The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

Oncogene

Volumn 24, Issue 27, 2005, Pages 4433-4441

  Luwor, Rodney B ^a   Lu, Yang ^a   Li, Xinqun ^a   Mendelsohn, John ^a   Fan, Zhen ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; EGF receptor; HIF 1 ; PTEN; Ras; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CETUXIMAB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTACYSTIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; VASCULOTROPIN; ANTINEOPLASTIC AGENT; HIF1A PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN A;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CHROMOSOME 10; CHROMOSOME DELETION 5; CHROMOSOME MUTATION; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; TUMOR CELL LINE;

ANIMALIA;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 21744454494     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208625     Document Type: Article

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