메뉴 건너뛰기




Volumn 48, Issue 12, 2009, Pages 761-804

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; ATOMOXETINE; CHLORPHENIRAMINE; CITALOPRAM; CODEINE; CYTOCHROME P450 2D6; DIHYDROCODEINE; DOLASETRON MESILATE; DONEPEZIL; GALANTAMINE; HALOPERIDOL; HYDROCODONE; LORATADINE; MIANSERIN; NEUROLEPTIC AGENT; NICERGOLINE; ONDANSETRON; OXYCODONE; PERPHENAZINE; PHENFORMIN; QUINIDINE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; TAMOXIFEN; THIORIDAZINE; TOLTERODINE; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; ZUCLOPENTHIXOL;

EID: 70449371633     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/11318070-000000000-00000     Document Type: Review
Times cited : (252)

References (455)
  • 1
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part i
    • Zhou S-F. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet 2009; 48: 689-723
    • (2009) Clin Pharmacokinet , vol.48 , pp. 689-723
    • Zhou, S.-F.1
  • 2
    • 35448935655 scopus 로고    scopus 로고
    • Metabolism of antidepressant and neuroleptic drugs by cytochrome P450s: Clinical and interethnic aspects
    • Bertilsson L. Metabolism of antidepressant and neuroleptic drugs by cytochrome P450s: clinical and interethnic aspects. Clin Pharmacol Ther 2007; 82: 606-609
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 606-609
    • Bertilsson, L.1
  • 3
    • 0018175260 scopus 로고
    • Tricyclic antidepressants (firstoftwo parts)
    • Hollister LE. Tricyclic antidepressants (firstoftwo parts). N EnglJ Med 1978; 299: 1106-1109
    • (1978) N EnglJ Med , vol.299 , pp. 1106-1109
    • Hollister, L.E.1
  • 4
    • 0019788132 scopus 로고
    • Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes
    • Mellstrom B, von Bahr C. Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes. Drug Metab Dispos 1981; 9: 565-568
    • (1981) Drug Metab Dispos , vol.9 , pp. 565-568
    • Mellstrom, B.1    Von Bahr, C.2
  • 5
    • 0034109883 scopus 로고    scopus 로고
    • Microsomal binding of amitriptyline: Effect on estimation of enzyme kinetic parameters in vitro
    • Venkatakrishnan K, Von Moltke LL, Obach RS, etal. Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro. J Pharmacol Exp Ther 2000; 293: 343-350
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 343-350
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Obach, R.S.3
  • 7
    • 0030992855 scopus 로고    scopus 로고
    • Hydroxylation and demethylation of the tricyclic an-tidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes
    • Olesen OV, Linnet K. Hydroxylation and demethylation of the tricyclic an-tidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos 1997; 25: 740-744
    • (1997) Drug Metab Dispos , vol.25 , pp. 740-744
    • Olesen, O.V.1    Linnet, K.2
  • 8
    • 7544225874 scopus 로고    scopus 로고
    • The metabolic fate of amitriptyline, nortriptyline and ami-triptylinoxide in man
    • Breyer-Pfaff U. The metabolic fate of amitriptyline, nortriptyline and ami-triptylinoxide in man. Drug Metab Rev 2004; 36: 723-746
    • (2004) Drug Metab Rev , vol.36 , pp. 723-746
    • Breyer-Pfaff, U.1
  • 9
    • 0026469799 scopus 로고
    • Enantioselective amitriptyline meta-bolism in patients phenotyped for two cytochrome P450 isozymes
    • Breyer-Pfaff U, Pfandl B, Nill K, et al. Enantioselective amitriptyline meta-bolism in patients phenotyped for two cytochrome P450 isozymes. Clin Pharmacol Ther 1992; 52: 350-358
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 350-358
    • Breyer-Pfaff, U.1    Pfandl, B.2    Nill, K.3    Al, E.4
  • 10
    • 0026001359 scopus 로고
    • Enantioselective hydroxylation of nor-triptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline
    • Dahl ML, Nordin C, Bertilsson L. Enantioselective hydroxylation of nor-triptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline. Ther Drug Monit 1991; 13: 189-194
    • (1991) Ther Drug Monit , vol.13 , pp. 189-194
    • Dahl, M.L.1    Nordin, C.2    Bertilsson, L.3
  • 11
    • 0028813788 scopus 로고
    • Active hydroxymetabolites of antidepressants: Em-phasis on E-10-hydroxy-nortriptyline
    • Nordin C, Bertilsson L. Active hydroxymetabolites of antidepressants: em-phasis on E-10-hydroxy-nortriptyline. Clin Pharmacokinet 1995; 28: 26-40
    • (1995) Clin Pharmacokinet , vol.28 , pp. 26-40
    • Nordin, C.1    Bertilsson, L.2
  • 12
    • 0022481136 scopus 로고
    • Amitriptyline metabolism: Associa-tion with debrisoquin hydroxylation in nonsmokers
    • Mellstrom B, Sawe J, Bertilsson L, et al. Amitriptyline metabolism: associa-tion with debrisoquin hydroxylation in nonsmokers. Clin Pharmacol Ther 1986; 39: 369-371
    • (1986) Clin Pharmacol Ther , vol.39 , pp. 369-371
    • Mellstrom, B.1    Sawe, J.2    Bertilsson, L.3    Al, E.4
  • 13
    • 0029926315 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: Relationship to the CYP2D6 genotype
    • Dahl ML, Bertilsson L, Nordin C. Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype. Psy-chopharmacology (Berl) 1996; 123: 315-319
    • (1996) Psy-chopharmacology (Berl) , vol.123 , pp. 315-319
    • Dahl, M.L.1    Bertilsson, L.2    Nordin, C.3
  • 14
    • 0019449455 scopus 로고
    • E-and Z-10-hydroxylation of nor-triptyline: Relationship to polymorphic debrisoquine hydroxylation
    • Mellstrom B, Bertilsson L, Sawe J, et al. E-and Z-10-hydroxylation of nor-triptyline: relationship to polymorphic debrisoquine hydroxylation. Clin Pharmacol Ther 1981; 30: 189-193
    • (1981) Clin Pharmacol Ther , vol.30 , pp. 189-193
    • Mellstrom, B.1    Bertilsson, L.2    Sawe, J.3    Al, E.4
  • 15
    • 0024465177 scopus 로고
    • Steady-state plasma levels of E-and Z-10-OH-nortriptyline in nortriptyline-treated patients: Significance of concurrent medication and the sparteine oxidation phenotype
    • Gram LF, Brosen K, Kragh-Sorensen P, et al. Steady-state plasma levels of E-and Z-10-OH-nortriptyline in nortriptyline-treated patients: significance of concurrent medication and the sparteine oxidation phenotype. Ther Drug Monit 1989; 11: 508-514
    • (1989) Ther Drug Monit , vol.11 , pp. 508-514
    • Gram, L.F.1    Brosen, K.2    Kragh-Sorensen, P.3    Al, E.4
  • 16
    • 0031949132 scopus 로고    scopus 로고
    • 10-Hydroxylation of nortriptyline in White persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
    • Dalen P, Dahl ML, Bernal Ruiz ML, et al. 10-Hydroxylation of nortriptyline in White persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 1998; 63: 444-452
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 444-452
    • Dalen, P.1    Dahl, M.L.2    Bernal Ruiz, M.L.3    Al, E.4
  • 17
    • 0031668683 scopus 로고    scopus 로고
    • Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes
    • Yue QY, Zhong ZH, Tybring G, et al. Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther 1998; 64: 384-390
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 384-390
    • Yue, Q.Y.1    Zhong, Z.H.2    Tybring, G.3    Al, E.4
  • 18
    • 0034115770 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: Impact of CYP2D6 genotype on the hydroxylation of nortriptyline
    • Morita S, Shimoda K, Someya T, et al. Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: impact of CYP2D6 genotype on the hydroxylation of nortriptyline. J Clin Psycho-pharmacol 2000; 20: 141-149
    • (2000) J Clin Psycho-pharmacol , vol.20 , pp. 141-149
    • Morita, S.1    Shimoda, K.2    Someya, T.3    Al, E.4
  • 19
    • 37249083501 scopus 로고    scopus 로고
    • The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population
    • Halling J, Weihe P, Brosen K. The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population. Br J Clin Pharmacol 2008; 65: 134-138
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 134-138
    • Halling, J.1    Weihe, P.2    Brosen, K.3
  • 20
    • 12944281041 scopus 로고    scopus 로고
    • Amitriptyline or not, that is the question: Pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy
    • Steimer W, Zopf K, von Amelunxen S, et al. Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. Clin Chem 2005; 51: 376-385
    • (2005) Clin Chem , vol.51 , pp. 376-385
    • Steimer, W.1    Zopf, K.2    Von Amelunxen, S.3    Al, E.4
  • 21
    • 0742307188 scopus 로고    scopus 로고
    • No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline
    • Roberts RL, Mulder RT, Joyce PR, et al. No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline. Hum Psychopharmacol 2004; 19: 17-23
    • (2004) Hum Psychopharmacol , vol.19 , pp. 17-23
    • Roberts, R.L.1    Mulder, R.T.2    Joyce, P.R.3
  • 22
    • 85008295004 scopus 로고    scopus 로고
    • Nortriptyline intoxication induced by ter-binafine
    • van der Kuy PH, Hooymans PM. Nortriptyline intoxication induced by ter-binafine. BMJ 1998; 316: 441
    • (1998) BMJ , vol.316 , pp. 441
    • Van Der Kuy, P.H.1    Hooymans, P.M.2
  • 23
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson L, Aberg-Wistedt A, Gustafsson LL, et al. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit 1985; 7: 478-480
    • (1985) Ther Drug Monit , vol.7 , pp. 478-480
    • Bertilsson, L.1    Aberg-Wistedt, A.2    Gustafsson, L.L.3    Al, E.4
  • 24
    • 0025344810 scopus 로고
    • Clomipramine: An antiobsessional tri-cyclic antidepressant
    • Peters II MD, Davis SK, Austin LS. Clomipramine: an antiobsessional tri-cyclic antidepressant. Clin Pharm 1990; 9: 165-178
    • (1990) Clin Pharm , vol.9 , pp. 165-178
    • Peters Ii, M.D.1    Davis, S.K.2    Austin, L.S.3
  • 26
    • 0030425332 scopus 로고    scopus 로고
    • The biotransformation of clomi-pramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways
    • Nielsen KK, Flinois JP, Beaune P, et al. The biotransformation of clomi-pramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J Pharmacol Exp Ther 1996; 277: 1659-1664
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1659-1664
    • Nielsen, K.K.1    Flinois, J.P.2    Beaune, P.3    Al, E.4
  • 27
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipra-mine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms
    • Nielsen KK, Brosen K, Hansen MG, et al. Single-dose kinetics of clomipra-mine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms. Clin Pharmacol Ther 1994; 55: 518-527
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brosen, K.2    Hansen, M.G.3    Al, E.4
  • 28
    • 0026739661 scopus 로고
    • Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism
    • Danish University Antidepressant Group
    • Nielsen KK, Brosen K, Gram LF. Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group. Eur J Clin Pharmacol 1992; 43: 405-411
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 405-411
    • Nielsen, K.K.1    Brosen, K.2    Gram, L.F.3
  • 29
    • 0025011753 scopus 로고
    • Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms: A double-blind cross-over study
    • Sindrup SH, Gram LF, Skjold T, et al. Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms: a double-blind cross-over study. Br J Clin Pharmacol 1990; 30: 683-691
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 683-691
    • Sindrup, S.H.1    Gram, L.F.2    Skjold, T.3    Al, E.4
  • 30
    • 0017336951 scopus 로고
    • Doxepin up-to-date: A review of its pharmacological properties and therapeutic efficacy with particular reference to depression
    • Pinder RM, Brogden RN, Speight TM, et al. Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression. Drugs 1977; 13: 161-218
    • (1977) Drugs , vol.13 , pp. 161-218
    • Pinder, R.M.1    Brogden, R.N.2    Speight, T.M.3    Al, E.4
  • 31
    • 0025124294 scopus 로고
    • The identification of urinary me-tabolites of doxepin in patients
    • Shu YZ, Hubbard JW, Cooper JK, et al. The identification of urinary me-tabolites of doxepin in patients. Drug Metab Dispos 1990; 18: 735-741
    • (1990) Drug Metab Dispos , vol.18 , pp. 735-741
    • Shu, Y.Z.1    Hubbard, J.W.2    Cooper, J.K.3    Al, E.4
  • 32
    • 0033786474 scopus 로고    scopus 로고
    • Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E-and Z-doxepin
    • Haritos VS, Ghabrial H, Ahokas JT, et al. Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E-and Z-doxepin. Pharma-cogenetics 2000; 10: 591-603
    • (2000) Pharma-cogenetics , vol.10 , pp. 591-603
    • Haritos, V.S.1    Ghabrial, H.2    Ahokas, J.T.3    Al, E.4
  • 33
    • 0035997338 scopus 로고    scopus 로고
    • The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19
    • Hartter S, Tybring G, Friedberg T, et al. The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res 2002; 19: 1034-1037
    • (2002) Pharm Res , vol.19 , pp. 1034-1037
    • Hartter, S.1    Tybring, G.2    Friedberg, T.3    Al, E.4
  • 34
    • 0036797601 scopus 로고    scopus 로고
    • Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E-and Z-doxepin in healthy volunteers
    • Kirchheiner J, Meineke I, Muller G, et al. Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E-and Z-doxepin in healthy volunteers. Pharmacogenetics 2002; 12: 571-580
    • (2002) Pharmacogenetics , vol.12 , pp. 571-580
    • Kirchheiner, J.1    Meineke, I.2    Muller, G.3    Al, E.4
  • 35
    • 34548284118 scopus 로고    scopus 로고
    • A fatal doxepin poisoning associated with a defective CYP2D6 genotype
    • Koski A, Ojanpera I, Sistonen J, et al. A fatal doxepin poisoning associated with a defective CYP2D6 genotype. Am J Forensic Med Pathol 2007; 28: 259-261
    • (2007) Am J Forensic Med Pathol , vol.28 , pp. 259-261
    • Koski, A.1    Ojanpera, I.2    Sistonen, J.3    Al, E.4
  • 36
    • 0025218419 scopus 로고
    • Clinical pharmacokinetics of imipramine and desi-pramine
    • Sallee FR, Pollock BG. Clinical pharmacokinetics of imipramine and desi-pramine. Clin Pharmacokinet 1990; 18: 346-364
    • (1990) Clin Pharmacokinet , vol.18 , pp. 346-364
    • Sallee, F.R.1    Pollock, B.G.2
  • 37
    • 0027230584 scopus 로고
    • Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver
    • Lemoine A, Gautier JC, Azoulay D, et al. Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. Mol Pharmacol 1993; 43: 827-832
    • (1993) Mol Pharmacol , vol.43 , pp. 827-832
    • Lemoine, A.1    Gautier, J.C.2    Azoulay, D.3    Al, E.4
  • 38
    • 0030976985 scopus 로고    scopus 로고
    • Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: A study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs
    • Koyama E, Chiba K, Tani M, et al. Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther 1997; 281: 1199-1210
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 1199-1210
    • Koyama, E.1    Chiba, K.2    Tani, M.3    Al, E.4
  • 39
    • 0025733250 scopus 로고
    • Roleof P450IID6, the targetofthe sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine
    • BrosenK, Zeugin T, Meyer UA. Roleof P450IID6, the targetofthe sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 1991; 49: 609-617
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 609-617
    • Brosenk Zeugin, T.1    Meyer, U.A.2
  • 40
    • 0036266825 scopus 로고    scopus 로고
    • Imipramine N-glucuronidation in human liver microsomes: Biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms
    • Nakajima M, Tanaka E, Kobayashi T, et al. Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms. Drug Metab Dispos 2002; 30: 636-642
    • (2002) Drug Metab Dispos , vol.30 , pp. 636-642
    • Nakajima, M.1    Tanaka, E.2    Kobayashi, T.3    Al, E.4
  • 41
    • 0027180803 scopus 로고
    • Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipra-mine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: Preliminary application to oxidation pharmacogenetics
    • Koyama E, Kikuchi Y, Echizen H, et al. Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipra-mine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogenetics. Ther Drug Monit 1993; 15: 224-235
    • (1993) Ther Drug Monit , vol.15 , pp. 224-235
    • Koyama, E.1    Kikuchi, Y.2    Echizen, H.3    Al, E.4
  • 42
    • 0023032092 scopus 로고
    • Imipramine demethylation and hydroxyla-tion: Impact of the sparteine oxidation phenotype
    • Brosen K, Otton SV, Gram LF. Imipramine demethylation and hydroxyla-tion: impact of the sparteine oxidation phenotype. Clin Pharmacol Ther 1986; 40: 543-549
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 543-549
    • Brosen, K.1    Otton, S.V.2    Gram, L.F.3
  • 43
    • 0023139103 scopus 로고
    • Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype
    • Spina E, Steiner E, Ericsson O, et al. Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype. Clin Pharmacol Ther 1987; 41: 314-319 (Pubitemid 17034185)
    • (1987) Clinical Pharmacology and Therapeutics , vol.41 , Issue.3 , pp. 314-319
    • Spina, E.1    Steiner, E.2    Ericsson, O.3    Sjoqvist, F.4
  • 44
    • 0023205985 scopus 로고
    • Differences in the inhibitory effect of cimetidine on desi-pramine metabolism between rapid and slow debrisoquin hydroxylators
    • Steiner E, Spina E. Differences in the inhibitory effect of cimetidine on desi-pramine metabolism between rapid and slow debrisoquin hydroxylators. Clin Pharmacol Ther 1987; 42: 278-282
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 278-282
    • Steiner, E.1    Spina, E.2
  • 45
    • 0031028101 scopus 로고    scopus 로고
    • Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: A prospective study
    • DOI 10.1007/s002280050220
    • Spina E, Gitto C, Avenoso A, et al. Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study. Eur J Clin Pharmacol 1997; 51: 395-398 (Pubitemid 27055908)
    • (1997) European Journal of Clinical Pharmacology , vol.51 , Issue.5 , pp. 395-398
    • Spina, E.1    Gitto, C.2    Avenoso, A.3    Campo, G.M.4    Caputi, A.P.5    Perucca, E.6
  • 46
    • 0034083791 scopus 로고    scopus 로고
    • Metabolism of desipramine in Japanese psychiatric patients: The impact of CYP2D6 genotype on the hydroxylation of desipramine
    • Shimoda K, Morita S, Hirokane G, et al. Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine. Pharmacol Toxicol 2000; 86: 245-249
    • (2000) Pharmacol Toxicol , vol.86 , pp. 245-249
    • Shimoda, K.1    Morita, S.2    Hirokane, G.3    Al, E.4
  • 47
    • 0022510805 scopus 로고
    • Steady-state concentrations of imi-pramine and its metabolites in relation to the sparteine/debrisoquine polymorphism
    • Brosen K, Klysner R, Gram LF, et al. Steady-state concentrations of imi-pramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. Eur J Clin Pharmacol 1986; 30: 679-684
    • (1986) Eur J Clin Pharmacol , vol.30 , pp. 679-684
    • Brosen, K.1    Klysner, R.2    Gram, L.F.3    Al, E.4
  • 48
    • 0025076711 scopus 로고
    • Nonlinear kinetics of imipramine in low and medium plasma level ranges
    • Sindrup SH, Brosen K, Gram LF. Nonlinear kinetics of imipramine in low and medium plasma level ranges. Ther Drug Monit 1990; 12: 445-449
    • (1990) Ther Drug Monit , vol.12 , pp. 445-449
    • Sindrup, S.H.1    Brosen, K.2    Gram, L.F.3
  • 49
    • 43949120461 scopus 로고    scopus 로고
    • Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients
    • Schenk PW, van Fessem MA, Verploegh-Van Rij S, et al. Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients. Mol Psychiatry 2008; 13: 597-605
    • (2008) Mol Psychiatry , vol.13 , pp. 597-605
    • Schenk, P.W.1    Van Fessem, M.A.2    Verploegh-Van Rij, S.3    Al, E.4
  • 50
    • 0017596046 scopus 로고
    • Maprotiline: A review of its pharmacological properties and therapeutic efficacy in mental depressive states
    • Pinder RM, Brogden RN, Speight TM, et al. Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive states. Drugs 1977; 13: 321-352
    • (1977) Drugs , vol.13 , pp. 321-352
    • Pinder, R.M.1    Brogden, R.N.2    Speight, T.M.3    Al, E.4
  • 51
    • 0036010090 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes contributing to demethylation of maprotiline in man
    • Brachtendorf L, Jetter A, Beckurts KT, et al. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol 2002; 90: 144-149
    • (2002) Pharmacol Toxicol , vol.90 , pp. 144-149
    • Brachtendorf, L.1    Jetter, A.2    Beckurts, K.T.3    Al, E.4
  • 52
    • 0021940456 scopus 로고
    • Isolation and identification of hydroxylated maprotiline metabolites
    • Breyer-Pfaff U, Kroeker M, Winkler T, et al. Isolation and identification of hydroxylated maprotiline metabolites. Xenobiotica 1985; 15: 57-66
    • (1985) Xenobiotica , vol.15 , pp. 57-66
    • Breyer-Pfaff, U.1    Kroeker, M.2    Winkler, T.3    Al, E.4
  • 53
    • 0027401927 scopus 로고
    • Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients
    • Hartter S, Wetzel H, Hammes E, et al. Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients. Psychopharmacology (Berl) 1993; 110: 302-308
    • (1993) Psychopharmacology (Berl) , vol.110 , pp. 302-308
    • Hartter, S.1    Wetzel, H.2    Hammes, E.3    Al, E.4
  • 54
    • 0036157240 scopus 로고    scopus 로고
    • Increased plasma concentration of mapro-tiline by coadministration of risperidone
    • Normann C, Lieb K, Walden J. Increased plasma concentration of mapro-tiline by coadministration of risperidone. J Clin Psychopharmacol 2002; 22: 92-94
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 92-94
    • Normann, C.1    Lieb, K.2    Walden, J.3
  • 55
    • 0030746157 scopus 로고    scopus 로고
    • Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression
    • Konig F, Wolfersdorf M, Loble M, et al. Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression. Pharmacopsychiatry 1997; 30: 125-127
    • (1997) Pharmacopsychiatry , vol.30 , pp. 125-127
    • Konig, F.1    Wolfersdorf, M.2    Loble, M.3    Al, E.4
  • 56
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study
    • Gram LF, Guentert TW, Grange S, et al. Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther 1995; 57: 670-677
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3    Al, E.4
  • 57
    • 0028282613 scopus 로고
    • Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debri-soquine
    • Firkusny L, Gleiter CH. Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debri-soquine. Br J Clin Pharmacol 1994; 37: 383-388
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 383-388
    • Firkusny, L.1    Gleiter, C.H.2
  • 58
    • 0024423207 scopus 로고
    • Clinical originality and new biology of trimipramine
    • discussion 49-50
    • Gastpar M. Clinical originality and new biology of trimipramine. Drugs 1989; 38 Suppl. 1: 43-8; discussion 49-50
    • (1989) Drugs , vol.38 , Issue.SUPPL 1 , pp. 43-8
    • Gastpar, M.1
  • 60
    • 0034072429 scopus 로고    scopus 로고
    • Steady state plasma levels of the en-antiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19-and CYP3A4/5-phenotyped patients
    • Eap CB, Bender S, Gastpar M, et al. Steady state plasma levels of the en-antiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19-and CYP3A4/5-phenotyped patients. Ther Drug Monit 2000; 22: 209-214
    • (2000) Ther Drug Monit , vol.22 , pp. 209-214
    • Eap, C.B.1    Bender, S.2    Gastpar, M.3    Al, E.4
  • 61
    • 0141705762 scopus 로고    scopus 로고
    • Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics
    • Kirchheiner J, Muller G, Meineke I, et al. Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics. J Clin Psychopharmacol 2003; 23: 459-466
    • (2003) J Clin Psychopharmacol , vol.23 , pp. 459-466
    • Kirchheiner, J.1    Muller, G.2    Meineke, I.3    Al, E.4
  • 62
    • 0026441360 scopus 로고
    • Influence of quinidine on the pharma-cokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers: A pilot study on two subjects
    • Eap CB, Laurian S, Souche A, et al. Influence of quinidine on the pharma-cokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers: a pilot study on two subjects. Neuropsychobiology 1992; 25: 214-220
    • (1992) Neuropsychobiology , vol.25 , pp. 214-220
    • Eap, C.B.1    Laurian, S.2    Souche, A.3    Al, E.4
  • 63
    • 0029147975 scopus 로고    scopus 로고
    • Paroxetine increases serum trimipra-mine concentration: A report of two cases
    • Leinonen E, Koponen HJ, Lepola U. Paroxetine increases serum trimipra-mine concentration: a report of two cases. Human Psychopharmacol Clin Exp 2004; 10: 345-347
    • (2004) Human Psychopharmacol Clin Exp , vol.10 , pp. 345-347
    • Leinonen, E.1    Koponen, H.J.2    Lepola, U.3
  • 64
    • 0032760610 scopus 로고    scopus 로고
    • Fatality caused by a combined trimipra-mine-citalopram intoxication
    • Musshoff F, Schmidt P, Madea B. Fatality caused by a combined trimipra-mine-citalopram intoxication. Forensic Sci Int 1999; 106: 125-131
    • (1999) Forensic Sci Int , vol.106 , pp. 125-131
    • Musshoff, F.1    Schmidt, P.2    Madea, B.3
  • 65
    • 0031979755 scopus 로고    scopus 로고
    • Metabolism of the newer antidepressants: An overview of the pharmacological and pharmacokinetic implications
    • Caccia S. Metabolism of the newer antidepressants: an overview of the pharmacological and pharmacokinetic implications. Clin Pharmacokinet 1998; 34: 281-302
    • (1998) Clin Pharmacokinet , vol.34 , pp. 281-302
    • Caccia, S.1
  • 66
    • 0344110152 scopus 로고    scopus 로고
    • Pharmacokinetics of selective serotonin reuptake in-hibitors
    • Hiemke C, Hartter S. Pharmacokinetics of selective serotonin reuptake in-hibitors. Pharmacol Ther 2000; 85: 11-28
    • (2000) Pharmacol Ther , vol.85 , pp. 11-28
    • Hiemke, C.1    Hartter, S.2
  • 67
    • 0031025875 scopus 로고    scopus 로고
    • Clinically relevant pharmacology of selective serotonin re-uptake inhibitors: An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism
    • Preskorn SH. Clinically relevant pharmacology of selective serotonin re-uptake inhibitors: an overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism. Clin Pharmacokinet 1997; 32 Suppl. 1: 1-21
    • (1997) Clin Pharmacokinet , vol.1 , Issue.32 SUPPL , pp. 1-21
    • Preskorn, S.H.1
  • 68
    • 0033136981 scopus 로고    scopus 로고
    • O-and N-demethyla-tion of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: Effect of metabolic inhibitors and SSRI anti-depressants
    • Fogelman SM, Schmider J, Venkatakrishnan K, et al. O-and N-demethyla-tion of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI anti-depressants. Neuropsychopharmacology 1999; 20: 480-490
    • (1999) Neuropsychopharmacology , vol.20 , pp. 480-490
    • Fogelman, S.M.1    Schmider, J.2    Venkatakrishnan, K.3    Al, E.4
  • 69
    • 33947728974 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of escitalopram
    • Rao N. The clinical pharmacokinetics of escitalopram. Clin Pharmacokinet 2007; 46: 281-290
    • (2007) Clin Pharmacokinet , vol.46 , pp. 281-290
    • Rao, N.1
  • 70
    • 0032706936 scopus 로고    scopus 로고
    • Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes
    • Olesen OV, Linnet K. Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes. Pharmacology 1999; 59: 298-309
    • (1999) Pharmacology , vol.59 , pp. 298-309
    • Olesen, O.V.1    Linnet, K.2
  • 71
    • 0034936466 scopus 로고    scopus 로고
    • Escitalopram (S-citalopram) and its metabolites in vitro: Cytochromes mediating bio-transformation, inhibitory effects, and comparison to R-citalopram
    • von Moltke LL, Greenblatt DJ, Giancarlo GM, et al. Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating bio-transformation, inhibitory effects, and comparison to R-citalopram. Drug Metab Dispos 2001; 29: 1102-1109
    • (2001) Drug Metab Dispos , vol.29 , pp. 1102-1109
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Giancarlo, G.M.3    Al, E.4
  • 72
    • 0141505009 scopus 로고    scopus 로고
    • Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes
    • Herrlin K, Yasui-Furukori N, Tybring G, et al. Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes. Br J Clin Pharmacol 2003; 56: 415-421
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 415-421
    • Herrlin, K.1    Yasui-Furukori, N.2    Tybring, G.3    Al, E.4
  • 73
    • 44849119612 scopus 로고    scopus 로고
    • Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample
    • Peters EJ, Slager SL, Kraft JB, et al. Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample. PLoS ONE 2008; 3: e1872
    • (2008) PLoS ONE , vol.3
    • Peters, E.J.1    Slager, S.L.2    Kraft, J.B.3    Al, E.4
  • 74
    • 0037380879 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of racemic citalopram: A 5-year experience in Sweden, 1992-1997
    • Reis M, Lundmark J, Bengtsson F. Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992-1997. Ther Drug Monit 2003; 25: 183-191
    • (2003) Ther Drug Monit , vol.25 , pp. 183-191
    • Reis, M.1    Lundmark, J.2    Bengtsson, F.3
  • 75
    • 0033762398 scopus 로고    scopus 로고
    • Fluvoxamine: An updated review of its use in the management of adults with anxiety disorders
    • Figgitt DP, McClellan KJ. Fluvoxamine: an updated review of its use in the management of adults with anxiety disorders. Drugs 2000; 60: 925-954
    • (2000) Drugs , vol.60 , pp. 925-954
    • Figgitt, D.P.1    McClellan, K.J.2
  • 76
    • 0027527214 scopus 로고
    • Fluvoxamine: An updated review of its pharmacology, and therapeutic use in depressive illness
    • Wilde MI, Plosker GL, Benfield P. Fluvoxamine: an updated review of its pharmacology, and therapeutic use in depressive illness. Drugs 1993; 46: 895-924
    • (1993) Drugs , vol.46 , pp. 895-924
    • Wilde, M.I.1    Plosker, G.L.2    Benfield, P.3
  • 78
    • 0028018498 scopus 로고
    • Clinical pharmacokinetics of fluvoxamine
    • Perucca E, Gatti G, Spina E. Clinical pharmacokinetics of fluvoxamine. Clin Pharmacokinet 1994; 27: 175-190
    • (1994) Clin Pharmacokinet , vol.27 , pp. 175-190
    • Perucca, E.1    Gatti, G.2    Spina, E.3
  • 79
    • 0035525466 scopus 로고    scopus 로고
    • The major fluvoxamine metabolite in urine is formed by CYP2D6
    • Spigset O, Axelsson S, Norstrom A, et al. The major fluvoxamine metabolite in urine is formed by CYP2D6. Eur J Clin Pharmacol 2001; 57: 653-658
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 653-658
    • Spigset, O.1    Axelsson, S.2    Norstrom, A.3    Al, E.4
  • 80
    • 0030906968 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of fluvoxamine: Applications to dosage regimen design
    • DeVane CL, Gill HS. Clinical pharmacokinetics of fluvoxamine: applications to dosage regimen design. J Clin Psychiatry 1997; 58 Suppl. 5: 7-14
    • (1997) J Clin Psychiatry , vol.58 , Issue.SUPPL 5 , pp. 7-14
    • Devane, C.L.1    Gill, H.S.2
  • 81
    • 0029160813 scopus 로고
    • Overview of the pharmacokinetics of fluvoxamine
    • van Harten J. Overview of the pharmacokinetics of fluvoxamine. Clin Pharmacokinet 1995; 29 Suppl. 1: 1-9
    • (1995) Clin Pharmacokinet , vol.29 , Issue.SUPPL 1 , pp. 1-9
    • Van Harten, J.1
  • 82
    • 48549093980 scopus 로고    scopus 로고
    • Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: An update
    • Spina E, Santoro V, D'Arrigo C. Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update. Clin Ther 2008; 30: 1206-1227
    • (2008) Clin Ther , vol.30 , pp. 1206-1227
    • Spina, E.1    Santoro, V.2    D'Arrigo, C.3
  • 83
    • 0029125983 scopus 로고
    • Fluvoxamine: A review of global drug-drug interaction data
    • discussion 31-32
    • WagnerW, Vause EW. Fluvoxamine: a review of global drug-drug interaction data. Clin Pharmacokinet 1995; 29 Suppl. 1: 26-31; discussion 31-32
    • (1995) Clin Pharmacokinet , vol.29 , Issue.SUPPL 1 , pp. 26-31
    • Wagner, W.1    Vause, E.W.2
  • 84
    • 0036212577 scopus 로고    scopus 로고
    • Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19)
    • Christensen M, Tybring G, Mihara K,et al. Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19). Clin Pharmacol Ther 2002; 71: 141-152
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 141-152
    • Christensen, M.1    Tybring, G.2    Mihara, K.3
  • 85
    • 33645024572 scopus 로고    scopus 로고
    • Polymorphisms in the 5-hydroxytryptamine 2A receptor and cytochrome P4502D6 genes synergistically predict fluvox-amine-induced side effects in Japanese depressed patients
    • Suzuki Y, Sawamura K, Someya T. Polymorphisms in the 5-hydroxytryptamine 2A receptor and cytochrome P4502D6 genes synergistically predict fluvox-amine-induced side effects in Japanese depressed patients. Neuropsycho-pharmacology 2006; 31: 825-831
    • (2006) Neuropsycho-pharmacology , vol.31 , pp. 825-831
    • Suzuki, Y.1    Sawamura, K.2    Someya, T.3
  • 86
    • 0034894010 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: A first step towards sub-population-specific dosages
    • Kirchheiner J, Brosen K, Dahl ML, et al. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards sub-population-specific dosages. Acta Psychiatr Scand 2001; 104: 173-192
    • (2001) Acta Psychiatr Scand , vol.104 , pp. 173-192
    • Kirchheiner, J.1    Brosen, K.2    Dahl, M.L.3    Al, E.4
  • 87
    • 33644888790 scopus 로고    scopus 로고
    • Fluoxetine metabolism and pharmaco-logical interactions: The role of cytochrome P450
    • Mandrioli R, Forti GC, Raggi MA. Fluoxetine metabolism and pharmaco-logical interactions: the role of cytochrome P450. Curr Drug Metab 2006; 7: 127-133
    • (2006) Curr Drug Metab , vol.7 , pp. 127-133
    • Mandrioli, R.1    Forti, G.C.2    Raggi, M.A.3
  • 88
    • 0033815944 scopus 로고    scopus 로고
    • (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes
    • Margolis JM, O'Donnell JP, Mankowski DC, et al. (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos 2000; 28: 1187-1191
    • (2000) Drug Metab Dispos , vol.28 , pp. 1187-1191
    • Margolis, J.M.1    O'Donnell, J.P.2    Mankowski, D.C.3
  • 89
    • 0035016503 scopus 로고    scopus 로고
    • Identification of the human cyto-chromes P450 responsible for in vitro formation of R-and S-norfluoxetine
    • Ring BJ, Eckstein JA, Gillespie JS, et al. Identification of the human cyto-chromes P450 responsible for in vitro formation of R-and S-norfluoxetine. J Pharmacol Exp Ther 2001; 297: 1044-1050
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1044-1050
    • Ring, B.J.1    Eckstein, J.A.2    Gillespie, J.S.3    Al, E.4
  • 90
    • 0029827303 scopus 로고    scopus 로고
    • The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin
    • Hamelin BA, Turgeon J, Vallee F, et al. The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin. Clin Pharmacol Ther 1996; 60: 512-521
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 512-521
    • Hamelin, B.A.1    Turgeon, J.2    Vallee, F.3    Al, E.4
  • 91
    • 0032891488 scopus 로고    scopus 로고
    • The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine
    • Fjordside L, Jeppesen U, Eap CB, et al. The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine. Pharmacoge-netics 1999; 9: 55-60
    • (1999) Pharmacoge-netics , vol.9 , pp. 55-60
    • Fjordside, L.1    Jeppesen, U.2    Eap, C.B.3    Al, E.4
  • 92
    • 27744566428 scopus 로고    scopus 로고
    • Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine
    • Scordo MG, Spina E, Dahl ML, et al. Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine. Basic Clin Pharmacol Toxicol 2005; 97: 296-301
    • (2005) Basic Clin Pharmacol Toxicol , vol.97 , pp. 296-301
    • Scordo, M.G.1    Spina, E.2    Dahl, M.L.3    Al, E.4
  • 93
    • 0035989059 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia
    • Stedman CA, Begg EJ, Kennedy MA, et al. Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia. Hum Psychopharmacol 2002; 17: 187-190
    • (2002) Hum Psychopharmacol , vol.17 , pp. 187-190
    • Stedman, C.A.1    Begg, E.J.2    Kennedy, M.A.3    Al, E.4
  • 94
    • 0031984009 scopus 로고    scopus 로고
    • Paroxetine: An update of its pharma-cology and therapeutic use in depression and a review of its use in other disorders
    • Gunasekara NS, Noble S, Benfield P. Paroxetine: an update of its pharma-cology and therapeutic use in depression and a review of its use in other disorders. Drugs 1998; 55: 85-120
    • (1998) Drugs , vol.55 , pp. 85-120
    • Gunasekara, N.S.1    Noble, S.2    Benfield, P.3
  • 95
    • 0026568846 scopus 로고
    • The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes
    • Bloomer JC, Woods FR, Haddock RE, et al. The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes. Br J Clin Pharmacol 1992; 33: 521-523
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 521-523
    • Bloomer, J.C.1    Woods, F.R.2    Haddock, R.E.3    Al, E.4
  • 96
    • 0026606822 scopus 로고
    • The relationship between paroxetine and the sparteine oxidation polymorphism
    • Sindrup SH, Brosen K, Gram LF, et al. The relationship between paroxetine and the sparteine oxidation polymorphism. Clin Pharmacol Ther 1992; 51: 278-287
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 278-287
    • Sindrup, S.H.1    Brosen, K.2    Gram, L.F.3    Al, E.4
  • 97
    • 0026576928 scopus 로고
    • Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism
    • Sindrup SH, Brosen K, Gram LF. Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism. Clin Pharmacol Ther 1992; 51: 288-295
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 288-295
    • Sindrup, S.H.1    Brosen, K.2    Gram, L.F.3
  • 98
    • 0032849017 scopus 로고    scopus 로고
    • Paroxetine steady-state plasma con-centration in relation to CYP2D6 genotype in extensive metabolizers
    • Ozdemir V, Tyndale RF, Reed K, et al. Paroxetine steady-state plasma con-centration in relation to CYP2D6 genotype in extensive metabolizers. J Clin Psychopharmacol 1999; 19: 472-475
    • (1999) J Clin Psychopharmacol , vol.19 , pp. 472-475
    • Ozdemir, V.1    Tyndale, R.F.2    Reed, K.3    Al, E.4
  • 99
    • 0036021208 scopus 로고    scopus 로고
    • CYP2D6 inhibition by selective serotonin reuptake inhibitors: Analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6
    • Lam YW, Gaedigk A, Ereshefsky L, et al. CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6. Pharmacotherapy 2002; 22: 1001-1006
    • (2002) Pharmacotherapy , vol.22 , pp. 1001-1006
    • Lam, Y.W.1    Gaedigk, A.2    Ereshefsky, L.3    Al, E.4
  • 100
    • 0345060779 scopus 로고    scopus 로고
    • Polymorphisms in the CYP2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
    • Charlier C, Broly F, Lhermitte M, et al. Polymorphisms in the CYP2D6 gene: association with plasma concentrations of fluoxetine and paroxetine. Ther Drug Monit 2003; 25: 738-742
    • (2003) Ther Drug Monit , vol.25 , pp. 738-742
    • Charlier, C.1    Broly, F.2    Lhermitte, M.3    Al, E.4
  • 101
    • 0036789442 scopus 로고    scopus 로고
    • Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment
    • Zourkova A, Hadasova E. Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment. J Sex Marital Ther 2002; 28: 451-461
    • (2002) J Sex Marital Ther , vol.28 , pp. 451-461
    • Zourkova, A.1    Hadasova, E.2
  • 102
    • 0642371335 scopus 로고    scopus 로고
    • Pharmacogenetics of anti-depressant medication intolerance
    • Murphy Jr GM, Kremer C, Rodrigues S, et al. Pharmacogenetics of anti-depressant medication intolerance. Am J Psychiatry 2003; 160: 1830-1835
    • (2003) Am J Psychiatry , vol.160 , pp. 1830-1835
    • Murphy Jr, G.M.1    Kremer, C.2    Rodrigues, S.3    Al, E.4
  • 103
    • 38949107641 scopus 로고    scopus 로고
    • Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea
    • Tanaka M, Kobayashi D, Murakami Y, et al. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. Int J Neuropsychopharmacol 2008; 11: 261-267
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 261-267
    • Tanaka, M.1    Kobayashi, D.2    Murakami, Y.3    Al, E.4
  • 104
    • 0020585707 scopus 로고
    • The potential therapeutic role of the enantiomers and metabolites of mianserin
    • Pinder RM, Van Delft AM. The potential therapeutic role of the enantiomers and metabolites of mianserin. Br J Clin Pharmacol 1983; 15 Suppl. 2: 269-76S
    • (1983) Br J Clin Pharmacol , vol.15 , Issue.SUPPL 2
    • Pinder, R.M.1    Van Delft, A.M.2
  • 105
  • 106
    • 0033810675 scopus 로고    scopus 로고
    • Metabolism of the anti-depressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4
    • Stormer E, von Moltke LL, Shader RI, et al. Metabolism of the anti-depressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos 2000; 28: 1168-1175
    • (2000) Drug Metab Dispos , vol.28 , pp. 1168-1175
    • Stormer, E.1    Von Moltke, L.L.2    Shader, R.I.3    Al, E.4
  • 107
    • 0030434501 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin en-antiomers
    • Koyama E, Chiba K, Tani M, et al. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin en-antiomers. J Pharmacol Exp Ther 1996; 278: 21-30
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 21-30
    • Koyama, E.1    Chiba, K.2    Tani, M.3    Al, E.4
  • 108
    • 0027980392 scopus 로고
    • Stereoselective disposition ofmianserin is related todebrisoquin hydroxylation polymorphism
    • Dahl ML, TybringG, Elwin CE, etal. Stereoselective disposition ofmianserin is related todebrisoquin hydroxylation polymorphism. Clin Pharmacol Ther 1994; 56: 176-183
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 176-183
    • Dahl, M.L.1    Tybringg Elwin, C.E.2
  • 109
    • 0030772110 scopus 로고    scopus 로고
    • Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients
    • Yasui N, Tybring G, Otani K, et al. Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients. Pharmacogenetics 1997; 7: 369-374
    • (1997) Pharmacogenetics , vol.7 , pp. 369-374
    • Yasui, N.1    Tybring, G.2    Otani, K.3
  • 110
    • 0026660470 scopus 로고
    • Lack of effect of mianserin on the symptoms of diabetic neuropathy
    • Sindrup SH, Tuxen C, Gram LF, et al. Lack of effect of mianserin on the symptoms of diabetic neuropathy. Eur J Clin Pharmacol 1992; 43: 251-255
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 251-255
    • Sindrup, S.H.1    Tuxen, C.2    Gram, L.F.3    Al, E.4
  • 111
    • 0026776937 scopus 로고
    • Debrisoquine hydroxylation phe-notypes of patients with high versus low to normal serum antidepressant concentrations
    • Tacke U, Leinonen E, Lillsunde P, et al. Debrisoquine hydroxylation phe-notypes of patients with high versus low to normal serum antidepressant concentrations. J Clin Psychopharmacol 1992; 12: 262-267
    • (1992) J Clin Psychopharmacol , vol.12 , pp. 262-267
    • Tacke, U.1    Leinonen, E.2    Lillsunde, P.3    Al, E.4
  • 112
    • 0024519844 scopus 로고
    • Variability in the elimination of mianserin in elderly patients
    • Begg EJ, Sharman JR, Kidd JE, et al. Variability in the elimination of mianserin in elderly patients. Br J Clin Pharmacol 1989; 27: 445-451
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 445-451
    • Begg, E.J.1    Sharman, J.R.2    Kidd, J.E.3    Al, E.4
  • 113
    • 0031400024 scopus 로고    scopus 로고
    • The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients
    • Mihara K, Otani K, Tybring G, et al. The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients. J Clin Psychopharmacol 1997; 17: 467-471
    • (1997) J Clin Psychopharmacol , vol.17 , pp. 467-471
    • Mihara, K.1    Otani, K.2    Tybring, G.3    Al, E.4
  • 114
    • 0035673798 scopus 로고    scopus 로고
    • Areview of the pharmacological and clinical profile of mirtazapine
    • Anttila SA, Leinonen EV. Areview of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 2001; 7: 249-264
    • (2001) CNS Drug Rev , vol.7 , pp. 249-264
    • Anttila, S.A.1    Leinonen, E.V.2
  • 116
    • 0031930087 scopus 로고    scopus 로고
    • Pharmacokinetics and biotransformation of mirtazapine in human volunteers
    • Delbressine LP, Moonen ME, Kaspersen FM, et al. Pharmacokinetics and biotransformation of mirtazapine in human volunteers. Clin Drug Investig 1998; 15: 45-55
    • (1998) Clin Drug Investig , vol.15 , pp. 45-55
    • Delbressine, L.P.1    Moonen, M.E.2    Kaspersen, F.M.3    Al, E.4
  • 118
    • 8744224452 scopus 로고    scopus 로고
    • Impact of the CYP2D6 ultra-rapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers
    • Kirchheiner J, Henckel HB, Meineke I, et al. Impact of the CYP2D6 ultra-rapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers. J Clin Psychopharmacol 2004; 24: 647-652
    • (2004) J Clin Psychopharmacol , vol.24 , pp. 647-652
    • Kirchheiner, J.1    Henckel, H.B.2    Meineke, I.3    Al, E.4
  • 119
    • 34247213955 scopus 로고    scopus 로고
    • Pharmacokinetics of mirtazapine: Enantioselective effects of the CYP2D6 ultra rapid metabolizer genotype and correlation with adverse effects
    • Brockmoller J, Meineke I, Kirchheiner J. Pharmacokinetics of mirtazapine: enantioselective effects of the CYP2D6 ultra rapid metabolizer genotype and correlation with adverse effects. Clin Pharmacol Ther 2007; 81: 699-707
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 699-707
    • Brockmoller, J.1    Meineke, I.2    Kirchheiner, J.3
  • 120
    • 0028801952 scopus 로고
    • Venlafaxine: A review of its pharmacology and therapeutic potential in depression
    • Holliday SM, Benfield P. Venlafaxine: a review of its pharmacology and therapeutic potential in depression. Drugs 1995; 49: 280-294
    • (1995) Drugs , vol.49 , pp. 280-294
    • Holliday, S.M.1    Benfield, P.2
  • 121
    • 0028568169 scopus 로고
    • Venlafaxine: A heterocyclic antidepressant
    • Ellingrod VL, Perry PJ. Venlafaxine: a heterocyclic antidepressant. Am J Hosp Pharm 1994; 51: 3033-3046
    • (1994) Am J Hosp Pharm , vol.51 , pp. 3033-3046
    • Ellingrod, V.L.1    Perry, P.J.2
  • 122
  • 123
    • 0141706469 scopus 로고    scopus 로고
    • Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine
    • Lindh JD, Annas A, Meurling L, et al. Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine. Eur J Clin Pharmacol 2003; 59: 401-406
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 401-406
    • Lindh, J.D.1    Annas, A.2    Meurling, L.3    Al, E.4
  • 124
    • 0032847231 scopus 로고    scopus 로고
    • Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans
    • Lessard E, Yessine MA, Hamelin BA, et al. Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans. Pharmacogenetics 1999; 9: 435-443
    • (1999) Pharmacogenetics , vol.9 , pp. 435-443
    • Lessard, E.1    Yessine, M.A.2    Hamelin, B.A.3    Al, E.4
  • 127
    • 0037245877 scopus 로고    scopus 로고
    • Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans
    • Eap CB, Lessard E, Baumann P, et al. Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans. Pharmacogenetics 2003; 13: 39-47
    • (2003) Pharmacogenetics , vol.13 , pp. 39-47
    • Eap, C.B.1    Lessard, E.2    Baumann, P.3    Al, E.4
  • 128
    • 33745914214 scopus 로고    scopus 로고
    • CYP2D6 genotype and venla-faxine-XR concentrationsindepressed elderly
    • Whyte EM, Romkes M, Mulsant BH, et al. CYP2D6 genotype and venla-faxine-XR concentrationsindepressed elderly. IntJGeriatr Psychiatry 2006; 21: 542-549
    • (2006) IntJGeriatr Psychiatry , vol.21 , pp. 542-549
    • Whyte, E.M.1    Romkes, M.2    Mulsant, B.H.3    Al, E.4
  • 129
    • 33748363505 scopus 로고    scopus 로고
    • CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine
    • Shams ME, Arneth B, Hiemke C, et al. CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther 2006; 31: 493-502
    • (2006) J Clin Pharm Ther , vol.31 , pp. 493-502
    • Shams, M.E.1    Arneth, B.2    Hiemke, C.3    Al, E.4
  • 130
    • 41049088156 scopus 로고    scopus 로고
    • Serum concentrations of venla-faxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenla-faxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele
    • Hermann M, Hendset M, Fosaas K, et al. Serum concentrations of venla-faxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenla- faxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele. Eur J Clin Pharmacol 2008; 64: 483-487
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 483-487
    • Hermann, M.1    Hendset, M.2    Fosaas, K.3    Al, E.4
  • 131
    • 34548399738 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype variation and venlafaxine dosage
    • McAlpine DE, O'Kane DJ, Black JL, et al. Cytochrome P450 2D6 genotype variation and venlafaxine dosage. Mayo Clin Proc 2007; 82: 1065-1068
    • (2007) Mayo Clin Proc , vol.82 , pp. 1065-1068
    • McAlpine, D.E.1    O'Kane, D.J.2    Black, J.L.3    Al, E.4
  • 132
    • 0032840038 scopus 로고    scopus 로고
    • Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver mi-crosomes
    • Xu ZH, Wang W, Zhao XJ, et al. Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver mi-crosomes. Br J Clin Pharmacol 1999; 48: 416-423
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 416-423
    • Xu, Z.H.1    Wang, W.2    Zhao, X.J.3    Al, E.4
  • 133
    • 0019450472 scopus 로고
    • Slow hydroxylation of nor-triptyline and concomitant poor debrisoquine hydroxylation: Clinical implications
    • Bertilsson L, Mellstrom B, Sjokvist F, et al. Slow hydroxylation of nor-triptyline and concomitant poor debrisoquine hydroxylation: clinical implications. Lancet 1981; 1: 560-561
    • (1981) Lancet , vol.1 , pp. 560-561
    • Bertilsson, L.1    Mellstrom, B.2    Sjokvist, F.3    Al, E.4
  • 134
    • 0027471030 scopus 로고
    • Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report
    • Bluhm RE, Wilkinson GR, Shelton R, et al. Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report. Clin Pharmacol Ther 1993; 53: 89-95
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 89-95
    • Bluhm, R.E.1    Wilkinson, G.R.2    Shelton, R.3    Al, E.4
  • 135
    • 0027534276 scopus 로고
    • Molecular basis for rational mega-prescribing in ultrarapid hydroxylators of debrisoquine
    • Bertilsson L, Dahl ML, Sjoqvist F, et al. Molecular basis for rational mega-prescribing in ultrarapid hydroxylators of debrisoquine. Lancet 1993; 341: 63
    • (1993) Lancet , vol.341 , pp. 63
    • Bertilsson, L.1    Dahl, M.L.2    Sjoqvist, F.3    Al, E.4
  • 136
    • 2042512985 scopus 로고    scopus 로고
    • CYP2D6 genotype: Impact on adverse effects and nonresponse during treatment with antidepressants A pilot study
    • Rau T, Wohlleben G, Wuttke H, et al. CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants. A pilot study. Clin Pharmacol Ther 2004; 75: 386-393
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 386-393
    • Rau, T.1    Wohlleben, G.2    Wuttke, H.3    Al, E.4
  • 137
    • 1242269894 scopus 로고    scopus 로고
    • Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: Ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
    • Kawanishi C, Lundgren S, Agren H, et al. Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study. Eur J Clin Pharmacol 2004; 59: 803-807
    • (2004) Eur J Clin Pharmacol , vol.59 , pp. 803-807
    • Kawanishi, C.1    Lundgren, S.2    Agren, H.3    Al, E.4
  • 138
    • 19244365359 scopus 로고    scopus 로고
    • Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting
    • Grasmader K, Verwohlt PL, Rietschel M, et al. Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Eur J Clin Pharmacol 2004; 60: 329-336
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 329-336
    • Grasmader, K.1    Verwohlt, P.L.2    Rietschel, M.3    Al, E.4
  • 139
    • 40549089935 scopus 로고    scopus 로고
    • Influence of the CYP2D6*4 poly-morphism on dose, switching and discontinuation of antidepressants
    • Bijl MJ, Visser LE, Hofman A, et al. Influence of the CYP2D6*4 poly-morphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol 2008; 65: 558-564
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 558-564
    • Bijl, M.J.1    Visser, L.E.2    Hofman, A.3    Al, E.4
  • 140
    • 68449101183 scopus 로고    scopus 로고
    • Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants
    • Kwadijk-de Gijsel S, Bijl MJ, Visser LE, et al. Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants. Br J Clin Pharmacol 2009; 68: 221-225
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 221-225
    • Kwadijk-De Gijsel, S.1    Bijl, M.J.2    Visser, L.E.3    Al, E.4
  • 141
    • 57049097080 scopus 로고    scopus 로고
    • Pharmacogenetics-guided dose modifications of antidepressants
    • Seeringer A, Kirchheiner J. Pharmacogenetics-guided dose modifications of antidepressants. Clin Lab Med 2008; 28: 619-626
    • (2008) Clin Lab Med , vol.28 , pp. 619-626
    • Seeringer, A.1    Kirchheiner, J.2
  • 142
    • 54049141721 scopus 로고    scopus 로고
    • Antipsychotic drugs: Com-parison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    • Lieberman JA, Bymaster FP, Meltzer HY, et al. Antipsychotic drugs: com-parison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol Rev 2008; 60: 358-403
    • (2008) Pharmacol Rev , vol.60 , pp. 358-403
    • Lieberman, J.A.1    Bymaster, F.P.2    Meltzer, H.Y.3    Al, E.4
  • 144
    • 34347344910 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs: Current issues of safety and efficacy in the management of schizophrenia
    • Vohora D. Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia. Curr Opin Investig Drugs 2007; 8: 531-8
    • (2007) Curr Opin Investig Drugs , vol.8 , pp. 531-8
    • Vohora, D.1
  • 146
    • 55049106809 scopus 로고    scopus 로고
    • Upcoming agents for the treatment of schizophrenia: Mechanism of action, efficacy and tolerability
    • Bishara D, Taylor D. Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability. Drugs 2008; 68: 2269-2292
    • (2008) Drugs , vol.68 , pp. 2269-2292
    • Bishara, D.1    Taylor, D.2
  • 147
    • 33748787999 scopus 로고    scopus 로고
    • Pharmacogenetics drug-metabolizing enzymes, and clinical practice
    • Gardiner SJ, Begg EJ. Pharmacogenetics drug-metabolizing enzymes, and clinical practice. Pharmacol Rev 2006; 58: 521-590
    • (2006) Pharmacol Rev , vol.58 , pp. 521-590
    • Gardiner, S.J.1    Begg, E.J.2
  • 148
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenom J 2005; 5: 6-13
    • (2005) Pharmacogenom J , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 149
    • 58149339953 scopus 로고    scopus 로고
    • Clinical pharmacogenetics and potential application in personalized medicine
    • Zhou SF, Di YM, Chan E, et al. Clinical pharmacogenetics and potential application in personalized medicine. Curr Drug Metab 2008; 9: 738-784
    • (2008) Curr Drug Metab , vol.9 , pp. 738-784
    • Zhou, S.F.1    Di Ym Chan, E.2    Al, E.3
  • 150
    • 4344714861 scopus 로고    scopus 로고
    • Aripiprazole: A review of its use in schi-zophrenia and schizoaffective disorder
    • Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schi-zophrenia and schizoaffective disorder. Drugs 2004; 64: 1715-1736
    • (2004) Drugs , vol.64 , pp. 1715-1736
    • Swainston Harrison, T.1    Perry, C.M.2
  • 151
    • 0042887023 scopus 로고    scopus 로고
    • Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology
    • Shapiro DA, Renock S, Arrington E, et al. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsycho- pharmacology 2003; 28: 1400-1411
    • (2003) Neuropsycho-pharmacology , vol.28 , pp. 1400-1411
    • Shapiro, D.A.1    Renock, S.2    Arrington, E.3    Al, E.4
  • 152
    • 33845713415 scopus 로고    scopus 로고
    • Pharmacokinetic variability of ar-ipiprazole and the active metabolite dehydroaripiprazole in psychiatric patients
    • Molden E, Lunde H, Lunder N, et al. Pharmacokinetic variability of ar-ipiprazole and the active metabolite dehydroaripiprazole in psychiatric patients. Ther Drug Monit 2006; 28: 744-749
    • (2006) Ther Drug Monit , vol.28 , pp. 744-749
    • Molden, E.1    Lunde, H.2    Lunder, N.3    Al, E.4
  • 153
    • 24144468204 scopus 로고    scopus 로고
    • Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic aripiprazole
    • Kubo M, Koue T, Inaba A, et al. Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic aripiprazole. Drug Metab Pharmacokinet 2005; 20: 55-64
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 55-64
    • Kubo, M.1    Koue, T.2    Inaba, A.3    Al, E.4
  • 154
    • 56549111520 scopus 로고    scopus 로고
    • Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients
    • Kim JR, Seo HB, Cho JY, et al. Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients. Br J Clin Pharmacol 2008; 66: 802-810
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 802-810
    • Kim, J.R.1    Seo, H.B.2    Cho, J.Y.3    Al, E.4
  • 155
    • 36048992549 scopus 로고    scopus 로고
    • Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males
    • Koue T, Kubo M, Funaki T, et al. Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males. Biol Pharm Bull 2007; 30: 2154-2158
    • (2007) Biol Pharm Bull , vol.30 , pp. 2154-2158
    • Koue, T.1    Kubo, M.2    Funaki, T.3    Al, E.4
  • 156
    • 38449084441 scopus 로고    scopus 로고
    • Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: Influence of CYP2D6 polymorphism
    • Kubo M, Koue T, Maune H, et al. Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: influence of CYP2D6 polymorphism. Drug Metab Pharmacokinet 2007; 22: 358-366
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 358-366
    • Kubo, M.1    Koue, T.2    Maune, H.3    Al, E.4
  • 157
    • 36148957447 scopus 로고    scopus 로고
    • Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole
    • Hendset M, Hermann M, Lunde H, et al. Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole. Eur J Clin Pharmacol 2007; 63: 1147-1151
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 1147-1151
    • Hendset, M.1    Hermann, M.2    Lunde, H.3    Al, E.4
  • 158
    • 33846507333 scopus 로고    scopus 로고
    • Safety of aripiprazole: High serum levels in a CYP2D6 mutated patient
    • Oosterhuis M, Van De Kraats G, Tenback D. Safety of aripiprazole: high serum levels in a CYP2D6 mutated patient. Am J Psychiatry 2007; 164: 175
    • (2007) Am J Psychiatry , vol.164 , pp. 175
    • Oosterhuis, M.1    Van De Kraats, G.2    Tenback, D.3
  • 159
    • 65349180154 scopus 로고    scopus 로고
    • Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole
    • Waade RB, Christensen H, Rudberg I, et al. Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole. Ther Drug Monit 2009; 31: 233-238
    • (2009) Ther Drug Monit , vol.31 , pp. 233-238
    • Waade, R.B.1    Christensen, H.2    Rudberg, I.3    Al, E.4
  • 160
    • 0020532457 scopus 로고
    • Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man
    • Hartmann F, Gruenke LD, Craig JC, et al. Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man. Drug Metab Dispos 1983; 11: 244-248
    • (1983) Drug Metab Dispos , vol.11 , pp. 244-248
    • Hartmann, F.1    Gruenke, L.D.2    Craig, J.C.3    Al, E.4
  • 161
    • 0034595672 scopus 로고    scopus 로고
    • Identification of human cyto-chrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes
    • Yoshii K, Kobayashi K, Tsumuji M, et al. Identification of human cyto-chrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci 2000; 67: 175-184
    • (2000) Life Sci , vol.67 , pp. 175-184
    • Yoshii, K.1    Kobayashi, K.2    Tsumuji, M.3    Al, E.4
  • 162
    • 0029926747 scopus 로고    scopus 로고
    • Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debriso-quine
    • Muralidharan G, Cooper JK, Hawes EM, et al. Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debriso-quine. Eur J Clin Pharmacol 1996; 50: 121-128
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 121-128
    • Muralidharan, G.1    Cooper, J.K.2    Hawes, E.M.3    Al, E.4
  • 163
    • 33748765879 scopus 로고    scopus 로고
    • Disposition of chlorpromazine in Korean healthy subjects with CYP2D6 wild-type and *10B mutation [abstract]
    • Sunwoo YE, Ryu J, Jung H, et al. Disposition of chlorpromazine in Korean healthy subjects with CYP2D6 wild-type and *10B mutation [abstract]. Clin Pharmacol Ther 2004; 73: PII-146
    • (2004) Clin Pharmacol Ther , vol.73
    • Sunwoo, Y.E.1    Ryu, J.2    Jung, H.3    Al, E.4
  • 164
    • 0033392246 scopus 로고    scopus 로고
    • Pharmacokinetics of haloperidol: An update
    • Kudo S, Ishizaki T. Pharmacokinetics of haloperidol: an update. Clin Phar-macokinet 1999; 37: 435-456
    • (1999) Clin Phar-macokinet , vol.37 , pp. 435-456
    • Kudo, S.1    Ishizaki, T.2
  • 165
    • 0036123131 scopus 로고    scopus 로고
    • The role of novel antipsychotics in bipolar disorders
    • Yatham LN. The role of novel antipsychotics in bipolar disorders. J Clin Psychiatry 2002; 63: 10-14
    • (2002) J Clin Psychiatry , vol.63 , pp. 10-14
    • Yatham, L.N.1
  • 166
    • 0034602294 scopus 로고    scopus 로고
    • CYP3A is responsible for N-deal-kylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes
    • Tateishi T, Watanabe M, Kumai T, et al. CYP3A is responsible for N-deal-kylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes. Life Sci 2000; 67: 2913-2920
    • (2000) Life Sci , vol.67 , pp. 2913-2920
    • Tateishi, T.1    Watanabe, M.2    Kumai, T.3    Al, E.4
  • 167
    • 0031834493 scopus 로고    scopus 로고
    • Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation
    • Kudo S, Odomi M. Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation. Eur J Clin Pharmacol 1998; 54: 253-259
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 253-259
    • Kudo, S.1    Odomi, M.2
  • 168
    • 0031712064 scopus 로고    scopus 로고
    • In-vitro characterization of the cyto-chrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol
    • Pan LP, De Vriendt C, Belpaire FM. In-vitro characterization of the cyto-chrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. Pharmacogenetics 1998; 8: 383-389
    • (1998) Pharmacogenetics , vol.8 , pp. 383-389
    • Pan, L.P.1    De Vriendt, C.2    Belpaire, F.M.3
  • 169
    • 8944229700 scopus 로고    scopus 로고
    • Effect of rifampin on the plasma con-centration and the clinical effect of haloperidol concomitantly administered to schizophrenic patients
    • Kim YH, Cha IJ, Shim JC, et al. Effect of rifampin on the plasma con-centration and the clinical effect of haloperidol concomitantly administered to schizophrenic patients. J Clin Psychopharmacol 1996; 16: 247-252
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 247-252
    • Kim, Y.H.1    Cha, I.J.2    Shim, J.C.3    Al, E.4
  • 170
    • 0030873010 scopus 로고    scopus 로고
    • Interaction between fluoxetine and haloperidol: Pharmacokinetic and clinical implications
    • Avenoso A, Spina E, Campo G, et al. Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications. Pharmacol Res 1997; 35: 335-339
    • (1997) Pharmacol Res , vol.35 , pp. 335-339
    • Avenoso, A.1    Spina, E.2    Campo, G.3    Al, E.4
  • 171
    • 0029068546 scopus 로고
    • Fluvoxamine and fluoxetine: In-teraction studies with amitriptyline, clomipramine and neuroleptics in phe-notyped patients
    • Vandel S, Bertschy G, Baumann P, et al. Fluvoxamine and fluoxetine: in-teraction studies with amitriptyline, clomipramine and neuroleptics in phe-notyped patients. Pharmacol Res 1995; 31: 347-353
    • (1995) Pharmacol Res , vol.31 , pp. 347-353
    • Vandel, S.1    Bertschy, G.2    Baumann, P.3    Al, E.4
  • 172
    • 0031891375 scopus 로고    scopus 로고
    • The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia
    • DOI 10.2165/00003088-199834030-00005
    • Ulrich S, Wurthmann C, Brosz M, et al. The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia. Clin Pharmacokinet 1998; 34: 227-263 (Pubitemid 28112401)
    • (1998) Clinical Pharmacokinetics , vol.34 , Issue.3 , pp. 227-263
    • Ulrich, S.1    Wurthmann, C.2    Brosz, M.3    Meyer, F.P.4
  • 173
    • 0030903753 scopus 로고    scopus 로고
    • Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients
    • Lane HY, Hu OY, Jann MW, et al. Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients. Psychiatry Res 1997; 69: 105-111
    • (1997) Psychiatry Res , vol.69 , pp. 105-111
    • Lane, H.Y.1    Hu, O.Y.2    Jann, M.W.3    Al, E.4
  • 174
    • 0026692983 scopus 로고
    • Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype
    • Llerena A, Alm C, Dahl ML, et al. Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype. Ther Drug Monit 1992; 14: 92-97
    • (1992) Ther Drug Monit , vol.14 , pp. 92-97
    • Llerena, A.1    Alm, C.2    Dahl, M.L.3    Al, E.4
  • 175
    • 0026780430 scopus 로고
    • Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
    • Llerena A, Dahl ML, Ekqvist B, etal. Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers. Ther Drug Monit 1992; 14: 261-264
    • (1992) Ther Drug Monit , vol.14 , pp. 261-264
    • Llerena, A.1    Dahl, M.L.2    Ekqvist, B.3
  • 176
    • 0028982509 scopus 로고
    • D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate
    • Nyberg S, Farde L, Halldin C, et al. D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate. Am J Psychiatry 1995; 152: 173-178
    • (1995) Am J Psychiatry , Issue.152 , pp. 173-178
    • Nyberg, S.1    Farde, L.2    Halldin, C.3    Al, E.4
  • 177
    • 0036796048 scopus 로고    scopus 로고
    • The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
    • Brockmoller J, Kirchheiner J, Schmider J, et al. The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther 2002; 72: 438-452
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 438-452
    • Brockmoller, J.1    Kirchheiner, J.2    Schmider, J.3    Al, E.4
  • 178
    • 34547697228 scopus 로고    scopus 로고
    • Depot haloperidol treatment in outpatients with schizophrenia on monotherapy: Impact of CYP2D6 polymorphism on pharmacokinetics and treatment outcome
    • Panagiotidis G, Arthur HW, Lindh JD, et al. Depot haloperidol treatment in outpatients with schizophrenia on monotherapy: impact of CYP2D6 polymorphism on pharmacokinetics and treatment outcome. Ther Drug Monit 2007; 29: 417-422
    • (2007) Ther Drug Monit , vol.29 , pp. 417-422
    • Panagiotidis, G.1    Arthur, H.W.2    Lindh, J.D.3    Al, E.4
  • 179
    • 0030826785 scopus 로고    scopus 로고
    • Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients
    • DOI 10.1097/00008571-199710000-00013
    • Suzuki A, Otani K, Mihara K, et al. Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients. Pharmacogenetics 1997; 7: 415-418 (Pubitemid 27427554)
    • (1997) Pharmacogenetics , vol.7 , Issue.5 , pp. 415-418
    • Suzuki, A.1    Otani, K.2    Mihara, K.3    Yasui, N.4    Kaneko, S.5    Inoue, Y.6    Hayashi, K.7
  • 181
    • 0035464647 scopus 로고    scopus 로고
    • Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
    • Roh HK, Chung JY, Oh DY, et al. Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients. Br J Clin Pharmacol 2001; 52: 265-271
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 265-271
    • Roh, H.K.1    Chung, J.Y.2    Oh, D.Y.3    Al, E.4
  • 182
    • 33646693836 scopus 로고    scopus 로고
    • Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharma-codynamics of haloperidol in healthy subjects
    • Park JY, Shon JH, Kim KA, et al. Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharma-codynamics of haloperidol in healthy subjects. J Clin Psychopharmacol 2006; 26: 135-142
    • (2006) J Clin Psychopharmacol , vol.26 , pp. 135-142
    • Park, J.Y.1    Shon, J.H.2    Kim, K.A.3    Al, E.4
  • 183
    • 0033624471 scopus 로고    scopus 로고
    • CYP2D6*10 alleles are not the de-terminant of the plasma haloperidol concentrations in Asian patients
    • Shimoda K, Morita S, Yokono A, et al. CYP2D6*10 alleles are not the de-terminant of the plasma haloperidol concentrations in Asian patients. Ther Drug Monit 2000; 22: 392-396
    • (2000) Ther Drug Monit , vol.22 , pp. 392-396
    • Shimoda, K.1    Morita, S.2    Yokono, A.3    Al, E.4
  • 184
    • 0041317367 scopus 로고    scopus 로고
    • Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6
    • Ohnuma T,Shibata N,MatsubaraY,et al. Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6. Br J Clin Pharmacol 2003; 56: 315-320
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 315-320
    • Ohnuma, T.1    Shibata, N.2    Matsubara, Y.3
  • 185
    • 0032852407 scopus 로고    scopus 로고
    • Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic in-patients
    • Pan L, Vander Stichele R, Rosseel MT, et al. Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic in-patients. Ther Drug Monit 1999; 21: 489-497
    • (1999) Ther Drug Monit , vol.21 , pp. 489-497
    • Pan, L.1    Vander Stichele, R.2    Rosseel, M.T.3    Al, E.4
  • 186
    • 0032752546 scopus 로고    scopus 로고
    • The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population
    • Someya T, Suzuki Y, Shimoda K, et al. The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: a preliminary study in a psychiatric population. Psychiatry Clin Neurosci 1999; 53: 593-597
    • (1999) Psychiatry Clin Neurosci , vol.53 , pp. 593-597
    • Someya, T.1    Suzuki, Y.2    Shimoda, K.3    Al, E.4
  • 188
    • 0034530735 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine
    • Olesen OV, Linnet K. Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol 2000; 50: 563-571
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 563-571
    • Olesen, O.V.1    Linnet, K.2
  • 189
    • 0027359095 scopus 로고
    • Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation
    • Bertilsson L, Dahl ML, Ekqvist B, et al. Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation. Psychopharmacol Ser 1993; 10: 230-237
    • (1993) Psychopharmacol ser , vol.10 , pp. 230-237
    • Bertilsson, L.1    Dahl, M.L.2    Ekqvist, B.3    Al, E.4
  • 190
    • 0024333471 scopus 로고
    • Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings
    • Dahl-Puustinen ML, Liden A, Alm C, et al. Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings. Clin Pharmacol Ther 1989; 46: 78-81
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 78-81
    • Dahl-Puustinen, M.L.1    Liden, A.2    Alm, C.3    Al, E.4
  • 191
    • 0029738332 scopus 로고    scopus 로고
    • Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism
    • Linnet K, Wiborg O. Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism. Clin Pharmacol Ther 1996; 60: 41-47 (Pubitemid 26279219)
    • (1996) Clinical Pharmacology and Therapeutics , vol.60 , Issue.1 , pp. 41-47
    • Linnet, K.1    Wiborg, O.2
  • 192
    • 0029930015 scopus 로고    scopus 로고
    • The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclo-penthixol
    • Jerling M, Dahl ML, Aberg-Wistedt A, et al. The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclo-penthixol. Clin Pharmacol Ther 1996; 59: 423-428
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 423-428
    • Jerling, M.1    Dahl, M.L.2    Aberg-Wistedt, A.3    Al, E.4
  • 193
    • 34247229036 scopus 로고    scopus 로고
    • CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited
    • Ozdemir V, Bertilsson L, Miura J, et al. CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited. Pharmacogenet Genomics 2007; 17: 339-347
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 339-347
    • Ozdemir, V.1    Bertilsson, L.2    Miura, J.3    Al, E.4
  • 194
    • 37349117305 scopus 로고    scopus 로고
    • CYP2D6 and DRD2 genes differen-tially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine
    • Aklillu E, Kalow W, Endrenyi L, et al. CYP2D6 and DRD2 genes differen-tially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics 2007; 17: 989-993
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 989-993
    • Aklillu, E.1    Kalow, W.2    Endrenyi, L.3    Al, E.4
  • 195
    • 51149107891 scopus 로고    scopus 로고
    • A review of the association between anti-psychotic use and hyperprolactinaemia
    • Bushe C, Shaw M, Peveler RC. A review of the association between anti-psychotic use and hyperprolactinaemia. J Psychopharmacol 2008; 22: 46-55
    • (2008) J Psychopharmacol , vol.22 , pp. 46-55
    • Bushe, C.1    Shaw, M.2    Peveler, R.C.3
  • 196
    • 51149097397 scopus 로고    scopus 로고
    • Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis inthe treatment of schizophrenia
    • O'Keane V. Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis inthe treatment of schizophrenia. J Psychopharmacol 2008; 22: 70-75
    • (2008) J Psychopharmacol , vol.22 , pp. 70-75
    • O'Keane, V.1
  • 197
    • 51149115350 scopus 로고    scopus 로고
    • Antipsychotics and hyperpro-lactinaemia: Clinical recommendations
    • Peveler RC, Branford D, Citrome L, et al. Antipsychotics and hyperpro-lactinaemia: clinical recommendations. J Psychopharmacol 2008; 22: 98-103
    • (2008) J Psychopharmacol , vol.22 , pp. 98-103
    • Peveler, R.C.1    Branford, D.2    Citrome, L.3
  • 198
    • 43049178224 scopus 로고    scopus 로고
    • Drugs and prolactin
    • Molitch ME. Drugs and prolactin. Pituitary 2008; 11: 209-18
    • (2008) Pituitary , vol.11 , pp. 209-18
    • Molitch, M.E.1
  • 199
    • 6344253360 scopus 로고    scopus 로고
    • Antipsychotic-induced hyperprolactinaemia: Me-chanisms, clinical features and management
    • Haddad PM, Wieck A. Antipsychotic-induced hyperprolactinaemia: me-chanisms, clinical features and management. Drugs 2004; 64: 2291-2314
    • (2004) Drugs , vol.64 , pp. 2291-2314
    • Haddad, P.M.1    Wieck, A.2
  • 200
    • 0037342251 scopus 로고    scopus 로고
    • Regeneration of serotonin from 5-methox-ytryptamine by polymorphic human CYP2D6
    • Yu AM, Idle JR, Byrd LG, et al. Regeneration of serotonin from 5-methox-ytryptamine by polymorphic human CYP2D6. Pharmacogenetics 2003; 13: 173-181
    • (2003) Pharmacogenetics , vol.13 , pp. 173-181
    • Yu, A.M.1    Idle, J.R.2    Byrd, L.G.3    Al, E.4
  • 201
    • 0031225744 scopus 로고    scopus 로고
    • Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cyto-chrome P4502D6 inhibition in vivo
    • Ozdemir V, Naranjo CA, Herrmann N, et al. Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cyto-chrome P4502D6 inhibition in vivo. Clin Pharmacol Ther 1997; 62: 334-347
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 334-347
    • Ozdemir, V.1    Naranjo, C.A.2    Herrmann, N.3    Al, E.4
  • 202
    • 0028822641 scopus 로고
    • Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia
    • Pollock BG, Mulsant BH, Sweet RA, et al. Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia. Psychopharmacol Bull 1995; 31: 327-331
    • (1995) Psychopharmacol Bull , vol.31 , pp. 327-331
    • Pollock, B.G.1    Mulsant, B.H.2    Sweet, R.A.3    Al, E.4
  • 203
    • 22444436230 scopus 로고    scopus 로고
    • Risperidone: A review of its usein the treatment of bipolar mania
    • Fenton C, Scott LJ. Risperidone: a review of its usein the treatment of bipolar mania. CNS Drugs 2005; 19: 429-444
    • (2005) CNS Drugs , vol.19 , pp. 429-444
    • Fenton, C.1    Scott, L.J.2
  • 204
    • 0028096538 scopus 로고
    • Risperidone: A review of its pharmacology and therapeutic potential in the treatment of schizophrenia
    • Grant S, Fitton A. Risperidone: a review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs 1994; 48: 253-273 (Pubitemid 24260357)
    • (1994) Drugs , vol.48 , Issue.2 , pp. 253-273
    • Grant, S.1    Fitton, A.2
  • 205
    • 0027433081 scopus 로고
    • Absorption, metabolism, and excretion of risperidone in humans
    • Mannens G, Huang ML, Meuldermans W, et al. Absorption, metabolism, and excretion of risperidone in humans. Drug Metab Dispos 1993; 21: 1134-1141
    • (1993) Drug Metab Dispos , vol.21 , pp. 1134-1141
    • Mannens, G.1    Huang, M.L.2    Meuldermans, W.3    Al, E.4
  • 206
    • 0034829228 scopus 로고    scopus 로고
    • Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes
    • Yasui-Furukori N, Hidestrand M, Spina E, et al. Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos 2001; 29: 1263-1268
    • (2001) Drug Metab Dispos , vol.29 , pp. 1263-1268
    • Yasui-Furukori, N.1    Hidestrand, M.2    Spina, E.3    Al, E.4
  • 207
    • 0033853419 scopus 로고    scopus 로고
    • Plasma concentrations of risperidone and 9-hydroxyrisperidone: Effect of comedication with carbamazepine or valproate
    • Spina E, Avenoso A, Facciola G, et al. Plasma concentrations of risperidone and 9-hydroxyrisperidone: effect of comedication with carbamazepine or valproate. Ther Drug Monit 2000; 22: 481-485
    • (2000) Ther Drug Monit , vol.22 , pp. 481-485
    • Spina, E.1    Avenoso, A.2    Facciola, G.3    Al, E.4
  • 208
    • 28144455896 scopus 로고    scopus 로고
    • Cytochrome P450 3A inhibitor itraco-nazole affects plasma concentrations of risperidone and 9-hydro-xyrisperidone inschizophrenic patients
    • Jung SM, Kim KA, Cho HK, et al. Cytochrome P450 3A inhibitor itraco-nazole affects plasma concentrations of risperidone and 9-hydro-xyrisperidone inschizophrenic patients. Clin Pharmacol Ther 2005; 78: 520-528
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 520-528
    • Jung, S.M.1    Kim, K.A.2    Cho, H.K.3    Al, E.4
  • 209
    • 0029930927 scopus 로고    scopus 로고
    • Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding
    • Schotte A, Janssen PF, Gommeren W, et al. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 1996; 124: 57-73
    • (1996) Psychopharmacology (Berl) , vol.124 , pp. 57-73
    • Schotte, A.1    Janssen, P.F.2    Gommeren, W.3    Al, E.4
  • 210
    • 0035012610 scopus 로고    scopus 로고
    • Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine
    • Spina E, Avenoso A, Facciola G, et al. Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine. Ther Drug Monit 2001; 23: 223-227
    • (2001) Ther Drug Monit , vol.23 , pp. 223-227
    • Spina, E.1    Avenoso, A.2    Facciola, G.3    Al, E.4
  • 211
    • 55349101286 scopus 로고    scopus 로고
    • Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy
    • Epub Aug 23
    • Mannheimer B, Bahr CV, Pettersson H, et al. Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy. Ther Drug Monit. Epub 2008 Aug 23
    • (2008) Ther Drug Monit
    • Mannheimer, B.1    Bahr, C.V.2    Pettersson, H.3
  • 212
    • 0033987060 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone
    • Scordo MG, Spina E, Facciola G, et al. Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl) 1999; 147: 300-305
    • (1999) Psychopharmacology (Berl) , vol.147 , pp. 300-305
    • Scordo, M.G.1    Spina, E.2    Facciola, G.3    Al, E.4
  • 213
    • 0036222136 scopus 로고    scopus 로고
    • The effect of fluoxetine on the phar-macokinetics and safety of risperidone in psychotic patients
    • Bondolfi G, Eap CB, Bertschy G, et al. The effect of fluoxetine on the phar-macokinetics and safety of risperidone in psychotic patients. Pharma-copsychiatry 2002; 35: 50-56
    • (2002) Pharma-copsychiatry , vol.35 , pp. 50-56
    • Bondolfi, G.1    Eap, C.B.2    Bertschy, G.3    Al, E.4
  • 214
    • 0031828859 scopus 로고    scopus 로고
    • Serum concentrations and side effects in psychiatric patients during risperidone therapy
    • Olesen OV, Licht RW, Thomsen E, et al. Serum concentrations and side effects in psychiatric patients during risperidone therapy. Ther Drug Monit 1998; 20: 380-384
    • (1998) Ther Drug Monit , vol.20 , pp. 380-384
    • Olesen, O.V.1    Licht, R.W.2    Thomsen, E.3    Al, E.4
  • 215
    • 0028989238 scopus 로고
    • A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone
    • Nyberg S, Dahl ML, Halldin C. A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone. Psychopharmacology (Berl) 1995; 119: 345-348
    • (1995) Psychopharmacology (Berl) , vol.119 , pp. 345-348
    • Nyberg, S.1    Dahl, M.L.2    Halldin, C.3
  • 216
    • 0035524739 scopus 로고    scopus 로고
    • Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients
    • Roh HK, Kim CE, Chung WG, et al. Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients. Eur J Clin Pharmacol 2001; 57: 671-675
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 671-675
    • Roh, H.K.1    Kim, C.E.2    Chung, W.G.3    Al, E.4
  • 217
    • 0033849669 scopus 로고    scopus 로고
    • Risperidone metabolism and the impact of being a cytochrome P450 2D6 ultrarapid metabolizer
    • Guzey C, Aamo T, Spigset O. Risperidone metabolism and the impact of being a cytochrome P450 2D6 ultrarapid metabolizer. J Clin Psychiatry 2000; 61: 600-601
    • (2000) J Clin Psychiatry , vol.61 , pp. 600-601
    • Guzey, C.1    Aamo, T.2    Spigset, O.3
  • 218
    • 13844320650 scopus 로고    scopus 로고
    • The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation
    • De Leon J, Susce MT, Pan RM, et al. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry 2005; 66: 15-27
    • (2005) J Clin Psychiatry , vol.66 , pp. 15-27
    • De Leon, J.1    Susce, M.T.2    Pan, R.M.3    Al, E.4
  • 219
    • 33344460427 scopus 로고    scopus 로고
    • Characterization of human cyto-chrome P450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine
    • Wojcikowski J, Maurel P, Daniel WA. Characterization of human cyto-chrome P450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. Drug Metab Dispos 2006; 34: 471-476
    • (2006) Drug Metab Dispos , vol.34 , pp. 471-476
    • Wojcikowski, J.1    Maurel, P.2    Daniel, W.A.3
  • 220
    • 0033860864 scopus 로고    scopus 로고
    • Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity
    • Llerena A, Berecz R,dela Rubia A, etal. Use of the mesoridazine/ thioridazine ratio as a marker for CYP2D6 enzyme activity. Ther Drug Monit 2000; 22: 397-401
    • (2000) Ther Drug Monit , vol.22 , pp. 397-401
    • Lleren, A.1    Berecz, R.2    Dela Rubia, A.3
  • 221
    • 0038469903 scopus 로고    scopus 로고
    • Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype
    • Berecz R, de la Rubia A, Dorado P, et al. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol 2003; 59: 45-50
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 45-50
    • Berecz, R.1    De La Rubia, A.2    Dorado, P.3    Al, E.4
  • 222
    • 0029897864 scopus 로고    scopus 로고
    • Plasma levels of the en-antiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dex-tromethorphan and mephenytoin
    • Eap CB, Guentert TW, Schaublin-Loidl M, et al. Plasma levels of the en-antiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dex-tromethorphan and mephenytoin. Clin Pharmacol Ther 1996; 59: 322-331
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 322-331
    • Eap, C.B.1    Guentert, T.W.2    Schaublin-Loidl, M.3    Al, E.4
  • 223
    • 0036903984 scopus 로고    scopus 로고
    • QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients
    • Llerena A, Berecz R, dela Rubia A, etal. QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients. J Psychopharmacol 2002; 16: 361-364
    • (2002) J Psychopharmacol , vol.16 , pp. 361-364
    • Llerena, A.1    Berecz, R.2    Dela Rubia, A.3
  • 224
    • 0026086815 scopus 로고
    • Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype
    • von Bahr C, Movin G, Nordin C, et al. Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype. Clin Pharmacol Ther 1991; 49: 234-240
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 234-240
    • Von Bahr, C.1    Movin, G.2    Nordin, C.3    Al, E.4
  • 225
    • 85034097231 scopus 로고    scopus 로고
    • Zuclopenthixol dihydrochloride for schizophrenia
    • Kumar A, Strech D. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev 2005; (4): CD005474
    • (2005) Cochrane Database Syst Rev , vol.4
    • Kumar, A.1    Strech, D.2
  • 226
    • 0025824216 scopus 로고
    • Disposition of the neuroleptic zuclo-penthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans
    • Dahl ML, Ekqvist B, Widen J, et al. Disposition of the neuroleptic zuclo-penthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans. Acta Psychiatr Scand 1991; 84: 99-102
    • (1991) Acta Psychiatr Scand , vol.84 , pp. 99-102
    • Dahl, M.L.1    Ekqvist, B.2    Widen, J.3    Al, E.4
  • 227
    • 0029805032 scopus 로고    scopus 로고
    • Influence of CYP2D6 genetic polymorphism on ratios of steady-state serum concentration to dose of the neuroleptic zuclopenthixol
    • LinnetK, Wiborg O. Influence of CYP2D6 genetic polymorphism on ratios of steady-state serum concentration to dose of the neuroleptic zuclopenthixol. Ther Drug Monit 1996; 18: 629-634
    • (1996) Ther Drug Monit , vol.18 , pp. 629-634
    • Linnetk Wiborg, O.1
  • 228
    • 0035987391 scopus 로고    scopus 로고
    • Maintenance therapy with zuclo-penthixol decanoate: Associations between plasma concentrations, neurological side effects and CYP2D6 genotype
    • Jaanson P, Marandi T, Kiivet RA, et al. Maintenance therapy with zuclo-penthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype. Psychopharmacology (Berl) 2002; 162: 67-73
    • (2002) Psychopharmacology (Berl) , vol.162 , pp. 67-73
    • Jaanson, P.1    Marandi, T.2    Kiivet, R.A.3    Al, E.4
  • 229
    • 0030077735 scopus 로고    scopus 로고
    • Identification of the human cytochromes P450 responsible for thein vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine
    • Ring BJ, Catlow J, Lindsay TJ, et al. Identification of the human cytochromes P450 responsible for thein vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. J Pharmacol Exp Ther 1996; 276: 658-666
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 658-666
    • Ring, B.J.1    Catlow, J.2    Lindsay, T.J.3    Al, E.4
  • 230
    • 0034925896 scopus 로고    scopus 로고
    • Contributionsoffive human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations
    • Olesen OV, Linnet K. Contributionsoffive human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. J Clin Pharmacol 2001; 41: 823-832
    • (2001) J Clin Pharmacol , vol.41 , pp. 823-832
    • Olesen, O.V.1    Linnet, K.2
  • 231
    • 0034997537 scopus 로고    scopus 로고
    • Isolation and identification of clozapine metabolites in patient urine
    • Schaber G, Wiatr G, Wachsmuth H, et al. Isolation and identification of clozapine metabolites in patient urine. Drug Metab Dispos 2001; 29: 923-931
    • (2001) Drug Metab Dispos , vol.29 , pp. 923-931
    • Schaber, G.1    Wiatr, G.2    Wachsmuth, H.3    Al, E.4
  • 232
    • 0034832934 scopus 로고    scopus 로고
    • Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine
    • Breyer-Pfaff U, Wachsmuth H. Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine. Drug Metab Dispos 2001; 29: 1343-1348
    • (2001) Drug Metab Dispos , vol.29 , pp. 1343-1348
    • Breyer-Pfaff, U.1    Wachsmuth, H.2
  • 233
    • 85017231452 scopus 로고    scopus 로고
    • Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes
    • Hagg S, Spigset O, Lakso HA, et al. Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes. Eur J Clin Pharmacol 2001; 57: 493-497
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 493-497
    • Hagg, S.1    Spigset, O.2    Lakso, H.A.3    Al, E.4
  • 234
    • 0037379568 scopus 로고    scopus 로고
    • Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine
    • Carrillo JA, Herraiz AG, Ramos SI, et al. Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine. J Clin Psychopharmacol 2003; 23: 119-127
    • (2003) J Clin Psychopharmacol , vol.23 , pp. 119-127
    • Carrillo, J.A.1    Herraiz, A.G.2    Ramos, S.I.3    Al, E.4
  • 235
    • 34249668494 scopus 로고    scopus 로고
    • Impactof CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients
    • Melkersson KI, Scordo MG, Gunes A, etal. Impactof CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients. J Clin Psychiatry 2007; 68: 697-704
    • (2007) J Clin Psychiatry , vol.68 , pp. 697-704
    • Melkersson, K.I.1    Scordo, M.G.2    Gunes, A.3
  • 236
    • 0033674522 scopus 로고    scopus 로고
    • Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: No association with myeloperoxidase and cytochrome P4502D6
    • Dettling M, Sachse C, Muller-Oerlinghausen B, et al. Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. Pharmacopsychiatry 2000; 33: 218-220
    • (2000) Pharmacopsychiatry , vol.33 , pp. 218-220
    • Dettling, M.1    Sachse, C.2    Muller-Oerlinghausen, B.3
  • 237
    • 34248529829 scopus 로고    scopus 로고
    • Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients
    • Uehlinger C, Crettol S, Chassot P, et al. Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients. J Clin Psychopharmacol 2007; 27: 273-278
    • (2007) J Clin Psychopharmacol , vol.27 , pp. 273-278
    • Uehlinger, C.1    Crettol, S.2    Chassot, P.3    Al, E.4
  • 238
    • 33750344176 scopus 로고    scopus 로고
    • The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment
    • Plesnicar BK, Zalar B, Breskvar K, et al. The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment. J Psychopharmacol 2006; 20: 829-833
    • (2006) J Psychopharmacol , vol.20 , pp. 829-833
    • Plesnicar, B.K.1    Zalar, B.2    Breskvar, K.3    Al, E.4
  • 239
    • 0001697297 scopus 로고    scopus 로고
    • Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
    • Chou WH, Yan FX, de Leon J, et al. Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol 2000; 20: 246-251
    • (2000) J Clin Psychopharmacol , vol.20 , pp. 246-251
    • Chou, W.H.1    Yan, F.X.2    De Leon, J.3    Al, E.4
  • 240
    • 0036073564 scopus 로고    scopus 로고
    • Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics: Useful aid to prescribing?
    • Dahl ML. Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing? Clin Pharmacokinet 2002; 41: 453-470
    • (2002) Clin Pharmacokinet , vol.41 , pp. 453-470
    • Dahl, M.L.1
  • 241
    • 0033974786 scopus 로고    scopus 로고
    • Pharmacogenetics of classical and new antipsychotic drugs
    • Otani K, Aoshima T. Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit 2000; 22: 118-121
    • (2000) Ther Drug Monit , vol.22 , pp. 118-121
    • Otani, K.1    Aoshima, T.2
  • 242
    • 17644423416 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: A meta-analysis
    • Patsopoulos NA, Ntzani EE, Zintzaras E, et al. CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis. Pharmaco-genet Genomics 2005; 15: 151-158
    • (2005) Pharmaco-genet Genomics , vol.15 , pp. 151-158
    • Patsopoulos, N.A.1    Ntzani, E.E.2    Zintzaras, E.3    Al, E.4
  • 243
    • 34249016361 scopus 로고    scopus 로고
    • The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine: Focus on antidepressants
    • Sjoqvist F, Eliasson E. The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine: focus on antidepressants. Clin Pharmacol Ther 2007; 81: 899-902
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 899-902
    • Sjoqvist, F.1    Eliasson, E.2
  • 244
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharma-codynamics of cholinesterase inhibitors
    • Jann MW, Shirley KL, Small GW. Clinical pharmacokinetics and pharma-codynamics of cholinesterase inhibitors. Clin Pharmacokinet 2002; 41: 719-739
    • (2002) Clin Pharmacokinet , vol.41 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 245
    • 0028240611 scopus 로고
    • The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes
    • Spaldin V, Madden S, Pool WF, et al. The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes. Br J Clin Pharmacol 1994; 38: 15-22
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 15-22
    • Spaldin, V.1    Madden, S.2    Pool, W.F.3    Al, E.4
  • 246
    • 0031910978 scopus 로고    scopus 로고
    • Donepezil use in Alzheimer disease
    • Barner EL, Gray SL. Donepezil use in Alzheimer disease. Ann Pharmacother 1998; 32: 70-77
    • (1998) Ann Pharmacother , vol.32 , pp. 70-77
    • Barner, E.L.1    Gray, S.L.2
  • 247
    • 0033408375 scopus 로고    scopus 로고
    • The O-demethylation of the anti-dementia drug galanthamine is catalysed by cytochrome P450 2D6
    • Bachus R, Bickel U, Thomsen T, et al. The O-demethylation of the anti-dementia drug galanthamine is catalysed by cytochrome P450 2D6. Phar-macogenetics 1999; 9: 661-8
    • (1999) Phar-macogenetics , vol.9 , pp. 661-8
    • Bachus, R.1    Bickel, U.2    Thomsen, T.3
  • 249
    • 33747888854 scopus 로고    scopus 로고
    • Impact of the CYP2D6 poly-morphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients
    • Varsaldi F, Miglio G, Scordo MG, et al. Impact of the CYP2D6 poly-morphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients. Eur J Clin Pharmacol 2006; 62: 721-726
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 721-726
    • Varsaldi, F.1    Miglio, G.2    Scordo, M.G.3
  • 250
    • 3242890974 scopus 로고    scopus 로고
    • Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: A meta-analysis of individual patient data from randomised controlled trials
    • Whitehead A, Perdomo C, Pratt RD, et al. Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials. Int J Geriatr Psychiatry 2004; 19: 624-633
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 624-633
    • Whitehead, A.1    Perdomo, C.2    Pratt, R.D.3    Al, E.4
  • 251
    • 0032200806 scopus 로고    scopus 로고
    • Metabolism and elimination of 14C-donepezil in healthy volunteers: A single-dose study
    • Tiseo PJ, Perdomo CA, Friedhoff LT. Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study. Br J Clin Pharmacol 1998; 46 Suppl. 1: 19-24
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL 1 , pp. 19-24
    • Tiseo, P.J.1    Perdomo, C.A.2    Friedhoff, L.T.3
  • 252
    • 34548671643 scopus 로고    scopus 로고
    • Pharmacogenetic aspects of therapy with cholinesterase inhibitors: The role of CYP2D6 in Alzheimer's disease pharmacogenetics
    • Cacabelos R, Llovo R, Fraile C, et al. Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics. Curr Alzheimer Res 2007; 4: 479-500
    • (2007) Curr Alzheimer Res , vol.4 , pp. 479-500
    • Cacabelos, R.1    Llovo, R.2    Fraile, C.3    Al, E.4
  • 253
    • 70349565396 scopus 로고    scopus 로고
    • Effect of a CYP2D6 poly-morphism on the efficacy of donepezil in patients with Alzheimer disease
    • Pilotto A, Franceschi M, D'Onofrio G, et al. Effect of a CYP2D6 poly-morphism on the efficacy of donepezil in patients with Alzheimer disease. Neurology 2009; 73: 761-767
    • (2009) Neurology , vol.73 , pp. 761-767
    • Pilotto, A.1    Franceschi, M.2    D'Onofrio, G.3    Al, E.4
  • 254
    • 0038359312 scopus 로고    scopus 로고
    • CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the-1584G promoter polymorphism
    • Gaedigk A, Ryder DL, Bradford LD, et al. CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the-1584G promoter polymorphism. Clin Chem 2003; 49: 1008-1011
    • (2003) Clin Chem , vol.49 , pp. 1008-1011
    • Gaedigk, A.1    Ryder, D.L.2    Bradford, L.D.3    Al, E.4
  • 255
    • 34547787131 scopus 로고    scopus 로고
    • Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: A meta-analysis of randomised controlled trials
    • Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol 2007; 6: 782-792
    • (2007) Lancet Neurol , vol.6 , pp. 782-792
    • Kavirajan, H.1    Schneider, L.S.2
  • 256
    • 0023029529 scopus 로고
    • Pharmacokinetics of galantha-mine (a long-acting anticholinesterase drug) in anaesthetized patients
    • Westra P, van Thiel MJ, Vermeer GA, et al. Pharmacokinetics of galantha-mine (a long-acting anticholinesterase drug) in anaesthetized patients. Br J Anaesth 1986; 58: 1303-1307
    • (1986) Br J Anaesth , vol.58 , pp. 1303-1307
    • Westra, P.1    Van Thiel, M.J.2    Vermeer, G.A.3    Al, E.4
  • 257
    • 18344368417 scopus 로고    scopus 로고
    • The metabolism and excretion of galantamine in rats, dogs, and humans
    • Mannens GS, Snel CA, Hendrickx J, et al. The metabolism and excretion of galantamine in rats, dogs, and humans. Drug Metab Dispos 2002; 30: 553-563
    • (2002) Drug Metab Dispos , vol.30 , pp. 553-563
    • Mannens, G.S.1    Snel, C.A.2    Hendrickx, J.3    Al, E.4
  • 258
    • 15544367221 scopus 로고    scopus 로고
    • Atomoxetine: The first nonstimulant for the management of attention-deficit/hyperactivity disorder
    • Corman SL, Fedutes BA, Culley CM. Atomoxetine: the first nonstimulant for the management of attention-deficit/hyperactivity disorder. Am J Health Syst Pharm 2004; 61: 2391-2399
    • (2004) Am J Health Syst Pharm , vol.61 , pp. 2391-2399
    • Corman, S.L.1    Fedutes, B.A.2    Culley, C.M.3
  • 259
    • 0442275989 scopus 로고    scopus 로고
    • Atomoxetine: A review of its use in adults with attention deficit hyperactivity disorder
    • Simpson D, Plosker GL. Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder. Drugs 2004; 64: 205-222
    • (2004) Drugs , vol.64 , pp. 205-222
    • Simpson, D.1    Plosker, G.L.2
  • 260
    • 0036181544 scopus 로고    scopus 로고
    • Identification of the human cyto-chromes P450 responsible for atomoxetine metabolism
    • Ring BJ, Gillespie JS, Eckstein JA, et al. Identification of the human cyto-chromes P450 responsible for atomoxetine metabolism. Drug Metab Dispos 2002; 30: 319-323
    • (2002) Drug Metab Dispos , vol.30 , pp. 319-323
    • Ring, B.J.1    Gillespie, J.S.2    Eckstein, J.A.3    Al, E.4
  • 261
    • 0021915377 scopus 로고
    • Single-dose and steady-state pharmacokinetics of tomoxetine in normal subjects
    • Farid NA, Bergstrom RF, Ziege EA, et al. Single-dose and steady-state pharmacokinetics of tomoxetine in normal subjects. J Clin Pharmacol 1985; 25: 296-301
    • (1985) J Clin Pharmacol , vol.25 , pp. 296-301
    • Farid, N.A.1    Bergstrom, R.F.2    Ziege, E.A.3    Al, E.4
  • 262
    • 38949171689 scopus 로고    scopus 로고
    • Enhancement of atomoxetine serum levels by co-administration of paroxetine
    • Paulzen M, Clement HW, Grunder G. Enhancement of atomoxetine serum levels by co-administration of paroxetine. Int J Neuropsychopharmacol 2008; 11: 289-291
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 289-291
    • Paulzen, M.1    Clement, H.W.2    Grunder, G.3
  • 263
    • 0013499111 scopus 로고    scopus 로고
    • Disposition and metabolic fate of atomoxetine hydrochloride: The role of CYP2D6 in human disposition and metabolism
    • Sauer JM, Ponsler GD, Mattiuz EL, et al. Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism. Drug Metab Dispos 2003; 31: 98-107
    • (2003) Drug Metab Dispos , vol.31 , pp. 98-107
    • Sauer, J.M.1    Ponsler, G.D.2    Mattiuz, E.L.3    Al, E.4
  • 264
    • 34548625125 scopus 로고    scopus 로고
    • Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6*10 allele
    • Cui YM, Teng CH, Pan AX, et al. Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6*10 allele. Br J Clin Pharmacol 2007; 64: 445-449
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 445-449
    • Cui, Y.M.1    Teng, C.H.2    Pan, A.X.3    Al, E.4
  • 265
    • 34547165040 scopus 로고    scopus 로고
    • Comparative metabolic capabilities and in-hibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17
    • Shen H, He MM, Liu H, et al. Comparative metabolic capabilities and in-hibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug Metab Dispos 2007; 35: 1292-1300
    • (2007) Drug Metab Dispos , vol.35 , pp. 1292-1300
    • Shen, H.1    He, M.M.2    Liu, H.3    Al, E.4
  • 266
    • 33846407239 scopus 로고    scopus 로고
    • CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD
    • Michelson D, Read HA, Ruff DD, et al. CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 2007; 46: 242-251
    • (2007) J Am Acad Child Adolesc Psychiatry , vol.46 , pp. 242-251
    • Michelson, D.1    Read, H.A.2    Ruff, D.D.3    Al, E.4
  • 267
    • 37349000292 scopus 로고    scopus 로고
    • CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD
    • Trzepacz PT, Williams DW, Feldman PD, et al. CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD. Eur Neuropsychopharmacol 2008; 18: 79-86
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 79-86
    • Trzepacz, P.T.1    Williams, D.W.2    Feldman, P.D.3    Al, E.4
  • 268
    • 0035511622 scopus 로고    scopus 로고
    • Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled, dose-response study
    • Michelson D, Faries D, Wernicke J, et al. Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study. Pediatrics 2001; 108: E83
    • (2001) Pediatrics , vol.108
    • Michelson, D.1    Faries, D.2    Wernicke, J.3    Al, E.4
  • 269
    • 0036929584 scopus 로고    scopus 로고
    • Safety profile of atomoxetine in the treatment of children and adolescents with ADHD
    • Wernicke JF, Kratochvil CJ. Safety profile of atomoxetine in the treatment of children and adolescents with ADHD. J Clin Psychiatry 2002; 63 Suppl. 12: 50-55
    • (2002) J Clin Psychiatry , vol.12 , Issue.63 SUPPL , pp. 50-55
    • Wernicke, J.F.1    Kratochvil, C.J.2
  • 270
    • 39849092897 scopus 로고    scopus 로고
    • Latino versus Caucasian re-sponse to atomoxetine in attention-deficit/ hyperactivity disorder
    • Tamayo JM, Pumariega A, Rothe EM, et al. Latino versus Caucasian re-sponse to atomoxetine in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2008; 18: 44-53
    • (2008) J Child Adolesc Psychopharmacol , vol.18 , pp. 44-53
    • Tamayo, J.M.1    Pumariega, A.2    Rothe, E.M.3    Al, E.4
  • 271
    • 38449108594 scopus 로고    scopus 로고
    • Vascular dementia: Pharmacological treatment approaches and perspectives
    • Baskys A, Hou AC. Vascular dementia: pharmacological treatment approaches and perspectives. Clin Interv Aging 2007; 2: 327-335
    • (2007) Clin Interv Aging , vol.2 , pp. 327-335
    • Baskys, A.1    Hou, A.C.2
  • 273
    • 0015509967 scopus 로고
    • Studies on the metabolism of ergoline derivatives: Metabolism of nicergoline in man and in animals
    • ArcamoneF,Glasser AG, GrafnetterovaJ, etal. Studies on the metabolism of ergoline derivatives: metabolism of nicergoline in man and in animals. Biochem Pharmacol 1972; 21: 2205-2213
    • (1972) Biochem Pharmacol , vol.21 , pp. 2205-2213
    • Arcamonefglasser, A.G.1    Grafnetterovaj2
  • 274
    • 10544231870 scopus 로고    scopus 로고
    • Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans
    • Bottiger Y, Dostert P, Benedetti MS, et al. Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans. Br J Clin Pharmacol 1996; 42: 707-711
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 707-711
    • Bottiger, Y.1    Dostert, P.2    Benedetti, M.S.3    Al, E.4
  • 276
    • 0031918465 scopus 로고    scopus 로고
    • Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes
    • Postlind H, Danielson A, Lindgren A, et al. Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos 1998; 26: 289-293
    • (1998) Drug Metab Dispos , vol.26 , pp. 289-293
    • Postlind, H.1    Danielson, A.2    Lindgren, A.3    Al, E.4
  • 277
    • 0030862931 scopus 로고    scopus 로고
    • Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine
    • Nilvebrant L, Gillberg PG, Sparf B. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol 1997; 81: 169-172
    • (1997) Pharmacol Toxicol , vol.81 , pp. 169-172
    • Nilvebrant, L.1    Gillberg, P.G.2    Sparf, B.3
  • 278
    • 0032847792 scopus 로고    scopus 로고
    • Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity
    • Brynne N, Forslund C, Hallen B, et al. Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity. Br J Clin Pharmacol 1999; 48: 564-572
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 564-572
    • Brynne, N.1    Forslund, C.2    Hallen, B.3    Al, E.4
  • 279
    • 0031836669 scopus 로고    scopus 로고
    • Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic oftolterodine
    • Brynne N, Dalen P, Alvan G, et al. Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic oftolterodine. Clin Pharmacol Ther 1998; 63: 529-539
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 529-539
    • Brynne, N.1    Dalen, P.2    Alvan, G.3    Al, E.4
  • 280
    • 0033064438 scopus 로고    scopus 로고
    • Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omepra-zole
    • Brynne N, Bottiger Y, Hallen B, et al. Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omepra-zole. Br J Clin Pharmacol 1999; 47: 145-150
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 145-150
    • Brynne, N.1    Bottiger, Y.2    Hallen, B.3    Al, E.4
  • 281
    • 0032869577 scopus 로고    scopus 로고
    • Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance
    • Brynne N, Svanstrom C, Aberg-Wistedt A, et al. Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance. Br J Clin Pharmacol 1999; 48: 553-563
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 553-563
    • Brynne, N.1    Svanstrom, C.2    Aberg-Wistedt, A.3    Al, E.4
  • 282
    • 0035071434 scopus 로고    scopus 로고
    • Food does not influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder
    • Olsson B, Szamosi J. Food does not influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder. Clin Pharmacokinet 2001; 40: 135-143
    • (2001) Clin Pharmacokinet , vol.40 , pp. 135-143
    • Olsson, B.1    Szamosi, J.2
  • 283
    • 0035062346 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolterodine
    • Olsson B, Szamosi J. Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolter-odine. Clin Pharmacokinet 2001; 40: 227-235 (Pubitemid 32324452)
    • (2001) Clinical Pharmacokinetics , vol.40 , Issue.3 , pp. 227-235
    • Olsson, B.1    Szamosi, J.2
  • 284
    • 44849134443 scopus 로고    scopus 로고
    • Chemotherapy-induced nausea and vomiting
    • Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med 2008; 358: 2482-2494
    • (2008) N Engl J Med , vol.358 , pp. 2482-2494
    • Hesketh, P.J.1
  • 285
    • 34547138127 scopus 로고    scopus 로고
    • Chemotherapy-induced nausea and vomiting: Which an-tiemetic for which therapy?
    • discussion 954, 959, 962 passim
    • Schwartzberg LS. Chemotherapy-induced nausea and vomiting: which an-tiemetic for which therapy? Oncology (Williston Park) 2007; 21: 946-53; discussion 954, 959, 962 passim
    • (2007) Oncology (Williston Park) , vol.21 , pp. 946-53
    • Schwartzberg, L.S.1
  • 286
    • 25444432562 scopus 로고    scopus 로고
    • 5-HT3-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment
    • Aapro M. 5-HT3-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment. Oncology 2005; 69: 97-109
    • (2005) Oncology , vol.69 , pp. 97-109
    • Aapro, M.1
  • 287
    • 20544448255 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: Can we safely reduce the dose of administered agents?
    • Aapro M, Blower P. 5-Hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: can we safely reduce the dose of administered agents? Cancer 2005; 104: 1-18
    • (2005) Cancer , vol.104 , pp. 1-18
    • Aapro, M.1    Blower, P.2
  • 289
    • 0026762327 scopus 로고
    • Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans
    • Fischer V, Baldeck JP, Tse FL. Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans. Drug Metab Dispos 1992; 20: 603-607
    • (1992) Drug Metab Dispos , vol.20 , pp. 603-607
    • Fischer, V.1    Baldeck, J.P.2    Tse, F.L.3
  • 290
    • 0027183378 scopus 로고
    • Pharmacology, toxicology and human pharmacokinetics of tropi-setron
    • Kutz K. Pharmacology, toxicology and human pharmacokinetics of tropi-setron. Ann Oncol 1993; 4 Suppl. 3: 15-18
    • (1993) Ann Oncol , vol.4 , Issue.SUPPL 3 , pp. 15-18
    • Kutz, K.1
  • 291
    • 0028223289 scopus 로고
    • The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron
    • Fischer V, Vickers AE, Heitz F, et al. The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metab Dispos 1994; 22: 269-274
    • (1994) Drug Metab Dispos , vol.22 , pp. 269-274
    • Fischer, V.1    Vickers, A.E.2    Heitz, F.3    Al, E.4
  • 292
    • 0029880344 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 en-zymes involved in the in vitro metabolism of dolasetron: Comparison with other indole-containing 5-HT3antagonists
    • Sanwald P, David M, Dow J. Characterization of the cytochrome P450 en-zymes involved in the in vitro metabolism of dolasetron: comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos 1996; 24: 602-609
    • (1996) Drug Metab Dispos , vol.24 , pp. 602-609
    • Sanwald, P.1    David, M.2    Dow, J.3
  • 293
    • 0034950010 scopus 로고    scopus 로고
    • Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12, 458), a pharmacologically active metabolite of ezlopitant: Enzyme kinetics and mechanism of an alkene hydration reaction
    • Obach RS. Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. Drug Metab Dis-pos 2001; 29: 1057-1067
    • (2001) Drug Metab Dis-pos , vol.29 , pp. 1057-1067
    • Obach, R.S.1
  • 294
    • 0036177763 scopus 로고    scopus 로고
    • The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6
    • Desta Z, Wu GM, Morocho AM, et al. The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6. Drug Metab Dispos 2002; 30: 336-343
    • (2002) Drug Metab Dispos , vol.30 , pp. 336-343
    • Desta, Z.1    Wu, G.M.2    Morocho, A.M.3    Al, E.4
  • 295
    • 0031594743 scopus 로고    scopus 로고
    • 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting: A comparison of their pharmacology and clinical efficacy
    • Gregory RE, Ettinger DS. 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting: a comparison of their pharmacology and clinical efficacy. Drugs 1998; 55: 173-189
    • (1998) Drugs , vol.55 , pp. 173-189
    • Gregory, R.E.1    Ettinger, D.S.2
  • 296
    • 0033840074 scopus 로고    scopus 로고
    • Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: Enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation
    • Obach RS. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Drug Metab Dispos 2000; 28: 1069-1076
    • (2000) Drug Metab Dispos , vol.28 , pp. 1069-1076
    • Obach, R.S.1
  • 297
    • 6944235904 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant
    • Sanchez RI, Wang RW, Newton DJ, et al. Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos 2004; 32: 1287-1292
    • (2004) Drug Metab Dispos , vol.32 , pp. 1287-1292
    • Sanchez, R.I.1    Wang, R.W.2    Newton, D.J.3    Al, E.4
  • 298
    • 0030739796 scopus 로고    scopus 로고
    • Dolasetron: A review of its pharmacology and ther-apeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery
    • Balfour JA, Goa KL. Dolasetron: a review of its pharmacology and ther-apeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery. Drugs 1997; 54: 273-298
    • (1997) Drugs , vol.54 , pp. 273-298
    • Balfour, J.A.1    Goa, K.L.2
  • 299
    • 0029147390 scopus 로고
    • Human metabolism of dolasetron me-sylate a 5-HT3 receptor antagonist
    • Reith MK, Sproles GD, Cheng LK. Human metabolism of dolasetron me-sylate, a 5-HT3 receptor antagonist. Drug Metab Dispos 1995; 23: 806-812
    • (1995) Drug Metab Dispos , vol.23 , pp. 806-812
    • Reith, M.K.1    Sproles, G.D.2    Cheng, L.K.3
  • 300
    • 33645526021 scopus 로고    scopus 로고
    • Prevention of post-operative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype
    • Janicki PK, Schuler HG, Jarzembowski TM, et al. Prevention of post-operative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype. Anesth Analg 2006; 102: 1127-1133
    • (2006) Anesth Analg , vol.102 , pp. 1127-1133
    • Janicki, P.K.1    Schuler, H.G.2    Jarzembowski, T.M.3    Al, E.4
  • 301
    • 0025827739 scopus 로고
    • Ondansetron: Therapeutic use as an antiemetic
    • Milne RJ, Heel RC. Ondansetron: therapeutic use as an antiemetic. Drugs 1991; 41: 574-595
    • (1991) Drugs , vol.41 , pp. 574-595
    • Milne, R.J.1    Heel, R.C.2
  • 302
    • 0028229191 scopus 로고
    • The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine
    • Ashforth EI, Palmer JL, Bye A, et al. The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine. Br J Clin Pharmacol 1994; 37: 389-391
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 389-391
    • Ashforth, E.I.1    Palmer, J.L.2    Bye, A.3    Al, E.4
  • 303
    • 14644400494 scopus 로고    scopus 로고
    • The impact of pharmaco-genomics on postoperative nausea and vomiting: Do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis?
    • Candiotti KA, Birnbach DJ, Lubarsky DA, et al. The impact of pharmaco-genomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology 2005; 102: 543-549
    • (2005) Anesthesiology , vol.102 , pp. 543-549
    • Candiotti, K.A.1    Birnbach, D.J.2    Lubarsky, D.A.3    Al, E.4
  • 304
    • 0034089129 scopus 로고    scopus 로고
    • Tropisetron: An update of its use in the prevention of chemotherapy-induced nausea and vomiting
    • Simpson K, Spencer CM, McClellan KJ. Tropisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs 2000; 59: 1297-1315
    • (2000) Drugs , vol.59 , pp. 1297-1315
    • Simpson, K.1    Spencer, C.M.2    McClellan, K.J.3
  • 305
    • 0027369365 scopus 로고
    • Tropisetron: A review of its pharmaco-dynamic and pharmacokinetic properties, and therapeutic potential as an antiemetic
    • Lee CR, Plosker GL, McTavish D. Tropisetron: a review of its pharmaco-dynamic and pharmacokinetic properties, and therapeutic potential as an antiemetic. Drugs 1993; 46: 925-943
    • (1993) Drugs , vol.46 , pp. 925-943
    • Lee, C.R.1    Plosker, G.L.2    McTavish, D.3
  • 306
    • 0029024335 scopus 로고
    • In vitro characterization of cyto-chrome P450 catalysed metabolism of the antiemetic tropisetron
    • Firkusny L, Kroemer HK, Eichelbaum M. In vitro characterization of cyto-chrome P450 catalysed metabolism of the antiemetic tropisetron. Biochem Pharmacol 1995; 49: 1777-1784
    • (1995) Biochem Pharmacol , vol.49 , pp. 1777-1784
    • Firkusny, L.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 307
    • 10744229524 scopus 로고    scopus 로고
    • Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects
    • Kim MK, Cho JY, Lim HS, et al. Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects. Eur J Clin Pharmacol 2003; 59: 111-116
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 111-116
    • Kim, M.K.1    Cho, J.Y.2    Lim, H.S.3    Al, E.4
  • 308
    • 0037096821 scopus 로고    scopus 로고
    • Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes
    • Kaiser R, Sezer O, Papies A, et al. Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes. J Clin Oncol 2002; 20: 2805-2811
    • (2002) J Clin Oncol , vol.20 , pp. 2805-2811
    • Kaiser, R.1    Sezer, O.2    Papies, A.3    Al, E.4
  • 309
    • 0036016092 scopus 로고    scopus 로고
    • Next generation antihistamines: Therapeutic rationale, accomplishments and advances
    • Oppenheimer JJ, Casale TB. Next generation antihistamines: therapeutic rationale, accomplishments and advances. Expert Opin Investig Drugs 2002; 11: 807-817
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 807-817
    • Oppenheimer, J.J.1    Casale, T.B.2
  • 310
    • 40549139803 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacody-namics of desloratadine, fexofenadine and levocetirizine: A comparative review
    • Devillier P, Roche N, Faisy C. Clinical pharmacokinetics and pharmacody-namics of desloratadine, fexofenadine and levocetirizine: a comparative review. Clin Pharmacokinet 2008; 47: 217-230
    • (2008) Clin Pharmacokinet , vol.47 , pp. 217-230
    • Devillier, P.1    Roche, N.2    Faisy, C.3
  • 311
    • 0030048830 scopus 로고    scopus 로고
    • Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6
    • Yumibe N, Huie K, Chen KJ, et al. Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. Biochem Pharmacol 1996; 51: 165-172
    • (1996) Biochem Pharmacol , vol.51 , pp. 165-172
    • Yumibe, N.1    Huie, K.2    Chen, K.J.3    Al, E.4
  • 312
    • 0029049546 scopus 로고
    • Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine
    • Yumibe N, Huie K, Chen KJ, et al. Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine. Int Arch Allergy Immunol 1995; 107: 420
    • (1995) Int Arch Allergy Immunol , vol.107 , pp. 420
    • Yumibe, N.1    Huie, K.2    Chen, K.J.3    Al, E.4
  • 313
    • 0029798503 scopus 로고    scopus 로고
    • CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist pro-methazine in human liver microsomes
    • Nakamura K, Yokoi T, Inoue K, et al. CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist pro-methazine in human liver microsomes. Pharmacogenetics 1996; 6: 449-457
    • (1996) Pharmacogenetics , vol.6 , pp. 449-457
    • Nakamura, K.1    Yokoi, T.2    Inoue, K.3
  • 314
    • 0035099756 scopus 로고    scopus 로고
    • Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine
    • Matsumoto S, Yamazoe Y. Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol 2001; 51: 133-142
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 133-142
    • Matsumoto, S.1    Yamazoe, Y.2
  • 315
    • 0031885943 scopus 로고    scopus 로고
    • Oxidation of histamine H1 an-tagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes
    • Nakamura K, Yokoi T, Kodama T, et al. Oxidation of histamine H1 an-tagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther 1998; 284: 437-442
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 437-442
    • Nakamura, K.1    Yokoi, T.2    Kodama, T.3    Al, E.4
  • 316
    • 0031691414 scopus 로고    scopus 로고
    • Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6
    • Jones BC, Hyland R, Ackland M, et al. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6. Drug Metab Dispos 1998; 26: 875-882
    • (1998) Drug Metab Dispos , vol.26 , pp. 875-882
    • Jones, B.C.1    Hyland, R.2    Ackland, M.3    Al, E.4
  • 317
    • 0032811809 scopus 로고    scopus 로고
    • In vitro identification of the human cyto-chrome P-450 enzymes involved in the N-demethylation of azelastine
    • Imai T, Taketani M, Suzu T, et al. In vitro identification of the human cyto-chrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos 1999; 27: 942-946
    • (1999) Drug Metab Dispos , vol.27 , pp. 942-946
    • Imai, T.1    Taketani, M.2    Suzu, T.3    Al, E.4
  • 318
    • 0032701770 scopus 로고    scopus 로고
    • Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: Evaluation of approach to predict the contribution of multiple CYPs
    • Nakajima M, Nakamura S, Tokudome S, et al. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos 1999; 27: 1381-1391
    • (1999) Drug Metab Dispos , vol.27 , pp. 1381-1391
    • Nakajima, M.1    Nakamura, S.2    Tokudome, S.3    Al, E.4
  • 319
    • 19444366142 scopus 로고    scopus 로고
    • Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants
    • Goto A, Ueda K, Inaba A, et al. Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull 2005; 28: 328-334
    • (2005) Biol Pharm Bull , vol.28 , pp. 328-334
    • Goto, A.1    Ueda, K.2    Inaba, A.3    Al, E.4
  • 320
    • 11844271574 scopus 로고    scopus 로고
    • Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity
    • Goto A, Adachi Y, Inaba A, et al. Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity. Biol Pharm Bull 2004; 27: 684-690
    • (2004) Biol Pharm Bull , vol.27 , pp. 684-690
    • Goto, A.1    Adachi, Y.2    Inaba, A.3    Al, E.4
  • 321
    • 0031433960 scopus 로고    scopus 로고
    • Metabolism of epinastine a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine
    • Kishimoto W, Hiroi T, Sakai K, et al. Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol 1997; 98: 273-292
    • (1997) Res Commun Mol Pathol Pharmacol , vol.98 , pp. 273-292
    • Kishimoto, W.1    Hiroi, T.2    Sakai, K.3
  • 322
    • 0027250210 scopus 로고
    • Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes
    • Narimatsu S, Kariya S, Isozaki S, et al. Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes. Biochem Biophys Res Commun 1993; 193: 1262-1268
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 1262-1268
    • Narimatsu, S.1    Kariya, S.2    Isozaki, S.3    Al, E.4
  • 323
    • 0029827090 scopus 로고    scopus 로고
    • Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes
    • Kariya S, Isozaki S, Uchino K, et al. Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull 1996; 19: 1511-1514
    • (1996) Biol Pharm Bull , vol.19 , pp. 1511-1514
    • Kariya, S.1    Isozaki, S.2    Uchino, K.3    Al, E.4
  • 324
    • 33845929539 scopus 로고    scopus 로고
    • Identification of human cyto-chrome P450 isozymes involved in diphenhydramine N-demethylation
    • Akutsu T, Kobayashi K, Sakurada K, et al. Identification of human cyto-chrome P450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 2007; 35: 72-78
    • (2007) Drug Metab Dispos , vol.35 , pp. 72-78
    • Akutsu, T.1    Kobayashi, K.2    Sakurada, K.3    Al, E.4
  • 325
    • 0036482802 scopus 로고    scopus 로고
    • 1-antihistamines on CYP2D6-and CYP2C9-mediated drug metabolic reactions in human liver microsomes
    • He N, Zhang WQ, Shockley D, et al. Inhibitory effects of H1-antihistamines on CYP2D6-and CYP2C9-mediated drug metabolic reactions in human liver microsomes. Eur J Clin Pharmacol 2002; 57: 847-851
    • (2002) Eur J Clin Pharmacol , vol.57 , pp. 847-851
    • He, N.1    Zhang, W.Q.2    Shockley, D.3    Al, E.4
  • 326
    • 0035999647 scopus 로고    scopus 로고
    • The roles of CYP2D6 and ste-reoselectivity in the clinical pharmacokinetics of chlorpheniramine
    • Yasuda SU, Zannikos P, Young AE, et al. The roles of CYP2D6 and ste-reoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol 2002; 53: 519-525
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 519-525
    • Yasuda, S.U.1    Zannikos, P.2    Young, A.E.3    Al, E.4
  • 327
    • 0018067018 scopus 로고
    • Histamine H1. receptors identified in mammalian brain membranes with [3]mepyramine
    • Tran VT, Chang RS, Snyder SH. Histamine H1. receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Natl Acad Sci U S A 1978; 75: 6290-6294
    • (1978) Proc Natl Acad Sci U S A , Issue.75 , pp. 6290-6294
    • Tran, V.T.1    Chang, R.S.2    Snyder, S.H.3
  • 329
    • 0029134120 scopus 로고
    • Chlorpheniramine plasma con-centration and histamine H1-receptor occupancy
    • Yasuda SU, Wellstein A, Likhari P, et al. Chlorpheniramine plasma con-centration and histamine H1-receptor occupancy. Clin Pharmacol Ther 1995; 58: 210-220
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 210-220
    • Yasuda, S.U.1    Wellstein, A.2    Likhari, P.3
  • 330
    • 34548609661 scopus 로고    scopus 로고
    • Diphenhydramine versus non-sedating antihistamines for acute allergic reactions: A literature review
    • Banerji A, Long AA, Camargo CA, et al. Diphenhydramine versus non-sedating antihistamines for acute allergic reactions: a literature review. Allergy Asthma Proc 2007; 28: 418-426
    • (2007) Allergy Asthma Proc , vol.28 , pp. 418-426
    • Banerji, A.1    Long, A.A.2    Camargo, C.A.3    Al, E.4
  • 331
    • 0001065807 scopus 로고
    • Drug-induced extrapyramidal reactions: Treatment with diphenhydramine hydrochloride and dihydrox-yphenylalanine
    • McGeer PL, Boulding JE, Gibson WC, et al. Drug-induced extrapyramidal reactions: treatment with diphenhydramine hydrochloride and dihydrox- yphenylalanine. JAMA 1961; 177: 665-670
    • (1961) JAMA , vol.177 , pp. 665-670
    • McGeer, P.L.1    Boulding, J.E.2    Gibson, W.C.3    Al, E.4
  • 332
    • 0016139632 scopus 로고
    • Identification of diphenydramine (Benadryl) metabolities in human subjects
    • Chang T, Okerholm RA, Glazko AJ. Identification of diphenydramine (Benadryl) metabolities in human subjects. Res Commun Chem Pathol Pharmacol 1974; 9: 391-404
    • (1974) Res Commun Chem Pathol Pharmacol , vol.9 , pp. 391-404
    • Chang, T.1    Okerholm, R.A.2    Glazko, A.J.3
  • 333
    • 0022535010 scopus 로고
    • Pharmacokinetics of di-phenhydramine and a demethylated metabolite following intravenous and oral administration
    • Blyden GT, Greenblatt DJ, Scavone JM, et al. Pharmacokinetics of di-phenhydramine and a demethylated metabolite following intravenous and oral administration. J Clin Pharmacol 1986; 26: 529-533
    • (1986) J Clin Pharmacol , vol.26 , pp. 529-533
    • Blyden, G.T.1    Greenblatt, D.J.2    Scavone, J.M.3    Al, E.4
  • 334
    • 0037388156 scopus 로고    scopus 로고
    • Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view
    • Sharma A, Hamelin BA. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab 2003; 4: 105-129
    • (2003) Curr Drug Metab , vol.4 , pp. 105-129
    • Sharma, A.1    Hamelin, B.A.2
  • 335
    • 0030974918 scopus 로고    scopus 로고
    • Biphasic kinetics of quaternary am-monium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes
    • Breyer-Pfaff U, Fischer D, Winne D. Biphasic kinetics of quaternary am-monium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes. Drug Metab Dispos 1997; 25: 340-345
    • (1997) Drug Metab Dispos , vol.25 , pp. 340-345
    • Breyer-Pfaff, U.1    Fischer, D.2    Winne, D.3
  • 336
    • 0030838552 scopus 로고    scopus 로고
    • Variability of diphenhydramine N-glucuronida-tion in healthy subjects
    • Fischer D, Breyer-Pfaff U. Variability of diphenhydramine N-glucuronida-tion in healthy subjects. Eur J Drug Metab Pharmacokinet 1997; 22: 151-154
    • (1997) Eur J Drug Metab Pharmacokinet , vol.22 , pp. 151-154
    • Fischer, D.1    Breyer-Pfaff, U.2
  • 337
    • 0025850248 scopus 로고
    • N+-glucuronidation of aliphatic tertiary amines a general phenomenon in the metabolism of H1-antihistamines in humans
    • Luo H, Hawes EM, McKay G, et al. N+-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans. Xenobiotica 1991; 21: 1281-1288
    • (1991) Xenobiotica , vol.21 , pp. 1281-1288
    • Luo, H.1    Hawes, E.M.2    McKay, G.3
  • 338
    • 0035106383 scopus 로고    scopus 로고
    • Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activityinhumans
    • Lessard E, Yessine MA, Hamelin BA, et al. Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activityinhumans. J Clin Psychopharmacol 2001; 21: 175-184
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 175-184
    • Lessard, E.1    Yessine, M.A.2    Hamelin, B.A.3    Al, E.4
  • 339
    • 0028593587 scopus 로고
    • Loratadine: A reappraisal of its pharmaco-logical properties and therapeutic use in allergic disorders
    • Haria M, Fitton A, Peters DH. Loratadine: a reappraisal of its pharmaco-logical properties and therapeutic use in allergic disorders. Drugs 1994; 48: 617-637
    • (1994) Drugs , vol.48 , pp. 617-637
    • Haria, M.1    Fitton, A.2    Peters, D.H.3
  • 340
    • 34447298334 scopus 로고    scopus 로고
    • Disposition of desloratadine in healthy volunteers
    • Ramanathan R, Reyderman L, Su AD, et al. Disposition of desloratadine in healthy volunteers. Xenobiotica 2007; 37: 770-787
    • (2007) Xenobiotica , vol.37 , pp. 770-787
    • Ramanathan, R.1    Reyderman, L.2    Su, A.D.3    Al, E.4
  • 342
    • 23944527343 scopus 로고    scopus 로고
    • Effect of CYP2D6*10 allele on the pharmacokinetics of loratadine in Chinese subjects
    • Yin OQ, Shi XJ, Tomlinson B, et al. Effect of CYP2D6*10 allele on the pharmacokinetics of loratadine in Chinese subjects. Drug Metab Dispos 2005; 33: 1283-1287
    • (2005) Drug Metab Dispos , vol.33 , pp. 1283-1287
    • Yin, O.Q.1    Shi, X.J.2    Tomlinson, B.3    Al, E.4
  • 343
    • 33751220503 scopus 로고    scopus 로고
    • Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia
    • Saruwatari J, Matsunaga M, Ikeda K, et al. Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia. Eur J Clin Pharmacol 2006; 62: 995-1001
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 995-1001
    • Saruwatari, J.1    Matsunaga, M.2    Ikeda, K.3
  • 345
    • 0023884310 scopus 로고
    • Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)
    • Dayer P, Desmeules J, Leemann T, et al. Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI). Biochem Biophys Res Commun 1988; 152: 411-416
    • (1988) Biochem Biophys Res Commun , vol.152 , pp. 411-416
    • Dayer, P.1    Desmeules, J.2    Leemann, T.3
  • 346
    • 0030887069 scopus 로고    scopus 로고
    • Different effects of inhibitors on the O-and N-demethyla-tion of codeine in human liver microsomes
    • Yue QY, Sawe J. Different effects of inhibitors on the O-and N-demethyla-tion of codeine in human liver microsomes. Eur J Clin Pharmacol 1997; 52: 41-47
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 41-47
    • Yue, Q.Y.1    Sawe, J.2
  • 347
    • 41549129500 scopus 로고    scopus 로고
    • Contribution of UDP-glucuronosyl-transferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties
    • Ohno S, Kawana K, Nakajin S. Contribution of UDP-glucuronosyl-transferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. Drug Metab Dispos 2008; 36: 688-694
    • (2008) Drug Metab Dispos , vol.36 , pp. 688-694
    • Ohno, S.1    Kawana, K.2    Nakajin, S.3
  • 348
    • 10044297116 scopus 로고    scopus 로고
    • Genetic predictorsofthe clinical response to opioid analgesics: Clinical utility and future perspectives
    • Lotsch J,SkarkeC, LiefholdJ, et al. Genetic predictorsofthe clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharma-cokinet 2004; 43: 983-1013
    • (2004) Clin Pharma-cokinet , vol.43 , pp. 983-1013
    • Jskarkec, L.1    Liefhold, J.2
  • 349
    • 0031746749 scopus 로고    scopus 로고
    • Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
    • Eckhardt K, Li S, Ammon S,et al. Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation. Pain 1998; 76: 27-33
    • (1998) Pain , vol.76 , pp. 27-33
    • Eckhardt, K.1    Li, S.2    Ammon, S.3
  • 350
    • 0030472254 scopus 로고    scopus 로고
    • Codeine and morphine in extensive and poor metabolizers of sparteine: Pharmacokinetics, analgesic effect and side effects
    • Poulsen L, Brosen K, Arendt-Nielsen L, et al. Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects. Eur J Clin Pharmacol 1996; 51: 289-295
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 289-295
    • Poulsen, L.1    Brosen, K.2    Arendt-Nielsen, L.3    Al, E.4
  • 351
    • 0030432381 scopus 로고    scopus 로고
    • Pharmacogenetic determination of the effects of codeine and prediction of drug interactions
    • Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther 1996; 278: 1165-1174
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1165-1174
    • Caraco, Y.1    Sheller, J.2    Wood, A.J.3
  • 352
    • 0030765119 scopus 로고    scopus 로고
    • Genetically deficient CYP2D6 metabo-lism provides protection against oral opiate dependence
    • Tyndale RF, Droll KP, Sellers EM. Genetically deficient CYP2D6 metabo-lism provides protection against oral opiate dependence. Pharmacogenetics 1997; 7: 375-379
    • (1997) Pharmacogenetics , vol.7 , pp. 375-379
    • Tyndale, R.F.1    Droll, K.P.2    Sellers, E.M.3
  • 353
    • 0028207482 scopus 로고
    • Endogenous codeine and mor-phine in poor and extensive metabolisers of the CYP2D6 (debrisoqui-ne/sparteine) polymorphism
    • Mikus G, Bochner F, Eichelbaum M, et al. Endogenous codeine and mor-phine in poor and extensive metabolisers of the CYP2D6 (debrisoqui-ne/sparteine) polymorphism. J Pharmacol Exp Ther 1994; 268: 546-551
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 546-551
    • Mikus, G.1    Bochner, F.2    Eichelbaum, M.3    Al, E.4
  • 354
    • 0032423497 scopus 로고    scopus 로고
    • Relevance of deficient CYP2D6 in opiate dependence
    • Mikus G, Morike K, Griese EU, et al. Relevance of deficient CYP2D6 in opiate dependence. Pharmacogenetics 1998; 8: 565-568
    • (1998) Pharmacogenetics , vol.8 , pp. 565-568
    • Mikus, G.1    Morike, K.2    Griese, E.U.3    Al, E.4
  • 356
    • 33747134323 scopus 로고    scopus 로고
    • Pharmacogenetics of morphine poi-soning in a breastfed neonate of a codeine-prescribed mother
    • Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphine poi-soning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006; 368: 704
    • (2006) Lancet , vol.368 , pp. 704
    • Koren, G.1    Cairns, J.2    Chitayat, D.3    Al, E.4
  • 357
    • 57749180179 scopus 로고    scopus 로고
    • Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
    • Madadi P, Ross CJ, Hayden MR, et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther 2009; 85: 31-35
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 31-35
    • Madadi, P.1    Ross, C.J.2    Hayden, M.R.3    Al, E.4
  • 359
    • 0030661633 scopus 로고    scopus 로고
    • Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine
    • Kirkwood LC, Nation RL, Somogyi AA. Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine. Br J Clin Pharmacol 1997; 44: 549-555
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 549-555
    • Kirkwood, L.C.1    Nation, R.L.2    Somogyi, A.A.3
  • 360
    • 0028862793 scopus 로고
    • Dihydrocodeine: A new opioid substrate for the polymorphic CYP2D6 in humans
    • Fromm MF, Hofmann U, Griese EU, et al. Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans. Clin Pharmacol Ther 1995; 58: 374-382
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 374-382
    • Fromm, M.F.1    Hofmann, U.2    Griese, E.U.3    Al, E.4
  • 361
    • 0031839871 scopus 로고    scopus 로고
    • The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihy-dromorphine: A cross-over study with extensive and quinidine-induced poor metabolizers
    • Wilder-Smith CH, Hufschmid E, Thormann W. The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihy-dromorphine: a cross-over study with extensive and quinidine-induced poor metabolizers. Br J Clin Pharmacol 1998; 45: 575-581
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 575-581
    • Wilder-Smith, C.H.1    Hufschmid, E.2    Thormann, W.3
  • 363
    • 0025830147 scopus 로고
    • Mu receptor binding of some com-monly used opioids and their metabolites
    • Chen ZR, Irvine RJ, Somogyi AA, et al. Mu receptor binding of some com-monly used opioids and their metabolites. Life Sci 1991; 48: 2165-2171
    • (1991) Life Sci , vol.48 , pp. 2165-2171
    • Chen, Z.R.1    Irvine, R.J.2    Somogyi, A.A.3    Al, E.4
  • 364
    • 1542359666 scopus 로고    scopus 로고
    • CYP2D6 and CYP3A4 in-volvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    • Hutchinson MR, Menelaou A, Foster DJ, et al. CYP2D6 and CYP3A4 in-volvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol 2004; 57: 287-297
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 287-297
    • Hutchinson, M.R.1    Menelaou, A.2    Foster, D.J.3    Al, E.4
  • 365
    • 0027381603 scopus 로고
    • CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone
    • Otton SV, Schadel M, Cheung SW, et al. CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone. Clin Pharmacol Ther 1993; 54: 463-472
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 463-472
    • Otton, S.V.1    Schadel, M.2    Cheung, S.W.3    Al, E.4
  • 366
    • 0033057632 scopus 로고    scopus 로고
    • Inhibitors of cytochrome P450 differen-tially modify discriminative- stimulus and antinociceptive effects of hydro-codone and hydromorphone in rhesus monkeys
    • Lelas S, Wegert S, Otton SV, et al. Inhibitors of cytochrome P450 differen-tially modify discriminative-stimulus and antinociceptive effects of hydro-codone and hydromorphone in rhesus monkeys. Drug Alcohol Depend 1999; 54: 239-249
    • (1999) Drug Alcohol Depend , vol.54 , pp. 239-249
    • Lelas, S.1    Wegert, S.2    Otton, S.V.3    Al, E.4
  • 367
    • 0030999676 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability
    • Kaplan HL, Busto UE, Baylon GJ, et al. Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability. J Pharmacol Exp Ther 1997; 281: 103-108
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 103-108
    • Kaplan, H.L.1    Busto, U.E.2    Baylon, G.J.3    Al, E.4
  • 368
    • 0027450550 scopus 로고
    • A review of oxycodone's clinical pharmaco-kinetics and pharmacodynamics
    • Poyhia R, Vainio A, Kalso E. A review of oxycodone's clinical pharmaco-kinetics and pharmacodynamics. J Pain Symptom Manage 1993; 8: 63-67
    • (1993) J Pain Symptom Manage , vol.8 , pp. 63-67
    • Poyhia, R.1    Vainio, A.2    Kalso, E.3
  • 369
    • 0026492647 scopus 로고
    • Single-dose and steady-state phar-macokinetics and pharmacodynamics of oxycodone in patients with cancer
    • Leow KP, Smith MT, Williams B, et al. Single-dose and steady-state phar-macokinetics and pharmacodynamics of oxycodone in patients with cancer. Clin Pharmacol Ther 1992; 52: 487-495
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 487-495
    • Leow, K.P.1    Smith, M.T.2    Williams, B.3    Al, E.4
  • 370
    • 1842536807 scopus 로고    scopus 로고
    • Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal mi-crosomes
    • Lalovic B, Phillips B, Risler LL, et al. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal mi-crosomes. Drug Metab Dispos 2004; 32: 447-454
    • (2004) Drug Metab Dispos , vol.32 , pp. 447-454
    • Lalovic, B.1    Phillips, B.2    Risler, L.L.3    Al, E.4
  • 372
    • 0032436459 scopus 로고    scopus 로고
    • Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
    • Heiskanen T, Olkkola KT, Kalso E. Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Clin Pharmacol Ther 1998; 64: 603-611
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 603-611
    • Heiskanen, T.1    Olkkola, K.T.2    Kalso, E.3
  • 373
    • 0343526837 scopus 로고    scopus 로고
    • Methadone: A review of its pharmacokinetic/ pharmacodynamic properties
    • Garrido MJ, Troconiz IF. Methadone: a review of its pharmacokinetic/ pharmacodynamic properties. J Pharmacol Toxicol Methods 1999; 42: 61-66
    • (1999) J Pharmacol Toxicol Methods , vol.42 , pp. 61-66
    • Garrido, M.J.1    Troconiz, I.F.2
  • 374
    • 0028970418 scopus 로고
    • 2 d, k opioid receptor binding profiles of methadone stereoisomers and morphine
    • Kristensen K, Christensen CB, Christrup LL. The m1, m2, d, k opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sci 1995; 56: PL45-50
    • (1995) Life Sci , vol.56
    • Kristensen, K.1    Christensen, C.B.2    Christrup, L.L.3
  • 375
    • 0029132157 scopus 로고
    • Pharmacokinetics of me-thadone and its primary metabolite in 20 opiate addicts
    • de Vos JW, Geerlings PJ, van den Brink W, et al. Pharmacokinetics of me-thadone and its primary metabolite in 20 opiate addicts. Eur J Clin Pharmacol 1995; 48: 361-366
    • (1995) Eur J Clin Pharmacol , vol.48 , pp. 361-366
    • De Vos, J.W.1    Geerlings, P.J.2    Van Den Brink, W.3    Al, E.4
  • 376
    • 0038193696 scopus 로고    scopus 로고
    • Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)-and (S)-methadone in vitro
    • Wang JS, DeVane CL. Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)-and (S)-methadone in vitro. Drug Metab Dispos 2003; 31: 742-747
    • (2003) Drug Metab Dispos , vol.31 , pp. 742-747
    • Wang, J.S.1    Devane, C.L.2
  • 377
    • 33847686540 scopus 로고    scopus 로고
    • Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)-and racemic-methadone
    • Coller JK, Joergensen C, Foster DJ, et al. Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)-and racemic-methadone. Int J Clin Pharmacol Ther 2007; 45: 410-417
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 410-417
    • Coller, J.K.1    Joergensen, C.2    Foster, D.J.3    Al, E.4
  • 378
    • 33845533592 scopus 로고    scopus 로고
    • ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment
    • Crettol S, Deglon JJ, Besson J, et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther 2006; 80: 668-681
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 668-681
    • Crettol, S.1    Deglon, J.J.2    Besson, J.3    Al, E.4
  • 379
    • 0042530185 scopus 로고    scopus 로고
    • A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing me-thadone maintenance treatment
    • Shiran MR, Chowdry J, Rostami-Hodjegan A, et al. A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing me-thadone maintenance treatment. Br J Clin Pharmacol 2003; 56: 220-224
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 220-224
    • Shiran, M.R.1    Chowdry, J.2    Rostami-Hodjegan, A.3    Al, E.4
  • 381
    • 0036213788 scopus 로고    scopus 로고
    • Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers
    • Begre S, von Bardeleben U, Ladewig D, et al. Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers. J Clin Psychopharmacol 2002; 22: 211-215
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 211-215
    • Begre, S.1    Von Bardeleben, U.2    Ladewig, D.3    Al, E.4
  • 382
    • 0030890624 scopus 로고    scopus 로고
    • Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of metha-done
    • Eap CB, Bertschy G, Powell K, et al. Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of metha-done. J Clin Psychopharmacol 1997; 17: 113-117
    • (1997) J Clin Psychopharmacol , vol.17 , pp. 113-117
    • Eap, C.B.1    Bertschy, G.2    Powell, K.3    Al, E.4
  • 383
    • 0031868559 scopus 로고    scopus 로고
    • The effectof fluconazole on the clinical pharmacokinetics of methadone
    • Cobb MN, DesaiJ, Brown Jr LS, etal. The effectof fluconazole on the clinical pharmacokinetics of methadone. Clin Pharmacol Ther 1998; 63: 655-662
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 655-662
    • Cobb, M.N.1    Desaij Brown Jr., L.S.2
  • 384
    • 7444229920 scopus 로고    scopus 로고
    • Clinical pharmacology of tramadol
    • Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmaco-kinet 2004; 43: 879-923
    • (2004) Clin Pharmaco-kinet , vol.43 , pp. 879-923
    • Grond, S.1    Sablotzki, A.2
  • 385
    • 0031460240 scopus 로고    scopus 로고
    • Polymorphic CYP2D6 mediates O-de-methylation of the opioid analgesic tramadol
    • Paar WD, Poche S, Gerloff J, et al. Polymorphic CYP2D6 mediates O-de-methylation of the opioid analgesic tramadol. Eur J Clin Pharmacol 1997; 53: 235-239
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 235-239
    • Paar, W.D.1    Poche, S.2    Gerloff, J.3    Al, E.4
  • 386
    • 0034946742 scopus 로고    scopus 로고
    • Identification of cyto-chrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
    • Subrahmanyam V, Renwick AB, Walters DG, et al. Identification of cyto-chrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos 2001; 29: 1146-1155
    • (2001) Drug Metab Dispos , vol.29 , pp. 1146-1155
    • Subrahmanyam, V.1    Renwick, A.B.2    Walters, D.G.3    Al, E.4
  • 387
    • 0036137195 scopus 로고    scopus 로고
    • Concordance between tra-madol and dextromethorphan parent/metabolite ratios: The influence of CYP2D6 and non-CYP2D6 pathways on biotransformation
    • Abdel-Rahman SM, Leeder JS, Wilson JT, et al. Concordance between tra-madol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation. J Clin Pharmacol 2002; 42: 24-29
    • (2002) J Clin Pharmacol , vol.42 , pp. 24-29
    • Abdel-Rahman, S.M.1    Leeder, J.S.2    Wilson, J.T.3    Al, E.4
  • 389
    • 29844453632 scopus 로고    scopus 로고
    • The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6
    • Enggaard TP, Poulsen L, Arendt-Nielsen L, et al. The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Anesth Analg 2006; 102: 146-150
    • (2006) Anesth Analg , vol.102 , pp. 146-150
    • Enggaard, T.P.1    Poulsen, L.2    Arendt-Nielsen, L.3    Al, E.4
  • 390
    • 33947518244 scopus 로고    scopus 로고
    • Miotic action of tramadol is determined by CYP2D6 genotype
    • Slanar O, Nobilis M, Kvetina J, et al. Miotic action of tramadol is determined by CYP2D6 genotype. Physiol Res 2007; 56: 129-136
    • (2007) Physiol Res , vol.56 , pp. 129-136
    • Slanar, O.1    Nobilis, M.2    Kvetina, J.3    Al, E.4
  • 391
    • 21244448805 scopus 로고    scopus 로고
    • The effects of tramadol on static and dynamic pupillometry in healthy subjects: The relationship between pharmacody-namics, pharmacokinetics and CYP2D6 metaboliser status
    • Fliegert F, Kurth B, Gohler K. The effects of tramadol on static and dynamic pupillometry in healthy subjects: the relationship between pharmacody-namics, pharmacokinetics and CYP2D6 metaboliser status. Eur J Clin Pharmacol 2005; 61: 257-266
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 257-266
    • Fliegert, F.1    Kurth, B.2    Gohler, K.3
  • 392
    • 33750492934 scopus 로고    scopus 로고
    • Effect of the CYP2D6*10 C188T poly-morphism on postoperative tramadol analgesia in a Chinese population
    • Wang G, Zhang H, He F, et al. Effect of the CYP2D6*10 C188T poly-morphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol 2006; 62: 927-931
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 927-931
    • Wang, G.1    Zhang, H.2    He, F.3    Al, E.4
  • 393
    • 7644227960 scopus 로고    scopus 로고
    • Population pharmacokinetic modelling of tramadol with application of the NPEM algorithms
    • Gan SH, Ismail R, Wan Adnan WA, et al. Population pharmacokinetic modelling of tramadol with application of the NPEM algorithms. J Clin Pharm Ther 2004; 29: 455-463
    • (2004) J Clin Pharm Ther , vol.29 , pp. 455-463
    • Gan, S.H.1    Ismail, R.2    Wan Adnan, W.A.3    Al, E.4
  • 394
    • 47249099319 scopus 로고    scopus 로고
    • Brosen K.CYP2D6 polymorphism inrelation to tramadol metabolism: A study of Faroese patients
    • Halling J, Weihe P, Brosen K.CYP2D6 polymorphism inrelation to tramadol metabolism: a study of Faroese patients. Ther Drug Monit 2008; 30: 271-275
    • (2008) Ther Drug Monit , vol.30 , pp. 271-275
    • Halling, J.1    Weihe, P.2
  • 395
    • 34250872182 scopus 로고    scopus 로고
    • Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics
    • Gan SH, Ismail R, Wan Adnan WA, et al. Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics. Mol Diagn Ther 2007; 11: 171-181
    • (2007) Mol Diagn Ther , vol.11 , pp. 171-181
    • Gan, S.H.1    Ismail, R.2    Wan Adnan, W.A.3    Al, E.4
  • 396
    • 20444477620 scopus 로고    scopus 로고
    • Tramadol asa new probe for cytochrome P450 2D6 phenotyping: A population study
    • Pedersen RS, Damkier P, Brosen K. Tramadol asa new probe for cytochrome P450 2D6 phenotyping: a population study. Clin Pharmacol Ther 2005; 77: 458-467
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 458-467
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 397
    • 33745699160 scopus 로고    scopus 로고
    • Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers
    • Pedersen RS, Damkier P, Brosen K. Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol 2006; 62: 513-521
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 513-521
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 398
    • 33846598505 scopus 로고    scopus 로고
    • Pharmacokinetics of tra-madol enantiomers and their respective phase i metabolites in relation to CYP2D6 phenotype
    • Garcia-Quetglas E, Azanza JR, Sadaba B, et al. Pharmacokinetics of tra-madol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol Res 2007; 55: 122-130
    • (2007) Pharmacol Res , vol.55 , pp. 122-130
    • Garcia-Quetglas, E.1    Azanza, J.R.2    Sadaba, B.3    Al, E.4
  • 399
    • 0141626841 scopus 로고    scopus 로고
    • Impact of CYP2D6 genotype on postoperative tramadol analgesia
    • Stamer UM, Lehnen K, Hothker F, et al. Impact of CYP2D6 genotype on postoperative tramadol analgesia. Pain 2003; 105: 231-238
    • (2003) Pain , vol.105 , pp. 231-238
    • Stamer, U.M.1    Lehnen, K.2    Hothker, F.3    Al, E.4
  • 400
    • 0031405796 scopus 로고    scopus 로고
    • Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine
    • Dalen P, Frengell C, Dahl ML, et al. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. Ther Drug Monit 1997; 19: 543-544
    • (1997) Ther Drug Monit , vol.19 , pp. 543-544
    • Dalen, P.1    Frengell, C.2    Dahl, M.L.3    Al, E.4
  • 401
    • 0042634370 scopus 로고    scopus 로고
    • Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers
    • De Leon J, Dinsmore L, Wedlund P. Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers. J Clin Psycho-pharmacol 2003; 23: 420-421
    • (2003) J Clin Psycho-pharmacol , vol.23 , pp. 420-421
    • De Leon, J.1    Dinsmore, L.2    Wedlund, P.3
  • 402
    • 38349163777 scopus 로고    scopus 로고
    • Effects of the CYP2D6 gene dupli-cation on the pharmacokinetics and pharmacodynamics of tramadol
    • Kirchheiner J, Keulen JT, Bauer S, et al. Effects of the CYP2D6 gene dupli-cation on the pharmacokinetics and pharmacodynamics of tramadol. J Clin Psychopharmacol 2008; 28: 78-83
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 78-83
    • Kirchheiner, J.1    Keulen, J.T.2    Bauer, S.3    Al, E.4
  • 403
    • 0025940021 scopus 로고
    • Pharmacokinetic optimisation of oral hypoglycaemic therapy
    • MarchettiP,GiannarelliR, di CarloA, etal. Pharmacokinetic optimisation of oral hypoglycaemic therapy. Clin Pharmacokinet 1991; 21: 308-317
    • (1991) Clin Pharmacokinet , vol.21 , pp. 308-317
    • Marchetti, P.1    Giannarelli, R.2    Di Carlo, A.3
  • 404
    • 0024558075 scopus 로고
    • Pharmacokinetic-pharmacodynamic relation-ships of oral hypoglycaemic agents An update
    • Marchetti P, Navalesi R. Pharmacokinetic-pharmacodynamic relation-ships of oral hypoglycaemic agents. An update. Clin Pharmacokinet 1989; 16: 100-128
    • (1989) Clin Pharmacokinet , vol.16 , pp. 100-128
    • Marchetti, P.1    Navalesi, R.2
  • 406
    • 0021967265 scopus 로고
    • The genetic control of phenformin 4-hydroxylation
    • Shah RR, Evans DA, Oates NS, et al. The genetic control of phenformin 4-hydroxylation. J Med Genet 1985; 22: 361-366
    • (1985) J Med Genet , vol.22 , pp. 361-366
    • Shah, R.R.1    Evans, D.A.2    Oates, N.S.3    Al, E.4
  • 407
    • 0018830695 scopus 로고
    • Genetic impairment of phenformin me-tabolism
    • Shah RR, Oates NS, Idle JR, et al. Genetic impairment of phenformin me-tabolism. Lancet 1980; 1: 1147
    • (1980) Lancet , vol.1 , pp. 1147
    • Shah, R.R.1    Oates, N.S.2    Idle, J.R.3    Al, E.4
  • 408
    • 0027939533 scopus 로고
    • Comparative tolerability profiles of oral antidiabetic agents
    • Krentz AJ, Ferner RE, Bailey CJ. Comparative tolerability profiles of oral antidiabetic agents. Drug Saf 1994; 11: 223-241
    • (1994) Drug Saf , vol.11 , pp. 223-241
    • Krentz, A.J.1    Ferner, R.E.2    Bailey, C.J.3
  • 409
    • 0021053140 scopus 로고
    • Influence of oxidation polymorphism on phenformin kinetics and dynamics
    • Oates NS, Shah RR, Idle JR, et al. Influence of oxidation polymorphism on phenformin kinetics and dynamics. Clin Pharmacol Ther 1983; 34: 827-834
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 827-834
    • Oates, N.S.1    Shah, R.R.2    Idle, J.R.3    Al, E.4
  • 410
    • 0019492870 scopus 로고
    • Phenformin-induced lacticacidosis asso-ciated with impaired debrisoquine hydroxylation
    • Oates NS, Shah RR, Idle JR, et al. Phenformin-induced lacticacidosis asso-ciated with impaired debrisoquine hydroxylation. Lancet 1981; 1: 837-838
    • (1981) Lancet , vol.1 , pp. 837-838
    • Oates, N.S.1    Shah, R.R.2    Idle, J.R.3    Al, E.4
  • 411
    • 0019505774 scopus 로고
    • Hydroxylation of debrisoquine in patients with lacticacidosis after phenformin
    • Wiholm BE, Alvan G, Bertilsson L, et al. Hydroxylation of debrisoquine in patients with lacticacidosis after phenformin. Lancet 1981; 1: 1098-1099
    • (1981) Lancet , vol.1 , pp. 1098-1099
    • Wiholm, B.E.1    Alvan, G.2    Bertilsson, L.3    Al, E.4
  • 412
    • 49649104084 scopus 로고    scopus 로고
    • Selective estrogen modulators as an anticancer tool: Mechanisms of efficiency and resistance
    • Sengupta S, Jordan VC. Selective estrogen modulators as an anticancer tool: mechanisms of efficiency and resistance. Adv Exp Med Biol 2008; 630: 206-219
    • (2008) Adv Exp Med Biol , vol.630 , pp. 206-219
    • Sengupta, S.1    Jordan, V.C.2
  • 413
    • 0037434618 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators-mechan-isms of action and application to clinical practice
    • Riggs BL, Hartmann LC. Selective estrogen-receptor modulators-mechan-isms of action and application to clinical practice. N Engl J Med 2003; 348: 618-629
    • (2003) N Engl J Med , vol.348 , pp. 618-629
    • Riggs, B.L.1    Hartmann, L.C.2
  • 414
    • 37649007431 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators and anti-hormonal resistance in breast cancer
    • Jordan VC, O'Malley BW. Selective estrogen-receptor modulators and anti-hormonal resistance in breast cancer. J Clin Oncol 2007; 25: 5815-5824
    • (2007) J Clin Oncol , vol.25 , pp. 5815-5824
    • Jordan, V.C.1    O'Malley, B.W.2
  • 415
    • 33845904405 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer with selective oestrogen-receptor modulators
    • Jordan VC. Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat Rev Cancer 2007; 7: 46-53
    • (2007) Nat Rev Cancer , vol.7 , pp. 46-53
    • Jordan, V.C.1
  • 416
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, et al. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 2004; 310: 1062-1075
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3    Al, E.4
  • 417
    • 34548650021 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and the impact on tamoxifen therapy
    • Beverage JN, Sissung TM, Sion AM, et al. CYP2D6 polymorphisms and the impact on tamoxifen therapy. J Pharm Sci 2007; 96: 2224-2231
    • (2007) J Pharm Sci , vol.96 , pp. 2224-2231
    • Beverage, J.N.1    Sissung, T.M.2    Sion, A.M.3    Al, E.4
  • 418
    • 0346602691 scopus 로고    scopus 로고
    • Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Stearns V, Johnson MD, Rae JM, et al. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 2003; 95: 1758-1764
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1758-1764
    • Stearns, V.1    Johnson, M.D.2    Rae, J.M.3    Al, E.4
  • 419
    • 0036325773 scopus 로고    scopus 로고
    • Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formationof the 4-hydroxy,4-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hy-droxytamoxifen
    • Crewe HK, Notley LM, Wunsch RM, et al. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formationof the 4-hydroxy, 40-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hy-droxytamoxifen. Drug Metab Dispos 2002; 30: 869-874
    • (2002) Drug Metab Dispos , vol.30 , pp. 869-874
    • Crewe, H.K.1    Notley, L.M.2    Wunsch, R.M.3
  • 420
    • 0030812209 scopus 로고    scopus 로고
    • CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver
    • Dehal SS, Kupfer D. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver. Cancer Res 1997; 57: 3402-3406
    • (1997) Cancer Res , vol.57 , pp. 3402-3406
    • Dehal, S.S.1    Kupfer, D.2
  • 421
    • 0033017135 scopus 로고    scopus 로고
    • Cytochrome P-450 3A and 2D6 catalyze ortho hydro-xylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins
    • Dehal SS, Kupfer D. Cytochrome P-450 3A and 2D6 catalyze ortho hydro-xylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos 1999; 27: 681-688
    • (1999) Drug Metab Dispos , vol.27 , pp. 681-688
    • Dehal, S.S.1    Kupfer, D.2
  • 422
    • 43749083482 scopus 로고    scopus 로고
    • CYP2D6 is primarily responsible for the metabolism of clomiphene
    • Ghobadi C, Gregory A, Crewe HK,et al. CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet 2008; 23: 101-105
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 101-105
    • Ghobadi, C.1    Gregory, A.2    Crewe, H.K.3
  • 423
    • 0027500825 scopus 로고
    • Analysis of phase i and phase II metabolites of tamoxifen in breast cancer patients
    • Poon GK, Chui YC, McCague R, et al. Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients. Drug Metab Dispos 1993; 21: 1119-1124
    • (1993) Drug Metab Dispos , vol.21 , pp. 1119-1124
    • Poon, G.K.1    Chui, Y.C.2    McCague, R.3    Al, E.4
  • 424
    • 0025872863 scopus 로고
    • Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes
    • Jacolot F, Simon I, Dreano Y, et al. Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes. Biochem Pharmacol 1991; 41: 1911-1919
    • (1991) Biochem Pharmacol , vol.41 , pp. 1911-1919
    • Jacolot, F.1    Simon, I.2    Dreano, Y.3    Al, E.4
  • 425
    • 0021348096 scopus 로고
    • Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of ta-moxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells
    • Katzenellenbogen BS, Norman MJ, Eckert RL, et al. Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of ta-moxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells. Cancer Res 1984; 44: 112-119
    • (1984) Cancer Res , vol.44 , pp. 112-119
    • Katzenellenbogen, B.S.1    Norman, M.J.2    Eckert, R.L.3    Al, E.4
  • 426
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y, Desta Z, Stearns V, et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 2005; 97: 30-39
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Jin, Y.1    Desta, Z.2    Stearns, V.3    Al, E.4
  • 427
    • 37849000864 scopus 로고    scopus 로고
    • Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy numberontamoxifen metabolism
    • Gjerde J, Hauglid M, Breilid H, et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy numberontamoxifen metabolism. Ann Oncol 2008; 19: 56-61
    • (2008) Ann Oncol , vol.19 , pp. 56-61
    • Gjerde, J.1    Hauglid, M.2    Breilid, H.3    Al, E.4
  • 428
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
    • Schroth W, Antoniadou L, Fritz P, et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 2007; 25: 5187-5193
    • (2007) J Clin Oncol , vol.25 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3    Al, E.4
  • 429
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz MP, Knox SK, Suman VJ, et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 2007; 101: 113-121
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3    Al, E.4
  • 430
    • 33747045564 scopus 로고    scopus 로고
    • Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxifen Trial
    • author reply 3709
    • Bonanni B, Macis D, Maisonneuve P, et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial. J Clin Oncol 2006; 24: 3708-9; author reply 3709
    • (2006) J Clin Oncol , vol.24 , pp. 3708-9
    • Bonanni, B.1    MacIs, D.2    Maisonneuve, P.3    Al, E.4
  • 431
    • 33745347897 scopus 로고    scopus 로고
    • Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
    • Borges S, Desta Z, Li L, et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther 2006; 80: 61-74
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 61-74
    • Borges, S.1    Desta, Z.2    Li, L.3    Al, E.4
  • 432
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen bio-transformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al. Pharmacogenetics of tamoxifen bio-transformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005; 23: 9312-9318
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3    Al, E.4
  • 433
    • 47749105202 scopus 로고    scopus 로고
    • Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
    • Xu Y, Sun Y, Yao L, et al. Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 2008; 19: 1423-1429
    • (2008) Ann Oncol , vol.19 , pp. 1423-1429
    • Xu, Y.1    Sun, Y.2    Yao, L.3    Al, E.4
  • 434
    • 43649090742 scopus 로고    scopus 로고
    • Impact of CYP2D6*10 on recur-rence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
    • Kiyotani K, Mushiroda T, Sasa M, et al. Impact of CYP2D6*10 on recur-rence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci 2008; 99: 995-999
    • (2008) Cancer Sci , vol.99 , pp. 995-999
    • Kiyotani, K.1    Mushiroda, T.2    Sasa, M.3    Al, E.4
  • 435
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
    • Lim HS, Ju Lee H, Seok Lee K, et al. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 2007; 25: 3837-3845
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.S.1    Ju Lee, H.2    Seok Lee, K.3    Al, E.4
  • 436
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in ta-moxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • Nowell SA, Ahn J, Rae JM, et al. Association of genetic variation in ta-moxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 2005; 91: 249-258
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.2    Rae, J.M.3    Al, E.4
  • 437
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman P, Vainikka L, Stal O, et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 2005; 7: R284-90
    • (2005) Breast Cancer Res , vol.7
    • Wegman, P.1    Vainikka, L.2    Stal, O.3    Al, E.4
  • 438
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in post-menopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, et al. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in post-menopausal patients with breast cancer. Breast Cancer Res 2007; 9: R7
    • (2007) Breast Cancer Res , vol.9
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3    Al, E.4
  • 439
    • 38349167330 scopus 로고    scopus 로고
    • CYP2D6 phenotype prediction from genotype: Which system is the best?
    • Kirchheiner J. CYP2D6 phenotype prediction from genotype: which system is the best? Clin Pharmacol Ther 2008; 83: 225-227
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 225-227
    • Kirchheiner, J.1
  • 440
    • 37549006389 scopus 로고    scopus 로고
    • Tamoxifen pharmacogenomics: The role of CYP2D6 as a predictor of drug response
    • Goetz MP, Kamal A, Ames MM. Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. Clin Pharmacol Ther 2008; 83: 160-166
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 160-166
    • Goetz, M.P.1    Kamal, A.2    Ames, M.M.3
  • 441
    • 33847633415 scopus 로고    scopus 로고
    • Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments?
    • Takimoto CH. Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments? Nat Clin Pract Oncol 2007; 4: 152-153
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 152-153
    • Takimoto, C.H.1
  • 442
    • 0036007579 scopus 로고    scopus 로고
    • The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity
    • Wennerholm A, Dandara C, Sayi J, et al. The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clin Pharmacol Ther 2002; 71: 77-88
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 77-88
    • Wennerholm, A.1    Dandara, C.2    Sayi, J.3    Al, E.4
  • 443
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • Griese EU, Zanger UM, Brudermanns U, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 1998; 8: 15-26
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.U.1    Zanger, U.M.2    Brudermanns, U.3    Al, E.4
  • 444
    • 4344613464 scopus 로고    scopus 로고
    • Allele-specific change of con-centration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    • Steimer W, Zopf K, von Amelunxen S, et al. Allele-specific change of con-centration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers. Clin Chem 2004; 50: 1623-1633
    • (2004) Clin Chem , vol.50 , pp. 1623-1633
    • Steimer, W.1    Zopf, K.2    Von Amelunxen, S.3    Al, E.4
  • 445
    • 53249127350 scopus 로고    scopus 로고
    • Semi-quantitative CYP2D6 gene doses in relation to metabolic ratios of psychotropics
    • Hinrichs JW, Loovers HM, Scholten B, etal. Semi-quantitative CYP2D6 gene doses in relation to metabolic ratios of psychotropics. Eur J Clin Pharmacol 2008; 64: 979-986
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 979-986
    • Hinrichs, J.W.1    Loovers, H.M.2    Scholten, B.3
  • 446
    • 38349132802 scopus 로고    scopus 로고
    • The CYP2D6 activity score: Trans-lating genotype information into a qualitative measure of phenotype
    • Gaedigk A, Simon SD, Pearce RE, et al. The CYP2D6 activity score: trans-lating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther 2008; 83: 234-242
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 234-242
    • Gaedigk, A.1    Simon, S.D.2    Pearce, R.E.3    Al, E.4
  • 447
    • 33645109079 scopus 로고    scopus 로고
    • CYP2D6*36 gene arrangements within theCYP2D6 locus: Association of CYP2D6*36 with poor metabolizer status
    • Gaedigk A, Bradford LD, Alander SW, et al. CYP2D6*36 gene arrangements within theCYP2D6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos 2006; 34: 563-569
    • (2006) Drug Metab Dispos , vol.34 , pp. 563-569
    • Gaedigk, A.1    Bradford, L.D.2    Alander, S.W.3    Al, E.4
  • 448
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in Black Americans
    • Gaedigk A, Bradford LD, Marcucci KA, et al. Unique CYP2D6 activity distribution and genotype-phenotype discordance in Black Americans. Clin Pharmacol Ther 2002; 72: 76-89
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 76-89
    • Gaedigk, A.1    Bradford, L.D.2    Marcucci, K.A.3    Al, E.4
  • 449
    • 0038548107 scopus 로고    scopus 로고
    • Discovery of a novel nonfunc-tional cytochrome P450 2D6 allele, CYP2D6*42, in African American subjects
    • Gaedigk A, Ndjountche L, Gaedigk R, et al. Discovery of a novel nonfunc-tional cytochrome P450 2D6 allele, CYP2D6*42, in African American subjects. Clin Pharmacol Ther 2003; 73: 575-576
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 575-576
    • Gaedigk, A.1    Ndjountche, L.2    Gaedigk, R.3    Al, E.4
  • 451
    • 70149110672 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 enzymes and its clinical impact
    • Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 2009; 41: 89-295
    • (2009) Drug Metab Rev , vol.41 , pp. 89-295
    • Zhou, S.F.1    Liu, J.P.2    Chowbay, B.3
  • 452
    • 33646092472 scopus 로고    scopus 로고
    • Crystal structure of human cyto-chrome P450 2D6
    • Rowland P, Blaney FE, Smyth MG, et al. Crystal structure of human cyto-chrome P450 2D6. J Biol Chem 2006; 281: 7614-7622
    • (2006) J Biol Chem , vol.281 , pp. 7614-7622
    • Rowland, P.1    Blaney, F.E.2    Smyth, M.G.3    Al, E.4
  • 453
    • 70349387884 scopus 로고    scopus 로고
    • Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development
    • Zhou SF, Liu JP, Lai XS. Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development. Curr Med Chem 2009; 16: 2661-2805
    • (2009) Curr Med Chem , vol.16 , pp. 2661-2805
    • Zhou, S.F.1    Liu, J.P.2    Lai, X.S.3
  • 454
    • 0037423276 scopus 로고    scopus 로고
    • Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6
    • Paine MJ, McLaughlin LA, Flanagan JU, et al. Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. J Biol Chem 2003; 278: 4021-4027
    • (2003) J Biol Chem , vol.278 , pp. 4021-4027
    • Paine, M.J.1    McLaughlin, L.A.2    Flanagan, J.U.3    Al, E.4
  • 455
    • 0030200485 scopus 로고    scopus 로고
    • Active-site topologies of human CYP2D6 and its aspartate-301-glutamate, asparagine, and glycine mutants
    • Mackman R, Tschirret-Guth RA, Smith G, et al. Active-site topologies of human CYP2D6 and its aspartate-301-glutamate, asparagine, and glycine mutants. Arch Biochem Biophys 1996; 331: 134-40
    • (1996) Arch Biochem Biophys , vol.331 , pp. 134-40
    • MacKman, R.1    Tschirret-Guth, R.A.2    Smith, G.3    Al, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.