메뉴 건너뛰기




Volumn 26, Issue 2, 2007, Pages 249-260

Regulation of DNA repair in hypoxic cancer cells

Author keywords

DNA damage response; DNA mismatch repair (MMR); Genetic instability; Homologous recombination (HR); Hypoxia; Tumor microenvironment

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; MAX PROTEIN; MYC PROTEIN; PROTEIN P130; PROTEIN P53;

EID: 34547114718     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-007-9061-3     Document Type: Review
Times cited : (172)

References (100)
  • 1
    • 0035863398 scopus 로고    scopus 로고
    • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures
    • 2
    • Li, C. Y., Little, J. B., Hu, K., Zhang, W., Zhang, L., Dewhirst, M. W., et al. (2001). Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Research, 61(2), 428-432.
    • (2001) Cancer Research , vol.61 , pp. 428-432
    • Li, C.Y.1    Little, J.B.2    Hu, K.3    Zhang, W.4    Zhang, L.5    Dewhirst, M.W.6
  • 2
    • 0028179096 scopus 로고
    • In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays
    • 12
    • Paquette, B., & Little, J. B. (1994). In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Research, 54(12), 3173-3178.
    • (1994) Cancer Research , vol.54 , pp. 3173-3178
    • Paquette, B.1    Little, J.B.2
  • 3
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • 24
    • Reynolds, T. Y., Rockwell, S., & Glazer, P. M. (1996). Genetic instability induced by the tumor microenvironment. Cancer Research, 56(24), 5754-5757.
    • (1996) Cancer Research , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 4
    • 0034662615 scopus 로고    scopus 로고
    • Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
    • 16
    • Yuan, J., Narayanan, L., Rockwell, S., & Glazer, P. M. (2000). Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Research, 60(16), 4372-4376.
    • (2000) Cancer Research , vol.60 , pp. 4372-4376
    • Yuan, J.1    Narayanan, L.2    Rockwell, S.3    Glazer, P.M.4
  • 5
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • 14
    • Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003). ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. Journal of Biological Chemistry, 278(14), 12207-12213.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 6
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • 2
    • Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., & Debatisse, M. (1997). Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell, 89(2), 215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 7
    • 0037206935 scopus 로고    scopus 로고
    • Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements
    • 50
    • Coquelle, A., Rozier, L., Dutrillaux, B., & Debatisse, M. (2002). Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements. Oncogene, 21(50), 7671-7679.
    • (2002) Oncogene , vol.21 , pp. 7671-7679
    • Coquelle, A.1    Rozier, L.2    Dutrillaux, B.3    Debatisse, M.4
  • 8
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • 2
    • Coquelle, A., Toledo, F., Stern, S., Bieth, A., & Debatisse, M. (1998). A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Molecular Cell, 2(2), 259-265.
    • (1998) Molecular Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 9
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • 3
    • Subarsky, P., & Hill, R. P. (2003). The hypoxic tumour microenvironment and metastatic progression. Clinical & Experimental Metastasis, 20(3), 237-250.
    • (2003) Clinical & Experimental Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 10
    • 0025150111 scopus 로고
    • Effects of reoxygenation on cells from hypoxic regions of solid tumors: Analysis of transplanted murine tumors for evidence of DNA overreplication
    • 16
    • Young, S. D., & Hill, R. P. (1990). Effects of reoxygenation on cells from hypoxic regions of solid tumors: Analysis of transplanted murine tumors for evidence of DNA overreplication. Cancer Research, 50(16), 5031-5038.
    • (1990) Cancer Research , vol.50 , pp. 5031-5038
    • Young, S.D.1    Hill, R.P.2
  • 12
    • 0037404420 scopus 로고    scopus 로고
    • Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells
    • 9
    • Mihaylova, V. T., Bindra, R. S., Yuan, J., Campisi, D., Narayanan, L., Jensen, R., et al. (2003). Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Molecular & Cellular Biology, 23(9), 3265-3273.
    • (2003) Molecular & Cellular Biology , vol.23 , pp. 3265-3273
    • Mihaylova, V.T.1    Bindra, R.S.2    Yuan, J.3    Campisi, D.4    Narayanan, L.5    Jensen, R.6
  • 13
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    • 6
    • Koshiji, M., To, K. K., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., et al. (2005). HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Molecular Cell, 17(6), 793-803.
    • (2005) Molecular Cell , vol.17 , pp. 793-803
    • Koshiji, M.1    To, K.K.2    Hammer, S.3    Kumamoto, K.4    Harris, A.L.5    Modrich, P.6
  • 14
    • 34248385293 scopus 로고    scopus 로고
    • Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network
    • (in press).
    • Bindra, R. S., & Glazer, P. M. (2007). Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network. Cancer Letters, (in press).
    • (2007) Cancer Letters
    • Bindra, R.S.1    Glazer, P.M.2
  • 15
    • 33749494456 scopus 로고    scopus 로고
    • Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    • 18
    • Chen, H., Yan, Y., Davidson, T. L., Shinkai, Y., & Costa, M. (2006). Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Research, 66(18), 9009-9016.
    • (2006) Cancer Research , vol.66 , pp. 9009-9016
    • Chen, H.1    Yan, Y.2    Davidson, T.L.3    Shinkai, Y.4    Costa, M.5
  • 16
    • 27644547797 scopus 로고    scopus 로고
    • Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: Implications for multicellular resistance to alkylating agents
    • 10
    • Francia, G., Green, S. K., Bocci, G., Man, S., Emmenegger, U., Ebos, J. M. L., et al. (2005). Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: Implications for multicellular resistance to alkylating agents. Molecular Cancer Theraphy, 4(10), 1484-1494.
    • (2005) Molecular Cancer Theraphy , vol.4 , pp. 1484-1494
    • Francia, G.1    Green, S.K.2    Bocci, G.3    Man, S.4    Emmenegger, U.5    Ebos, J.M.L.6
  • 17
    • 23244464226 scopus 로고    scopus 로고
    • Microenvironmental influences on mutagenesis in mammary epithelial cells
    • 5
    • Papp-Szabo, E., Josephy, P. D., & Coomber, B. L. (2005). Microenvironmental influences on mutagenesis in mammary epithelial cells. International Journal of Cancer, 116(5), 679-685.
    • (2005) International Journal of Cancer , vol.116 , pp. 679-685
    • Papp-Szabo, E.1    Josephy, P.D.2    Coomber, B.L.3
  • 18
    • 24944539099 scopus 로고    scopus 로고
    • Ischemia-induced K-ras mutations in human colorectal cancer cells: Role of microenvironmental regulation of MSH2 expression
    • 18
    • Shahrzad, S., Quayle, L., Stone, C., Plumb, C., Shirasawa, S., Rak, J. W., et al. (2005). Ischemia-induced K-ras mutations in human colorectal cancer cells: Role of microenvironmental regulation of MSH2 expression. Cancer Research, 65(18), 8134-8141.
    • (2005) Cancer Research , vol.65 , pp. 8134-8141
    • Shahrzad, S.1    Quayle, L.2    Stone, C.3    Plumb, C.4    Shirasawa, S.5    Rak, W.J.6
  • 20
    • 34547113862 scopus 로고    scopus 로고
    • Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
    • (in press).
    • Bindra, R. S., & Glazer, P. M. (2006). Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene, (in press).
    • (2006) Oncogene
    • Bindra, R.S.1    Glazer, P.M.2
  • 21
    • 28444478320 scopus 로고    scopus 로고
    • Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells
    • 2
    • Meng, A. X., Jalali, F., Cuddihy, A., Chan, N., Bindra, R. S., Glazer, P. M., et al. (2005). Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiotherapy and Oncology, 76(2), 168-176.
    • (2005) Radiotherapy and Oncology , vol.76 , pp. 168-176
    • Meng, A.X.1    Jalali, F.2    Cuddihy, A.3    Chan, N.4    Bindra, R.S.5    Glazer, P.M.6
  • 22
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-A key regulatory factor in tumour growth
    • 1
    • Harris, A. L. (2002). Hypoxia-A key regulatory factor in tumour growth. Nature Reviews Cancer, 2(1), 38-47.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 25
    • 28244496609 scopus 로고    scopus 로고
    • Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner
    • 23
    • Gibson, S. L., Bindra, R. S., & Glazer, P. M. (2005). Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Research, 65(23), 10734-10741.
    • (2005) Cancer Research , vol.65 , pp. 10734-10741
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 26
    • 33749163797 scopus 로고    scopus 로고
    • CHK2-dependent phosphorylation of BRCA1 in hypoxia
    • 4
    • Gibson, S. L., Bindra, R. S., & Glazer, P. M. (2006). CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiation Research, 166(4), 646-651.
    • (2006) Radiation Research , vol.166 , pp. 646-651
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 28
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • 18
    • Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2004). Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research, 64(18), 6556-6562.
    • (2004) Cancer Research , vol.64 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 29
    • 0345708265 scopus 로고    scopus 로고
    • Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest
    • 1-2
    • Hammond, E. M., Green, S. L., & Giaccia, A. J. (2003). Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation Research, 532(1-2), 205-213.
    • (2003) Mutation Research , vol.532 , pp. 205-213
    • Hammond, E.M.1    Green, S.L.2    Giaccia, A.J.3
  • 32
    • 0022596441 scopus 로고
    • Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids
    • 3
    • Mueller-Klieser, W., Freyer, J. P., & Sutherland, R. M. (1986). Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. British Journal of Cancer, 53(3), 345-353.
    • (1986) British Journal of Cancer , vol.53 , pp. 345-353
    • Mueller-Klieser, W.1    Freyer, J.P.2    Sutherland, R.M.3
  • 33
    • 31144478127 scopus 로고    scopus 로고
    • Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
    • 11
    • Corn, P. G., Ricci, M. S., Scata, K. A., Arsham, A. M., Simon, M. C., Dicker, D. T., et al. (2005). Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biological Therapy, 4(11), 1285-1294.
    • (2005) Cancer Biological Therapy , vol.4 , pp. 1285-1294
    • Corn, P.G.1    Ricci, M.S.2    Scata, K.A.3    Arsham, A.M.4    Simon, M.C.5    Dicker, D.T.6
  • 34
    • 33947217823 scopus 로고    scopus 로고
    • Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    • 2
    • Kaidi, A., Williams, A. C., & Paraskeva, C. (2007). Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nature Cell Biology, 9(2), 210-217.
    • (2007) Nature Cell Biology , vol.9 , pp. 210-217
    • Kaidi, A.1    Williams, A.C.2    Paraskeva, C.3
  • 35
    • 33645378251 scopus 로고    scopus 로고
    • Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy
    • Khaitan, D., Chandna, S., Arya, M. B., & Dwarakanath, B. S. (2006). Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy. Journal of Translation Med, 4, 12.
    • (2006) Journal of Translation Med , vol.4 , pp. 12
    • Khaitan, D.1    Chandna, S.2    Arya, M.B.3    Dwarakanath, B.S.4
  • 36
    • 33749164424 scopus 로고    scopus 로고
    • Functional analysis of p53 binding under differential stresses
    • 19
    • Krieg, A. J., Hammond, E. M., & Giaccia, A. J. (2006). Functional analysis of p53 binding under differential stresses. Molecular and Cellular Biology, 26(19), 7030-7045.
    • (2006) Molecular and Cellular Biology , vol.26 , pp. 7030-7045
    • Krieg, A.J.1    Hammond, E.M.2    Giaccia, A.J.3
  • 38
    • 2942701935 scopus 로고    scopus 로고
    • Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
    • 13
    • Kim, J. W., Zeller, K. I., Wang, Y., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., et al. (2004). Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Molecular Cellular Biology, 24(13), 5923-5936.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 5923-5936
    • Kim, J.W.1    Zeller, K.I.2    Wang, Y.3    Jegga, A.J.4    Aronow, B.J.5    O'Donnell, K.A.6
  • 39
    • 4644312405 scopus 로고    scopus 로고
    • Mnt: Master regulator of the Max network
    • 5
    • Nilsson, J. A., & Cleveland, J. L. (2004). Mnt: Master regulator of the Max network. Cell Cycle, 3(5), 588-590.
    • (2004) Cell Cycle , vol.3 , pp. 588-590
    • Nilsson, J.A.1    Cleveland, J.L.2
  • 40
    • 4544324453 scopus 로고    scopus 로고
    • Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells
    • 19
    • Bindra, R. S., Schaffer, P. J., Meng, A., Woo, J., Maseide, K., Roth, M. E., et al. (2004). Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Molecular and Cellular Biology, 24(19), 8504-8518.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 8504-8518
    • Bindra, R.S.1    Schaffer, P.J.2    Meng, A.3    Woo, J.4    Maseide, K.5    Roth, M.E.6
  • 41
    • 0037202608 scopus 로고    scopus 로고
    • Recombinational DNA repair and human disease
    • 1-2
    • Thompson, L. H., & Schild, D. (2002). Recombinational DNA repair and human disease. Mutation Research, 509(1-2), 49-78.
    • (2002) Mutation Research , vol.509 , pp. 49-78
    • Thompson, L.H.1    Schild, D.2
  • 42
    • 0035835827 scopus 로고    scopus 로고
    • P107 and p130: Versatile proteins with interesting pockets
    • 1
    • Classon, M., & Dyson, N. (2001). p107 and p130: Versatile proteins with interesting pockets. Experimental Cell Research, 264(1), 135-147.
    • (2001) Experimental Cell Research , vol.264 , pp. 135-147
    • Classon, M.1    Dyson, N.2
  • 43
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • 17
    • Cobrinik, D. (2005). Pocket proteins and cell cycle control. Oncogene, 24(17), 2796-2809.
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 45
    • 8644281106 scopus 로고    scopus 로고
    • A common set of gene regulatory networks links metabolism and growth inhibition
    • 3
    • Cam, H., Balciunaite, E., Blais, A., Spektor, A., Scarpulla, R. C., Young, R., et al. (2004). A common set of gene regulatory networks links metabolism and growth inhibition. Molecular Cell, 16(3), 399-411.
    • (2004) Molecular Cell , vol.16 , pp. 399-411
    • Cam, H.1    Balciunaite, E.2    Blais, A.3    Spektor, A.4    Scarpulla, R.C.5    Young, R.6
  • 46
    • 0141707813 scopus 로고    scopus 로고
    • Emerging roles for E2F: Beyond the G1/S transition and DNA replication
    • 4
    • Cam, H., & Dynlacht, B. D. (2003). Emerging roles for E2F: Beyond the G1/S transition and DNA replication. Cancer Cell, 3(4), 311-316.
    • (2003) Cancer Cell , vol.3 , pp. 311-316
    • Cam, H.1    Dynlacht, B.D.2
  • 47
    • 0035878122 scopus 로고    scopus 로고
    • Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
    • 14
    • Lin, W. C., Lin, F. T., & Nevins, J. R. (2001). Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes & Development, 15(14), 1833-1844.
    • (2001) Genes & Development , vol.15 , pp. 1833-1844
    • Lin, W.C.1    Lin, F.T.2    Nevins, J.R.3
  • 48
    • 0038142184 scopus 로고    scopus 로고
    • Differential regulation of E2F1 apoptotic target genes in response to DNA damage
    • 6
    • Pediconi, N., Ianari, A., Costanzo, A., Belloni, L., Gallo, R., Cimino, L., et al. (2003). Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nature Cell Biology, 5(6), 552-558.
    • (2003) Nature Cell Biology , vol.5 , pp. 552-558
    • Pediconi, N.1    Ianari, A.2    Costanzo, A.3    Belloni, L.4    Gallo, R.5    Cimino, L.6
  • 49
    • 2342640317 scopus 로고    scopus 로고
    • A new role for E2F-1 in checkpoint control
    • 5
    • Stevens, C., & La Thangue, N. B. (2003). A new role for E2F-1 in checkpoint control. Cell Cycle, 2(5), 435-437.
    • (2003) Cell Cycle , vol.2 , pp. 435-437
    • Stevens, C.1    La Thangue, N.B.2
  • 50
    • 3242880237 scopus 로고    scopus 로고
    • The emerging role of E2F-1 in the DNA damage response and checkpoint control
    • 8-9
    • Stevens, C., & La Thangue, N. B. (2004). The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst), 3(8-9), 1071-1079.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1071-1079
    • Stevens, C.1    La Thangue, N.B.2
  • 51
    • 0038752083 scopus 로고    scopus 로고
    • Chk2 activates E2F-1 in response to DNA damage
    • 5
    • Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409.
    • (2003) Nature Cell Biology , vol.5 , pp. 401-409
    • Stevens, C.1    Smith, L.2    La Thangue, N.B.3
  • 53
    • 0034959651 scopus 로고    scopus 로고
    • Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes
    • 15
    • Helt, A. M., & Galloway, D. A. (2001). Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes. Journal of Virology, 75(15), 6737-6747.
    • (2001) Journal of Virology , vol.75 , pp. 6737-6747
    • Helt, A.M.1    Galloway, D.A.2
  • 54
    • 0028211070 scopus 로고
    • Interaction of HPV E6 with p53 and associated proteins
    • 1
    • Crook, T., & Vousden, K. H. (1994). Interaction of HPV E6 with p53 and associated proteins. Biochemical Society Transactions, 22(1), 52-55.
    • (1994) Biochemical Society Transactions , vol.22 , pp. 52-55
    • Crook, T.1    Vousden, K.H.2
  • 55
    • 0035834945 scopus 로고    scopus 로고
    • Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes
    • 1-2
    • Dimitrov, S., Brennerova, M., & Forejt, J. (2001). Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. Gene, 262(1-2), 89-98.
    • (2001) Gene , vol.262 , pp. 89-98
    • Dimitrov, S.1    Brennerova, M.2    Forejt, J.3
  • 56
    • 0030799598 scopus 로고    scopus 로고
    • Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene
    • 7
    • Xu, C. F., Brown, M. A., Nicolai, H., Chambers, J. A., Griffiths, B. L., & Solomon, E. (1997). Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Human Molecular Genetics, 6(7), 1057-1062.
    • (1997) Human Molecular Genetics , vol.6 , pp. 1057-1062
    • Xu, C.F.1    Brown, M.A.2    Nicolai, H.3    Chambers, J.A.4    Griffiths, B.L.5    Solomon, E.6
  • 57
    • 0037080674 scopus 로고    scopus 로고
    • Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
    • 2
    • Weinmann, A. S., Yan, P. S., Oberley, M. J., Huang, T. H., & Farnham, P. J. (2002). Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes & Development, 16(2), 235-244.
    • (2002) Genes & Development , vol.16 , pp. 235-244
    • Weinmann, A.S.1    Yan, P.S.2    Oberley, M.J.3    Huang, T.H.4    Farnham, P.J.5
  • 58
    • 0036024957 scopus 로고    scopus 로고
    • Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation
    • 1
    • Wells, J., & Farnham, P. J. (2002). Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods, 26(1), 48-56.
    • (2002) Methods , vol.26 , pp. 48-56
    • Wells, J.1    Farnham, P.J.2
  • 59
    • 9644288108 scopus 로고    scopus 로고
    • Differential regulation of expression of the mammalian DNA repair genes by growth stimulation
    • 53
    • Iwanaga, R., Komori, H., & Ohtani, K. (2004). Differential regulation of expression of the mammalian DNA repair genes by growth stimulation. Oncogene, 23(53), 8581-8590.
    • (2004) Oncogene , vol.23 , pp. 8581-8590
    • Iwanaga, R.1    Komori, H.2    Ohtani, K.3
  • 61
    • 0032142792 scopus 로고    scopus 로고
    • Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation
    • Pt 3
    • Garriga, J., Limon, A., Mayol, X., Rane, S. G., Albrecht, J. H., Reddy, E. P., et al. (1998). Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation. Biochemical Journal, 333(Pt 3), 645-654.
    • (1998) Biochemical Journal , vol.333 , pp. 645-654
    • Garriga, J.1    Limon, A.2    Mayol, X.3    Rane, S.G.4    Albrecht, J.H.5    Reddy, E.P.6
  • 62
    • 0034719409 scopus 로고    scopus 로고
    • Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function
    • 4
    • Barrientes, S., Cooke, C., & Goodrich, D. W. (2000). Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function. Oncogene, 19(4), 562-570.
    • (2000) Oncogene , vol.19 , pp. 562-570
    • Barrientes, S.1    Cooke, C.2    Goodrich, D.W.3
  • 64
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
    • 2
    • Lonergan, K. M., Iliopoulos, O., Ohh, M., Kamura, T., Conaway, R. C., Conaway, J. W., et al. (1998). Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Molecular and Cellular Biology, 18(2), 732-741.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 732-741
    • Lonergan, K.M.1    Iliopoulos, O.2    Ohh, M.3    Kamura, T.4    Conaway, R.C.5    Conaway, J.W.6
  • 65
    • 0344513855 scopus 로고    scopus 로고
    • BRCA1 and p53: Compensatory roles in DNA repair
    • 11
    • Hartman, A. R., & Ford, J. M. (2003). BRCA1 and p53: Compensatory roles in DNA repair. Journal of Molecular Medecine, 81(11), 700-707.
    • (2003) Journal of Molecular Medecine , vol.81 , pp. 700-707
    • Hartman, A.R.1    Ford, J.M.2
  • 67
    • 0031472370 scopus 로고    scopus 로고
    • Association of BRCA1 with Rad51 in mitotic and meiotic cells
    • 2
    • Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., et al. (1997). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88(2), 265-275.
    • (1997) Cell , vol.88 , pp. 265-275
    • Scully, R.1    Chen, J.2    Plug, A.3    Xiao, Y.4    Weaver, D.5    Feunteun, J.6
  • 69
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • 37
    • Valerie, K., & Povirk, L. F. (2003). Regulation and mechanisms of mammalian double-strand break repair. Oncogene, 22(37), 5792-5812.
    • (2003) Oncogene , vol.22 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 70
    • 0033569684 scopus 로고    scopus 로고
    • XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    • 20
    • Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999). XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes & Development, 13(20), 2633-2638.
    • (1999) Genes & Development , vol.13 , pp. 2633-2638
    • Pierce, A.J.1    Johnson, R.D.2    Thompson, L.H.3    Jasin, M.4
  • 71
    • 3242776224 scopus 로고    scopus 로고
    • Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells
    • 3
    • Um, J. H., Kang, C. D., Bae, J. H., Shin, G. G., Kim, D. W., Kim, D. W., et al. (2004). Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells. Experimental and Molecular Medicine, 36(3), 233-242.
    • (2004) Experimental and Molecular Medicine , vol.36 , pp. 233-242
    • Um, J.H.1    Kang, C.D.2    Bae, J.H.3    Shin, G.G.4    Kim, D.W.5    Kim, D.W.6
  • 72
    • 0038282482 scopus 로고    scopus 로고
    • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
    • 21
    • Unruh, A., Ressell, A., Mohamed, H. G., Johnson, R. S., Nadrowitz, R., Richter, E., et al. (2003). The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene, 22(21), 3213-3220.
    • (2003) Oncogene , vol.22 , pp. 3213-3220
    • Unruh, A.1    Ressel, A.2    Mohamed, H.G.3    Johnson, R.S.4    Nadrowitz, R.5    Richter, E.6
  • 73
    • 33646117239 scopus 로고    scopus 로고
    • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    • 2
    • Bekker-Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bartek, J., et al. (2006). Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. Journal of Cell Biology, 173(2), 195-206.
    • (2006) Journal of Cell Biology , vol.173 , pp. 195-206
    • Bekker-Jensen, S.1    Lukas, C.2    Kitagawa, R.3    Melander, F.4    Kastan, M.B.5    Bartek, J.6
  • 74
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • 3
    • Shiloh, Y. (2003). ATM and related protein kinases: Safeguarding genome integrity. Nature Reviews Cancer, 3(3), 155-168.
    • (2003) Nature Reviews Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 75
    • 3242882820 scopus 로고    scopus 로고
    • PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways
    • 8-9
    • Abraham, R. T. (2004). PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways. DNA Repair (Amst), 3(8-9), 883-887.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 883-887
    • Abraham, R.T.1
  • 76
    • 3242886117 scopus 로고    scopus 로고
    • The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways
    • 8-9
    • Abraham, R. T. (2004). The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst), 3(8-9), 919-925.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 919-925
    • Abraham, R.T.1
  • 78
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • 6922
    • Bakkenist, C. J., & Kastan, M. B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 421(6922), 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 79
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • 5547
    • Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001). ATR and ATRIP: partners in checkpoint signaling. Science, 294(5547), 1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 80
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • 5442
    • Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999). Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science, 286(5442), 1162-1166.
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 81
    • 12544250589 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
    • 2
    • Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005). Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. Journal of Biological Chemistry, 280(2), 1186-1192.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 1186-1192
    • Helt, C.E.1    Cliby, W.A.2    Keng, P.C.3    Bambara, R.A.4    O'Reilly, M.A.5
  • 82
    • 0035145591 scopus 로고    scopus 로고
    • P21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
    • 4
    • Green, S. L., Freiberg, R. A., & Giaccia, A. J. (2001). p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Molecular & Cellular Biology, 21(4), 1196-1206.
    • (2001) Molecular & Cellular Biology , vol.21 , pp. 1196-1206
    • Green, S.L.1    Freiberg, R.A.2    Giaccia, A.J.3
  • 85
    • 4744373121 scopus 로고    scopus 로고
    • Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
    • 20
    • Zhang, X., Succi, J., Feng, Z., Prithivirajsingh, S., Story, M. D., Legerski, R. J. (2004). Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Molecular and Cellular Biology, 24(20), 9207-9220.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 9207-9220
    • Zhang, X.1    Succi, J.2    Feng, Z.3    Prithivirajsingh, S.4    Story, M.D.5    Legerski, R.J.6
  • 86
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • 6792
    • Li, S., Ting, N. S., Zheng, L., Chen, P. L., Ziv, Y., Shiloh, Y., et al. (2000). Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature, 406(6792), 210-215.
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1    Ting, N.S.2    Zheng, L.3    Chen, P.L.4    Ziv, Y.5    Shiloh, Y.6
  • 87
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • 3
    • Chehab, N. H., Malikzay, A., Appel, M., & Halazonetics, T. D. (2000). Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Development, 14(3), 278-288.
    • (2000) Genes Development , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 89
    • 14844314790 scopus 로고    scopus 로고
    • The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
    • 8
    • Au, W. W., & Henderson, B. R. (2005). The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. Journal of Biological Chemistry, 280(8), 6993-7001.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 6993-7001
    • Au, W.W.1    Henderson, B.R.2
  • 90
    • 0030839860 scopus 로고    scopus 로고
    • Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage
    • 7
    • Thomas, J. E., Smith, M., Tonkinson, J. L., Rubinfeld, B., & Polakis, P. (1997). Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage. Cell Growth Differ, 8(7), 801-809.
    • (1997) Cell Growth Differ , vol.8 , pp. 801-809
    • Thomas, J.E.1    Smith, M.2    Tonkinson, J.L.3    Rubinfeld, B.4    Polakis, P.5
  • 92
    • 33749000596 scopus 로고    scopus 로고
    • The role of BRCA1 in transcriptional regulation and cell cycle control
    • 43
    • Mullan, P. B., Quinn, J. E., & Harkin, D. P. (2006). The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene, 25(43), 5854-5863.
    • (2006) Oncogene , vol.25 , pp. 5854-5863
    • Mullan, P.B.1    Quinn, J.E.2    Harkin, D.P.3
  • 94
    • 0034624718 scopus 로고    scopus 로고
    • HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • 6774
    • Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000). hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature, 404(6774), 201-204.
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 95
    • 0037449747 scopus 로고    scopus 로고
    • Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization
    • 3
    • Okada, S., & Ouchi, T. (2003). Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. Journal of Biological Chemistry, 278(3), 2015-2020.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 2015-2020
    • Okada, S.1    Ouchi, T.2
  • 96
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • 2
    • Venkitaraman, A. R. (2002). Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell, 108(2), 171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 97
    • 33744964884 scopus 로고    scopus 로고
    • BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression
    • 19
    • Kang, H. J., Kim, H. J., Rin, J.-K., Mattson, T. L., Kim, K. W., Cho, C.-H., et al. (2006). BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression. Journal of Biological Chemistry, 281(19), 13047-13056.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 13047-13056
    • Kang, H.J.1    Kim, H.J.2    Rin, J.-K.3    Mattson, T.L.4    Kim, K.W.5    Cho, C.-H.6
  • 98
    • 0001501341 scopus 로고    scopus 로고
    • Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes
    • 3
    • Flygare, J., Benson, F., & Hellgren, D. (1996). Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochimica et Biophysica acta, 1312(3), 231-236.
    • (1996) Biochimica et Biophysica Acta , vol.1312 , pp. 231-236
    • Flygare, J.1    Benson, F.2    Hellgren, D.3
  • 100
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • 14
    • Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003). ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. Journal of Biological Chemistry, 278(14), 12207-12213.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.