-
1
-
-
0017695082
-
Polymorphic hydroxylation of debrisoquine in man
-
A. Mahgoub, J.R. Idle, L.G. Dring, R. Lancaster, R.L. Smith Polymorphic hydroxylation of debrisoquine in man Lancet 2 1977 584 586
-
(1977)
Lancet
, vol.2
, pp. 584-586
-
-
Mahgoub, A.1
Idle, J.R.2
Dring, L.G.3
Lancaster, R.4
Smith, R.L.5
-
2
-
-
0021719455
-
Characterization of a common genetic defect of cytochrome P-450 function (debrisoquinine-sparteine type polymorphism)
-
P. Dayer, R. Gasser, J. Gut, T. Kronbach, G.M. Robertz, M. Eichelbaum Characterization of a common genetic defect of cytochrome P-450 function (debrisoquinine-sparteine type polymorphism) Biomed Biophys Res Commun 125 1984 374 380
-
(1984)
Biomed Biophys Res Commun
, vol.125
, pp. 374-380
-
-
Dayer, P.1
Gasser, R.2
Gut, J.3
Kronbach, T.4
Robertz, G.M.5
Eichelbaum, M.6
-
3
-
-
0029059649
-
Pharmacokinetics of dextromethorphan and metabolites in humans: Influence of the CYP2D6 phenotype and quinidine inhibition
-
M. Schadel, D.A. Wu, S.V. Otton, W. Kalow, E.M. Sellers Pharmacokinetics of dextromethorphan and metabolites in humans influence of the CYP2D6 phenotype and quinidine inhibition J Clin Psychopharmacol 15 1995 263 269
-
(1995)
J Clin Psychopharmacol
, vol.15
, pp. 263-269
-
-
Schadel, M.1
Wu, D.A.2
Otton, S.V.3
Kalow, W.4
Sellers, E.M.5
-
4
-
-
0020409410
-
Oxidation phenotype-a major determinant of metroprolol metabolism and response
-
M.S. Lennard, J.H. Silas, S. Freestone, L.E. Ramsay, G.T. Tucker, H.F. Woods Oxidation phenotype-a major determinant of metroprolol metabolism and response N Engl J Med 307 1982 1558 1560
-
(1982)
N Engl J Med
, vol.307
, pp. 1558-1560
-
-
Lennard, M.S.1
Silas, J.H.2
Freestone, S.3
Ramsay, L.E.4
Tucker, G.T.5
Woods, H.F.6
-
7
-
-
0034007388
-
Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
-
D.S. Streetman, J.S. Bertino, A.N. Nafziger Phenotyping of drug-metabolizing enzymes in adults a review of in-vivo cytochrome P450 phenotyping probes Pharmacogenetics 10 2000 187 216
-
(2000)
Pharmacogenetics
, vol.10
, pp. 187-216
-
-
Streetman, D.S.1
Bertino, J.S.2
Nafziger, A.N.3
-
8
-
-
0029587052
-
Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans
-
T. Ebner, C.O. Meese, M. Eichelbaum Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans Mol Pharmacol 48 1995 1078 1086
-
(1995)
Mol Pharmacol
, vol.48
, pp. 1078-1086
-
-
Ebner, T.1
Meese, C.O.2
Eichelbaum, M.3
-
9
-
-
0346363770
-
CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR
-
E. Schaeffeler, M. Schwab, M. Eichelbaum, U.M. Zanger CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR Hum Mutat 22 2003 476 485
-
(2003)
Hum Mutat
, vol.22
, pp. 476-485
-
-
Schaeffeler, E.1
Schwab, M.2
Eichelbaum, M.3
Zanger, U.M.4
-
11
-
-
0017863203
-
On separation of isomeres, structural elucidation and pharmacological characterization of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol [in German]
-
E. Frankus, E. Friderichs, S.M. Kim, G. Osterloh On separation of isomeres, structural elucidation and pharmacological characterization of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol [in German] Arzneimittelforschung 28 1978 114 121
-
(1978)
Arzneimittelforschung
, vol.28
, pp. 114-121
-
-
Frankus, E.1
Friderichs, E.2
Kim, S.M.3
Osterloh, G.4
-
12
-
-
0026575516
-
Tramadol-pain relief by an opioid without depression of respiration
-
M.D. Vickers, D. Oflaherty, S.M. Szekely, M. Read, J. Yoshizumi Tramadol-pain relief by an opioid without depression of respiration Anaesthesia 47 1992 291 296
-
(1992)
Anaesthesia
, vol.47
, pp. 291-296
-
-
Vickers, M.D.1
Oflaherty, D.2
Szekely, S.M.3
Read, M.4
Yoshizumi, J.5
-
13
-
-
0027194499
-
Tramadol. a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states
-
C.R. Lee, D. McTavish, E.M. Sorkim Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states Drugs 46 1993 313 340
-
(1993)
Drugs
, vol.46
, pp. 313-340
-
-
Lee, C.R.1
McTavish, D.2
Sorkim, E.M.3
-
14
-
-
0031764451
-
The clinical use of tramadol hydrochloride
-
T.A. Bamigbade, R.M. Langford The clinical use of tramadol hydrochloride Pain Rev 5 1998 155 182
-
(1998)
Pain Rev
, vol.5
, pp. 155-182
-
-
Bamigbade, T.A.1
Langford, R.M.2
-
15
-
-
0026512239
-
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an atypical opioid analgesic
-
R.B. Raffa, E. Friederichs, W. Reimann, R.P. Shank, E.E. Codd, J.L. Vaught Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an atypical opioid analgesic J Pharmacol Exp Ther 260 1992 275 285
-
(1992)
J Pharmacol Exp Ther
, vol.260
, pp. 275-285
-
-
Raffa, R.B.1
Friederichs, E.2
Reimann, W.3
Shank, R.P.4
Codd, E.E.5
Vaught, J.L.6
-
16
-
-
0030898817
-
Tolerability profile of tramadol: Findings from international studies and postmarketing surveillance data
-
M. Cossmann, C. Kohnen, R. Langford, C. McCartney Tolerability profile of tramadol findings from international studies and postmarketing surveillance data Drugs 53 1997 50 62
-
(1997)
Drugs
, vol.53
, pp. 50-62
-
-
Cossmann, M.1
Kohnen, C.2
Langford, R.3
McCartney, C.4
-
18
-
-
0029775785
-
Pharmacokinetics, efficacy and safety of analgesia with a focus on tramadol HCl
-
T.P. Gibson Pharmacokinetics, efficacy and safety of analgesia with a focus on tramadol HCl Am J Med 101 1996 47S 53S
-
(1996)
Am J Med
, vol.101
-
-
Gibson, T.P.1
-
19
-
-
0034002778
-
Pharmacokinetics of tramadol after i.v. or caudal epidural administration
-
B.V.S. Murthy, K.S. Pandya, P.D. Booker, A. Murray, W. Lintz, R. Terlinden Pharmacokinetics of tramadol after i.v. or caudal epidural administration Br J Anaesth 84 2000 346 349
-
(2000)
Br J Anaesth
, vol.84
, pp. 346-349
-
-
Murthy, B.V.S.1
Pandya, K.S.2
Booker, P.D.3
Murray, A.4
Lintz, W.5
Terlinden, R.6
-
20
-
-
0033140423
-
Tramadol drops in children: Analgesic efficacy, lack of respiratory effects, and normal recovery times
-
K.A. Payne, F. Fanzca, J.A. Roelofse Tramadol drops in children analgesic efficacy, lack of respiratory effects, and normal recovery times Anesth Prog 46 1999 91 96
-
(1999)
Anesth Prog
, vol.46
, pp. 91-96
-
-
Payne, K.A.1
Fanzca, F.2
Roelofse, J.A.3
-
21
-
-
0036878989
-
Comparative study of two protocols with tramadol for postoperative analgesia in children [in French]
-
O. Kaabachi, H. El Jaouani, H. Safi, Chakib Jelel, M. Ben Ghachem Comparative study of two protocols with tramadol for postoperative analgesia in children [in French] Tunis Med 80 2002 685 690
-
(2002)
Tunis Med
, vol.80
, pp. 685-690
-
-
Kaabachi, O.1
El Jaouani, H.2
Safi, H.3
Chakib, J.4
Ben Ghachem, M.5
-
22
-
-
0036276786
-
Metabolism of the analgesic drug Ultram (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites
-
W.N. Wu, L.A. McKown, S. Liao Metabolism of the analgesic drug Ultram (tramadol hydrochloride) in humans API-MS and MS/MS characterization of metabolites Xenobiotica 32 2002 411 425
-
(2002)
Xenobiotica
, vol.32
, pp. 411-425
-
-
Wu, W.N.1
McKown, L.A.2
Liao, S.3
-
24
-
-
0026649268
-
The metabolism of tramadol by human liver microsomes
-
W.D. Paar, P. Frankus, H.J. Dengler The metabolism of tramadol by human liver microsomes Clin Investig 70 1992 708 710
-
(1992)
Clin Investig
, vol.70
, pp. 708-710
-
-
Paar, W.D.1
Frankus, P.2
Dengler, H.J.3
-
25
-
-
0034946742
-
Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
-
V. Subrahmanyam, A.B. Renwick, D.G. Walters, P.J. Young, R.J. Price, A.P. Tonelli Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes Drug Metab Dispos 29 2001 1146 1155
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1146-1155
-
-
Subrahmanyam, V.1
Renwick, A.B.2
Walters, D.G.3
Young, P.J.4
Price, R.J.5
Tonelli, A.P.6
-
26
-
-
0031460240
-
Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol
-
W.D. Paar, S. Poche, J. Gerloff, H.J. Dengler Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol Eur J Pharmacol 53 1997 235 239
-
(1997)
Eur J Pharmacol
, vol.53
, pp. 235-239
-
-
Paar, W.D.1
Poche, S.2
Gerloff, J.3
Dengler, H.J.4
-
27
-
-
0036137195
-
Concordance between tramadol and dextromethorphan parent/metabolite ratios: The influence of CYP2D6 and non-CYP2D6 pathways on biotransformation
-
S.M. Abdel-Rahman, J.S. Leeder, J.T. Wilson, A. Gaedigk, R.R. Gotschall, R. Medve Concordance between tramadol and dextromethorphan parent/metabolite ratios the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation J Clin Pharmacol 42 2002 24 29
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 24-29
-
-
Abdel-Rahman, S.M.1
Leeder, J.S.2
Wilson, J.T.3
Gaedigk, A.4
Gotschall, R.R.5
Medve, R.6
-
28
-
-
0037348173
-
Enantioselective HPLC method for quantitative determination of tramadol and O-desmethyltramadol in plasma and urine: Application to clinical studies
-
R.S. Pedersen, K. Brosen, F. Nielsen Enantioselective HPLC method for quantitative determination of tramadol and O-desmethyltramadol in plasma and urine application to clinical studies Chromatographia 57 2003 279 285
-
(2003)
Chromatographia
, vol.57
, pp. 279-285
-
-
Pedersen, R.S.1
Brosen, K.2
Nielsen, F.3
-
29
-
-
16344365900
-
Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol
-
S. Laugesen, T.P. Enggaard, R.S. Pedersen, S.H. Sindrup, K. Brosen Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol Clin Pharmacol Ther 77 2005 312 323
-
(2005)
Clin Pharmacol Ther
, vol.77
, pp. 312-323
-
-
Laugesen, S.1
Enggaard, T.P.2
Pedersen, R.S.3
Sindrup, S.H.4
Brosen, K.5
-
30
-
-
0025036544
-
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes
-
M. Kagimoto, M. Heim, K. Kagimoto, T. Zeugin, U.A. Meyer Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes J Biol Chem 265 1990 17209 17214
-
(1990)
J Biol Chem
, vol.265
, pp. 17209-17214
-
-
Kagimoto, M.1
Heim, M.2
Kagimoto, K.3
Zeugin, T.4
Meyer, U.A.5
-
31
-
-
0030860004
-
Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
-
D. Marez, M. Legrand, N. Sabbagh, J.M. LoGuidice, C. Spire, J.J. Lafitte Polymorphism of the cytochrome P450 CYP2D6 gene in a European population characterization of 48 mutations and 53 alleles, their frequencies and evolution Pharmacogenetics 7 1997 193 202
-
(1997)
Pharmacogenetics
, vol.7
, pp. 193-202
-
-
Marez, D.1
Legrand, M.2
Sabbagh, N.3
Loguidice, J.M.4
Spire, C.5
Lafitte, J.J.6
-
32
-
-
0025243460
-
The human CYP2D locus associated with a common genetic defect in drug oxidation: A G1934-A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3′ splice recognition site
-
N. Hanioka, S. Kimura, U.A. Meyer, F.J. Gonzalez The human CYP2D locus associated with a common genetic defect in drug oxidation a G1934-A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3′ splice recognition site Am J Hum Genet 47 1990 994 1001
-
(1990)
Am J Hum Genet
, vol.47
, pp. 994-1001
-
-
Hanioka, N.1
Kimura, S.2
Meyer, U.A.3
Gonzalez, F.J.4
-
34
-
-
0028046321
-
Cloning and sequencing of a new non-functional CYP2D6 allele: Deletion of T1795 in exon 3 generates a premature stop codon
-
B. Evert, E.U. Griese, M. Eichelbaum Cloning and sequencing of a new non-functional CYP2D6 allele deletion of T1795 in exon 3 generates a premature stop codon Pharmacogenetics 4 1994 271 274
-
(1994)
Pharmacogenetics
, vol.4
, pp. 271-274
-
-
Evert, B.1
Griese, E.U.2
Eichelbaum, M.3
-
35
-
-
0028929652
-
An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution
-
A.K. Daly, J.B. Leathart, S.J. London, J.R. Idle An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution Hum Genet 95 1995 337 341
-
(1995)
Hum Genet
, vol.95
, pp. 337-341
-
-
Daly, A.K.1
Leathart, J.B.2
London, S.J.3
Idle, J.R.4
-
36
-
-
0028305240
-
Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
-
R. Saxena, G.L. Shaw, M.W. Relling, J.N. Frame, D.T. Moir, W.E. Evans Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype Hum Mol Genet 3 1994 923 926
-
(1994)
Hum Mol Genet
, vol.3
, pp. 923-926
-
-
Saxena, R.1
Shaw, G.L.2
Relling, M.W.3
Frame, J.N.4
Moir, D.T.5
Evans, W.E.6
-
37
-
-
0026240145
-
Identification of a new variant CYP2D6 allele lacking the codon encoding LYS-281: Possible association with the poor metabolizer phenotype
-
R. Tyndale, T. Aoyama, F. Broly, T. Matsunaga, T. Inaba, W. Kalow Identification of a new variant CYP2D6 allele lacking the codon encoding LYS-281 possible association with the poor metabolizer phenotype Pharmacogenetics 1 1991 26 32
-
(1991)
Pharmacogenetics
, vol.1
, pp. 26-32
-
-
Tyndale, R.1
Aoyama, T.2
Broly, F.3
Matsunaga, T.4
Inaba, T.5
Kalow, W.6
-
38
-
-
0027273757
-
Debrisoquine oxidation polymorphism: Phenotypic consequence of a 3-base-pair deletion in exon 5 of the CYP2D6 gene
-
F. Broly, U.A. Meyer Debrisoquine oxidation polymorphism phenotypic consequence of a 3-base-pair deletion in exon 5 of the CYP2D6 gene Pharmacogenetics 3 1993 123 130
-
(1993)
Pharmacogenetics
, vol.3
, pp. 123-130
-
-
Broly, F.1
Meyer, U.A.2
-
39
-
-
0025572192
-
Hydroxylation polymorphism of debrisoquine and mephenytoin in European populations
-
G. Alvan, P. Bechtel, L. Iselius, U. Gundertremy Hydroxylation polymorphism of debrisoquine and mephenytoin in European populations Eur J Clin Pharmacol 39 1990 533 537
-
(1990)
Eur J Clin Pharmacol
, vol.39
, pp. 533-537
-
-
Alvan, G.1
Bechtel, P.2
Iselius, L.3
Gundertremy, U.4
-
41
-
-
0025805934
-
Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug-metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
-
A. Gaedigk, M. Blum, R. Gaedigk, M. Eichelbaum, U.A. Meyer Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug-metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism Am J Hum Genet 48 1991 943 950
-
(1991)
Am J Hum Genet
, vol.48
, pp. 943-950
-
-
Gaedigk, A.1
Blum, M.2
Gaedigk, R.3
Eichelbaum, M.4
Meyer, U.A.5
-
42
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
L.D. Bradford CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants Pharmacogenomics 3 2002 229 243
-
(2002)
Pharmacogenomics
, vol.3
, pp. 229-243
-
-
Bradford, L.D.1
|