Codeine and morphine in extensive and poor metabolizers of sparteine: Pharmacokinetics, analgesic effect and side effects

European Journal of Clinical Pharmacology

Volumn 51, Issue 3-4, 1996, Pages 289-295

  Poulsen, L ^c   Brosen K ^c   Arendt Nielsen, L ^a   Gram, L F ^c   Elbaek K ^b   Sindrup, S H ^c  

^a AALBORG UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

adverse effects; analgesic effect; codeine; CYP2D6; morphine; pharmacokinetics

Indexed keywords

CODEINE; DRUG METABOLITE; MORPHINE; MORPHINE 6 GLUCURONIDE; PLACEBO; SPARTEINE;

ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEMETHYLATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; EUPHORIA; FEMALE; HEADACHE; HUMAN; MALE; NAUSEA; NORMAL HUMAN; PAIN; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; VERTIGO; XEROSTOMIA;

ADULT; ANALGESICS, OPIOID; CODEINE; CYTOCHROME P-450 CYP2D6; DEALKYLATION; FEMALE; HUMANS; MALE; MORPHINE; SPARTEINE;

EID: 0030472254     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050200     Document Type: Article

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