The effects of tramadol on static and dynamic pupillometry in healthy subjects - The relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status

European Journal of Clinical Pharmacology

Volumn 61, Issue 4, 2005, Pages 257-266

  Fliegert, Frank ^a   Kurth, Burkhard ^a   Göhler, Karin ^a  

^a GRÜNENTHAL GMBH   (Germany)

Author keywords

CYP2D6; Pharmacodynamics; Pharmacokinetics; Pupillometry; Tramadol

Indexed keywords

CYTOCHROME P450 2D6; DRUG METABOLITE; PLACEBO; TRAMADOL;

ADULT; AMPLITUDE MODULATION; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIZZINESS; DOSE RESPONSE; DROWSINESS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INDUCED HEADACHE; DRUG MECHANISM; ENANTIOMER; FATIGUE; FEMALE; HUMAN; MALE; MIOSIS; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; PUPIL; PUPILLOMETRY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ANALGESICS, OPIOID; AREA UNDER CURVE; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP2D6; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HALF-LIFE; HUMANS; MALE; METABOLIC CLEARANCE RATE; PUPIL; TIME FACTORS; TRAMADOL; VARIATION (GENETICS);

EID: 21244448805     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-005-0920-y     Document Type: Article

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