Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 11, 1996, Pages 1511-1514

  Kariya, Satoru ^a   Isozaki, Sadao ^a   Uchino, Katsuyoshi ^a   Suzuki, Tokuji ^b   Narimatsu, Shizuo ^b  

^a TOKYO TEISHIN HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

cinnarizine; CYP2B6; CYP2D6; flunarizine; human cytochrome P450; p hydroxylation

Indexed keywords

CINNARIZINE; CYTOCHROME P450; FLUNARIZINE;

AEROBIC METABOLISM; ARTICLE; B LYMPHOCYTE; CEREBROVASCULAR DISEASE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; LIVER MICROSOME; LYMPHOBLASTOID CELL;

EID: 0029827090     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.1511     Document Type: Article

References (26)

1. Goldfraind T., Towse G., Van Nueten J. M., Drugs Today, 18, 27-42 (1982).
2. Singh B. N., Br. J. Clin. Pharmacol., 21, 109S-121S (1986).
3. Todd P. A., Benfield P., Drugs, 38, 481-499 (1989).
4. Chouza C., Scaramelli A., Caamano J. L., De Medina O., Aljanati R., Romero S., Lancet, i, 1303-1304 (1986).
5. Capella D., Laporte J. R., Castel J. M., Tristan C., Cos A., Morales-Olivas F. J., Br. Med. J.. 297, 722-723 (1988).
6. Soudijin W., Van Wijngaarden I., Life Sci., 7, 231-238 (1968).
7. Allewijin F. T. N., Life Sci., 7, 989-994 (1968).
8. Dell H. D., Fiedler J., Fres Z., Anal. Chem., 284, 126-127 (1977).
9. Michiels M., Hendriks R., Knaeps F., Woestenborghs R., Heykants J., Arzneim.-Forsch./Drug Res., 33, 1135-1142 (1983).
10. Meuldermans W., Hendrickx J., Hurkmans R., Swysen E., Woestenborghs R., Lauwers W., Heykants J., Arzneim.-Forsch./ Drug Res., 33, 1142-1151 (1983).
11. Lavrijisen K., Van Hondt J., Van Dyck D., Hendrickx J., Bockx M., Hurkmans R., Meuldermans W., Le Jeune L., Lauwers W., Heykants J., Xenobiotica, 22, 815-836 (1992).
12. Kariya S., Isozaki S., Narimatsu S., Suzuki T., Biochem. Pharmacol., 44, 1471-1474 (1992).
13. Kariya S., Isozaki S., Narimatsu S., Suzuki T., Res. Commun. Chem. Pathol. Pharmacol., 78, 85-95 (1992).
14. Narimatsu S., Kariya S., Isozaki S., Ohmori S., Kitada M., Hosokawa S., Masubuchi Y., Suzuki T., Biochem. Biophys. Res. Commun., 193, 1262-1268 (1993).
15. "Methods in Enzymology," Vol. 206, ed. by Waterman M. R., Johnson E. F., Academic Press, Inc., San Diego, 1991, pp. 85-145.
16. Gonzalez F. J., Skoda R. C., Kimura S., Umeno M., Zanger U. M., Nebert D. W., Gelboin H. V., Hardwick J. P., Meyer U. A., Nature (London), 331, 442-446 (1988).
17. Relling M. V., Aoyama T., Gonzalez F. J., Meyer U. A., J. Pharmacol. Exp. Ther., 252, 442-447 (1990).
18. Goldstein J. A., Faletto M. B., Romkes-Sparks M., Sullivan T., Kitareewan S., Raucy J. L., Lasker J. M., Ghanayem B. I., Biochemistry, 33, 1743-1752 (1994).
19. Wheeler C. W., Park S. S., Guenthner T. M., Mol. Pharmacol., 38, 634-643 (1990).
20. Castaneda-Hernandez G., Hoyo-Vadillo C, Herrera J. E., Salazar L. A., Ortiz C., Hong E., Proc. West. Pharmacol. Soc., 34, 421-424 (1991).
21. Heykant J., De Cree J., Horig C., Arzneim.-Forsch./Drug Res., 29, 1168-1171 (1979).
22. Araki G., Saitoh T., Ishii A., Deguchi T., Kiso To Rinsho, 16, 1901-1907 (1982).
23. Kobayashi S., Murray S., Watson D., Sesardic D., Davies D. S., Boobis A. R., Biochem. Pharmacol., 38, 2795-2799 (1989).
24. Shimada T., Yamazaki H., Miura M., Inui Y., Guengerich F. P., J. Pharmacol. Exp. Ther., 270, 414-423 (1994).
25. Yun C-H., Okerholm R. A., Guengerich F. P., Drug Metab. Dispos., 21, 403-409 (1993).
26. Ling K. J., Leeson G. A., Burmaster S. D., Hook R. H., Reith M. K., Cheng L. K., Drug Metab. Dispos., 23, 631-636 (1995).