Hypoxia and radiotherapy: Opportunities for improved outcomes in cancer treatment

Cancer and Metastasis Reviews

Volumn 26, Issue 2, 2007, Pages 241-248

  Moeller, Benjamin J ^a   Richardson, Rachel A ^a   Dewhirst, Mark W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cancer; HIF 1; Hypoxia; Radiation

Indexed keywords

CARBOGEN; CISPLATIN; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1; NICOTINAMIDE; NITROIMIDAZOLE; TIRAPAZAMINE; TRANSCRIPTION FACTOR;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER SURVIVAL; CLINICAL TRIAL; GENE ACTIVITY; HEAD AND NECK CARCINOMA; HUMAN; HYPOXIA; OXYGENATION; PRIORITY JOURNAL; RADIOSENSITIVITY; REVIEW; SOFT TISSUE CANCER; TREATMENT OUTCOME; UPREGULATION; UTERINE CERVIX CARCINOMA;

CELL HYPOXIA; HUMANS; NEOPLASMS; OXYGEN CONSUMPTION; RADIATION TOLERANCE; TREATMENT OUTCOME;

EID: 34547103992     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-007-9056-0     Document Type: Review

References (56)

1. Deschner, E. E., & Gray, L. H. (1959) Influence of oxygen tension on x-ray-induced chromosomal damage in Ehrlich ascites tumor cells irradiated in vitro and in vivo. Radiation Research, 11, 115-146.
2. Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. (1953). The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. British Journal of Radiology, 26, 638-648.
3. Henk, J. M., Kunkler, P. B., & Smith, C. W. (1977). Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet, 2, 101-103.
4. Dische, S., Anderson, P. J., Sealy, R., & Watson, E. R. (1983). Carcinoma of the cervix-anaemia, radiotherapy and hyperbaric oxygen. British Journal of Radiology, 56, 251-255.
5. Bennett, M., Feldmeier, J., Smee, R., & Milross, C. (2005) Hyperbaric oxygenation for tumour sensitisation to radiotherapy. Cochrane Database Syst Rev, CD005007.
6. Evans, J. C., & Bergsjo, P. (1965). The influence of anemia on the results of radiotherapy in carcinoma of the cervix. Radiology, 84, 709-717.
7. Henke, M., Laszig, R., Rube, C., Schafer, U., Haase, K. D., Schilcher, B., et al. (2003). Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. Lancet, 362, 1255-1260.
8. Hill, S. A., Collingridge, D. R., Vojnovic, B., & Chaplin, D. J. (1998). Tumour radiosensitization by high-oxygen-content gases: Influence of the carbon dioxide content of the inspired gas on PO2, microcirculatory function and radiosensitivity. International Journal of Radiation Oncology Biology Physics, 40, 943-951.
9. Powell, M. E., Collingridge, D. R., Saunders, M. I., Hoskin, P. J., Hill, S. A., & Chaplin, D. J. (1999). Improvement in human tumour oxygenation with carbogen of varying carbon dioxide concentrations. Radiotherapy and Oncology, 50, 167-171.
10. Dewhirst, M. W., Ong, E. T., Rosner, G. L., Rehmus, S. W., Shan, S., Braun, R., et al. (1996). Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content. British Journal of Cancer Supplement, 27, S241-S246.
11. Horsman, M. R., Chaplin, D. J., & Brown, J. M. (1989). Tumor radiosensitization by nicotinamide: A result of improved perfusion and oxygenation. Radiation Research, 118, 139-150.
12. Kaanders, J. H., Bussink, J., & van der Kogel, A. J. (2002). ARCON: A novel biology-based approach in radiotherapy. Lancet Oncology, 3, 728-737.
13. Kavanagh, B. D., Khandelwal, S. R., Schmidt-Ullrich, R. K., Roberts, J. D., Shaw, E. G., Pearlman, A. D., et al. (2001). A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: Tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics. International Journal of Radiation Oncology Biology Physics, 49, 1133-1139.
14. Teicher, B. A., Herman, T. S., & Menon, K. (1992). Enhancement of fractionated radiation therapy by an experimental concentrated perflubron emulsion (Oxygent) in the Lewis lung carcinoma. Biomaterials Artificial Cells and Immobilization Biotechnology, 20, 899-902.
15. Teicher, B. A., Holden, S. A., Ara, G., Herman, T. S., Hopkins, R. E., & Menon, K. (1992). Effect of a bovine hemoglobin preparation (SBHS) on the response of two murine solid tumors to radiation therapy or chemotherapeutic alkylating agents. Biomaterials Artificial Cells and Immobilization Biotechnology, 20, 657-660.
16. Kavanagh, B. D., Coffey, B. E., Needham, D., Hochmuth, R. M., & Dewhirst, M. W. (1993). The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. British Journal of Cancer, 67, 734-741.
17. Chapman, J. D. (1979). Hypoxic sensitizers-Implications for radiation therapy. New England Journal of Medicine, 301, 1429-1432.
18. Overgaard, J. (1994). Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncology Research, 6, 509-518.
19. Rischin, D., Peters, L., Fisher, R., Macann, A., Denham, J., Poulsen, M., et al. (2005). Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). Journal of Clinical Oncology, 23, 79-87.
20. Song, C. W., Park, H. J., Lee, C. K., & Griffin, R. (2005). Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. International Journal of Hyperthermia, 21, 761-767.
21. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L. J., Dodge, R. K., Charles, H. C., et al. (1996). Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Research, 56, 5347-5350.
22. Jones, E. L., Oleson, J. R., Prosnitzm, L. R., Samulski, T. V., Vujaskovic, Z., Yu, D., et al. (2005). Randomized trial of hyperthermia and radiation for superficial tumors. Journal of Clinical Oncology, 23, 3079-3085.
23. Secomb, T. W., Hsu, R., & Dewhirst, M. W. (2004). Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: A theoretical model. International Journal of Radiation Oncology Biology Physics, 59, 572-578.
24. Kirkpatrick, J. P., Brizel, D. M., & Dewhirst, M. W. (2003). A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiation Research, 159, 336-344.
25. Snyder, S. A., Lanzen, J. L., Braun, R. D., Rosner, G., Secomb, T. W., Biaglow, J., et al. (2001). Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. International Journal of Radiation Oncology Biology Physics, 51, 494-506.
26. Shrieve, D. C., & Harris, J. W. (1985). The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizers. International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine, 48, 127-138.
27. Pettersen, E. O., & Wang, H. (1996). Radiation-modifying effect of oxygen in synchronized cells pre-treated with acute or prolonged hypoxia. International Journal of Radiation Biology, 70, 319-326.
28. Moeller, B. J., Dreher, M. R., Rabbani Z. N., Schroeder, T., Cao, Y., Li, C. Y., et al. (2005). Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell, 8, 99-110.
29. Moeller, B. J., & Dewhirst, M. W. (2006). HIF-1 and tumour radiosensitivity. British Journal of Cancer, 95, 1-5.
30. Moeller, B. J., Cao, Y., Li, C. Y., & Dewhirst, M. W. (2004). Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell, 5, 429-441.
31. Williams, K. J., Telfer, B. A., Xenaki, D., Sheridan, M. R., Desbaillets, I., Peters, H. J.,et al. (2005). Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiotherapy and Oncology, 75, 89-98.
32. Folkman, J. (2002). Role of angiogenesis in tumor growth and metastasis. Seminars in Oncology, 29, 15-18.
33. Garcia-Barros, M., Paris, F., Cordon-Cardo, C., Lyden, D., Rafii, S., Haimovitz-Friedman, A., et al. (2003). Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science, 300, 1155-1159.
34. Geng, L., Donnelly, E., McMahon, G., Lin, P. C., Sierra-Rivera, E., Oshinka, H., et al. (2001). Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Research, 61, 2413-2419.
35. Hess, C., Vuong, V., Hegyi, I., Riesterer, O., Wood, J., Fabbro, D., et al. (2001). Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth. British Journal of Cancer, 85, 2010-2016.
36. Kozin, S. V., Boucher, Y., Hicklin, D. J., Bohlen, P., Jain, R. K., & Suit, H. D. (2001). Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Research, 61, 39-44.
37. Lund, E. L., Bastholm, L., & Kristjansen, P. E. (2000). Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts. Clincal Cancer Research, 6, 971-978.
38. Ning, S., Laird, D., Cherrington, J. M., & Knox, S. J. (2002). The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiation Research, 157, 45-51.
39. Dunst, J., Stadler, P., Becker, A., Lautenschlager, C., Pelz, T., Hansgen, G., et al. (2003). Tumor volume and tumor hypoxia in head and neck cancers. The amount of the hypoxic volume is important. Strahlentherapie und Onkologie, 179, 521-526.
40. Nordsmark, M., & Overgaard, J. (2000). A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiotherapy and Oncology, 57, 39-43.
41. Stadler, P., Becker, A., Feldmann, H. J., Hansgen, G., Dunst, J., Wurschmidt, F., et al. (1999). Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. International Journal of Radiation Oncology Biology Physics, 44, 749-754.
42. Nordsmark, M., Overgaard, M., & Overgaard, J. (1996). Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiotherapy and Oncology, 41, 31-39.
43. Nordsmark, M., Bentzen, S. M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., et al. (2005). Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiotherapy and Oncology, 77, 18-24.
44. Brizel, D. M., Dodge, R. K., Clough, R. W., & Dewhirst, M. W. (1999). Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiotherapy and Oncology, 53, 113-117.
45. Rudat, V., Stadler, P., Becker, A., Vanselow, B., Dietz, A., Wannenmacher, M., et al. (2001). Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer. Strahlentherapie und Onkologie, 177, 462-468.
46. Rudat, V., Vanselow, B., Wollensack, P., Bettscheider, C., Osman-Ahmet, S., Eble, M. J., et al. (2000). Repeatability and prognostic impact of the pretreatment pO(2) histography in patients with advanced head and neck cancer. Radiotherapy and Oncology, 57, 31-37.
47. Adam, M. F., Gabalski, E. C., Bloch, D. A., Oehlert, J. W., Brown, J. M., Elsaid, A. A., et al. (1999). Tissue oxygen distribution in head and neck cancer patients. Head Neck, 21, 146-153.
48. Gatenby, R. A., Kessler, H. B., Rosenblum, J. S., Coia, L. R., Moldofsky, P. J., Hartz, W. H., et al. (1988). Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. International Journal of Radiation Oncology Biology Physics, 14, 831-838.
49. Fyles, A., Milosevic, M., Hedley, D., Pintilie, M., Levin, W., Manchul, L., et al. (2002). Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. Journal of Clinical Oncology, 20, 680-687.
50. Rofstad, E. K., Sundfor, K., Lyng, H., & Trope, C. G. (2000). Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. British Journal of Cancer, 83, 354-359.
51. Sundfor, K., Lyng, H., Trope, C. G., & Rofstad, E. K. (2000). Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: Relationships to pretreatment tumor oxygenation and vascularization. Radiotherapy and Oncology, 54, 101-107.
52. Fyles, A. W., Milosevic, M., Wong, R., Kavanagh, M. C., Pintilie, M., Sun, A., et al. (1998). Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiotherapy and Oncology, 48, 149-156.
53. Knocke, T. H., Weitmann, H. D., Feldmann, H. J., Selzer, E., & Potter, R. (1999). Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiotherapy Oncology, 53, 99-104.
54. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., & Vaupel, P. (1996). Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Research, 56, 4509-4515.
55. Nordsmark, M., Alsner, J., Keller, J., Nielsen, O. S., Jensen, O. M., Horsman, M. R., et al. (2001). Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations. British Journal Cancer, 84, 1070-1075.
56. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L. J., Bean, J. M., Prosnitz L. R., et al. (1996). Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Research, 56, 941-943.