B.8
Dierlamm, J.9
Feller, A.C.10
-
14
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin W.G. Proline hydroxylation and gene expression. Annu. Rev. Biochem. 74 (2005) 115-128
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
15
-
-
24144467846
-
ROS: really involved in oxygen sensing
-
Kaelin Jr. W.G. ROS: really involved in oxygen sensing. Cell Metab. 1 (2005) 357-358
-
(2005)
Cell Metab.
, vol.1
, pp. 357-358
-
-
Kaelin Jr., W.G.1
-
16
-
-
0038107350
-
Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations
-
Karlsson A., Giuriato S., Tang F., Fung-Weier J., Levan G., and Felsher D.W. Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood 101 (2003) 2797-2803
-
(2003)
Blood
, vol.101
, pp. 2797-2803
-
-
Karlsson, A.1
Giuriato, S.2
Tang, F.3
Fung-Weier, J.4
Levan, G.5
Felsher, D.W.6
-
17
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly B.D., Hackett S.F., Hirota K., Oshima Y., Cai Z., Berg-Dixon S., Rowan A., Yan Z., Campochiaro P.A., and Semenza G.L. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 93 (2003) 1074-1081
-
(2003)
Circ. Res.
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
Oshima, Y.4
Cai, Z.5
Berg-Dixon, S.6
Rowan, A.7
Yan, Z.8
Campochiaro, P.A.9
Semenza, G.L.10
-
18
-
-
0037446983
-
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells
-
Knowles H.J., Raval R.R., Harris A.L., and Ratcliffe P.J. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res. 63 (2003) 1764-1768
-
(2003)
Cancer Res.
, vol.63
, pp. 1764-1768
-
-
Knowles, H.J.1
Raval, R.R.2
Harris, A.L.3
Ratcliffe, P.J.4
-
19
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M., Kageyama Y., Pete E.A., Horikawa I., Barrett J.C., and Huang L.E. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 23 (2004) 1949-1956
-
(2004)
EMBO J.
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
20
-
-
15244344206
-
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
-
Koshiji M., To K.K., Hammer S., Kumamoto K., Harris A.L., Modrich P., and Huang L.E. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol. Cell 17 (2005) 793-803
-
(2005)
Mol. Cell
, vol.17
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
Kumamoto, K.4
Harris, A.L.5
Modrich, P.6
Huang, L.E.7
-
21
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
Krishnamachary B., Zagzag D., Nagasawa H., Rainey K., Okuyama H., Baek J.H., and Semenza G.L. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 66 (2006) 2725-2731
-
(2006)
Cancer Res.
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
Zagzag, D.2
Nagasawa, H.3
Rainey, K.4
Okuyama, H.5
Baek, J.H.6
Semenza, G.L.7
-
22
-
-
0038745839
-
Persistent oxidative stress in chromosomally unstable cells
-
Limoli C.L., Giedzinski E., Morgan W.F., Swarts S.G., Jones G.D., and Hyun W. Persistent oxidative stress in chromosomally unstable cells. Cancer Res. 63 (2003) 3107-3111
-
(2003)
Cancer Res.
, vol.63
, pp. 3107-3111
-
-
Limoli, C.L.1
Giedzinski, E.2
Morgan, W.F.3
Swarts, S.G.4
Jones, G.D.5
Hyun, W.6
-
23
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Liu Y.V., Baek J.H., Zhang H., Diez R., Cole R.N., and Semenza G.L. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol. Cell 25 (2007) 207-217
-
(2007)
Mol. Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
24
-
-
22144453538
-
c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
-
Louis S.F., Vermolen B.J., Garini Y., Young I.T., Guffei A., Lichtensztejn Z., Kuttler F., Chuang T.C., Moshir S., Mougey V., et al. c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proc. Natl. Acad. Sci. USA 102 (2005) 9613-9618
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9613-9618
-
-
Louis, S.F.1
Vermolen, B.J.2
Garini, Y.3
Young, I.T.4
Guffei, A.5
Lichtensztejn, Z.6
Kuttler, F.7
Chuang, T.C.8
Moshir, S.9
Mougey, V.10
-
25
-
-
29644442625
-
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
-
Lu H., Dalgard C.L., Mohyeldin A., McFate T., Tait A.S., and Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J. Biol. Chem. 280 (2005) 41928-41939
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41928-41939
-
-
Lu, H.1
Dalgard, C.L.2
Mohyeldin, A.3
McFate, T.4
Tait, A.S.5
Verma, A.6
-
26
-
-
0242319858
-
Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress
-
Mantovani G., Maccio A., Madeddu C., Mura L., Gramignano G., Lusso M.R., Massa E., Mocci M., and Serpe R. Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J. Mol. Med. 81 (2003) 664-673
-
(2003)
J. Mol. Med.
, vol.81
, pp. 664-673
-
-
Mantovani, G.1
Maccio, A.2
Madeddu, C.3
Mura, L.4
Gramignano, G.5
Lusso, M.R.6
Massa, E.7
Mocci, M.8
Serpe, R.9
-
27
-
-
33845301978
-
Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets
-
Narayanan B.A. Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. Curr. Cancer Drug Targets 6 (2006) 711-727
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 711-727
-
-
Narayanan, B.A.1
-
28
-
-
0022411105
-
Effect of dietary ascorbic acid on the incidence of spontaneous mammary tumors in RIII mice
-
Pauling L., Nixon J.C., Stitt F., Marcuson R., Dunham W.B., Barth R., Bensch K., Herman Z.S., Blaisdell B.E., Tsao C., et al. Effect of dietary ascorbic acid on the incidence of spontaneous mammary tumors in RIII mice. Proc. Natl. Acad. Sci. USA 82 (1985) 5185-5189
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 5185-5189
-
-
Pauling, L.1
Nixon, J.C.2
Stitt, F.3
Marcuson, R.4
Dunham, W.B.5
Barth, R.6
Bensch, K.7
Herman, Z.S.8
Blaisdell, B.E.9
Tsao, C.10
-
29
-
-
3543129379
-
Chemical-induced DNA damage and human cancer risk
-
Poirier M.C. Chemical-induced DNA damage and human cancer risk. Nat. Rev. Cancer 4 (2004) 630-637
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 630-637
-
-
Poirier, M.C.1
-
30
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J., Dayan F., and Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
31
-
-
33750569401
-
Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model
-
Raman V., Artemov D., Pathak A.P., Winnard Jr. P.T., McNutt S., Yudina A., Bogdanov Jr. A., and Bhujwalla Z.M. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 66 (2006) 9929-9936
-
(2006)
Cancer Res.
, vol.66
, pp. 9929-9936
-
-
Raman, V.1
Artemov, D.2
Pathak, A.P.3
Winnard Jr., P.T.4
McNutt, S.5
Yudina, A.6
Bogdanov Jr., A.7
Bhujwalla, Z.M.8
-
32
-
-
33745263216
-
Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice
-
Reliene R., and Schiestl R.H. Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice. DNA Repair (Amst.) 5 (2006) 852-859
-
(2006)
DNA Repair (Amst.)
, vol.5
, pp. 852-859
-
-
Reliene, R.1
Schiestl, R.H.2
-
33
-
-
3442902484
-
Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice
-
Reliene R., Fischer E., and Schiestl R.H. Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res. 64 (2004) 5148-5153
-
(2004)
Cancer Res.
, vol.64
, pp. 5148-5153
-
-
Reliene, R.1
Fischer, E.2
Schiestl, R.H.3
-
34
-
-
28644447272
-
The antioxidant function of the p53 tumor suppressor
-
Sablina A.A., Budanov A.V., Ilyinskaya G.V., Agapova L.S., Kravchenko J.E., and Chumakov P.M. The antioxidant function of the p53 tumor suppressor. Nat. Med. 11 (2005) 1306-1313
-
(2005)
Nat. Med.
, vol.11
, pp. 1306-1313
-
-
Sablina, A.A.1
Budanov, A.V.2
Ilyinskaya, G.V.3
Agapova, L.S.4
Kravchenko, J.E.5
Chumakov, P.M.6
-
35
-
-
26944493084
-
Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model
-
Sander S., Bullinger L., Karlsson A., Giuriato S., Hernandez-Boussard T., Felsher D.W., and Pollack J.R. Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model. Oncogene 24 (2005) 6101-6107
-
(2005)
Oncogene
, vol.24
, pp. 6101-6107
-
-
Sander, S.1
Bullinger, L.2
Karlsson, A.3
Giuriato, S.4
Hernandez-Boussard, T.5
Felsher, D.W.6
Pollack, J.R.7
-
36
-
-
0033523928
-
Control of cell growth by c-Myc in the absence of cell division
-
Schuhmacher M., Staege M.S., Pajic A., Polack A., Weidle U.H., Bornkamm G.W., Eick D., and Kohlhuber F. Control of cell growth by c-Myc in the absence of cell division. Curr. Biol. 9 (1999) 1255-1258
-
(1999)
Curr. Biol.
, vol.9
, pp. 1255-1258
-
-
Schuhmacher, M.1
Staege, M.S.2
Pajic, A.3
Polack, A.4
Weidle, U.H.5
Bornkamm, G.W.6
Eick, D.7
Kohlhuber, F.8
-
37
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
38
-
-
4143078133
-
Biological relevance of adduct detection to the chemoprevention of cancer
-
Sharma R.A., and Farmer P.B. Biological relevance of adduct detection to the chemoprevention of cancer. Clin. Cancer Res. 10 (2004) 4901-4912
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 4901-4912
-
-
Sharma, R.A.1
Farmer, P.B.2
-
39
-
-
0036285034
-
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
-
Vafa O., Wade M., Kern S., Beeche M., Pandita T.K., Hampton G.M., and Wahl G.M. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell 9 (2002) 1031-1044
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
Beeche, M.4
Pandita, T.K.5
Hampton, G.M.6
Wahl, G.M.7
-
40
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Zeller K.I., Dang C.V., and Semenza G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11 (2007) 407-420
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.V.7
Semenza, G.L.8
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