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Volumn 26, Issue 2, 2007, Pages 261-271

Metastasis and stem cell pathways

Author keywords

Hypoxia; Metastasis; Stem cell; Tumor

Indexed keywords

ABC TRANSPORTER; CHEMOKINE RECEPTOR CXCR4; DNA BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; METALLOPROTEINASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN LYSINE 6 OXIDASE; UVOMORULIN;

EID: 34547118111     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-007-9053-3     Document Type: Review
Times cited : (62)

References (90)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., & Jain, R. K. (2000). Angiogenesis in cancer and other diseases. Nature, 407, 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 2
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur, J., Dayan, F., & Mazure, N. M. (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature, 441, 437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 3
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown, J. M., & Wilson, W. R. (2004). Exploiting tumour hypoxia in cancer treatment. Nature Reviews Cancer, 4, 437-447.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 4
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel, M., & Vaupel, P. (2001). Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. Journal of the National Cancer Institute, 93, 266-276.
    • (2001) Journal of the National Cancer Institute , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 5
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., et al. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 6
    • 0026782588 scopus 로고
    • Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy
    • Rodesch, F., Simon, P., Donner, C., & Jauniaux, E. (1992). Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstetrics & Gynecology, 80, 283-285.
    • (1992) Obstetrics & Gynecology , vol.80 , pp. 283-285
    • Rodesch, F.1    Simon, P.2    Donner, C.3    Jauniaux, E.4
  • 7
    • 0035142809 scopus 로고    scopus 로고
    • Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development
    • Lee, Y. M., Jeong, C. H., Koo, S. Y., Son, M. J., Song, H. S., Bae, S. K. et al., (2001). Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development. Developmental Dynamics, 220, 175-186.
    • (2001) Developmental Dynamics , vol.220 , pp. 175-186
    • Lee, Y.M.1    Jeong, C.H.2    Koo, S.Y.3    Son, M.J.4    Song, H.S.5    Bae, S.K.6
  • 8
    • 0018651820 scopus 로고
    • Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos
    • Morriss, G. M., & New, D. A. (1979). Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos. Journal of Embryology and Experimental Morphology, 54, 17-35.
    • (1979) Journal of Embryology and Experimental Morphology , vol.54 , pp. 17-35
    • Morriss, G.M.1    New, D.A.2
  • 10
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997). Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature, 386, 403-407.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 11
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., et al. (1998). Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes & Development, 12, 149-162.
    • (1998) Genes & Development , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3    Leung, S.W.4    Laughner, E.5    Wenger, R.H.6
  • 12
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan, H. E., Lo, J., & Johnson, R. S. (1998). HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO Journal, 17, 3005-3015.
    • (1998) EMBO Journal , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 13
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal, R., Clarke, M. F., & Morrison, S. J. (2003). Applying the principles of stem-cell biology to cancer. Nature Reviews Cancer, 3, 895-902.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 14
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., et al. (1994). A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature, 367, 645-648.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5    Caceres-Cortes, J.6
  • 15
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D., & Dick, J. E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine, 3, 730-737.
    • (1997) Natural Medicines , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 19
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien, C. A., Pollett, A., Gallinger, S., & Dick, J. E. (2007). A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature, 445, 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 21
    • 0030933062 scopus 로고    scopus 로고
    • Regulatory mechanisms in stem cell biology
    • Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997). Regulatory mechanisms in stem cell biology. Cell, 88, 287-298.
    • (1997) Cell , vol.88 , pp. 287-298
    • Morrison, S.J.1    Shah, N.M.2    Anderson, D.J.3
  • 22
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore, K. A., & Lemischka, I. R. (2006). Stem cells and their niches. Science, 311, 1880-1885.
    • (2006) Science , vol.311 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 23
    • 22944463642 scopus 로고    scopus 로고
    • Toward an understanding of the physiological function of Mammalian stem cells
    • Joseph, N. M., & Morrison, S. J. (2005). Toward an understanding of the physiological function of Mammalian stem cells. Developments in Cell, 9, 173-183.
    • (2005) Developments in Cell , vol.9 , pp. 173-183
    • Joseph, N.M.1    Morrison, S.J.2
  • 26
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison, S. J., & Kimble, J. (2006). Asymmetric and symmetric stem-cell divisions in development and cancer. Nature, 441, 1068-1074.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 27
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden, D. T. (2006). The stem-cell niche as an entity of action. Nature, 441, 1075-1079.
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 28
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • Li, L., & Neaves, W. B. (2006). Normal stem cells and cancer stem cells: The niche matters. Cancer Research, 66, 4553-4557.
    • (2006) Cancer Research , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 30
    • 0027443181 scopus 로고
    • The role of hypoxia in the maintenance of hematopoietic stem cells
    • Cipolleschi, M. G., Dello Sbarba, P., & Olivotto, M. (1993). The role of hypoxia in the maintenance of hematopoietic stem cells. Blood, 82, 2031-2037.
    • (1993) Blood , vol.82 , pp. 2031-2037
    • Cipolleschi, M.G.1    Dello Sbarba, P.2    Olivotto, M.3
  • 31
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C., & Morrison, S. J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121, 1109-1121.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Terhorst, C.4    Morrison, S.J.5
  • 33
    • 0033214848 scopus 로고    scopus 로고
    • Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
    • Adelman, D. M., Maltepe, E., & Simon, M. C. (1999). Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes & Development, 13, 2478-2483.
    • (1999) Genes & Development , vol.13 , pp. 2478-2483
    • Adelman, D.M.1    Maltepe, E.2    Simon, M.C.3
  • 34
    • 0034671706 scopus 로고    scopus 로고
    • Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
    • Adelman, D. M., Gertsenstein, M., Nagy, A., Simon, M. C., & Maltepe, E. (2000). Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes & Development, 14, 3191-3203.
    • (2000) Genes & Development , vol.14 , pp. 3191-3203
    • Adelman, D.M.1    Gertsenstein, M.2    Nagy, A.3    Simon, M.C.4    Maltepe, E.5
  • 35
    • 6944233515 scopus 로고    scopus 로고
    • Hypoxia affects mesoderm and enhances hemangioblast specification during early development
    • Ramirez-Bergeron, D. L., Runge, A., Dahl, K. D., Fehling, H. J., Keller, G., & Simon, M. C. (2004). Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development, 131, 4623-4634.
    • (2004) Development , vol.131 , pp. 4623-4634
    • Ramirez-Bergeron, D.L.1    Runge, A.2    Dahl, K.D.3    Fehling, H.J.4    Keller, G.5    Simon, M.C.6
  • 36
    • 33745490023 scopus 로고    scopus 로고
    • HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature
    • Ramirez-Bergeron, D. L., Runge, A., Adelman, D. M., Gohil, M., & Simon, M. C. (2006). HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Developmental Cell, 11, 81-92.
    • (2006) Developmental Cell , vol.11 , pp. 81-92
    • Ramirez-Bergeron, D.L.1    Runge, A.2    Adelman, D.M.3    Gohil, M.4    Simon, M.C.5
  • 37
    • 0030879909 scopus 로고    scopus 로고
    • Regulation of human placental development by oxygen tension
    • Genbacev, O., Zhou, Y., Ludlow, J. W., & Fisher, S. J. (1997). Regulation of human placental development by oxygen tension. Science, 277, 1669-1672.
    • (1997) Science , vol.277 , pp. 1669-1672
    • Genbacev, O.1    Zhou, Y.2    Ludlow, J.W.3    Fisher, S.J.4
  • 38
    • 0034307432 scopus 로고    scopus 로고
    • Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells
    • Morrison, S. J., Csete, M., Groves, A. K., Melega, W., Wold, B., & Anderson, D. J. (2000). Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. Journal of Neuroscience, 20, 7370-7376.
    • (2000) Journal of Neuroscience , vol.20 , pp. 7370-7376
    • Morrison, S.J.1    Csete, M.2    Groves, A.K.3    Melega, W.4    Wold, B.5    Anderson, D.J.6
  • 39
    • 0034307725 scopus 로고    scopus 로고
    • Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen
    • Studer, L., Csete, M., Lee, S. H., Kabbani, N., Walikonis, J., Wold, B., et al. (2000). Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. Journal of Neuroscience, 20, 7377-7383.
    • (2000) Journal of Neuroscience , vol.20 , pp. 7377-7383
    • Studer, L.1    Csete, M.2    Lee, S.H.3    Kabbani, N.4    Walikonis, J.5    Wold, B.6
  • 40
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: Stem cells in cancer
    • Polyak, K., & Hahn, W. C. (2006). Roots and stems: Stem cells in cancer. Nature Medicine, 12, 296-300.
    • (2006) Natural Medicines , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 41
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: The origin of the cancer stem cell: Current controversies and new insights
    • Bjerkvig, R., Tysnes, B. B., Aboody, K. S., Najbauer, J., & Terzis, A. J. (2005). Opinion: The origin of the cancer stem cell: current controversies and new insights. Nature Reviews. Cancer, 5, 899-904.
    • (2005) Nature Reviews. Cancer , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3    Najbauer, J.4    Terzis, A.J.5
  • 42
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh, Y. H., Wu, Q, Chew, J. L., Vega, V. B., Zhang, W., Chen, X., et al. (2006). The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics, 38, 431-440.
    • (2006) Nature Genetics , vol.38 , pp. 431-440
    • Loh, Y.H.1    Wu, Q.2    Chew, J.L.3    Vega, V.B.4    Zhang, W.5    Chen, X.6
  • 43
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang, G. L., & Semenza, G. L. (1995). Purification and characterization of hypoxia-inducible factor 1. Journal of Biological Chemistry, 270, 1230-1237.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 44
    • 33846254999 scopus 로고    scopus 로고
    • RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    • Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007). RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Molecular Cell, 25, 207-217.
    • (2007) Molecular Cell , vol.25 , pp. 207-217
    • Liu, Y.V.1    Baek, J.H.2    Zhang, H.3    Diez, R.4    Cole, R.N.5    Semenza, G.L.6
  • 45
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu, C. J., Wang, L. Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003). Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Molecular and Cellular Biology, 23, 9361-9374.
    • (2003) Molecular and Cellular Biology , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 46
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang, V., Davis, D. A., Haque, M., Huang, L. E., & Yarchoan, R. (2005). Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Research, 65, 3299-3306.
    • (2005) Cancer Research , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 47
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval, R. R., Lau, K. W., Tran, M. G., Sowter, H. M., Mandriota, S. J., Li, J. L., et al. (2005). Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology, 25, 5675-5686.
    • (2005) Molecular and Cellular Biology , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6
  • 48
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003). Targeting HIF-1 for cancer therapy. Nature Reviews. Cancer, 3, 721-732.
    • (2003) Nature Reviews. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 49
    • 33644747418 scopus 로고    scopus 로고
    • HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
    • Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C. J., et al. (2006). HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes & Development, 20, 557-570.
    • (2006) Genes & Development , vol.20 , pp. 557-570
    • Covello, K.L.1    Kehler, J.2    Yu, H.3    Gordan, J.D.4    Arsham, A.M.5    Hu, C.J.6
  • 50
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., et al. (1998). Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell, 95, 379-391.
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3    Niwa, H.4    Klewe-Nebenius, D.5    Chambers, I.6
  • 51
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa, H., Miyazaki, J., & Smith, A. G. (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics, 24, 372-376.
    • (2000) Nature Genetics , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 52
    • 28344436489 scopus 로고    scopus 로고
    • Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
    • Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., et al. (2005). Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell, 123, 917-929.
    • (2005) Cell , vol.123 , pp. 917-929
    • Niwa, H.1    Toyooka, Y.2    Shimosato, D.3    Strumpf, D.4    Takahashi, K.5    Yagi, R.6
  • 53
    • 0344063368 scopus 로고    scopus 로고
    • Oct-3/4 is a dose-dependent oncogenic fate determinant
    • Gidekel, S., Pizov, G., Bergman, Y., & Pikarsky, E. (2003). Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell, 4, 361-370.
    • (2003) Cancer Cell , vol.4 , pp. 361-370
    • Gidekel, S.1    Pizov, G.2    Bergman, Y.3    Pikarsky, E.4
  • 54
    • 16844386959 scopus 로고    scopus 로고
    • Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth
    • Covello, K. L., Simon, M. C., & Keith, B. (2005). Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Research, 65, 2277-2286.
    • (2005) Cancer Research , vol.65 , pp. 2277-2286
    • Covello, K.L.1    Simon, M.C.2    Keith, B.3
  • 55
    • 33646551228 scopus 로고    scopus 로고
    • Multiple functions of Notch signaling in self-renewing organs and cancer
    • Wilson, A., & Radtke, F. (2006). Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Letters, 580, 2860-2868.
    • (2006) FEBS Letters , vol.580 , pp. 2860-2868
    • Wilson, A.1    Radtke, F.2
  • 56
    • 0032915458 scopus 로고    scopus 로고
    • Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
    • Nofziger, D., Miyamoto, A., Lyons, K. M., & Weinmaster, G. (1999). Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development, 126, 1689-1702.
    • (1999) Development , vol.126 , pp. 1689-1702
    • Nofziger, D.1    Miyamoto, A.2    Lyons, K.M.3    Weinmaster, G.4
  • 57
  • 59
    • 33947217823 scopus 로고    scopus 로고
    • Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    • Kaidi, A., Williams, A. C., & Paraskeva, C. (2007). Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nature Cell Biology.
    • (2007) Nature Cell Biology
    • Kaidi, A.1    Williams, A.C.2    Paraskeva, C.3
  • 61
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
    • (in press).
    • Gordan, J. D., Bertout, J. A., Hu, C. J., Diehl, J. A., & Simon, M. C. (2007). HIF-2alpha promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity. Cancer Cell (in press).
    • (2007) Cancer Cell
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 62
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 63
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    • Koshiji, M., To, K. K., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., et al. (2005). HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Molecular Cell, 17, 793-803.
    • (2005) Molecular Cell , vol.17 , pp. 793-803
    • Koshiji, M.1    To, K.K.2    Hammer, S.3    Kumamoto, K.4    Harris, A.L.5    Modrich, P.6
  • 65
    • 24344440832 scopus 로고    scopus 로고
    • Hypoxia-induced dedifferentiation of tumor cells-A mechanism behind heterogeneity and aggressiveness of solid tumors
    • Axelson, H., Fredlund, E., Ovenberger, M., Landberg, G., & Pahlman, S. (2005). Hypoxia-induced dedifferentiation of tumor cells-A mechanism behind heterogeneity and aggressiveness of solid tumors. Seminars in Cell & Developmental Biology, 16, 554-563.
    • (2005) Seminars in Cell & Developmental Biology , vol.16 , pp. 554-563
    • Axelson, H.1    Fredlund, E.2    Ovenberger, M.3    Landberg, G.4    Pahlman, S.5
  • 67
    • 0037380791 scopus 로고    scopus 로고
    • Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ
    • Helczynska, K., Kronblad, A., Jogi, A., Nilsson, E., Beckman, S., Landberg, G., et al. (2003). Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Research, 63, 1441-1444.
    • (2003) Cancer Research , vol.63 , pp. 1441-1444
    • Helczynska, K.1    Kronblad, A.2    Jogi, A.3    Nilsson, E.4    Beckman, S.5    Landberg, G.6
  • 68
    • 4544361863 scopus 로고    scopus 로고
    • Induction of ID2 expression by hypoxia-inducible factor-1: A role in dedifferentiation of hypoxic neuroblastoma cells
    • Lofstedt, T., Jogi, A., Sigvardsson, M., Gradin K, Poellinger, L., Pahlman, S., et al. (2004). Induction of ID2 expression by hypoxia-inducible factor-1: A role in dedifferentiation of hypoxic neuroblastoma cells. Journal of Biological Chemistry, 279, 39223-39231.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 39223-39231
    • Lofstedt, T.1    Jogi, A.2    Sigvardsson, M.3    Gradin, K.4    Poellinger, L.5    Pahlman, S.6
  • 69
    • 20544465985 scopus 로고    scopus 로고
    • Regulation of transcription and translation by hypoxia
    • Liu, L., & Simon, M. C. (2004). Regulation of transcription and translation by hypoxia. Cancer Biology & Therapy, 3, 492-497.
    • (2004) Cancer Biology & Therapy , vol.3 , pp. 492-497
    • Liu, L.1    Simon, M.C.2
  • 70
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham, A. M., Howell, J. J., & Simon, M. C. (2003). A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. Journal of Biological Chemistry, 278, 29655-29660.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 71
    • 33646550165 scopus 로고    scopus 로고
    • Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
    • Connolly. E, Braunstein, S., Formenti, S., & Schneider, R. J. (2006). Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Molecular and Cellular Biology, 26, 3955-3965.
    • (2006) Molecular and Cellular Biology , vol.26 , pp. 3955-3965
    • Connolly, E.1    Braunstein, S.2    Formenti, S.3    Schneider, R.J.4
  • 72
    • 0345732640 scopus 로고    scopus 로고
    • MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar, D. C., Richardson, C. J., Tee, A. R., Cheatham, L., Tsou, C., & Blenis, J. (2004). mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Molecular and Cellular Biology, 24, 200-216.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 73
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes & Development, 16, 1472-1487.
    • (2002) Genes & Development , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 74
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • Easton, J. B., & Houghton, P. J. (2006). mTOR and cancer therapy. Oncogene, 25, 6436-6446.
    • (2006) Oncogene , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 75
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., et al. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell, 126, 955-968.
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Ouyang, H.2    Zhu, T.3    Lindvall, C.4    Wang, Y.5    Zhang, X.6
  • 76
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • Li, F., Tiede, B., Massague, J., & Kang, Y. (2007). Beyond tumorigenesis: cancer stem cells in metastasis. Cell Research, 17, 3-14.
    • (2007) Cell Research , vol.17 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 77
    • 0022479536 scopus 로고
    • Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell
    • Fidler, I. J., & Talmadge, J. E. (1986). Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell. Cancer Research, 46, 5167-5171.
    • (1986) Cancer Research , vol.46 , pp. 5167-5171
    • Fidler, I.J.1    Talmadge, J.E.2
  • 78
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai, T., Horiuchi, A., Wang, C., Oka, K., Ohira, S., & Nikaido, T., et al. (2003). Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. American Journal of Pathology, 163, 1437-1447.
    • (2003) American Journal of Pathology , vol.163 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3    Oka, K.4    Ohira, S.5    Nikaido, T.6
  • 80
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    • Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., & Baek, J. H., et al. (2006). Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Research, 66, 2725-2731.
    • (2006) Cancer Research , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Baek, J.H.6
  • 81
  • 83
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • Boccaccio C., & Comoglio, P. M. (2006). Invasive growth: A MET-driven genetic programme for cancer and stem cells. Nature Reviews. Cancer, 6, 637-645.
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 84
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003). Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature, 425, 307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 85
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers. A. F., Groom, A. C., & MacDonald, I. C. (2002). Dissemination and growth of cancer cells in metastatic sites. Nature Reviews. Cancer, 2, 563-572.
    • (2002) Nature Reviews. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 86
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean, M., Fojo, T., & Bates S. (2005). Tumour stem cells and drug resistance. Nature Reviews. Cancer, 5, 275-284.
    • (2005) Nature Reviews. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 88
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., et al. (2006). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature, 444, 756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6
  • 90
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    • Holmquist-Mengelbier, L., Fredlund, E., Lofstedt, T., Noguera, R., Navarro, S., Nilsson, H., et al. (2006). Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell, 10, 413-423.
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Lofstedt, T.3    Noguera, R.4    Navarro, S.5    Nilsson, H.6


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