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Volumn 47, Issue 4, 2008, Pages 217-230

Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine: A comparative review

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CETIRIZINE; CIMETIDINE; CYTOCHROME P450; DESLORATADINE; ERYTHROMYCIN; FEXOFENADINE; FLUOXETINE; GLYCOPROTEIN P; HISTAMINE H1 RECEPTOR; HYPERICUM PERFORATUM EXTRACT; ITRACONAZOLE; KETOCONAZOLE; LEVOCETIRIZINE; LOPINAVIR PLUS RITONAVIR; LORATADINE; PILSICAINIDE; PLACEBO; RIFAMPICIN; RITONAVIR;

EID: 40549139803     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200847040-00001     Document Type: Review
Times cited : (80)

References (148)
  • 1
    • 40549112267 scopus 로고    scopus 로고
    • Clarinex [prescribing information]. Kenilworth (NJ): Schering-Plough Corporation, 2005
    • Clarinex [prescribing information]. Kenilworth (NJ): Schering-Plough Corporation, 2005
  • 2
    • 18144368022 scopus 로고    scopus 로고
    • prescribing information
    • Brussels: Schering-Plough Europe
    • Aerius [prescribing information]. Brussels: Schering-Plough Europe, 2006
    • (2006)
    • Aerius1
  • 3
    • 40549107932 scopus 로고    scopus 로고
    • Allegra [prescribing information]. Bridgewater (NJ): Sanofi-Aventis US, LLC, 2007
    • Allegra [prescribing information]. Bridgewater (NJ): Sanofi-Aventis US, LLC, 2007
  • 4
    • 40549139065 scopus 로고    scopus 로고
    • Telfast 120 and 180 [prescribing information; online]. Guildford: Sanofi-Aventis, 2007 Feb 20. Available from URL: http://emc.medicines.org.uk/ emc/assets/c/html/displaydoc.asp?.documentid=6659 [Accessed 2008 Feb 18]
    • Telfast 120 and 180 [prescribing information; online]. Guildford: Sanofi-Aventis, 2007 Feb 20. Available from URL: http://emc.medicines.org.uk/ emc/assets/c/html/displaydoc.asp?.documentid=6659 [Accessed 2008 Feb 18]
  • 5
    • 40549134451 scopus 로고    scopus 로고
    • Telfast 30 [prescribing information; online]. Guildford: Sanofi-Aventis, 2007 Apr 17. Available from URL: http://emc.medicines.org.uk/emc/assets/c/html/ displaydoc.asp?.documentid=14464 [Accessed 2008 Feb 18]
    • Telfast 30 [prescribing information; online]. Guildford: Sanofi-Aventis, 2007 Apr 17. Available from URL: http://emc.medicines.org.uk/emc/assets/c/html/ displaydoc.asp?.documentid=14464 [Accessed 2008 Feb 18]
  • 6
    • 40549135606 scopus 로고    scopus 로고
    • Xyzal [prescribing information]. Atlanta (GA): UCB, Inc., 2007
    • Xyzal [prescribing information]. Atlanta (GA): UCB, Inc., 2007
  • 7
    • 40549088194 scopus 로고    scopus 로고
    • Xyzal [prescribing information; online]. Slough: UCB Pharma Limited, 2007 Jul. Available from URL: http://emc.medicines.org.uk/industry/default.asp?. page=displaydoc.asp&documentid=19877 [Accessed 2008 Feb 18]
    • Xyzal [prescribing information; online]. Slough: UCB Pharma Limited, 2007 Jul. Available from URL: http://emc.medicines.org.uk/industry/default.asp?. page=displaydoc.asp&documentid=19877 [Accessed 2008 Feb 18]
  • 12
    • 0034711258 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes
    • Oda T, Morikawa N, Saito Y, et al. Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. J Biol Chem 2000; 275: 36781-6
    • (2000) J Biol Chem , vol.275 , pp. 36781-36786
    • Oda, T.1    Morikawa, N.2    Saito, Y.3
  • 16
    • 33947167689 scopus 로고    scopus 로고
    • 3 receptor decreases caloric intake in higher mammalian species
    • 3 receptor decreases caloric intake in higher mammalian species. Biochem Pharmacol 2007; 73: 1237-42
    • (2007) Biochem Pharmacol , vol.73 , pp. 1237-1242
    • Malmlöf, K.1    Hastrup, S.2    Wulff, B.S.3
  • 18
    • 7644220658 scopus 로고    scopus 로고
    • 3 receptor as a novel therapeutic target for cognitive and sleep disorders
    • 3 receptor as a novel therapeutic target for cognitive and sleep disorders. Trends Pharmacol Sci 2004; 25: 618-25
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 618-625
    • Passani, M.B.1    Lin, J.-S.2    Hancock, A.3
  • 21
    • 3442892181 scopus 로고    scopus 로고
    • Co-localization of histamine and dopamine-β-hydroxylase in sympathetic ganglion and release of histamine from cardiac sympathetic terminals of guinea-pig
    • Li M, Luo X, Chen L, et al. Co-localization of histamine and dopamine-β-hydroxylase in sympathetic ganglion and release of histamine from cardiac sympathetic terminals of guinea-pig. Auton Autacoid Pharmacol 2004; 23: 327-33
    • (2004) Auton Autacoid Pharmacol , vol.23 , pp. 327-333
    • Li, M.1    Luo, X.2    Chen, L.3
  • 23
    • 0347948452 scopus 로고    scopus 로고
    • 3 receptors in -human nasal mucosa inhibits sympathetic vasoconstriction
    • 3 receptors in -human nasal mucosa inhibits sympathetic vasoconstriction. Eur J Pharmacol 2004; 484: 83-9
    • (2004) Eur J Pharmacol , vol.484 , pp. 83-89
    • Varty, L.M.1    Gustafson, E.2    Laverty, M.3
  • 25
    • 0345167199 scopus 로고    scopus 로고
    • 4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo
    • 4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J Pharmacol Exp Ther 2003; 307: 1072-8
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 1072-1078
    • Takeshita, K.1    Sakai, K.2    Bacon, K.B.3
  • 26
    • 33646857548 scopus 로고    scopus 로고
    • 4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells
    • 4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 2006; 176: 7062-70
    • (2006) J Immunol , vol.176 , pp. 7062-7070
    • Dunford, P.J.1    O'Donnell, N.2    Riley, J.P.3
  • 27
    • 2942530381 scopus 로고    scopus 로고
    • 1 receptors in scratching induced by histamine receptor agonists in BalbC mice
    • 1 receptors in scratching induced by histamine receptor agonists in BalbC mice. Br J Pharmacol 2004; 142: 374-80
    • (2004) Br J Pharmacol , vol.142 , pp. 374-380
    • Bell, J.K.1    McQueen, D.S.2    Rees, J.L.3
  • 28
    • 33845924770 scopus 로고    scopus 로고
    • 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
    • 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol 2007; 119: 176-83
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 176-183
    • Dunford, P.J.1    Williams, K.N.2    Desai, P.J.3
  • 29
    • 8644255952 scopus 로고    scopus 로고
    • 1-antihistamines
    • 1-antihistamines. N Engl J Med 2004; 351: 2203-17
    • (2004) N Engl J Med , vol.351 , pp. 2203-2217
    • Simons, F.E.R.1
  • 30
    • 33644775585 scopus 로고    scopus 로고
    • Histamine receptors are hot in immunopharmacology
    • Akdis CA, Simons FER. Histamine receptors are hot in immunopharmacology. Eur J Pharmacol 2006; 533: 69-76
    • (2006) Eur J Pharmacol , vol.533 , pp. 69-76
    • Akdis, C.A.1    Simons, F.E.R.2
  • 32
    • 0141918855 scopus 로고    scopus 로고
    • Histamine: A mediator of inflammation
    • MacGlashan Jr D. Histamine: a mediator of inflammation. J Allergy Clin Immunol 2003; 112 (4 Suppl. 1): S53-9
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.4 SUPPL. 1
    • MacGlashan Jr, D.1
  • 33
    • 0037999835 scopus 로고    scopus 로고
    • Histamine in the immune regulation of allergic inflammation
    • Akdis CA, Blaser K. Histamine in the immune regulation of allergic inflammation. J Allergy Clin Immunol 2003; 112: 15-22
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 15-22
    • Akdis, C.A.1    Blaser, K.2
  • 34
    • 0027257155 scopus 로고
    • 2 receptors in peripheral blood mononuclear cells: Comparison with IL-1 receptor antagonist
    • 2 receptors in peripheral blood mononuclear cells: comparison with IL-1 receptor antagonist. J Clin Invest 1993; 92: 281-7
    • (1993) J Clin Invest , vol.92 , pp. 281-287
    • Vannier, E.1    Dinarello, C.A.2
  • 35
    • 0026165184 scopus 로고
    • Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines
    • Meretey K, Falus A, Taga T, et al. Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines. Agents Actions 1991; 33: 189-91
    • (1991) Agents Actions , vol.33 , pp. 189-191
    • Meretey, K.1    Falus, A.2    Taga, T.3
  • 36
    • 0028070733 scopus 로고
    • Histamine induces interleukin-8 secretion by endothelial cells
    • Jeannin P, Delneste Y, Gosset P, et al. Histamine induces interleukin-8 secretion by endothelial cells. Blood 1994; 84: 2229-33
    • (1994) Blood , vol.84 , pp. 2229-2233
    • Jeannin, P.1    Delneste, Y.2    Gosset, P.3
  • 39
    • 34250805322 scopus 로고    scopus 로고
    • Involvement of histamine released from mast cells in acute radiation dermatitis in mice
    • Moriyasu S, Yamamoto K, Kureyama N, et al. Involvement of histamine released from mast cells in acute radiation dermatitis in mice. J Pharmacol Sci 2007; 104: 187-90
    • (2007) J Pharmacol Sci , vol.104 , pp. 187-190
    • Moriyasu, S.1    Yamamoto, K.2    Kureyama, N.3
  • 40
    • 0036010766 scopus 로고    scopus 로고
    • 1-antihistamines: Inverse agonism, anti-inflammatory actions and cardiac effects
    • 1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 2002; 32: 489-98
    • (2002) Clin Exp Allergy , vol.32 , pp. 489-498
    • Leurs, R.1    Church, M.K.2    Taglialatela, M.3
  • 43
    • 40549120258 scopus 로고    scopus 로고
    • 1 receptors. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: S279
    • 1 receptors. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: S279
  • 45
    • 26844534592 scopus 로고    scopus 로고
    • Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
    • Liu H, Farley JM. Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport. BMC Pharmacology 2005; 5: 8
    • (2005) BMC Pharmacology , vol.5 , pp. 8
    • Liu, H.1    Farley, J.M.2
  • 46
    • 0033999939 scopus 로고    scopus 로고
    • 1 receptor antagonist. 1st communication: Receptor selectivity, antihistaminic activity, and antiallergenic effects
    • 1 receptor antagonist. 1st communication: receptor selectivity, antihistaminic activity, and antiallergenic effects. Arzneimittelforschung 2000; 50: 345-52
    • (2000) Arzneimittelforschung , vol.50 , pp. 345-352
    • Kreutner, W.1    Hey, J.A.2    Anthes, J.3
  • 48
    • 0033028937 scopus 로고    scopus 로고
    • Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle
    • Cardelús I, Antón F, Beleta J, et al. Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle. Eur J Pharmacol 1999; 374: 249-54
    • (1999) Eur J Pharmacol , vol.374 , pp. 249-254
    • Cardelús, I.1    Antón, F.2    Beleta, J.3
  • 49
    • 0035137186 scopus 로고    scopus 로고
    • The pharmacologic profile of desloratadine: A review
    • Henz BM. The pharmacologic profile of desloratadine: a review. Allergy 2001; 56: 7-13
    • (2001) Allergy , vol.56 , pp. 7-13
    • Henz, B.M.1
  • 50
    • 0037391529 scopus 로고    scopus 로고
    • 1 antagonists: Receptor affinity versus selectivity
    • 1 antagonists: receptor affinity versus selectivity. Inflamm Res 2003; 52 Suppl. 1: S49-50
    • (2003) Inflamm Res , vol.52 , Issue.SUPPL. 1
    • Gillard, M.1    Christope, B.2    Wels, B.3
  • 51
    • 13544250581 scopus 로고    scopus 로고
    • Second-generation antihistamines: Actions and efficacy in the management of allergic disorders
    • Golightly LK, Greos LS. Second-generation antihistamines: actions and efficacy in the management of allergic disorders. Drugs 2005; 65: 341-84
    • (2005) Drugs , vol.65 , pp. 341-384
    • Golightly, L.K.1    Greos, L.S.2
  • 53
    • 0034845227 scopus 로고    scopus 로고
    • Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine
    • Schroeder JT, Schleimer RP, Lichtenstein LM, et al. Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy 2001; 31: 1369-77
    • (2001) Clin Exp Allergy , vol.31 , pp. 1369-1377
    • Schroeder, J.T.1    Schleimer, R.P.2    Lichtenstein, L.M.3
  • 54
    • 0030968998 scopus 로고    scopus 로고
    • Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human FcεRI+ cells
    • Genovese A, Patella V, De Crescenzo G, et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human FcεRI+ cells. Clin Exp Allergy 1997; 27: 559-67
    • (1997) Clin Exp Allergy , vol.27 , pp. 559-567
    • Genovese, A.1    Patella, V.2    De Crescenzo, G.3
  • 55
    • 4544304411 scopus 로고    scopus 로고
    • Anti-inflammatory properties of desloratadine
    • Agrawal DK. Anti-inflammatory properties of desloratadine. Clin Exp Allergy 2004; 34: 1342-8
    • (2004) Clin Exp Allergy , vol.34 , pp. 1342-1348
    • Agrawal, D.K.1
  • 57
    • 0030819485 scopus 로고    scopus 로고
    • Inhibitor activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells
    • Molet S, Gosset P, Lassalle P, et al. Inhibitor activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells. Clin Exp Allergy 1997; 27: 1167-74
    • (1997) Clin Exp Allergy , vol.27 , pp. 1167-1174
    • Molet, S.1    Gosset, P.2    Lassalle, P.3
  • 58
    • 0029130433 scopus 로고
    • 1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines
    • 1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines. Exp Dermatol 1995; 4: 272-6
    • (1995) Exp Dermatol , vol.4 , pp. 272-276
    • Lippert, U.1    Krüger-Krasagakes, S.2    Möller, A.3
  • 60
    • 1542314278 scopus 로고    scopus 로고
    • Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: Histamine and leukotriene antagonism
    • Ciprandi G, Tosca MA, Milanese M, et al. Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism. Eur Ann Allergy Clin Immunol 2004; 36: 67-72
    • (2004) Eur Ann Allergy Clin Immunol , vol.36 , pp. 67-72
    • Ciprandi, G.1    Tosca, M.A.2    Milanese, M.3
  • 62
    • 25644434174 scopus 로고    scopus 로고
    • The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils
    • Vancheri C, Mastruzzo C, Tomaselli V, et al. The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc 2005; 26: 292-8
    • (2005) Allergy Asthma Proc , vol.26 , pp. 292-298
    • Vancheri, C.1    Mastruzzo, C.2    Tomaselli, V.3
  • 63
    • 4344708990 scopus 로고    scopus 로고
    • Supressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro
    • Asano K, Kanai K, Suzaki H. Supressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro. Arzneimittelforschung 2004; 54: 436-43
    • (2004) Arzneimittelforschung , vol.54 , pp. 436-443
    • Asano, K.1    Kanai, K.2    Suzaki, H.3
  • 64
    • 0036041764 scopus 로고    scopus 로고
    • Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells
    • Thomson L, Blaylock MG, Sexton DW, et al. Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells. Clin Exp Allergy 2002; 32: 1187-92
    • (2002) Clin Exp Allergy , vol.32 , pp. 1187-1192
    • Thomson, L.1    Blaylock, M.G.2    Sexton, D.W.3
  • 65
    • 27744444340 scopus 로고    scopus 로고
    • A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions
    • Wu P, Mitchell S, Walsh GM. A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions. Clin Exp Allergy 2005; 35: 1073-9
    • (2005) Clin Exp Allergy , vol.35 , pp. 1073-1079
    • Wu, P.1    Mitchell, S.2    Walsh, G.M.3
  • 66
  • 67
    • 33750066947 scopus 로고    scopus 로고
    • The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine
    • Petecchia L, Serpero L, Silvestri M, et al. The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine. Am J Rhinol 2006; 20: 445-9
    • (2006) Am J Rhinol , vol.20 , pp. 445-449
    • Petecchia, L.1    Serpero, L.2    Silvestri, M.3
  • 68
    • 33846910490 scopus 로고    scopus 로고
    • The effects of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18, and TGF beta in patients suffering from seasonal allergic rhinitis
    • Tworek D, Bochénska-Marciniak M, Kupczyk M, et al. The effects of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18, and TGF beta in patients suffering from seasonal allergic rhinitis. Pulm Pharmacol Ther 2007; 20: 244-9
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 244-249
    • Tworek, D.1    Bochénska-Marciniak, M.2    Kupczyk, M.3
  • 69
  • 70
    • 33644987428 scopus 로고    scopus 로고
    • 11C-doxepin in a placebo-controlled crossover study design in healthy subjects: A comparison of olopatadine and ketotifen
    • 11C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen. Br J Clin Pharmacol 2005; 61: 16-26
    • (2005) Br J Clin Pharmacol , vol.61 , pp. 16-26
    • Tashiro, M.1    Mochizuki, H.2    Sakurada, Y.3
  • 72
    • 0028984069 scopus 로고
    • 1 antagonists measured by positron emission tomography
    • 1 antagonists measured by positron emission tomography. Br J Pharmacol 1995; 116: 1649-55
    • (1995) Br J Pharmacol , vol.116 , pp. 1649-1655
    • Yanai, K.1    Ryu, J.H.2    Watanabe, T.3
  • 74
    • 0032810664 scopus 로고    scopus 로고
    • Why are non-sedating antihistamines non-sedating?
    • Timmerman H. Why are non-sedating antihistamines non-sedating? Clin Exp Allergy 1999; 29 Suppl. 3: 13-8
    • (1999) Clin Exp Allergy , vol.29 , Issue.SUPPL. 3 , pp. 13-18
    • Timmerman, H.1
  • 76
    • 4644302246 scopus 로고    scopus 로고
    • Effects of bepostatine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance
    • Takahashi H, Ishida-Yamamoto A, Iizuka H. Effects of bepostatine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance. Clin Exp Dermatol 2004; 29 (5): 526-32
    • (2004) Clin Exp Dermatol , vol.29 , Issue.5 , pp. 526-532
    • Takahashi, H.1    Ishida-Yamamoto, A.2    Iizuka, H.3
  • 78
    • 0037945443 scopus 로고    scopus 로고
    • A single-center, randomized, double-blind, placebo-controlled, crossover investigation of fexofenadine hydrochloride 180mg alone and with alcohol, with hydroxyzine hydrochloride 50mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car
    • Ridout F, Shamsi Z, Meadows R, et al. A single-center, randomized, double-blind, placebo-controlled, crossover investigation of fexofenadine hydrochloride 180mg alone and with alcohol, with hydroxyzine hydrochloride 50mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car. Clin Ther 2003; 25: 1518-38
    • (2003) Clin Ther , vol.25 , pp. 1518-1538
    • Ridout, F.1    Shamsi, Z.2    Meadows, R.3
  • 79
    • 4043089083 scopus 로고    scopus 로고
    • Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements
    • Vuurman EFPM, Rikken GH, Muntjewerff ND, et al. Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements. Eur J Clin Pharmacol 2004; 60: 307-13
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 307-313
    • Vuurman, E.F.P.M.1    Rikken, G.H.2    Muntjewerff, N.D.3
  • 80
    • 0141577188 scopus 로고    scopus 로고
    • No sedation or performance impairment with desloratadine, a novel antihistamine [abstract]
    • Kay G. No sedation or performance impairment with desloratadine, a novel antihistamine [abstract]. Ann Allergy Asthma Immunol 2001; 86 Suppl.: 84
    • (2001) Ann Allergy Asthma Immunol , vol.86 , Issue.SUPPL. 84
    • Kay, G.1
  • 81
    • 40549144798 scopus 로고    scopus 로고
    • Scharf MB, Kay G, Rikken GH, et al. Desloratadine has no effect on wakefulness or psychomotor performance. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: 280
    • Scharf MB, Kay G, Rikken GH, et al. Desloratadine has no effect on wakefulness or psychomotor performance. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: 280
  • 82
    • 40549099983 scopus 로고    scopus 로고
    • Rikken GH, Scharf MB, Danzig MR, et al. Desloratadine and alcohol co-administration: no increase in impairment of performance over that induced by alcohol alone. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: S277
    • Rikken GH, Scharf MB, Danzig MR, et al. Desloratadine and alcohol co-administration: no increase in impairment of performance over that induced by alcohol alone. In: XIX European Academy of Allergology and Clinical Immunology; 2000 Jul 1-5; Lisbon. Allergy 2000; 55 Suppl. 63: S277
  • 84
    • 0034111253 scopus 로고    scopus 로고
    • 1 receptor antagonist. 2nd communication: Lack of central nervous system effects
    • 1 receptor antagonist. 2nd communication: lack of central nervous system effects. Arzneimittelforschung 2000; 50: 441-8
    • (2000) Arzneimittelforschung , vol.50 , pp. 441-448
    • Kreutner, W.1    Hey, J.A.2    Chiu, P.3
  • 85
    • 0001339719 scopus 로고    scopus 로고
    • Electrocardiographic effects of multiple high doses of desloratadine [abstract]
    • Banfield C, Padhi D, Glue P, et al. Electrocardiographic effects of multiple high doses of desloratadine [abstract]. J Allergy Clin Immunol 2000; 104 Suppl. P2: S383
    • (2000) J Allergy Clin Immunol , vol.104 , Issue.SUPPL. P2
    • Banfield, C.1    Padhi, D.2    Glue, P.3
  • 86
    • 1842591089 scopus 로고    scopus 로고
    • Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU)
    • Day JH, Briscoe MP, Rafeiro E, et al. Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU). Int J Clin Pract 2004; 58: 109-18
    • (2004) Int J Clin Pract , vol.58 , pp. 109-118
    • Day, J.H.1    Briscoe, M.P.2    Rafeiro, E.3
  • 87
    • 25644434175 scopus 로고    scopus 로고
    • Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the Environmental Exposure Unit
    • Day JH, Briscoe MP, Rafeiro E, et al. Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the Environmental Exposure Unit. Allergy Asthma Proc 2005; 26: 275-82
    • (2005) Allergy Asthma Proc , vol.26 , pp. 275-282
    • Day, J.H.1    Briscoe, M.P.2    Rafeiro, E.3
  • 88
    • 4944246449 scopus 로고    scopus 로고
    • Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    • Bachert C, Bousquet J, Canonica GW, et al. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. J Allergy Clin Immunol 2004; 114: 838-44
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 838-844
    • Bachert, C.1    Bousquet, J.2    Canonica, G.W.3
  • 89
    • 33749426910 scopus 로고    scopus 로고
    • Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: A prescription-event monitoring study in England
    • Layton D, Wilton LV, Boshier A, et al. Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England. Drug Saf 2006; 29: 897-909
    • (2006) Drug Saf , vol.29 , pp. 897-909
    • Layton, D.1    Wilton, L.V.2    Boshier, A.3
  • 90
    • 0042877021 scopus 로고    scopus 로고
    • Driving ability after acute and subchronic administration of levocetirizine and diphenhydramine: A randomized, double-blind, placebo-controlled trial
    • Verster JC, de Weert AM, Bijtjes SIR, et al. Driving ability after acute and subchronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. Psychopharmacology 2003; 169: 84-90
    • (2003) Psychopharmacology , vol.169 , pp. 84-90
    • Verster, J.C.1    de Weert, A.M.2    Bijtjes, S.I.R.3
  • 91
    • 0035713576 scopus 로고    scopus 로고
    • The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and a placebo on cognitive function, psychomotor performance, and weal and flare
    • Hindmarch I, Johnson S, Meadows R, et al. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and a placebo on cognitive function, psychomotor performance, and weal and flare. Curr Med Res Opin 2001; 17: 241-55
    • (2001) Curr Med Res Opin , vol.17 , pp. 241-255
    • Hindmarch, I.1    Johnson, S.2    Meadows, R.3
  • 92
    • 0036968218 scopus 로고    scopus 로고
    • Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers
    • Gandon JM, Allain H. Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers. Br J Clin Pharmacol 2002; 54: 51-8
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 51-58
    • Gandon, J.M.1    Allain, H.2
  • 93
    • 0037340413 scopus 로고    scopus 로고
    • Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood
    • Verster JC, Volkerts ER, van Oosterwijck AWAA, et al. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol 2003; 111: 623-7
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 623-627
    • Verster, J.C.1    Volkerts, E.R.2    van Oosterwijck, A.W.A.A.3
  • 94
    • 4544292987 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans
    • Molimard M, Diquet B, Strolin Benedetti M. Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundam Clin Pharmacol 2004; 18: 399-411
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 399-411
    • Molimard, M.1    Diquet, B.2    Strolin Benedetti, M.3
  • 95
    • 0034796935 scopus 로고    scopus 로고
    • Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers
    • Baltes E, Coupez R, Giezek H, et al. Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam Clin Pharmacol 2001; 15: 269-77
    • (2001) Fundam Clin Pharmacol , vol.15 , pp. 269-277
    • Baltes, E.1    Coupez, R.2    Giezek, H.3
  • 96
    • 40549139064 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed 2008 Feb 18
    • US FDA Center for Drug Evaluation and Research. Approval package for: application number 21-165. Pharmacology review(s) [online]. Available from URL: http://www.fda.gov/cder/foi/nda/2001/21-165_Clarinex_pharmr_P1.pdf [Accessed 2008 Feb 18]
    • Approval package for: Application number 21-165. Pharmacology review(s)
  • 97
    • 0034754319 scopus 로고    scopus 로고
    • 14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers
    • 14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers. Eur J Clin Pharmacol 2001; 57: 571-82
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 571-582
    • Benedetti, M.S.1    Plisnier, M.2    Kaise, J.3
  • 98
    • 4644327579 scopus 로고    scopus 로고
    • Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine
    • Ghosal A, Yuan Y, Hapangama N, et al. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos 2004; 25: 243-52
    • (2004) Biopharm Drug Dispos , vol.25 , pp. 243-252
    • Ghosal, A.1    Yuan, Y.2    Hapangama, N.3
  • 101
    • 0034028690 scopus 로고    scopus 로고
    • The metabolic profile of second-generation antihistamines
    • Nicolas JM. The metabolic profile of second-generation antihistamines. Allergy 2000; 55 Suppl. 60: 46-52
    • (2000) Allergy , vol.55 , Issue.SUPPL. 60 , pp. 46-52
    • Nicolas, J.M.1
  • 102
    • 0036074366 scopus 로고    scopus 로고
    • A pharmacokinetic profile of desloratadine in healthy adults, including elderly
    • Affrime M, Gupta S, Banfield C, et al. A pharmacokinetic profile of desloratadine in healthy adults, including elderly. Clin Pharmacokinet 2002; 41 Suppl. 1: 13-9
    • (2002) Clin Pharmacokinet , vol.41 , Issue.SUPPL. 1 , pp. 13-19
    • Affrime, M.1    Gupta, S.2    Banfield, C.3
  • 104
    • 0141616512 scopus 로고    scopus 로고
    • Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin
    • Purohit A, Melac M, Pauli G, et al. Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin. Br J Clin Pharmacol 2003; 56: 388-94
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 388-394
    • Purohit, A.1    Melac, M.2    Pauli, G.3
  • 105
    • 0035060955 scopus 로고    scopus 로고
    • Twenty-four hours of activity of cetirizine and fexofenadine in the skin
    • Purohit A, Duvernelle C, Melac M, et al. Twenty-four hours of activity of cetirizine and fexofenadine in the skin. Ann Allergy Asthma Immunol 2001; 86: 387-92
    • (2001) Ann Allergy Asthma Immunol , vol.86 , pp. 387-392
    • Purohit, A.1    Duvernelle, C.2    Melac, M.3
  • 106
    • 0036179361 scopus 로고    scopus 로고
    • A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: Suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects
    • Grant JA, Riethusien JM, Moulaert B, et al. A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Ann Allergy Asthma Immunol 2002; 88: 190-7
    • (2002) Ann Allergy Asthma Immunol , vol.88 , pp. 190-197
    • Grant, J.A.1    Riethusien, J.M.2    Moulaert, B.3
  • 107
    • 85058198658 scopus 로고    scopus 로고
    • Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines
    • Monroe EW, Daly AF, Shalhoub RF. Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines. J Allergy Clin Immunol 1997; 99: S798-806
    • (1997) J Allergy Clin Immunol , vol.99
    • Monroe, E.W.1    Daly, A.F.2    Shalhoub, R.F.3
  • 108
    • 33847771905 scopus 로고    scopus 로고
    • Inhibition of the histamine-induced weal and flare response: A valid surrogate measure for antihistamine clinical efficacy?
    • Devillier P, Bousquet J. Inhibition of the histamine-induced weal and flare response: a valid surrogate measure for antihistamine clinical efficacy? Clin Exp Allergy 2007; 37: 400-14
    • (2007) Clin Exp Allergy , vol.37 , pp. 400-414
    • Devillier, P.1    Bousquet, J.2
  • 109
    • 40549137078 scopus 로고    scopus 로고
    • Draft guidance for industry
    • online, Available from URL:, Accessed 2008 Feb 18
    • US FDA Center for Drug Evaluation and Research. Draft guidance for industry. Allergic rhinitis: clinical development programs for drug products [online]. Available from URL: http://www.fda.gov/cder/guidance/2718dft.htm [Accessed 2008 Feb 18]
    • Allergic rhinitis: Clinical development programs for drug products
  • 110
    • 0035658287 scopus 로고    scopus 로고
    • Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: Confirmation of a test system
    • Day JH, Briscoe M, Rafeiro E, et al. Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: confirmation of a test system. Ann Allergy Asthma Immunol 2001; 87: 474-81
    • (2001) Ann Allergy Asthma Immunol , vol.87 , pp. 474-481
    • Day, J.H.1    Briscoe, M.2    Rafeiro, E.3
  • 111
    • 0031971826 scopus 로고    scopus 로고
    • Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: Effects after controlled ragweed pollen challenge in an environmental exposure unit
    • Day JH, Briscoe MP, Widlitz MD. Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmental exposure unit. J Allergy Clin Immunol 1998; 101: 638-45
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 638-645
    • Day, J.H.1    Briscoe, M.P.2    Widlitz, M.D.3
  • 112
    • 0030763484 scopus 로고    scopus 로고
    • Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis
    • Day JH, Briscoe MP, Clark RH, et al. Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Ann Allergy Asthma Immunol 1997; 79: 163-72
    • (1997) Ann Allergy Asthma Immunol , vol.79 , pp. 163-172
    • Day, J.H.1    Briscoe, M.P.2    Clark, R.H.3
  • 113
    • 0026795769 scopus 로고
    • Onset and duration of the effects of three antihistamines in current use - astemizole, loratadine and terfenadine forte - studied during prolonged controlled allergen challenges in volunteers
    • Horak F, Jäger S, Berger U. Onset and duration of the effects of three antihistamines in current use - astemizole, loratadine and terfenadine forte - studied during prolonged controlled allergen challenges in volunteers. J Int Med Res 1992; 20: 422-34
    • (1992) J Int Med Res , vol.20 , pp. 422-434
    • Horak, F.1    Jäger, S.2    Berger, U.3
  • 114
    • 3042684544 scopus 로고    scopus 로고
    • A direct comparison of the efficacy of antihistamines in SAR and PAR: Randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit: the Vienna Challenge Chamber (VCC)
    • Stübner P, Zieglmayer R, Horak F. A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit: the Vienna Challenge Chamber (VCC). Curr Med Res Opin 2004; 6: 891-902
    • (2004) Curr Med Res Opin , vol.6 , pp. 891-902
    • Stübner, P.1    Zieglmayer, R.2    Horak, F.3
  • 115
    • 0030976630 scopus 로고    scopus 로고
    • Onset of action on the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis
    • Frossard N, Lacronique J, Melac M, et al. Onset of action on the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis. Allergy 1997; 52: 205-9
    • (1997) Allergy , vol.52 , pp. 205-209
    • Frossard, N.1    Lacronique, J.2    Melac, M.3
  • 116
    • 1642394844 scopus 로고    scopus 로고
    • Randomized double-blind comparison of cetirizine and fexofenadine after pollen challenge in the Environmental Exposure Unit: Duration of effect in subjects with seasonal allergic rhinitis
    • Day JH, Briscoe MP, Rafeiro E, et al. Randomized double-blind comparison of cetirizine and fexofenadine after pollen challenge in the Environmental Exposure Unit: duration of effect in subjects with seasonal allergic rhinitis. Allergy Asthma Proc 2004; 25: 59-68
    • (2004) Allergy Asthma Proc , vol.25 , pp. 59-68
    • Day, J.H.1    Briscoe, M.P.2    Rafeiro, E.3
  • 117
    • 33645032466 scopus 로고    scopus 로고
    • Comparing the new antihistamines: The role of pharmacological parameters
    • Devillier P. Comparing the new antihistamines: the role of pharmacological parameters. Clin Exp Allergy 2005; 36: 5-7
    • (2005) Clin Exp Allergy , vol.36 , pp. 5-7
    • Devillier, P.1
  • 118
    • 22844436333 scopus 로고    scopus 로고
    • Pharmacological profile of the new antihistamines
    • Tillement J-P. Pharmacological profile of the new antihistamines. Clin Exp Allergy Rev 2005; 5: 7-11
    • (2005) Clin Exp Allergy Rev , vol.5 , pp. 7-11
    • Tillement, J.-P.1
  • 119
    • 5644263658 scopus 로고    scopus 로고
    • Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours
    • Passalacqua G, Guerra L, Compalati E, et al. Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours. Int Arch Allergy Immunol 2004; 135: 143-7
    • (2004) Int Arch Allergy Immunol , vol.135 , pp. 143-147
    • Passalacqua, G.1    Guerra, L.2    Compalati, E.3
  • 120
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I, Nezu J, Uchino H, et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Comm 2000; 273: 251-60
    • (2000) Biochem Biophys Res Comm , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3
  • 121
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M, Leak B, Fromm MF, et al. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 1999; 27: 866-71
    • (1999) Drug Metab Dispos , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leak, B.2    Fromm, M.F.3
  • 122
    • 0034943050 scopus 로고    scopus 로고
    • Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein
    • Wang E-J, Casciano CN, Clement RP, et al. Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos 2001; 29: 1080-3
    • (2001) Drug Metab Dispos , vol.29 , pp. 1080-1083
    • Wang, E.-J.1    Casciano, C.N.2    Clement, R.P.3
  • 123
    • 0036286921 scopus 로고    scopus 로고
    • Effect of St. John's wort on the pharmacokinetics of fexofenadine
    • Wang Z, Hamman MA, Huang S-M, et al. Effect of St. John's wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther 2002; 71: 414-20
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 414-420
    • Wang, Z.1    Hamman, M.A.2    Huang, S.-M.3
  • 124
    • 33745070264 scopus 로고    scopus 로고
    • Time-dependent interaction between lopinavir/ritonavir and fexofenadine
    • van Heeswijk RP, Bourbeau M, Campbell P, et al. Time-dependent interaction between lopinavir/ritonavir and fexofenadine. J Clin Pharmacol 2006; 46: 758-67
    • (2006) J Clin Pharmacol , vol.46 , pp. 758-767
    • van Heeswijk, R.P.1    Bourbeau, M.2    Campbell, P.3
  • 125
    • 13944275994 scopus 로고    scopus 로고
    • Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: Possible role of organic anion transporting polypeptides
    • Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 2005; 77: 170-7
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 170-177
    • Dresser, G.K.1    Kim, R.B.2    Bailey, D.G.3
  • 126
    • 33847662941 scopus 로고    scopus 로고
    • Intestinal drug transporter expression and the impact of grapefruit juice in humans
    • Glaeser H, Bailey DG, Dresser GK, et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 2007; 81: 362-70
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 362-370
    • Glaeser, H.1    Bailey, D.G.2    Dresser, G.K.3
  • 127
    • 0036091282 scopus 로고    scopus 로고
    • Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine
    • Banfield C, Gupta S, Marino M, et al. Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin Pharmacokinet 2002; 41: 311-8
    • (2002) Clin Pharmacokinet , vol.41 , pp. 311-318
    • Banfield, C.1    Gupta, S.2    Marino, M.3
  • 128
    • 0034876431 scopus 로고    scopus 로고
    • In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes
    • Barecki ME, Casciano CN, Johnson WW, et al. In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos 2001; 29: 1173-5
    • (2001) Drug Metab Dispos , vol.29 , pp. 1173-1175
    • Barecki, M.E.1    Casciano, C.N.2    Johnson, W.W.3
  • 129
    • 6344226111 scopus 로고    scopus 로고
    • Pharmacokinetics/ pharmacodynamics of desloratadine and fluoxetine in healthy volunteers
    • Gupta S, Banfield C, Kantesaria B, et al. Pharmacokinetics/ pharmacodynamics of desloratadine and fluoxetine in healthy volunteers. J Clin Pharmacol 2004; 44: 1252-9
    • (2004) J Clin Pharmacol , vol.44 , pp. 1252-1259
    • Gupta, S.1    Banfield, C.2    Kantesaria, B.3
  • 130
    • 0035049380 scopus 로고    scopus 로고
    • Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: A randomized, placebo-controlled, parallel-group study
    • Gupta S, Banfield C, Kantesaria B, et al. Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study. Clin Ther 2001; 23: 451-66
    • (2001) Clin Ther , vol.23 , pp. 451-466
    • Gupta, S.1    Banfield, C.2    Kantesaria, B.3
  • 131
    • 0036071091 scopus 로고    scopus 로고
    • Lack of clinically relevant interaction between desloratadine and erythromycin
    • Banfield C, Hunt T, Reyderman L, et al. Lack of clinically relevant interaction between desloratadine and erythromycin. Clin Pharmacokinet 2002; 41 Suppl. 1: 29-35
    • (2002) Clin Pharmacokinet , vol.41 , Issue.SUPPL. 1 , pp. 29-35
    • Banfield, C.1    Hunt, T.2    Reyderman, L.3
  • 132
    • 0141577191 scopus 로고    scopus 로고
    • Lack of an interaction with coadministration of desloratadine and cimetidine
    • Khalilieh S, Krishna G, Marino M, et al. Lack of an interaction with coadministration of desloratadine and cimetidine. Ann Allergy Asthma Immunol 2002; 88: 110
    • (2002) Ann Allergy Asthma Immunol , vol.88 , pp. 110
    • Khalilieh, S.1    Krishna, G.2    Marino, M.3
  • 133
    • 0036074083 scopus 로고    scopus 로고
    • Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole
    • Banfield C, Herron J, Keung A, et al. Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole. Clin Pharmacokinet 2002; 41 Suppl. 1: 37-44
    • (2002) Clin Pharmacokinet , vol.41 , Issue.SUPPL. 1 , pp. 37-44
    • Banfield, C.1    Herron, J.2    Keung, A.3
  • 134
    • 0034466892 scopus 로고    scopus 로고
    • Hepatic disposition of fexofenadine: Influence of the transport inhibitors erythromycin and dibromosulphothalein
    • Milne RW, Larsen LA, Jørgensen KL, et al. Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein. Pharm Res 2000; 17: 1511-5
    • (2000) Pharm Res , vol.17 , pp. 1511-1515
    • Milne, R.W.1    Larsen, L.A.2    Jørgensen, K.L.3
  • 135
    • 0344687432 scopus 로고    scopus 로고
    • The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion techmines nique
    • Tannergren C, Knutson T, Knutson L, et al. The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion techmines nique Br J Clin Pharmacol 2003; 55: 182-90
    • (2003) Br J Clin Pharmacol , vol.55 , pp. 182-190
    • Tannergren, C.1    Knutson, T.2    Knutson, L.3
  • 136
    • 21244437148 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic interaction between cetirizine and ritonavir, an HIV-1 protease inhibitor, in healthy male volunteers
    • Peytavin G, Gauran C, Otoul C, et al. Evaluation of pharmacokinetic interaction between cetirizine and ritonavir, an HIV-1 protease inhibitor, in healthy male volunteers. Eur J Clin Pharmacol 2005; 61: 267-73
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 267-273
    • Peytavin, G.1    Gauran, C.2    Otoul, C.3
  • 137
    • 33646094207 scopus 로고    scopus 로고
    • Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: First case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2
    • Tsuruoka S, Ioka T, Wakaumi M, et al. Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2. Clin Pharmacol Ther 2006; 79: 389-96
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 389-396
    • Tsuruoka, S.1    Ioka, T.2    Wakaumi, M.3
  • 138
    • 13844309828 scopus 로고    scopus 로고
    • A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings
    • Horita Y, Kanaya H, Uno Y, et al. A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings. Jpn Heart J 2004; 45: 1049-56
    • (2004) Jpn Heart J , vol.45 , pp. 1049-1056
    • Horita, Y.1    Kanaya, H.2    Uno, Y.3
  • 139
    • 34447342871 scopus 로고    scopus 로고
    • Desloratadine dose selection in children aged 6 months to 2 years: Comparison of population pharmacokinetics between children and adults
    • Gupta SK, Kantesaria B, Banfield C, et al. Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults. Br J Clin Pharmacol 2007; 64: 174-84
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 174-184
    • Gupta, S.K.1    Kantesaria, B.2    Banfield, C.3
  • 140
    • 34247379147 scopus 로고    scopus 로고
    • Pharmacokinetics of desloratadine in children between 2 and 11 years of age
    • Gupta S, Khalilieh S, Kantesaria B, et al. Pharmacokinetics of desloratadine in children between 2 and 11 years of age. Br J Clin Pharmacol 2007; 63: 534-40
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 534-540
    • Gupta, S.1    Khalilieh, S.2    Kantesaria, B.3
  • 142
    • 17444411907 scopus 로고    scopus 로고
    • Levocetirizine in 1-2 year old children: Pharmacokinetic and pharmacodynamic profile
    • Cranswick N, Turziková J, Fuchs M, et al. Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile. Int J Clin Pharmacol Ther 2005; 43: 172-7
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 172-177
    • Cranswick, N.1    Turziková, J.2    Fuchs, M.3
  • 143
    • 17044390173 scopus 로고    scopus 로고
    • on behalf of the ETAC Study Group. Population pharmacokinetics of levocetirizine in very young children: The pediatricians' perspective
    • Simons FER, on behalf of the ETAC Study Group. Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective. Pediatr Allergy Immunol 2005; 16: 97-103
    • (2005) Pediatr Allergy Immunol , vol.16 , pp. 97-103
    • Simons, F.E.R.1
  • 144
    • 23244461751 scopus 로고    scopus 로고
    • Levocetirizine: Pharmacokinetics and pharmacodynamics in children age 6 to 11 years
    • Simons FER, Simons KJ. Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years. J Allergy Clin Immunol 2005; 116: 355-61
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 355-361
    • Simons, F.E.R.1    Simons, K.J.2
  • 145
    • 0036071053 scopus 로고    scopus 로고
    • Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine
    • Affrime M, Banfield C, Gupta S, et al. Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine. Clin Pharmacokinet 2002; 41 Suppl. 1: 21-8
    • (2002) Clin Pharmacokinet , vol.41 , Issue.SUPPL. 1 , pp. 21-28
    • Affrime, M.1    Banfield, C.2    Gupta, S.3
  • 146
    • 34648819503 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and safety of desloratadine in subjects with moderate hepatic impairment
    • Gupta SK, Kantesaria B, Wang Z. Multiple-dose pharmacokinetics and safety of desloratadine in subjects with moderate hepatic impairment. J Clin Pharmacol 2007; 47: 1283-91
    • (2007) J Clin Pharmacol , vol.47 , pp. 1283-1291
    • Gupta, S.K.1    Kantesaria, B.2    Wang, Z.3
  • 148
    • 33644906907 scopus 로고    scopus 로고
    • Adult and paediatric poor metabolisers of desloratadine: An assessment of pharmacokinetics and safety
    • Prenner B, Kim K, Gupta S, et al. Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety. Expert Opin Drug Saf 2006; 5: 211-23
    • (2006) Expert Opin Drug Saf , vol.5 , pp. 211-223
    • Prenner, B.1    Kim, K.2    Gupta, S.3


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