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Volumn 30, Issue 3, 2008, Pages 271-275

CYP2D6 polymorphism in relation to tramadol metabolism: A study of faroese patients

Author keywords

CYP2D6 polymorphism; Faroe Islands; Pharmacokinetics; Steady state condition; Therapeutic drug monitoring; Tramadol

Indexed keywords

CYTOCHROME P450 2D6; SPARTEINE; TRAMADOL; NARCOTIC ANALGESIC AGENT;

EID: 47249099319     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3181666b2f     Document Type: Article
Times cited : (38)

References (29)
  • 1
    • 0017863203 scopus 로고
    • On separation of isomeres, structural elucidation and pharmacological characterization of 1-(mmethoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol
    • in German
    • Frankus E, Friderichs E, Kim SM, et al. On separation of isomeres, structural elucidation and pharmacological characterization of 1-(mmethoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol [in German]. Arzneimittelforschung. 1978;28:114-121.
    • (1978) Arzneimittelforschung , vol.28 , pp. 114-121
    • Frankus, E.1    Friderichs, E.2    Kim, S.M.3
  • 2
    • 0031003065 scopus 로고    scopus 로고
    • Pharmacology of tramadol
    • in French
    • Dayer P, Desmeules J, Collart L. Pharmacology of tramadol [in French]. Drugs. 1997;53(Suppl 2):18-24.
    • (1997) Drugs , vol.53 , Issue.SUPPL. 2 , pp. 18-24
    • Dayer, P.1    Desmeules, J.2    Collart, L.3
  • 3
    • 0344081910 scopus 로고    scopus 로고
    • A rapid and simple CYP2D6 genotyping assay: Case study with the analgetic tramadol
    • Borlak J, Hermann R, Erb K, et al. A rapid and simple CYP2D6 genotyping assay: case study with the analgetic tramadol. Metabolism. 2003;52:1439-1443.
    • (2003) Metabolism , vol.52 , pp. 1439-1443
    • Borlak, J.1    Hermann, R.2    Erb, K.3
  • 4
    • 0033770078 scopus 로고    scopus 로고
    • Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy
    • Potschka H, Friderichs E, Loscher W. Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy. Br J Pharmacol. 2000;131:203-212.
    • (2000) Br J Pharmacol , vol.131 , pp. 203-212
    • Potschka, H.1    Friderichs, E.2    Loscher, W.3
  • 5
    • 33748557223 scopus 로고    scopus 로고
    • Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography-mass spectrometry and application to postoperative patients receiving tramadol
    • Musshoff F, Madea B, Stuber F, et al. Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography-mass spectrometry and application to postoperative patients receiving tramadol. J Anal Toxicol. 2006;30:463-467.
    • (2006) J Anal Toxicol , vol.30 , pp. 463-467
    • Musshoff, F.1    Madea, B.2    Stuber, F.3
  • 6
    • 0019847479 scopus 로고
    • Biotransformation of tramadol in man and animal
    • in German
    • Lintz W, Erlacin S, Frankus E, et al. Biotransformation of tramadol in man and animal [in German]. Arzneimittelforschung. 1981;31:1932-1943.
    • (1981) Arzneimittelforschung , vol.31 , pp. 1932-1943
    • Lintz, W.1    Erlacin, S.2    Frankus, E.3
  • 7
    • 0034946742 scopus 로고    scopus 로고
    • Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
    • Subrahmanyam V, Renwick AB, Walters DG, et al. Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos. 2001;29:1146-1155.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1146-1155
    • Subrahmanyam, V.1    Renwick, A.B.2    Walters, D.G.3
  • 8
    • 0026512239 scopus 로고
    • Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic
    • Raffa RB, Friderichs E, Reimann W, et al. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther. 1993;260:275-285.
    • (1993) J Pharmacol Exp Ther , vol.260 , pp. 275-285
    • Raffa, R.B.1    Friderichs, E.2    Reimann, W.3
  • 9
    • 7444229920 scopus 로고    scopus 로고
    • Clinical pharmacology of tramadol
    • Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43:879-923.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 879-923
    • Grond, S.1    Sablotzki, A.2
  • 10
    • 0030907496 scopus 로고    scopus 로고
    • Tramadol: A new centrally acting analgesic
    • Lewis KS, Han NH. Tramadol: a new centrally acting analgesic. Am J Health Syst Pharm. 1997;54:643-652.
    • (1997) Am J Health Syst Pharm , vol.54 , pp. 643-652
    • Lewis, K.S.1    Han, N.H.2
  • 11
    • 0030471120 scopus 로고    scopus 로고
    • The hypoalgesic effect of tramadol in relation to CYP2D6
    • Poulsen L, Arendt-Nielsen L, Brosen K, et al. The hypoalgesic effect of tramadol in relation to CYP2D6. Clin Pharmacol Ther. 1996;60: 636-644.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 636-644
    • Poulsen, L.1    Arendt-Nielsen, L.2    Brosen, K.3
  • 12
    • 0033901486 scopus 로고    scopus 로고
    • Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor
    • Gillen C, Haurand M, Kobelt DJ, et al. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn Schmiedebergs Arch Pharmacol. 2000;362:116-121.
    • (2000) Naunyn Schmiedebergs Arch Pharmacol , vol.362 , pp. 116-121
    • Gillen, C.1    Haurand, M.2    Kobelt, D.J.3
  • 13
    • 0030571489 scopus 로고    scopus 로고
    • Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells
    • Lai J, Ma SW, Porreca F, et al. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. Eur J Pharmacol. 1996;316:369-372.
    • (1996) Eur J Pharmacol , vol.316 , pp. 369-372
    • Lai, J.1    Ma, S.W.2    Porreca, F.3
  • 14
    • 0031460240 scopus 로고    scopus 로고
    • Polymorphic CYP2D6 mediates Odemethylation of the opioid analgesic tramadol
    • Paar WD, Poche S, Gerloff J, et al. Polymorphic CYP2D6 mediates Odemethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol. 1997;53:235-239.
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 235-239
    • Paar, W.D.1    Poche, S.2    Gerloff, J.3
  • 15
    • 20444477620 scopus 로고    scopus 로고
    • Tramadol as a new probe for cytochrome P450 2D6 phenotyping: A population study
    • Pedersen RS, Damkier P, Brosen K. Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study. Clin Pharmacol Ther. 2005;77:458-467.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 458-467
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 16
    • 0037348173 scopus 로고    scopus 로고
    • Enantioselective HPLC method for quantitative determination of tramadol and O-desmethyltramadol in plasma and urine: Application to clinical studies
    • Pedersen RS, Brosen K, Nielsen F. Enantioselective HPLC method for quantitative determination of tramadol and O-desmethyltramadol in plasma and urine: application to clinical studies. Chromatographia. 2003; 57:279-285.
    • (2003) Chromatographia , vol.57 , pp. 279-285
    • Pedersen, R.S.1    Brosen, K.2    Nielsen, F.3
  • 17
    • 16344365900 scopus 로고    scopus 로고
    • Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol
    • Laugesen S, Enggaard TP, Pedersen RS, et al. Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol. Clin Pharmacol Ther. 2005; 77:312-323.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 312-323
    • Laugesen, S.1    Enggaard, T.P.2    Pedersen, R.S.3
  • 18
    • 21244448805 scopus 로고    scopus 로고
    • The effects of tramadol on static and dynamic pupillometry in healthy subjects: The relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status
    • Fliegert F, Kurth B, Gohler K. The effects of tramadol on static and dynamic pupillometry in healthy subjects: the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status. Eur J Clin Pharmacol. 2005;61:257-266.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 257-266
    • Fliegert, F.1    Kurth, B.2    Gohler, K.3
  • 19
    • 0018615011 scopus 로고
    • Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
    • Eichelbaum M, Spannbrucker N, Steinke B, et al. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol. 1979;16:183-187.
    • (1979) Eur J Clin Pharmacol , vol.16 , pp. 183-187
    • Eichelbaum, M.1    Spannbrucker, N.2    Steinke, B.3
  • 20
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of Debrisoquine in man
    • Mahgoub A, Idle JR, Dring LG, et al. Polymorphic hydroxylation of Debrisoquine in man. Lancet. 1977;2:584-586.
    • (1977) Lancet , vol.2 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 21
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics. 2002;3: 229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 22
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan G, Bechtel P, Iselius L, et al. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol. 1990;39:533-537.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3
  • 23
    • 24044471025 scopus 로고    scopus 로고
    • Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population
    • Halling J, Petersen MS, Damkier P, et al. Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population. Eur J Clin Pharmacol. 2005;61:491-497.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 491-497
    • Halling, J.1    Petersen, M.S.2    Damkier, P.3
  • 24
    • 37249083501 scopus 로고    scopus 로고
    • The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population
    • Halling J, Weihe P, Brosen K. The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population. Br J Clin Pharmacol. 2008;65:134-138.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 134-138
    • Halling, J.1    Weihe, P.2    Brosen, K.3
  • 26
    • 0141626841 scopus 로고    scopus 로고
    • Impact of CYP2D6 genotype on postoperative tramadol analgesia
    • Stamer UM, Lehnen K, Hothker F, et al. Impact of CYP2D6 genotype on postoperative tramadol analgesia. Pain. 2003;105:231-238.
    • (2003) Pain , vol.105 , pp. 231-238
    • Stamer, U.M.1    Lehnen, K.2    Hothker, F.3
  • 27
    • 0020034761 scopus 로고
    • Sparteine metabolism in Canadian Caucasians
    • Vinks A, Inaba T, Otton SV, et al. Sparteine metabolism in Canadian Caucasians. Clin Pharmacol Ther. 1982;31:23-29.
    • (1982) Clin Pharmacol Ther , vol.31 , pp. 23-29
    • Vinks, A.1    Inaba, T.2    Otton, S.V.3
  • 29
    • 0029068546 scopus 로고
    • Fluvoxamine and fluoxetine: Interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients
    • Vandel S, Bertschy G, Baumann P, et al. Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients. Pharmacol Res. 1995;31:347-353.
    • (1995) Pharmacol Res , vol.31 , pp. 347-353
    • Vandel, S.1    Bertschy, G.2    Baumann, P.3


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