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Volumn 4, Issue 4, 2007, Pages 479-500

Pharmacogenetic aspects of therapy with cholinesterase inhibitors: The role of CYP2D6 in Alzheimer's disease pharmacogenetics

Author keywords

Alzheimer's disease; APOE; Cholinesterase inhibitors; CYP2D6; Genetics; Genomics; Multifactorial treatment; Pharmacogenetics; Pharmacogenomics

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALPHA SECRETASE ACTIVATOR; APOLIPOPROTEIN E4; BETA SECRETASE INHIBITOR; CASPASE INHIBITOR; CHAPERONE; CHELATING AGENT; CHOLINESTERASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450 2D6; DONEPEZIL; DOPAMINE UPTAKE INHIBITOR; ENZYME ACTIVATOR; GALANTAMINE; GAMMA SECRETASE INHIBITOR; GROWTH FACTOR; LY 450139; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPEPTIDE; NGX 83232; NICOTINIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; RIVASTIGMINE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TACRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE;

EID: 34548671643     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720507781788846     Document Type: Conference Paper
Times cited : (73)

References (121)
  • 1
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431: 931-945 (2004).
    • (2004) Nature , vol.431 , pp. 931-945
  • 3
    • 0141851356 scopus 로고    scopus 로고
    • The application of functional genomics to Alzheimer's disease
    • Cacabelos R. The application of functional genomics to Alzheimer's disease. Pharmacogenomics 4(5): 597-621 (2003).
    • (2003) Pharmacogenomics , vol.4 , Issue.5 , pp. 597-621
    • Cacabelos, R.1
  • 5
    • 0036484691 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics in Alzheimer's disease. Min Rev Med Chem 2: 59-84 (2002).
    • (2002) Min Rev Med Chem , vol.2 , pp. 59-84
    • Cacabelos, R.1
  • 6
    • 0036434139 scopus 로고    scopus 로고
    • Pharmacogenomics for the treatment of dementia
    • Cacabelos R. Pharmacogenomics for the treatment of dementia. Ann Med 34: 357-379 (2002).
    • (2002) Ann Med , vol.34 , pp. 357-379
    • Cacabelos, R.1
  • 7
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • Roses AD. Pharmacogenetics and drug development: the path to safer and more effective drugs. Nature Rev Genet 5: 645-656 (2004).
    • (2004) Nature Rev Genet , vol.5 , pp. 645-656
    • Roses, A.D.1
  • 8
    • 27744539497 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic prospects in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics and therapeutic prospects in Alzheimer's disease. Exp Opin Pharmacother 6(12): 1967-1987 (2005).
    • (2005) Exp Opin Pharmacother , vol.6 , Issue.12 , pp. 1967-1987
    • Cacabelos, R.1
  • 9
    • 33751001487 scopus 로고    scopus 로고
    • Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer's disease. Aging Health 1(2): 303-348 (2005).
    • (2005) Aging Health , vol.1 , Issue.2 , pp. 303-348
    • Cacabelos, R.1
  • 11
  • 12
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature Genet 39(1): 17-23 (2007).
    • (2007) Nature Genet , vol.39 , Issue.1 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 13
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and α-synuclein: Molecular pahogenesis and pharmacological applications in Alzheimer's disease
    • Suh Y-H, Checler F. Amyloid precursor protein, presenilins, and α-synuclein: Molecular pahogenesis and pharmacological applications in Alzheimer's disease. Phamacol Rev 54: 469-525 (2002).
    • (2002) Phamacol Rev , vol.54 , pp. 469-525
    • Suh, Y.-H.1    Checler, F.2
  • 15
    • 0002011707 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics
    • Eds: Rimoin DL, Connor JM, Pyeritz R, Korf BR, Churchill-Livingstone, Edinburgh, p
    • th (Eds: Rimoin DL, Connor JM, Pyeritz R, Korf BR). Churchill-Livingstone, Edinburgh, p. 590-631 (2002).
    • (2002) th , pp. 590-631
    • Nebert, D.W.1    Jorge-Nebert, L.F.2
  • 17
    • 1542708761 scopus 로고    scopus 로고
    • From pharmacogenetics and ecogenetics to pharmacogenomics
    • Motulski AG. From pharmacogenetics and ecogenetics to pharmacogenomics. Med Secoli 14(3): 683-705 (2002).
    • (2002) Med Secoli , vol.14 , Issue.3 , pp. 683-705
    • Motulski, A.G.1
  • 18
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N Engl J Med 348: 529-537 (2003).
    • (2003) N Engl J Med , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 19
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-Drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. Pharmacogenomics-Drug disposition, drug targets, and side effects. N Engl J Med 348: 538-549 (2003).
    • (2003) N Engl J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 20
    • 7044238416 scopus 로고    scopus 로고
    • Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs
    • Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nature Med 10(10): 1055-1063 (2004).
    • (2004) Nature Med , vol.10 , Issue.10 , pp. 1055-1063
    • Forman, M.S.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 21
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 296: 1991-1995 (2002).
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 22
    • 17444382678 scopus 로고    scopus 로고
    • National estimates of medication use in nursing homes: Findings from 1997 Medicare Current Beneficiary Survey and the 1996 Medical Expenditure Survey
    • Doshi JA, Shaffer T, Briesacher BA. National estimates of medication use in nursing homes: Findings from 1997 Medicare Current Beneficiary Survey and the 1996 Medical Expenditure Survey. J Am Geriatr Soc 53: 438-443 (2005).
    • (2005) J Am Geriatr Soc , vol.53 , pp. 438-443
    • Doshi, J.A.1    Shaffer, T.2    Briesacher, B.A.3
  • 23
    • 14044259998 scopus 로고    scopus 로고
    • Antidepressant drugs prescribing among elderly subjects: A population-based study
    • Percudani M, Barbui C, Fortino I, Petrovich L. Antidepressant drugs prescribing among elderly subjects: a population-based study. Int J Geriat Psychiat 20: 113-118 (2005).
    • (2005) Int J Geriat Psychiat , vol.20 , pp. 113-118
    • Percudani, M.1    Barbui, C.2    Fortino, I.3    Petrovich, L.4
  • 24
    • 20044362718 scopus 로고    scopus 로고
    • Potentially inappropriate medication use among elderly home care patients in Europe
    • Fialová D, Topinková E, Gambassi G, Finne-Soveri H, Johnsson PV, Carpenter I, et al. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA 293(11): 1348-1358 (2005).
    • (2005) JAMA , vol.293 , Issue.11 , pp. 1348-1358
    • Fialová, D.1    Topinková, E.2    Gambassi, G.3    Finne-Soveri, H.4    Johnsson, P.V.5    Carpenter, I.6
  • 25
    • 15044340359 scopus 로고    scopus 로고
    • Potentially inappropriate medication use by elderly persons in U.S. Health Maintenance Organizations, 2000-2001
    • Simon SR, Chan KA, Soumerai SB, Wagner AK, Andrade SE, Feldstein AC, et al. Potentially inappropriate medication use by elderly persons in U.S. Health Maintenance Organizations, 2000-2001. J Am Geriatr Soc. 53: 227-232 (2005).
    • (2005) J Am Geriatr Soc , vol.53 , pp. 227-232
    • Simon, S.R.1    Chan, K.A.2    Soumerai, S.B.3    Wagner, A.K.4    Andrade, S.E.5    Feldstein, A.C.6
  • 26
    • 0011589226 scopus 로고    scopus 로고
    • Psychogeriatric research. A conceptual introduction to geriatric neuroscience
    • Cacabelos R. Psychogeriatric research. A conceptual introduction to geriatric neuroscience. Psychogeriatrics 1: 158-88 (2001).
    • (2001) Psychogeriatrics , vol.1 , pp. 158-188
    • Cacabelos, R.1
  • 27
    • 0033850870 scopus 로고    scopus 로고
    • Pharmacological treatment of Alzheimer disease: From phychotropic drugs and cholinesterase inhibitors to pharmacogenomics
    • Cacabelos R, Alvarez XA, Lombardi V, Fernández-Novoa L, Corzo L, Pérez P, et al. Pharmacological treatment of Alzheimer disease: From phychotropic drugs and cholinesterase inhibitors to pharmacogenomics. Drugs Today 36: 415-99 (2000).
    • (2000) Drugs Today , vol.36 , pp. 415-499
    • Cacabelos, R.1    Alvarez, X.A.2    Lombardi, V.3    Fernández-Novoa, L.4    Corzo, L.5    Pérez, P.6
  • 28
    • 34548690520 scopus 로고    scopus 로고
    • www.ncbi.nlm.nih.gov/OMIM
  • 29
    • 34548676126 scopus 로고    scopus 로고
    • www.molgen.ua.ac.be/ADMutations/
  • 30
    • 34548684290 scopus 로고    scopus 로고
    • www.mitomap.org/
  • 32
    • 0041385937 scopus 로고    scopus 로고
    • Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications
    • Cacabelos R, Fernández-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y. Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications. Neurol Res 25: 567-580 (2003).
    • (2003) Neurol Res , vol.25 , pp. 567-580
    • Cacabelos, R.1    Fernández-Novoa, L.2    Lombardi, V.3    Corzo, L.4    Pichel, V.5    Kubota, Y.6
  • 33
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genet 33(Suppl): 245-254 (2003).
    • (2003) Nature Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 34
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • Hunter DJ. Gene-environment interactions in human diseases. Nature Rev Genet 6: 287-298 (2005).
    • (2005) Nature Rev Genet , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 35
    • 4544233053 scopus 로고    scopus 로고
    • Caliban's heritance and the genetics of neuronal aging
    • Teter B, Finch CE. Caliban's heritance and the genetics of neuronal aging. Trends Neurosci 27(10): 627-632 (2004).
    • (2004) Trends Neurosci , vol.27 , Issue.10 , pp. 627-632
    • Teter, B.1    Finch, C.E.2
  • 36
    • 13244276460 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory formation
    • Levenson JM, Sweatt JD. Epigenetic mechanisms in memory formation. Nature Rev Neurosci 6:108-118 (2005).
    • (2005) Nature Rev Neurosci , vol.6 , pp. 108-118
    • Levenson, J.M.1    Sweatt, J.D.2
  • 37
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson KD. DNA methylation and human disease. Nature Rev Genet 6:597-610 (2005).
    • (2005) Nature Rev Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 38
    • 4344580888 scopus 로고    scopus 로고
    • Strategies for disease modification in Alzheimer's disease
    • Citron M. Strategies for disease modification in Alzheimer's disease. Nature Rev Neurosci 5: 679-685 (2004).
    • (2004) Nature Rev Neurosci , vol.5 , pp. 679-685
    • Citron, M.1
  • 39
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe DJ, Schenk D. Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43: 545-584 (2003).
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 40
    • 0037248301 scopus 로고    scopus 로고
    • Alzheimer disease therapy: Can the amyloid cascade be halted?
    • Golde TE. Alzheimer disease therapy: Can the amyloid cascade be halted? J Clin Invest 111(1):11-18 (2003).
    • (2003) J Clin Invest , vol.111 , Issue.1 , pp. 11-18
    • Golde, T.E.1
  • 41
    • 0037606205 scopus 로고    scopus 로고
    • Vaccines for Alzheimer's disease: How close are we?
    • Janus C. Vaccines for Alzheimer's disease: how close are we? CNS Drugs 17(7): 457-474 (2003).
    • (2003) CNS Drugs , vol.17 , Issue.7 , pp. 457-474
    • Janus, C.1
  • 42
    • 0037369507 scopus 로고    scopus 로고
    • Drugs targeting Alzheimer's disease: Some things old and some things new
    • Michaelis ML. Drugs targeting Alzheimer's disease: Some things old and some things new. J Pharmacol Exper Ther 304:897-904 (2003).
    • (2003) J Pharmacol Exper Ther , vol.304 , pp. 897-904
    • Michaelis, M.L.1
  • 44
    • 11044230530 scopus 로고    scopus 로고
    • Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia
    • Cacabelos R. Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 5(8): 1049-1105 (2004).
    • (2004) Pharmacogenomics , vol.5 , Issue.8 , pp. 1049-1105
    • Cacabelos, R.1
  • 47
    • 0035001864 scopus 로고    scopus 로고
    • Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease
    • Doody RS, Dunn JK, Clark CM, Farlow M, Foster NL, Liao T, et al. Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease. Dement Geriatr Cogn Disord 12(4):295-300 (2001).
    • (2001) Dement Geriatr Cogn Disord , vol.12 , Issue.4 , pp. 295-300
    • Doody, R.S.1    Dunn, J.K.2    Clark, C.M.3    Farlow, M.4    Foster, N.L.5    Liao, T.6
  • 48
    • 0038796988 scopus 로고    scopus 로고
    • Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer's disease trial
    • Farlow M, Potkin S, Koumaras B, Veach J, Mirski D. Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer's disease trial. Arch Neurol 60(6): 843-848 (2003).
    • (2003) Arch Neurol , vol.60 , Issue.6 , pp. 843-848
    • Farlow, M.1    Potkin, S.2    Koumaras, B.3    Veach, J.4    Mirski, D.5
  • 49
    • 4544246618 scopus 로고    scopus 로고
    • Comparison studies of cholinesterase inhibitors for Alzheimer's disease
    • Hogan DB, Goldlist B, Naglie G, Patterson C. Comparison studies of cholinesterase inhibitors for Alzheimer's disease. Lancet Neurol 3: 622-628 (2004).
    • (2004) Lancet Neurol , vol.3 , pp. 622-628
    • Hogan, D.B.1    Goldlist, B.2    Naglie, G.3    Patterson, C.4
  • 50
    • 0345735594 scopus 로고    scopus 로고
    • Evaluation of memantine for the treatment of Alzheimer's disease
    • Ferris SH. Evaluation of memantine for the treatment of Alzheimer's disease. Expert Opin Pharmacother 4(12): 2305-2313 (2003).
    • (2003) Expert Opin Pharmacother , vol.4 , Issue.12 , pp. 2305-2313
    • Ferris, S.H.1
  • 52
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group
    • Raskind MA, Peskind ER, Wessel T, Yuan W. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 54(12): 2261-2268 (2000).
    • (2000) Neurology , vol.54 , Issue.12 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3    Yuan, W.4
  • 53
    • 4444334993 scopus 로고    scopus 로고
    • Economic effect of cholinesterase inhibitor therapy: Implications for managed care
    • Sano M. Economic effect of cholinesterase inhibitor therapy: implications for managed care. Manag Care Interface 17(8): 44-49 (2004).
    • (2004) Manag Care Interface , vol.17 , Issue.8 , pp. 44-49
    • Sano, M.1
  • 54
    • 4043148531 scopus 로고    scopus 로고
    • Cost effectiveness of memantine in Alzheimer's disease: An analysis based on a probabilistic Markov model from a UK perspective
    • Jones RW, McCrone P, Guilhaume C. Cost effectiveness of memantine in Alzheimer's disease: an analysis based on a probabilistic Markov model from a UK perspective. Drugs Aging 21(9): 607-620 (2004).
    • (2004) Drugs Aging , vol.21 , Issue.9 , pp. 607-620
    • Jones, R.W.1    McCrone, P.2    Guilhaume, C.3
  • 55
    • 0036035695 scopus 로고    scopus 로고
    • Galantamine: A pharmacoeconomic review of its use in Alzheimer's disease
    • Lyseng-Williamson KA, Plosker GL. Galantamine: a pharmacoeconomic review of its use in Alzheimer's disease. Pharmacoeconomics 20(13): 919-942 (2002).
    • (2002) Pharmacoeconomics , vol.20 , Issue.13 , pp. 919-942
    • Lyseng-Williamson, K.A.1    Plosker, G.L.2
  • 56
    • 18544403400 scopus 로고    scopus 로고
    • Clinical and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: A rapid and systematic review
    • Clegg A, Bryant J, Nicholson T, McIntyre L, De Broe S, Gerard K, et al. Clinical and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review. Health Technol Assess 5(1): 1-137 (2001).
    • (2001) Health Technol Assess , vol.5 , Issue.1 , pp. 1-137
    • Clegg, A.1    Bryant, J.2    Nicholson, T.3    McIntyre, L.4    De Broe, S.5    Gerard, K.6
  • 57
    • 3042567016 scopus 로고    scopus 로고
    • Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomised double-blind trial
    • Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 363: 2105-2115 (2004).
    • (2004) Lancet , vol.363 , pp. 2105-2115
    • Courtney, C.1    Farrell, D.2    Gray, R.3    Hills, R.4    Lynch, L.5    Sellwood, E.6
  • 58
    • 1942467820 scopus 로고    scopus 로고
    • Cost effectiveness of cholinesterase inhibitors in the treatment of Alzheimer's disease: A review with methodological considerations
    • Wimo A. Cost effectiveness of cholinesterase inhibitors in the treatment of Alzheimer's disease: a review with methodological considerations. Drug Aging 21(5): 279-295 (2004).
    • (2004) Drug Aging , vol.21 , Issue.5 , pp. 279-295
    • Wimo, A.1
  • 59
    • 0347917026 scopus 로고    scopus 로고
    • Economic aspects on drug therapy of dementia
    • Wimo A, Winblad B. Economic aspects on drug therapy of dementia. Curr Pharm Des 10(3): 295-301 (2004).
    • (2004) Curr Pharm Des , vol.10 , Issue.3 , pp. 295-301
    • Wimo, A.1    Winblad, B.2
  • 60
    • 0042011518 scopus 로고    scopus 로고
    • Assessment of health economics in Alzheimer's disease (AHEAD): Treatment with galantamine in UK
    • Ward A, Caro JJ, Getsios D, Ishak K, O'Brien J, Bullock E. Assessment of health economics in Alzheimer's disease (AHEAD): treatment with galantamine in UK. Int J Geriatr Psychiatry 18(8): 740-747 (2003).
    • (2003) Int J Geriatr Psychiatry , vol.18 , Issue.8 , pp. 740-747
    • Ward, A.1    Caro, J.J.2    Getsios, D.3    Ishak, K.4    O'Brien, J.5    Bullock, E.6
  • 61
    • 4444367747 scopus 로고    scopus 로고
    • Evidence-based pharmacotherapy of Alzheimer's disease
    • Evans JG, Wilcock G, Birks J. Evidence-based pharmacotherapy of Alzheimer's disease. Int J Neuropsychopharmacol 7(3): 351-369 (2004).
    • (2004) Int J Neuropsychopharmacol , vol.7 , Issue.3 , pp. 351-369
    • Evans, J.G.1    Wilcock, G.2    Birks, J.3
  • 62
    • 5744242292 scopus 로고    scopus 로고
    • The place of memantine in the treatment of Alzheimer's disease: A number needed to treat analysis
    • Livingstone G, Katona C. The place of memantine in the treatment of Alzheimer's disease: a number needed to treat analysis. Int J Geriatr Psychiatry 19(10): 919-925 (2004).
    • (2004) Int J Geriatr Psychiatry , vol.19 , Issue.10 , pp. 919-925
    • Livingstone, G.1    Katona, C.2
  • 63
    • 0037247048 scopus 로고    scopus 로고
    • Resource utilization and cost analysis of memantine in patients with moderate to severe Alzheimer's disease
    • Wimo A, Winblad B, Stoffler A, Wirth Y, Möbius HJ. Resource utilization and cost analysis of memantine in patients with moderate to severe Alzheimer's disease. Pharmacoeconomics 21(5): 327-340 (2003).
    • (2003) Pharmacoeconomics , vol.21 , Issue.5 , pp. 327-340
    • Wimo, A.1    Winblad, B.2    Stoffler, A.3    Wirth, Y.4    Möbius, H.J.5
  • 64
    • 0037371057 scopus 로고    scopus 로고
    • Drug development and Alzheimer's disease
    • Roses AD, Pangalos MN. Drug development and Alzheimer's disease. Am J Geriat Psychiat 11: 123-130 (2003).
    • (2003) Am J Geriat Psychiat , vol.11 , pp. 123-130
    • Roses, A.D.1    Pangalos, M.N.2
  • 65
    • 20944442186 scopus 로고    scopus 로고
    • Alzheimer's associated inflammation, potential drug targets and future therapies
    • Stuchbury G, Munch G. Alzheimer's associated inflammation, potential drug targets and future therapies. J Neural Transm 112(3): 429-453 (2005).
    • (2005) J Neural Transm , vol.112 , Issue.3 , pp. 429-453
    • Stuchbury, G.1    Munch, G.2
  • 66
    • 4143097904 scopus 로고    scopus 로고
    • Lahiri DK. Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene. J Mol Neurosci 23(3): 225-233 (2004).
    • Lahiri DK. Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene. J Mol Neurosci 23(3): 225-233 (2004).
  • 67
    • 11344254770 scopus 로고    scopus 로고
    • Immunotherapy of Alzheimer disease
    • Nitsch RM. Immunotherapy of Alzheimer disease. Alzheimer Dis Assoc Disord 18(4): 185-189 (2004).
    • (2004) Alzheimer Dis Assoc Disord , vol.18 , Issue.4 , pp. 185-189
    • Nitsch, R.M.1
  • 68
    • 4944262700 scopus 로고    scopus 로고
    • Gamma-secretase as a target for drug intervention in Alzheimer's disease
    • Harrison T, Churcher I, Beher D. Gamma-secretase as a target for drug intervention in Alzheimer's disease. Curr Opin Drug Discov Devel 7(5): 709-719 (2004).
    • (2004) Curr Opin Drug Discov Devel , vol.7 , Issue.5 , pp. 709-719
    • Harrison, T.1    Churcher, I.2    Beher, D.3
  • 69
    • 22144494112 scopus 로고    scopus 로고
    • An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • Greig NH, Sambamurti K, Qian-sheng Y, Brossie A, Bruinsma GB, Lahiri DK. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res 2: 281-290 (2005).
    • (2005) Curr Alzheimer Res , vol.2 , pp. 281-290
    • Greig, N.H.1    Sambamurti, K.2    Qian-sheng, Y.3    Brossie, A.4    Bruinsma, G.B.5    Lahiri, D.K.6
  • 70
    • 22144489808 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease
    • Klegeris A, McGeer PL. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr Alzheimer Res 2: 355-365 (2005).
    • (2005) Curr Alzheimer Res , vol.2 , pp. 355-365
    • Klegeris, A.1    McGeer, P.L.2
  • 71
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics - five decades of therapeutic lessons from genetic diversity
    • Meyer UA. Pharmacogenetics - five decades of therapeutic lessons from genetic diversity. Nature Rev Genet 5: 669-676 (2004).
    • (2004) Nature Rev Genet , vol.5 , pp. 669-676
    • Meyer, U.A.1
  • 72
    • 20244384575 scopus 로고    scopus 로고
    • Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: Randomized double blind placebo controlled trial
    • Ballard C, Margallo-Lana M, Juszczak E, Douglas S, Swann A, Thomas A, et al. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomized double blind placebo controlled trial. BMJ 330(7496): 874 (2005)
    • (2005) BMJ , vol.330 , Issue.7496 , pp. 874
    • Ballard, C.1    Margallo-Lana, M.2    Juszczak, E.3    Douglas, S.4    Swann, A.5    Thomas, A.6
  • 73
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia. A review of the evidence
    • Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia. A review of the evidence. JAMA 293: 596-608 (2005).
    • (2005) JAMA , vol.293 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 74
    • 0000866681 scopus 로고    scopus 로고
    • Pharmacogenetics
    • Eds: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B, McGraw-Hill, New York, p
    • Kalow W, Grant DM. Pharmacogenetics. In: The Metabolic & Molecular Bases of Inherited Disease. (Eds: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B). McGraw-Hill, New York, p. 225-255 (2001).
    • (2001) The Metabolic & Molecular Bases of Inherited Disease , pp. 225-255
    • Kalow, W.1    Grant, D.M.2
  • 76
    • 0033828454 scopus 로고    scopus 로고
    • The CYP2C19 enzyme polymorphism
    • Wedlund P. The CYP2C19 enzyme polymorphism. Pharmacology 61: 174-183 (2000).
    • (2000) Pharmacology , vol.61 , pp. 174-183
    • Wedlund, P.1
  • 77
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 60: 284-295 (1997).
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 78
    • 0034469337 scopus 로고    scopus 로고
    • Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
    • Isaza CA, Henao J, López AM, Cacabelos R. Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population. Meth Find Exp Clin Pharmacol 22: 695-705 (2000).
    • (2000) Meth Find Exp Clin Pharmacol , vol.22 , pp. 695-705
    • Isaza, C.A.1    Henao, J.2    López, A.M.3    Cacabelos, R.4
  • 79
    • 0038647390 scopus 로고    scopus 로고
    • Catalog of 680 variants among eight cytochrome P450 (CYP) genes: Nine esterase genes, and two other genes in the Japanese population
    • Saito S, Ishida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, et al. Catalog of 680 variants among eight cytochrome P450 (CYP) genes: nine esterase genes, and two other genes in the Japanese population. J Hum Genet 48: 249-70 (2003).
    • (2003) J Hum Genet , vol.48 , pp. 249-270
    • Saito, S.1    Ishida, A.2    Sekine, A.3    Kawauchi, S.4    Higuchi, S.5    Ogawa, C.6
  • 80
    • 0036724899 scopus 로고    scopus 로고
    • DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: Implications for human population history and natural selection
    • Wooding SP, Watkins WS, Bamshad MJ, Dunn DM, Weiss RB, Jorde LB. DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: implications for human population history and natural selection. Am J Hum Genet 71: 528-542 (2002).
    • (2002) Am J Hum Genet , vol.71 , pp. 528-542
    • Wooding, S.P.1    Watkins, W.S.2    Bamshad, M.J.3    Dunn, D.M.4    Weiss, R.B.5    Jorde, L.B.6
  • 81
    • 0042357440 scopus 로고    scopus 로고
    • PM frequencies of major CYPs in Asians and Caucasians
    • Mizutani T. PM frequencies of major CYPs in Asians and Caucasians. Drug Metab Rev 35: 99-106 (2003).
    • (2003) Drug Metab Rev , vol.35 , pp. 99-106
    • Mizutani, T.1
  • 82
    • 0041410075 scopus 로고    scopus 로고
    • Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population
    • Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmöller J, Frötschl R, Köpke K, et al. Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population. Eur J Clin Pharmacol 59: 303-12 (2003).
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 303-312
    • Gaikovitch, E.A.1    Cascorbi, I.2    Mrozikiewicz, P.M.3    Brockmöller, J.4    Frötschl, R.5    Köpke, K.6
  • 83
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic ditribution and functional significance
    • Xie HG, Prasad HG, Kim RB, Stein CM. CYP2C9 allelic variants: ethnic ditribution and functional significance. Adv Drug Deliv Rev 54: 1257-70 (2002).
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.G.2    Kim, R.B.3    Stein, C.M.4
  • 85
    • 0035028479 scopus 로고    scopus 로고
    • Molecular basis of ethnic differences in drug disposition and response
    • Xie HG, Kim RB, Wood AJ, Stein CM. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharm Toxicol 41: 815-50 (2001).
    • (2001) Annu Rev Pharm Toxicol , vol.41 , pp. 815-850
    • Xie, H.G.1    Kim, R.B.2    Wood, A.J.3    Stein, C.M.4
  • 86
    • 0037379409 scopus 로고    scopus 로고
    • Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    • Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos 31: 421-31 (2003).
    • (2003) Drug Metab Dispos , vol.31 , pp. 421-431
    • Madan, A.1    Graham, R.A.2    Carroll, K.M.3    Mudra, D.R.4    Burton, L.A.5    Krueger, L.A.6
  • 88
    • 0035060793 scopus 로고    scopus 로고
    • Nuts and bolts of psychiatric genetics: Building on the human genome project
    • Evans KL, Muir WJ, Blackwood DHR, Porteus DJ. Nuts and bolts of psychiatric genetics: building on the human genome project. Trends Genet 17: 35-40 (2001).
    • (2001) Trends Genet , vol.17 , pp. 35-40
    • Evans, K.L.1    Muir, W.J.2    Blackwood, D.H.R.3    Porteus, D.J.4
  • 89
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286: 487-491 (1999).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 90
    • 0035749505 scopus 로고    scopus 로고
    • Pharmacogenetics for the individualization of psychiatric treatment
    • Arranz MJ, Collier D, Kerwin RW. Pharmacogenetics for the individualization of psychiatric treatment. Am J Pharmacogenomics 1: 3-10 (2001).
    • (2001) Am J Pharmacogenomics , vol.1 , pp. 3-10
    • Arranz, M.J.1    Collier, D.2    Kerwin, R.W.3
  • 91
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits treatment outcome in Alzheimer disease
    • Poirier J, Delisle M-C, Quirion R, Aubert I, Farlow M, Lahiri D, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits treatment outcome in Alzheimer disease. Proc Natl Acad Sci. USA 92: 12260-12264 (1995).
    • (1995) Proc Natl Acad Sci. USA , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.-C.2    Quirion, R.3    Aubert, I.4    Farlow, M.5    Lahiri, D.6
  • 92
    • 0032921441 scopus 로고    scopus 로고
    • E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease
    • Poirier J. Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease. J Psychiat Neurosci 24: 147-153 (1999).
    • (1999) J Psychiat Neurosci , vol.24 , pp. 147-153
    • Apolipoprotein, P.J.1
  • 93
    • 0035189162 scopus 로고    scopus 로고
    • Responder characteristics to a single oral dose of cholinesterase inhibitor: A double-blind placebo-controlled study with tacrine in Alzheimer patients
    • Almkvist O, Jelic V, Amberla K, Hellstrom-Lindahl E, Meurling L, Nordberg A. Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord 12: 22-32 (2001).
    • (2001) Dement Geriatr Cogn Disord , vol.12 , pp. 22-32
    • Almkvist, O.1    Jelic, V.2    Amberla, K.3    Hellstrom-Lindahl, E.4    Meurling, L.5    Nordberg, A.6
  • 94
    • 0034901335 scopus 로고    scopus 로고
    • Tacrine and rate of progression in Alzheimer's disease -relation to ApoE allele genotype
    • Sjögren M, Hesse C, Basun H, Kol G, Thostrup H, Kilander L, et al. Tacrine and rate of progression in Alzheimer's disease -relation to ApoE allele genotype. J Neural Transm 108: 451-8 (2001).
    • (2001) J Neural Transm , vol.108 , pp. 451-458
    • Sjögren, M.1    Hesse, C.2    Basun, H.3    Kol, G.4    Thostrup, H.5    Kilander, L.6
  • 95
    • 0036253645 scopus 로고    scopus 로고
    • ApoE genotype influences the biological effects of donepezil on APP metabolism in Alzheimer disease: Evidence from a peripheral model
    • Borroni B, Colciaghi F, Pastorino L, Archetti S, Corsini P, Cattabeni F, et al. ApoE genotype influences the biological effects of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model. Eur Neuropsychopharmacol 12: 195-200 (2002).
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 195-200
    • Borroni, B.1    Colciaghi, F.2    Pastorino, L.3    Archetti, S.4    Corsini, P.5    Cattabeni, F.6
  • 96
    • 0035130170 scopus 로고    scopus 로고
    • APOE genotype: No influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease
    • Aerssens J, Raeymaekers P, Lilienfeld S, Geerts H, Konings F, Parys W. APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease. Dement Geriatr Cogn Disord 2(2): 69-77 (2001).
    • (2001) Dement Geriatr Cogn Disord , vol.2 , Issue.2 , pp. 69-77
    • Aerssens, J.1    Raeymaekers, P.2    Lilienfeld, S.3    Geerts, H.4    Konings, F.5    Parys, W.6
  • 97
    • 3142523591 scopus 로고    scopus 로고
    • ApoE genotyping and response to galanthamine in Alzheimer's disease-a real life retrospective study
    • Babic T, Lakusic DM, Sertic J, Petrovecki M, Stavljenic-Rukavina A. ApoE genotyping and response to galanthamine in Alzheimer's disease-a real life retrospective study. Coll Antropol 28(1): 199-204 (2004).
    • (2004) Coll Antropol , vol.28 , Issue.1 , pp. 199-204
    • Babic, T.1    Lakusic, D.M.2    Sertic, J.3    Petrovecki, M.4    Stavljenic-Rukavina, A.5
  • 98
    • 0031657809 scopus 로고    scopus 로고
    • Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimer's disease
    • MacGowan SH, Wilcock GK, Scott M. Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimer's disease. Int J Geriatr Psychiatry 13(9): 625-630 (1998).
    • (1998) Int J Geriatr Psychiatry , vol.13 , Issue.9 , pp. 625-630
    • MacGowan, S.H.1    Wilcock, G.K.2    Scott, M.3
  • 99
    • 0034351513 scopus 로고    scopus 로고
    • The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimer's disease
    • Rigaud AS, Traykov L, Caputo L, Guelfi MC, Latour F, Courdec R, et al. The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimer's disease. Eur J Neurol 7: 255-258 (2000).
    • (2000) Eur J Neurol , vol.7 , pp. 255-258
    • Rigaud, A.S.1    Traykov, L.2    Caputo, L.3    Guelfi, M.C.4    Latour, F.5    Courdec, R.6
  • 100
    • 0036021007 scopus 로고    scopus 로고
    • Presence of absence of least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease
    • Rigaud AS, Traykov L, Latour F, Couderc R, Moulin F, Forette F. Presence of absence of least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Pharmacogenetics 12: 415-20 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 415-420
    • Rigaud, A.S.1    Traykov, L.2    Latour, F.3    Couderc, R.4    Moulin, F.5    Forette, F.6
  • 101
    • 0033403796 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion
    • Alvarez XA, Mouzo R, Pichel V, Pérez P, Laredo M, Fernández-Novoa L, et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion. Meth Find Exp Clin Pharmacol 21: 633-644 (1999).
    • (1999) Meth Find Exp Clin Pharmacol , vol.21 , pp. 633-644
    • Alvarez, X.A.1    Mouzo, R.2    Pichel, V.3    Pérez, P.4    Laredo, M.5    Fernández-Novoa, L.6
  • 102
    • 0034525674 scopus 로고    scopus 로고
    • Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: Effects on cognition, brain bioelectrical activity and cerebral hemodynamics
    • Alvarez XA, Pichel V, Pérez PA, Laredo M, Corzo L, Zas R, et al. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Meth Find Exp Clin Pharmacol 22: 585-594 (2000).
    • (2000) Meth Find Exp Clin Pharmacol , vol.22 , pp. 585-594
    • Alvarez, X.A.1    Pichel, V.2    Pérez, P.A.3    Laredo, M.4    Corzo, L.5    Zas, R.6
  • 104
    • 0242403526 scopus 로고    scopus 로고
    • Clinically significant drug interactions with cholinesterase inhibitors: A guide for neurologists
    • Bentué-Ferrer D, Tribut O, Polard E, Allain H. Clinically significant drug interactions with cholinesterase inhibitors: a guide for neurologists. CNS Drugs 17(13): 947-963 (2003).
    • (2003) CNS Drugs , vol.17 , Issue.13 , pp. 947-963
    • Bentué-Ferrer, D.1    Tribut, O.2    Polard, E.3    Allain, H.4
  • 105
    • 34548671584 scopus 로고    scopus 로고
    • www.imm.ki.se/CYPalleles/cyp2d6.htm.
  • 106
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • Griese E-U, Zanger UM, Brudermanns U, Gaedigk A, Mikus G, Morike K, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 8: 15-26 (1998).
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.-U.1    Zanger, U.M.2    Brudermanns, U.3    Gaedigk, A.4    Mikus, G.5    Morike, K.6
  • 107
    • 0032718495 scopus 로고    scopus 로고
    • Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine
    • Bernal ML, Sinues B, Johansson I, McLellan RA, Wenerholm A, Dahl ML, et al. Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine. Pharmacogenetics 9: 657-660 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 657-660
    • Bernal, M.L.1    Sinues, B.2    Johansson, I.3    McLellan, R.A.4    Wenerholm, A.5    Dahl, M.L.6
  • 108
    • 32944461710 scopus 로고    scopus 로고
    • Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: Clinical implications
    • Bernard S, Neville KA, Nguyen AT, Flockhart DA. Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: Clinical implications. Oncologist 11(2): 126-135 (2006).
    • (2006) Oncologist , vol.11 , Issue.2 , pp. 126-135
    • Bernard, S.1    Neville, K.A.2    Nguyen, A.T.3    Flockhart, D.A.4
  • 109
    • 0033790979 scopus 로고    scopus 로고
    • Elucidation of the genetic basis of the common intermediate metabolizer phenotype for drug oxidation by CYP2D6
    • Raimundo S, Fischer J, Eichelbaum M, Griese EU, Schwab M, Zanger. Elucidation of the genetic basis of the common intermediate metabolizer phenotype for drug oxidation by CYP2D6. Pharmacogenetics 10: 577-581 (2000).
    • (2000) Pharmacogenetics , vol.10 , pp. 577-581
    • Raimundo, S.1    Fischer, J.2    Eichelbaum, M.3    Griese, E.U.4    Schwab, M.5    Zanger6
  • 112
    • 0029122803 scopus 로고
    • The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease
    • Chen X, Xia Y, Alford M, DeTeresa R, Hansen L, Klauber MR, et al. The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease. Ann Neurol 38(4): 653-658 (1995).
    • (1995) Ann Neurol , vol.38 , Issue.4 , pp. 653-658
    • Chen, X.1    Xia, Y.2    Alford, M.3    DeTeresa, R.4    Hansen, L.5    Klauber, M.R.6
  • 113
    • 0033558071 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification
    • Cervilla JA, Russ C, Holmes C, Aitchison K, Smith CA, Powell J, et al. CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification. Biol Psychiatry 45(4): 426-429 (1999).
    • (1999) Biol Psychiatry , vol.45 , Issue.4 , pp. 426-429
    • Cervilla, J.A.1    Russ, C.2    Holmes, C.3    Aitchison, K.4    Smith, C.A.5    Powell, J.6
  • 114
    • 0032918986 scopus 로고    scopus 로고
    • CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy bodies or Alzheimer's disease
    • Atkinson A, Singleton AB, Steward A, Ince PG, Perry RH, McKeith IG, et al. CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy bodies or Alzheimer's disease. Pharmacogenetics 9(1): 31-35 (1999).
    • (1999) Pharmacogenetics , vol.9 , Issue.1 , pp. 31-35
    • Atkinson, A.1    Singleton, A.B.2    Steward, A.3    Ince, P.G.4    Perry, R.H.5    McKeith, I.G.6
  • 115
    • 0032740464 scopus 로고    scopus 로고
    • A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism
    • Nicholl DJ, Bennett P, Hiller L, Bonifatti V, Vanacore N, Fabbrini G, et al. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism. Neurology 53(7): 1415-1421 (1999).
    • (1999) Neurology , vol.53 , Issue.7 , pp. 1415-1421
    • Nicholl, D.J.1    Bennett, P.2    Hiller, L.3    Bonifatti, V.4    Vanacore, N.5    Fabbrini, G.6
  • 116
    • 0035432460 scopus 로고    scopus 로고
    • CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population
    • Woo SI, Kim JW, Seo HG, Park CH, Han SH, Kim SH, et al. CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population. Psychiatry Clin Neurosci 55(4): 373-377 (2001).
    • (2001) Psychiatry Clin Neurosci , vol.55 , Issue.4 , pp. 373-377
    • Woo, S.I.1    Kim, J.W.2    Seo, H.G.3    Park, C.H.4    Han, S.H.5    Kim, S.H.6
  • 117
    • 0035040634 scopus 로고    scopus 로고
    • No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies
    • Furuno T, Kawanishi C, Iseki E, Onishi H, Sugiyama N, Suzuki K, et al. No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies. Psychiatry Clin Neurosci 55(2): 89-92 (2001).
    • (2001) Psychiatry Clin Neurosci , vol.55 , Issue.2 , pp. 89-92
    • Furuno, T.1    Kawanishi, C.2    Iseki, E.3    Onishi, H.4    Sugiyama, N.5    Suzuki, K.6
  • 118
    • 29344441249 scopus 로고    scopus 로고
    • No association between CYP2D6 polymorphisms and Alzheimer's disease in an Italian population
    • Scordo MG, Dahl ML, Spina E, Cordici F, Arena MG. No association between CYP2D6 polymorphisms and Alzheimer's disease in an Italian population. Pharmacol Res 53(2): 162-165 (2006).
    • (2006) Pharmacol Res , vol.53 , Issue.2 , pp. 162-165
    • Scordo, M.G.1    Dahl, M.L.2    Spina, E.3    Cordici, F.4    Arena, M.G.5
  • 119
    • 0346099110 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of galantamine
    • Farlow MR. Clinical pharmacokinetics of galantamine. Clin Pharmacokinet 42(15): 1383-1392 (2003).
    • (2003) Clin Pharmacokinet , vol.42 , Issue.15 , pp. 1383-1392
    • Farlow, M.R.1
  • 120
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    • Jann MW, Shirley KL, Small GW. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet 41(10): 719-739 (2002).
    • (2002) Clin Pharmacokinet , vol.41 , Issue.10 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 121
    • 0031910978 scopus 로고    scopus 로고
    • Donepezil use in Alzheimer disease
    • Barner EL, Gray SL. Donepezil use in Alzheimer disease. Ann Pharmacother 32(1): 70-77 (1998).
    • (1998) Ann Pharmacother , vol.32 , Issue.1 , pp. 70-77
    • Barner, E.L.1    Gray, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.