The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19

Pharmaceutical Research

Volumn 19, Issue 7, 2002, Pages 1034-1037

  Hartter S ^a   Tybring, G ^b   Friedberg, T ^c   Weigmann, H ^a   Hiemke, C ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cis trans isomers; Doxepin; In vitro; Metabolism; Tricyclic antidepressants

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DIAZEPAM; DOXEPIN; FURAFYLLINE; NORDAZEPAM; OXAZEPAM; QUINIDINE; SULFAPHENAZOLE; TEMAZEPAM; TRANYLCYPROMINE; TROLEANDOMYCIN; CYP2C19 PROTEIN, HUMAN; DRUG DERIVATIVE; ISOENZYME; ISOTHIOCYANIC ACID DERIVATIVE; MIXED FUNCTION OXIDASE; NORDOXEPIN; PHENETHYL ISOTHIOCYANATE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA POLYMORPHISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; ISOMER; LIVER MICROSOME; PRIORITY JOURNAL; CATALYSIS; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; DOXEPIN; HUMAN; ISOENZYMES; ISOTHIOCYANATES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; SUPPORT, NON-U.S. GOV'T; TRANYLCYPROMINE; HUMANS;

EID: 0035997338     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016478708902     Document Type: Article

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