Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients

Molecular Psychiatry

Volumn 13, Issue 6, 2008, Pages 597-605

  Schenk, P W ^a   Van Fessem, M A C ^a   Verploegh Van Rij, S ^a   Mathot, R A A ^a   Van Gelder, T ^a   Vulto, A G ^a   Van Vliet, M ^a   Lindemans, J ^a   Bruijn, J A ^a   Van Schaik, R H N ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Cytochromes; Depression; Drug dose prediction; Genetic polymorphism; Imipramine; Pharmacogenetics; Tricyclic antidepressive agents

Indexed keywords

CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; DESIPRAMINE; IMIPRAMINE;

ADULT; AGED; ALLELE; ARTICLE; CYTOCHROME P450 2C19 GENE; CYTOCHROME P450 2D6 GENE; DEPRESSION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; GENE; GENE DUPLICATION; GENE FUNCTION; GENOTYPE; HUMAN; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; NULL ALLELE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2D6; DEPRESSIVE DISORDER; DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GENOTYPE; HUMANS; IMIPRAMINE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES;

EID: 43949120461     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4002057     Document Type: Article

References (52)