Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D6*42, in African American subjects

Clinical Pharmacology and Therapeutics

Volumn 73, Issue 6, 2003, Pages 575-576

  Gaedigk, Andrea ^a   Ndjountché, Liliane ^a   Gaedigk, Roger ^a   Leeder, J Steven ^a   Bradford, L DiAnne ^b  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN;

ALLELE; ENZYME ACTIVITY; EXON; GENE SEQUENCE; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOSITY; HUMAN; INTRON; LETTER; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE; CASE REPORT; GENETICS; GENOTYPE; MALE; NEGRO; NEWBORN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; CYTOCHROME P-450 CYP2D6; GENOTYPE; HUMANS; INFANT, NEWBORN; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0038548107     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(03)00067-5     Document Type: Letter

References (4)

1. Leeder JS, Gaedigk A, Gotschall RR, Wilson JT, Kearns GL. Acquisition of CYP2D6 and CYP3A activities in the first year of life [abstract]. Clin Pharmacol Ther 2000;67:169.
2. Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in African Americans. Clin Pharmacol Ther 2002;72:76-89.
3. Human Cytochrome P450 (CYP) Allele Nomenclature Committee Web site. Available at www.imm.ki.se/CYPalleles. Accessed Feb 28, 2003.
4. Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999;9:669-82.