메뉴 건너뛰기




Volumn 124, Issue 4, 2009, Pages 763-771

HIF-1α and HIF-2α have divergent roles in colon cancer

Author keywords

Angiogenesis; Colon cancer; HIF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SMALL INTERFERING RNA; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; UNCLASSIFIED DRUG;

EID: 58149478525     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24032     Document Type: Article
Times cited : (147)

References (57)
  • 1
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev 2000;14:1983-91.
    • (2000) Genes Dev , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 2
    • 0034533143 scopus 로고    scopus 로고
    • Targeting tumors through the HIF system
    • Ratcliffe PJ, Pugh CW, Maxwell PH. Targeting tumors through the HIF system. Nat Med 2000;6:1315-16.
    • (2000) Nat Med , vol.6 , pp. 1315-1316
    • Ratcliffe, P.J.1    Pugh, C.W.2    Maxwell, P.H.3
  • 3
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 5
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 6
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 7
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxiainducible factor-2alpha in HEK293T cells
    • Wang V, Davis DA, Haque M, Huang LE, Yarchoan R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxiainducible factor-2alpha in HEK293T cells. Cancer Res 2005;65: 3299-306.
    • (2005) Cancer Res , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 8
    • 0035104252 scopus 로고    scopus 로고
    • Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha
    • Akeno N, Czyzyk-Krzeska MF, Gross TS, Clemens TL. Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha. Endocrinology 2001;142:959-62.
    • (2001) Endocrinology , vol.142 , pp. 959-962
    • Akeno, N.1    Czyzyk-Krzeska, M.F.2    Gross, T.S.3    Clemens, T.L.4
  • 10
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
    • Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 2003;63:6130-4.
    • (2003) Cancer Res , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 11
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG, Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 15
    • 2442625634 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours
    • Jubb AM, Pham TQ, Hanby AM, Frantz GD, Peale FV, Wu TD, Koeppen HW, Hillan KJ. Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours. J Clin Pathol 2004;57:504-12.
    • (2004) J Clin Pathol , vol.57 , pp. 504-512
    • Jubb, A.M.1    Pham, T.Q.2    Hanby, A.M.3    Frantz, G.D.4    Peale, F.V.5    Wu, T.D.6    Koeppen, H.W.7    Hillan, K.J.8
  • 16
    • 0037064010 scopus 로고    scopus 로고
    • Insulinlike growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulinlike growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002;277:38205-11.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 17
    • 32944477859 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha promotes nonhypoxia- mediated proliferation in colon cancer cells and xenografts
    • Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH. Hypoxia-inducible factor-1alpha promotes nonhypoxia- mediated proliferation in colon cancer cells and xenografts. Cancer Res 2006;66:1684-936.
    • (2006) Cancer Res , vol.66 , pp. 1684-1936
    • Dang, D.T.1    Chen, F.2    Gardner, L.B.3    Cummins, J.M.4    Rago, C.5    Bunz, F.6    Kantsevoy, S.V.7    Dang, L.H.8
  • 19
    • 1642329821 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-independent regulation of vascular endo thelial growth factor by hypoxia in colon cancer
    • Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endo thelial growth factor by hypoxia in colon cancer. Cancer Res 2004; 64:1765-72.
    • (2004) Cancer Res , vol.64 , pp. 1765-1772
    • Mizukami, Y.1    Li, J.2    Zhang, X.3    Zimmer, M.A.4    Iliopoulos, O.5    Chung, D.C.6
  • 24
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 28
    • 33646707041 scopus 로고    scopus 로고
    • Effect of antisense hypoxia- inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer
    • Chang Q, Qin R, Huang T, Gao J, Feng Y. Effect of antisense hypoxia- inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas 2006;32:297-305.
    • (2006) Pancreas , vol.32 , pp. 297-305
    • Chang, Q.1    Qin, R.2    Huang, T.3    Gao, J.4    Feng, Y.5
  • 29
    • 33751071832 scopus 로고    scopus 로고
    • Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines
    • Liu YL, Yu JM, Song XR, Wang XW, Xing LG, Gao BB. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol Ther 2006;5:1320-6.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1320-1326
    • Liu, Y.L.1    Yu, J.M.2    Song, X.R.3    Wang, X.W.4    Xing, L.G.5    Gao, B.B.6
  • 30
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006;3:177-85.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 31
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006;3:187-97.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 32
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994;269:23757-63.
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 33
    • 0037155247 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
    • Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 2002;277: 6183-7.
    • (2002) J Biol Chem , vol.277 , pp. 6183-6187
    • Minchenko, A.1    Leshchinsky, I.2    Opentanova, I.3    Sang, N.4    Srinivas, V.5    Armstead, V.6    Caro, J.7
  • 37
    • 0037431557 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    • Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M, Chayama K. Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 2003;105:176-81.
    • (2003) Int J Cancer , vol.105 , pp. 176-181
    • Kuwai, T.1    Kitadai, Y.2    Tanaka, S.3    Onogawa, S.4    Matsutani, N.5    Kaio, E.6    Ito, M.7    Chayama, K.8
  • 39
    • 0035899332 scopus 로고    scopus 로고
    • Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
    • Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, Hamelin R. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 2001;20:5025-32.
    • (2001) Oncogene , vol.20 , pp. 5025-5032
    • Gayet, J.1    Zhou, X.P.2    Duval, A.3    Rolland, S.4    Hoang, J.M.5    Cottu, P.6    Hamelin, R.7
  • 40
    • 23944436339 scopus 로고    scopus 로고
    • SW480, a p53 double-mutant cell line retains proficiency for some p53 functions
    • Rochette PJ, Bastien N, Lavoie J, Guerin SL, Drouin R. SW480, a p53 double-mutant cell line retains proficiency for some p53 functions. J Mol Biol 2005;352:44-57.
    • (2005) J Mol Biol , vol.352 , pp. 44-57
    • Rochette, P.J.1    Bastien, N.2    Lavoie, J.3    Guerin, S.L.4    Drouin, R.5
  • 41
    • 0028865988 scopus 로고
    • Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
    • Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 1995;55:6161-5.
    • (1995) Cancer Res , vol.55 , pp. 6161-6165
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 42
    • 11144222884 scopus 로고    scopus 로고
    • Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: Correlation with tumor angiogenesis and cyclooxygenase-2 expression
    • Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 2004;10:8554-60.
    • (2004) Clin Cancer Res , vol.10 , pp. 8554-8560
    • Yoshimura, H.1    Dhar, D.K.2    Kohno, H.3    Kubota, H.4    Fujii, T.5    Ueda, S.6    Kinugasa, S.7    Tachibana, M.8    Nagasue, N.9
  • 43
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, et al. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 2003;162:1283-91.
    • (2003) Am J Pathol , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.2    Nakada, K.3    Kuge, Y.4    Tamaki, N.5    Okada, F.6    Wang, J.7    Shindo, M.8    Higashino, F.9    Takeda, K.10    Asaka, M.11    Katoh, H.12
  • 46
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997;386:403-7.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 47
    • 1342280515 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
    • Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res 2004;2:89-95.
    • (2004) Mol Cancer Res , vol.2 , pp. 89-95
    • Zimmer, M.1    Doucette, D.2    Siddiqui, N.3    Iliopoulos, O.4
  • 49
    • 33744954065 scopus 로고    scopus 로고
    • Concordant regulation of gene expression by hypoxia and 2- oxoglutarate-dependent dioxygenase inhibition: The role of HIF- 1alpha. HIF-2alpha, and other pathways
    • Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2- oxoglutarate-dependent dioxygenase inhibition: the role of HIF- 1alpha. HIF-2alpha, and other pathways. J Biol Chem 2006;281: 15215-26.
    • (2006) J Biol Chem , vol.281 , pp. 15215-15226
    • Elvidge, G.P.1    Glenny, L.2    Appelhoff, R.J.3    Ratcliffe, P.J.4    Ragoussis, J.5    Gleadle, J.M.6
  • 50
    • 33745274488 scopus 로고    scopus 로고
    • Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
    • Aprelikova O, Wood M, Tackett S, Chandramouli GV, Barrett JC. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res 2006;66:5641-7.
    • (2006) Cancer Res , vol.66 , pp. 5641-5647
    • Aprelikova, O.1    Wood, M.2    Tackett, S.3    Chandramouli, G.V.4    Barrett, J.C.5
  • 51
    • 36749055738 scopus 로고    scopus 로고
    • Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest
    • Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC. Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res 2006;312:4181-204.
    • (2006) Exp Cell Res , vol.312 , pp. 4181-4204
    • Arachchige Don, A.S.1    Dallapiazza, R.F.2    Bennin, D.A.3    Brake, T.4    Cowan, C.E.5    Horne, M.C.6
  • 52
    • 0037178863 scopus 로고    scopus 로고
    • Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
    • Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem 2002;277:27449-67.
    • (2002) J Biol Chem , vol.277 , pp. 27449-27467
    • Bennin, D.A.1    Don, A.S.2    Brake, T.3    McKenzie, J.L.4    Rosenbaum, H.5    Ortiz, L.6    DePaoli-Roach, A.A.7    Horne, M.C.8
  • 54
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007;11:335-47.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.