-
1
-
-
0026665305
-
Haloperidol and reduced haloperidol serum levels: Correlation with psychopathology in acute schizophrenia
-
Stevens A, Mahal A, Gaertner HJ. Haloperidol and reduced haloperidol serum levels: correlation with psychopathology in acute schizophrenia. Pharmacopsychiatry 1992; 25: 218-223.
-
(1992)
Pharmacopsychiatry
, vol.25
, pp. 218-223
-
-
Stevens, A.1
Mahal, A.2
Gaertner, H.J.3
-
2
-
-
0031789164
-
Therapeutic window of serum haloperidol concentration in acute schizophrenia and schizoaffective disorder
-
Ulrich S, Neuhof S, Braun V, Meyer FP. Therapeutic window of serum haloperidol concentration in acute schizophrenia and schizoaffective disorder. Pharmacopsychiatry 1998; 31: 163-169.
-
(1998)
Pharmacopsychiatry
, vol.31
, pp. 163-169
-
-
Ulrich, S.1
Neuhof, S.2
Braun, V.3
Meyer, F.P.4
-
3
-
-
0022390883
-
In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase
-
Inaba T, Jurima M, Mahon WA, Kalow W. In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase. Drug Metab Dispos 1985; 13: 443-448.
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 443-448
-
-
Inaba, T.1
Jurima, M.2
Mahon, W.A.3
Kalow, W.4
-
4
-
-
0025782876
-
Oxidation of reduced haloperidol to haloperidol: Involvement of human P450IID6 (sparteine/debrisoquine monooxygenase)
-
Tyndale RF, Kalow W, Inaba T. Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase). Br J Clin Pharmacol 1991; 31: 655-660.
-
(1991)
Br J Clin Pharmacol
, vol.31
, pp. 655-660
-
-
Tyndale, R.F.1
Kalow, W.2
Inaba, T.3
-
5
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 1989; 45: 889-904.
-
(1989)
Am J Hum Genet
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
6
-
-
0025114258
-
Identification of the primary gene defect at the cytochrome P450 CYP2D locus
-
Gough AC, Miles JS, Spurr NK et al. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature 1990; 347: 773-776.
-
(1990)
Nature
, vol.347
, pp. 773-776
-
-
Gough, A.C.1
Miles, J.S.2
Spurr, N.K.3
-
7
-
-
0027968799
-
DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): Evidence for two major allozymes in extensive metabolisers
-
Panserat S, Mura C, Gerard N et al. DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers. Hum Genet 1994; 94: 401-406.
-
(1994)
Hum Genet
, vol.94
, pp. 401-406
-
-
Panserat, S.1
Mura, C.2
Gerard, N.3
-
8
-
-
0033374688
-
Genetic association between cytochrome P-450 2D6 gene polymorphism and plasma concentration of haloperidol in Japanese schizophrenics
-
Shibata N, Ohnuma T, Baba H, Shimada H, Takahashi T, Arai H. Genetic association between cytochrome P-450 2D6 gene polymorphism and plasma concentration of haloperidol in Japanese schizophrenics. Psychiatr Genet 1999; 9: 145-148.
-
(1999)
Psychiatr Genet
, vol.9
, pp. 145-148
-
-
Shibata, N.1
Ohnuma, T.2
Baba, H.3
Shimada, H.4
Takahashi, T.5
Arai, H.6
-
9
-
-
0032752546
-
The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population
-
Someya T, Suzuki Y, Shimoda K et al. The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: a preliminary study in a psychiatric population. Psychiatry Clin Neurosci 1999; 53: 593-597.
-
(1999)
Psychiatry Clin Neurosci
, vol.53
, pp. 593-597
-
-
Someya, T.1
Suzuki, Y.2
Shimoda, K.3
-
10
-
-
0032588999
-
Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
-
Mihara K, Suzuki A, Kondo T et al. Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia. Clin Pharmacol Ther 1999; 65: 291-294.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 291-294
-
-
Mihara, K.1
Suzuki, A.2
Kondo, T.3
-
11
-
-
0030826785
-
Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients
-
Suzuki A, Otani K, Mihara K et al. Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients. Pharmacogenetics 1997; 7: 415-418.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 415-418
-
-
Suzuki, A.1
Otani, K.2
Mihara, K.3
-
12
-
-
0035464647
-
Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
-
Roh HK, Chung JY, Oh DY et al. Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients. Br J Clin Pharmacol 2001; 52: 265-271.
-
(2001)
Br J Clin Pharmacol
, vol.52
, pp. 265-271
-
-
Roh, H.K.1
Chung, J.Y.2
Oh, D.Y.3
-
13
-
-
0030432585
-
Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
-
Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278: 441-446.
-
(1996)
J Pharmacol Exp Ther
, vol.278
, pp. 441-446
-
-
Aklillu, E.1
Persson, I.2
Bertilsson, L.3
Johansson, I.4
Rodrigues, F.5
Ingelman-Sundberg, M.6
-
14
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
-
Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90: 11825-11829.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
Dahl, M.L.4
Sjoqvist, F.5
Ingelman-Sundberg, M.6
-
15
-
-
0031960328
-
Ultrarapid metabolism of sparteine: Frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction
-
Bathum L, Johansson I, Ingelman-Sundberg M, Horder M, Brosen K. Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction. Pharmacogenetics 1998; 8: 119-123.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 119-123
-
-
Bathum, L.1
Johansson, I.2
Ingelman-Sundberg, M.3
Horder, M.4
Brosen, K.5
-
16
-
-
0028150994
-
Coadministration of fluvoxamine increases serum concentrations of haloperidol
-
Daniel DG, Randolph C, Jaskiw G et al. Coadministration of fluvoxamine increases serum concentrations of haloperidol. J Clin Psychopharmacol 1994; 14: 340-343.
-
(1994)
J Clin Psychopharmacol
, vol.14
, pp. 340-343
-
-
Daniel, D.G.1
Randolph, C.2
Jaskiw, G.3
-
17
-
-
0032985593
-
Interindividual variation of plasma haloperidol concentrations and the impact of concomitant medications: The analysis of therapeutic drug monitoring data
-
Hirokane G, Someya T, Takahashi S, Morita S, Shimoda K. Interindividual variation of plasma haloperidol concentrations and the impact of concomitant medications: the analysis of therapeutic drug monitoring data. Ther Drug Monit 1999; 21: 82-86.
-
(1999)
Ther Drug Monit
, vol.21
, pp. 82-86
-
-
Hirokane, G.1
Someya, T.2
Takahashi, S.3
Morita, S.4
Shimoda, K.5
-
18
-
-
0028358565
-
The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population
-
Armstrong M, Fairbrother K, Idle JR, Daly AK. The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population. Pharmacogenetics 1994; 4: 73-81.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 73-81
-
-
Armstrong, M.1
Fairbrother, K.2
Idle, J.R.3
Daly, A.K.4
-
19
-
-
0031923119
-
Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication
-
Steijns LS, Van Der Weide J. Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication. Clin Chem 1998; 44: 914-917.
-
(1998)
Clin Chem
, vol.44
, pp. 914-917
-
-
Steijns, L.S.1
Van Der Weide, J.2
-
20
-
-
0007293059
-
Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
-
Lovlie R, Daly AK, Molven A, Idle JR, Steen VM. Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Lett 1996; 392: 30-34.
-
(1996)
FEBS Lett
, vol.392
, pp. 30-34
-
-
Lovlie, R.1
Daly, A.K.2
Molven, A.3
Idle, J.R.4
Steen, V.M.5
-
21
-
-
0032586732
-
Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population
-
Tateishi T, Chida M, Ariyoshi N, Mizorogi Y, Kamataki T, Kobayashi S. Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population. Clin Pharmacol Ther 1999; 65: 570-575.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 570-575
-
-
Tateishi, T.1
Chida, M.2
Ariyoshi, N.3
Mizorogi, Y.4
Kamataki, T.5
Kobayashi, S.6
-
22
-
-
0027527966
-
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism
-
Yokota H, Tamura S, Furuya H et al. Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics 1993; 3: 256-263.
-
(1993)
Pharmacogenetics
, vol.3
, pp. 256-263
-
-
Yokota, H.1
Tamura, S.2
Furuya, H.3
-
23
-
-
0024580258
-
Substantial rise in sparteine metabolic ratio during haloperidol treatment
-
Gram LF, Debruyne D, Caillard V et al. Substantial rise in sparteine metabolic ratio during haloperidol treatment. Br J Clin Pharmacol 1989; 27: 272-275.
-
(1989)
Br J Clin Pharmacol
, vol.27
, pp. 272-275
-
-
Gram, L.F.1
Debruyne, D.2
Caillard, V.3
-
24
-
-
0026780430
-
Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
-
Llerena A, Dahl ML, Ekqvist B, Bertilsson L. Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers. Ther Drug Monit 1992; 14: 261-264.
-
(1992)
Ther Drug Monit
, vol.14
, pp. 261-264
-
-
Llerena, A.1
Dahl, M.L.2
Ekqvist, B.3
Bertilsson, L.4
-
25
-
-
0031949132
-
10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
-
Dalen P, Dahl ML, Ruiz ML, Nordin J, Bertilsson L. 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 1998; 63: 444-452.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 444-452
-
-
Dalen, P.1
Dahl, M.L.2
Ruiz, M.L.3
Nordin, J.4
Bertilsson, L.5
-
26
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997; 60: 284-295.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
27
-
-
0036796048
-
The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
-
Brockmoller J, Kirchheiner J, Schmider J et al. The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther 2002; 72: 438-452
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 438-452
-
-
Brockmoller, J.1
Kirchheiner, J.2
Schmider, J.3
-
29
-
-
0031834493
-
Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation
-
Kudo S, Odomi M. Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation. Eur J Clin Pharmacol 1998; 54: 253-259.
-
(1998)
Eur J Clin Pharmacol
, vol.54
, pp. 253-259
-
-
Kudo, S.1
Odomi, M.2
-
30
-
-
0031712064
-
In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol
-
Pan LP, De Vriendt C, Belpaire FM. In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. Pharmacogenetics 1998; 8: 383-389.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 383-389
-
-
Pan, L.P.1
De Vriendt, C.2
Belpaire, F.M.3
-
31
-
-
0030716846
-
Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol
-
Pan LP, Wijnant P, DeVriendt C, Rosseel MT, Belpaire FM. Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. Br J Clin Pharmacol 1997; 44: 557-564.
-
(1997)
Br J Clin Pharmacol
, vol.44
, pp. 557-564
-
-
Pan, L.P.1
Wijnant, P.2
DeVriendt, C.3
Rosseel, M.T.4
Belpaire, F.M.5
-
32
-
-
0024362052
-
Haloperidol reductase in human and guinea pig livers
-
Inaba T, Kovacs J. Haloperidol reductase in human and guinea pig livers. Drug Metab Dispos 1989; 17: 330-333.
-
(1989)
Drug Metab Dispos
, vol.17
, pp. 330-333
-
-
Inaba, T.1
Kovacs, J.2
-
33
-
-
0026638785
-
Haloperidol metabolism in psychiatric patients: Importance of glucuronidation and carbonyl reduction
-
Someya T, Shibasaki M, Noguchi T, Takahashi S, Inaba T. Haloperidol metabolism in psychiatric patients: importance of glucuronidation and carbonyl reduction. J Clin Psychopharmacol 1992; 12: 169-174.
-
(1992)
J Clin Psychopharmacol
, vol.12
, pp. 169-174
-
-
Someya, T.1
Shibasaki, M.2
Noguchi, T.3
Takahashi, S.4
Inaba, T.5
-
34
-
-
0024405788
-
Use of antisera in the isolation of human specific conjugates of haloperidol
-
Oida T, Terauchi Y, Yoshida K, Kagemoto A, Sekine Y. Use of antisera in the isolation of human specific conjugates of haloperidol. Xenobiotica 1989; 19: 781-793.
-
(1989)
Xenobiotica
, vol.19
, pp. 781-793
-
-
Oida, T.1
Terauchi, Y.2
Yoshida, K.3
Kagemoto, A.4
Sekine, Y.5
|