Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia

Human Psychopharmacology

Volumn 17, Issue 4, 2002, Pages 187-190

  Stedman, Catherine A M ^a   Begg, Evan J ^a   Kennedy, Martin A ^b   Roberts, Rebecca ^b   Wilkinson, Timothy J ^b  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

CYP2D6; Fluoxetine; Genotype; Hyponatraemia; Norfluoxetine; Paroxetine

Indexed keywords

ANTIDEPRESSANT AGENT; BENDROFLUMETHIAZIDE; CHLORPROMAZINE; CILAZAPRIL; CYTOCHROME P450 2D6; DICLOFENAC; DOXEPIN; ENALAPRIL; FLUOXETINE; FUROSEMIDE; GENOMIC DNA; NORFLUOXETINE; PAROXETINE; QUINAPRIL; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ALLELE; ARTICLE; BIOASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DNA DETERMINATION; DRUG BLOOD LEVEL; DRUG METABOLISM; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; HUMAN; HYPONATREMIA; HYPOTHESIS; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; PUBLICATION; REFERENCE VALUE; STATISTICAL ANALYSIS; BLOOD; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; RISK FACTOR;

AGED; AGED, 80 AND OVER; CYTOCHROME P-450 CYP2D6; DEPRESSIVE DISORDER; FEMALE; FLUOXETINE; GENOTYPE; HUMAN; HYPONATREMIA; MALE; MIDDLE AGE; PAROXETINE; RISK FACTORS; SEROTONIN UPTAKE INHIBITORS; SUPPORT, NON-U.S. GOV'T; HUMANS; MIDDLE AGED;

EID: 0035989059     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/hup.394     Document Type: Article

References (16)

1. Hyponatremic-hypertensive syndrome with renal ischemia. An underrecognised disorder
2. Paroxetine in human milk
3. Fluoxetine and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
4. Alkaline transfer of DNA to plastic membrane
5. A simple method for DNA purification from peripheral blood
6. The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects
7. Syndrome of inappropriate secretion of antidiuretic hormone in two elderly women with elevated serum fluoxetine
8. The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquine
9. Distribution and excretion of fluoxetine and norfluoxetine in human milk
10. Hyponatraemia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: A review of spontaneous reports
11. A method for estimating the probability of adverse drug reactions
12. Fluoxetine and hyponatraemia-a potential hazard in the elderly
13. Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction
14. Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
15. Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people