-
1
-
-
0034663989
-
HIF-1 and human disease: One highly involved factor
-
Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev 2000;14:1983-91.
-
(2000)
Genes Dev
, vol.14
, pp. 1983-1991
-
-
Semenza, G.L.1
-
3
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
4
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
5
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
6
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-8.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
7
-
-
17144416530
-
Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxiainducible factor-2alpha in HEK293T cells
-
Wang V, Davis DA, Haque M, Huang LE, Yarchoan R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxiainducible factor-2alpha in HEK293T cells. Cancer Res 2005;65: 3299-306.
-
(2005)
Cancer Res
, vol.65
, pp. 3299-3306
-
-
Wang, V.1
Davis, D.A.2
Haque, M.3
Huang, L.E.4
Yarchoan, R.5
-
8
-
-
0035104252
-
Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha
-
Akeno N, Czyzyk-Krzeska MF, Gross TS, Clemens TL. Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha. Endocrinology 2001;142:959-62.
-
(2001)
Endocrinology
, vol.142
, pp. 959-962
-
-
Akeno, N.1
Czyzyk-Krzeska, M.F.2
Gross, T.S.3
Clemens, T.L.4
-
9
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs
-
Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. Faseb J 2003;17:271-3.
-
(2003)
Faseb J
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
Jurgensen, J.S.2
Rosenberger, C.3
Scholze, C.K.4
Horstrup, J.H.5
Warnecke, C.6
Mandriota, S.7
Bechmann, I.8
Frei, U.A.9
Pugh, C.W.10
Ratcliffe, P.J.11
Bachmann, S.12
-
10
-
-
0141988698
-
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
-
Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 2003;63:6130-4.
-
(2003)
Cancer Res
, vol.63
, pp. 6130-6134
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
11
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
Kondo K, Kim WY, Lechpammer M, Kaelin WG, Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
-
(2003)
PLoS Biol
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
12
-
-
33750630119
-
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
-
Holmquist-Mengelbier L, Fredlund E, Lofstedt T, Noguera R, Navarro S, Nilsson H, Pietras A, Vallon-Christersson J, Borg A, Gradin K, Poellinger L, Pahlman S. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 2006;10:413-23.
-
(2006)
Cancer Cell
, vol.10
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Lofstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
Pietras, A.7
Vallon-Christersson, J.8
Borg, A.9
Gradin, K.10
Poellinger, L.11
Pahlman, S.12
-
13
-
-
23644435597
-
Genetic evidence for a tumor suppressor role of HIF-2alpha
-
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 2005;8:131-41.
-
(2005)
Cancer Cell
, vol.8
, pp. 131-141
-
-
Acker, T.1
Diez-Juan, A.2
Aragones, J.3
Tjwa, M.4
Brusselmans, K.5
Moons, L.6
Fukumura, D.7
Moreno-Murciano, M.P.8
Herbert, J.M.9
Burger, A.10
Riedel, J.11
Elvert, G.12
-
14
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P, Semenza GL. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 2003;63:1138-43.
-
(2003)
Cancer Res
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
Berg-Dixon, S.2
Kelly, B.3
Agani, F.4
Feldser, D.5
Ferreira, G.6
Iyer, N.7
LaRusch, J.8
Pak, B.9
Taghavi, P.10
Semenza, G.L.11
-
15
-
-
2442625634
-
Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours
-
Jubb AM, Pham TQ, Hanby AM, Frantz GD, Peale FV, Wu TD, Koeppen HW, Hillan KJ. Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours. J Clin Pathol 2004;57:504-12.
-
(2004)
J Clin Pathol
, vol.57
, pp. 504-512
-
-
Jubb, A.M.1
Pham, T.Q.2
Hanby, A.M.3
Frantz, G.D.4
Peale, F.V.5
Wu, T.D.6
Koeppen, H.W.7
Hillan, K.J.8
-
16
-
-
0037064010
-
Insulinlike growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulinlike growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002;277:38205-11.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
17
-
-
32944477859
-
Hypoxia-inducible factor-1alpha promotes nonhypoxia- mediated proliferation in colon cancer cells and xenografts
-
Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH. Hypoxia-inducible factor-1alpha promotes nonhypoxia- mediated proliferation in colon cancer cells and xenografts. Cancer Res 2006;66:1684-936.
-
(2006)
Cancer Res
, vol.66
, pp. 1684-1936
-
-
Dang, D.T.1
Chen, F.2
Gardner, L.B.3
Cummins, J.M.4
Rago, C.5
Bunz, F.6
Kantsevoy, S.V.7
Dang, L.H.8
-
18
-
-
33646864077
-
Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis
-
Giles RH, Lolkema MP, Snijckers CM, Belderbos M, van der Groep P, Mans DA, van Beest M, van Noort M, Goldschmeding R, van Diest PJ, Clevers H, Voest EE. Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene 2006;25:3065-70.
-
(2006)
Oncogene
, vol.25
, pp. 3065-3070
-
-
Giles, R.H.1
Lolkema, M.P.2
Snijckers, C.M.3
Belderbos, M.4
van der Groep, P.5
Mans, D.A.6
van Beest, M.7
van Noort, M.8
Goldschmeding, R.9
van Diest, P.J.10
Clevers, H.11
Voest, E.E.12
-
19
-
-
1642329821
-
Hypoxia-inducible factor-1-independent regulation of vascular endo thelial growth factor by hypoxia in colon cancer
-
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endo thelial growth factor by hypoxia in colon cancer. Cancer Res 2004; 64:1765-72.
-
(2004)
Cancer Res
, vol.64
, pp. 1765-1772
-
-
Mizukami, Y.1
Li, J.2
Zhang, X.3
Zimmer, M.A.4
Iliopoulos, O.5
Chung, D.C.6
-
20
-
-
4644237401
-
Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors
-
Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. J Cell Biochem 2004; 92:491-501.
-
(2004)
J Cell Biochem
, vol.92
, pp. 491-501
-
-
Aprelikova, O.1
Chandramouli, G.V.2
Wood, M.3
Vasselli, J.R.4
Riss, J.5
Maranchie, J.K.6
Linehan, W.M.7
Barrett, J.C.8
-
21
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50-6.
-
(2001)
Nature
, vol.410
, pp. 50-56
-
-
Muller, A.1
Homey, B.2
Soto, H.3
Ge, N.4
Catron, D.5
Buchanan, M.E.6
McClanahan, T.7
Murphy, E.8
Yuan, W.9
Wagner, S.N.10
Barrera, J.L.11
Mohar, A.12
-
22
-
-
27544469796
-
HIN-1, an inhibitor of cell growth, invasion, and AKT activation
-
Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K. HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res 2005;65:9659-69.
-
(2005)
Cancer Res
, vol.65
, pp. 9659-9669
-
-
Krop, I.1
Parker, M.T.2
Bloushtain-Qimron, N.3
Porter, D.4
Gelman, R.5
Sasaki, H.6
Maurer, M.7
Terry, M.B.8
Parsons, R.9
Polyak, K.10
-
23
-
-
11144356448
-
Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression
-
Imamura T, Kanai F, Kawakami T, Amarsanaa J, Ijichi H, Hoshida Y, Tanaka Y, Ikenoue T, Tateishi K, Kawabe T, Arakawa Y, Miyagishi M, et al. Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression. Biochem Biophys Res Commun 2004;318:289-96.
-
(2004)
Biochem Biophys Res Commun
, vol.318
, pp. 289-296
-
-
Imamura, T.1
Kanai, F.2
Kawakami, T.3
Amarsanaa, J.4
Ijichi, H.5
Hoshida, Y.6
Tanaka, Y.7
Ikenoue, T.8
Tateishi, K.9
Kawabe, T.10
Arakawa, Y.11
Miyagishi, M.12
-
24
-
-
0026083903
-
Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
-
Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
-
(1991)
N Engl J Med
, vol.324
, pp. 1-8
-
-
Weidner, N.1
Semple, J.P.2
Welch, W.R.3
Folkman, J.4
-
25
-
-
24744438663
-
Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
-
Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med 2005;11:992-7.
-
(2005)
Nat Med
, vol.11
, pp. 992-997
-
-
Mizukami, Y.1
Jo, W.S.2
Duerr, E.M.3
Gala, M.4
Li, J.5
Zhang, X.6
Zimmer, M.A.7
Iliopoulos, O.8
Zukerberg, L.R.9
Kohgo, Y.10
Lynch, M.P.11
Rueda, B.R.12
Chung, D.C.13
-
26
-
-
28744458859
-
Bioconductor: Open software development for computational biology and bioinformatics
-
Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80.
-
(2004)
Genome Biol
, vol.5
-
-
Gentleman, R.C.1
Carey, V.J.2
Bates, D.M.3
Bolstad, B.4
Dettling, M.5
Dudoit, S.6
Ellis, B.7
Gautier, L.8
Ge, Y.9
Gentry, J.10
Hornik, K.11
Hothorn, T.12
-
27
-
-
10844290766
-
A model based background adjustment for oligonucleotide expression arrays
-
Wu Z, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F. A model based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 2004;99:909-917.
-
(2004)
J Am Stat Assoc
, vol.99
, pp. 909-917
-
-
Wu, Z.1
Irizarry, R.A.2
Gentleman, R.3
Martinez-Murillo, F.4
Spencer, F.5
-
28
-
-
33646707041
-
Effect of antisense hypoxia- inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer
-
Chang Q, Qin R, Huang T, Gao J, Feng Y. Effect of antisense hypoxia- inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas 2006;32:297-305.
-
(2006)
Pancreas
, vol.32
, pp. 297-305
-
-
Chang, Q.1
Qin, R.2
Huang, T.3
Gao, J.4
Feng, Y.5
-
29
-
-
33751071832
-
Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines
-
Liu YL, Yu JM, Song XR, Wang XW, Xing LG, Gao BB. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol Ther 2006;5:1320-6.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1320-1326
-
-
Liu, Y.L.1
Yu, J.M.2
Song, X.R.3
Wang, X.W.4
Xing, L.G.5
Gao, B.B.6
-
30
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006;3:177-85.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
31
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006;3:187-97.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
32
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994;269:23757-63.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
33
-
-
0037155247
-
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
-
Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 2002;277: 6183-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 6183-6187
-
-
Minchenko, A.1
Leshchinsky, I.2
Opentanova, I.3
Sang, N.4
Srinivas, V.5
Armstead, V.6
Caro, J.7
-
34
-
-
33751341522
-
Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
-
Cazes A, Galaup A, Chomel C, Bignon M, Brechot N, Le Jan S, Weber H, Corvol P, Muller L, Germain S, Monnot C. Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res 2006;99:1207-15.
-
(2006)
Circ Res
, vol.99
, pp. 1207-1215
-
-
Cazes, A.1
Galaup, A.2
Chomel, C.3
Bignon, M.4
Brechot, N.5
Le Jan, S.6
Weber, H.7
Corvol, P.8
Muller, L.9
Germain, S.10
Monnot, C.11
-
35
-
-
33845485627
-
Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness
-
Galaup A, Cazes A, Le Jan S, Philippe J, Connault E, Le Coz E, Mekid H, Mir LM, Opolon P, Corvol P, Monnot C, Germain S. Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Proc Natl Acad Sci USA 2006;103:18721-6.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18721-18726
-
-
Galaup, A.1
Cazes, A.2
Le Jan, S.3
Philippe, J.4
Connault, E.5
Le Coz, E.6
Mekid, H.7
Mir, L.M.8
Opolon, P.9
Corvol, P.10
Monnot, C.11
Germain, S.12
-
36
-
-
10844253962
-
Cyclin G2 dysregulation in human oral cancer
-
Kim Y, Shintani S, Kohno Y, Zhang R, Wong DT. Cyclin G2 dysregulation in human oral cancer. Cancer Res 2004;64:8980-6.
-
(2004)
Cancer Res
, vol.64
, pp. 8980-8986
-
-
Kim, Y.1
Shintani, S.2
Kohno, Y.3
Zhang, R.4
Wong, D.T.5
-
37
-
-
0037431557
-
Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
-
Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M, Chayama K. Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 2003;105:176-81.
-
(2003)
Int J Cancer
, vol.105
, pp. 176-181
-
-
Kuwai, T.1
Kitadai, Y.2
Tanaka, S.3
Onogawa, S.4
Matsutani, N.5
Kaio, E.6
Ito, M.7
Chayama, K.8
-
38
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 2000;14:34-44.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
39
-
-
0035899332
-
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
-
Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, Hamelin R. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 2001;20:5025-32.
-
(2001)
Oncogene
, vol.20
, pp. 5025-5032
-
-
Gayet, J.1
Zhou, X.P.2
Duval, A.3
Rolland, S.4
Hoang, J.M.5
Cottu, P.6
Hamelin, R.7
-
40
-
-
23944436339
-
SW480, a p53 double-mutant cell line retains proficiency for some p53 functions
-
Rochette PJ, Bastien N, Lavoie J, Guerin SL, Drouin R. SW480, a p53 double-mutant cell line retains proficiency for some p53 functions. J Mol Biol 2005;352:44-57.
-
(2005)
J Mol Biol
, vol.352
, pp. 44-57
-
-
Rochette, P.J.1
Bastien, N.2
Lavoie, J.3
Guerin, S.L.4
Drouin, R.5
-
41
-
-
0028865988
-
Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
-
Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 1995;55:6161-5.
-
(1995)
Cancer Res
, vol.55
, pp. 6161-6165
-
-
Mukhopadhyay, D.1
Tsiokas, L.2
Sukhatme, V.P.3
-
42
-
-
11144222884
-
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: Correlation with tumor angiogenesis and cyclooxygenase-2 expression
-
Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 2004;10:8554-60.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8554-8560
-
-
Yoshimura, H.1
Dhar, D.K.2
Kohno, H.3
Kubota, H.4
Fujii, T.5
Ueda, S.6
Kinugasa, S.7
Tachibana, M.8
Nagasue, N.9
-
43
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, et al. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 2003;162:1283-91.
-
(2003)
Am J Pathol
, vol.162
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
Kuge, Y.4
Tamaki, N.5
Okada, F.6
Wang, J.7
Shindo, M.8
Higashino, F.9
Takeda, K.10
Asaka, M.11
Katoh, H.12
-
44
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
-
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-62.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
45
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 2004;6:33-43.
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
Freedman, S.J.4
Tanner, E.A.5
Vieira, A.6
Cornell-Kennon, S.7
Lee, J.8
Wang, B.9
Wang, J.10
Memmert, K.11
Naegeli, H.U.12
-
46
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997;386:403-7.
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
47
-
-
1342280515
-
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
-
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res 2004;2:89-95.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 89-95
-
-
Zimmer, M.1
Doucette, D.2
Siddiqui, N.3
Iliopoulos, O.4
-
48
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005;25:5675-86.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
Pugh, C.W.7
Maxwell, P.H.8
Harris, A.L.9
Ratcliffe, P.J.10
-
49
-
-
33744954065
-
Concordant regulation of gene expression by hypoxia and 2- oxoglutarate-dependent dioxygenase inhibition: The role of HIF- 1alpha. HIF-2alpha, and other pathways
-
Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2- oxoglutarate-dependent dioxygenase inhibition: the role of HIF- 1alpha. HIF-2alpha, and other pathways. J Biol Chem 2006;281: 15215-26.
-
(2006)
J Biol Chem
, vol.281
, pp. 15215-15226
-
-
Elvidge, G.P.1
Glenny, L.2
Appelhoff, R.J.3
Ratcliffe, P.J.4
Ragoussis, J.5
Gleadle, J.M.6
-
50
-
-
33745274488
-
Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
-
Aprelikova O, Wood M, Tackett S, Chandramouli GV, Barrett JC. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res 2006;66:5641-7.
-
(2006)
Cancer Res
, vol.66
, pp. 5641-5647
-
-
Aprelikova, O.1
Wood, M.2
Tackett, S.3
Chandramouli, G.V.4
Barrett, J.C.5
-
51
-
-
36749055738
-
Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest
-
Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC. Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res 2006;312:4181-204.
-
(2006)
Exp Cell Res
, vol.312
, pp. 4181-4204
-
-
Arachchige Don, A.S.1
Dallapiazza, R.F.2
Bennin, D.A.3
Brake, T.4
Cowan, C.E.5
Horne, M.C.6
-
52
-
-
0037178863
-
Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
-
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem 2002;277:27449-67.
-
(2002)
J Biol Chem
, vol.277
, pp. 27449-27467
-
-
Bennin, D.A.1
Don, A.S.2
Brake, T.3
McKenzie, J.L.4
Rosenbaum, H.5
Ortiz, L.6
DePaoli-Roach, A.A.7
Horne, M.C.8
-
53
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel AJ, Riggins GJ. Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst 2001;93: 1337-43.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1337-1343
-
-
Lal, A.1
Peters, H.2
St Croix, B.3
Haroon, Z.A.4
Dewhirst, M.W.5
Strausberg, R.L.6
Kaanders, J.H.7
van der Kogel, A.J.8
Riggins, G.J.9
-
54
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007;11:335-47.
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
55
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. Embo J 2004;23:1949-56.
-
(2004)
Embo J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
56
-
-
33847421328
-
Cell type-specific, topoisomerase II-dependent inhibition of hypoxiainducible factor-1alpha protein accumulation by NSC 644221
-
Creighton-Gutteridge M, Cardellina JH, II, Stephen AG, Rapisarda A, Uranchimeg B, Hite K, Denny WA, Shoemaker RH, Melillo G. Cell type-specific, topoisomerase II-dependent inhibition of hypoxiainducible factor-1alpha protein accumulation by NSC 644221. Clin Cancer Res 2007;13:1010-18.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1010-1018
-
-
Creighton-Gutteridge, M.1
Cardellina II, J.H.2
Stephen, A.G.3
Rapisarda, A.4
Uranchimeg, B.5
Hite, K.6
Denny, W.A.7
Shoemaker, R.H.8
Melillo, G.9
-
57
-
-
34547660100
-
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
-
Shin DH, Kim JH, Jung YJ, Kim KE, Jeong JM, Chun YS, Park JW. Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading. Cancer Lett 2007;255:107-16.
-
(2007)
Cancer Lett
, vol.255
, pp. 107-116
-
-
Shin, D.H.1
Kim, J.H.2
Jung, Y.J.3
Kim, K.E.4
Jeong, J.M.5
Chun, Y.S.6
Park, J.W.7
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