메뉴 건너뛰기




Volumn 63, Issue 4, 1998, Pages 444-452

10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; NORTRIPTYLINE;

EID: 0031949132     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(98)90040-6     Document Type: Article
Times cited : (275)

References (35)
  • 4
    • 0001935587 scopus 로고
    • Interindividual and interethnic differences in polymorphic drug oxidation: Implications for drug therapy with focus on psychoactive drugs
    • Pacifici GM, Fracchia GN, editor. Luxembourg: European Commission
    • Bertilsson L, Dahl ML, Ingelman-Sundberg M, Johansson I, Sjöqvist F. Interindividual and interethnic differences in polymorphic drug oxidation: implications for drug therapy with focus on psychoactive drugs. In: Pacifici GM, Fracchia GN, editor. Advances in drug metabolism in man. Luxembourg: European Commission; 1995. p. 85-136.
    • (1995) Advances in Drug Metabolism in Man , pp. 85-136
    • Bertilsson, L.1    Dahl, M.L.2    Ingelman-Sundberg, M.3    Johansson, I.4    Sjöqvist, F.5
  • 5
    • 0001668414 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism: Clinical aspects
    • Kalow W, editor. New York: Pergamon Press
    • Eichelbaum M, Gross S. The genetic polymorphism of debrisoquine/sparteine metabolism: clinical aspects. In: Kalow W, editor. Pharmacogenetics of drug metabolism. New York: Pergamon Press; 1992. p. 625-48.
    • (1992) Pharmacogenetics of Drug Metabolism , pp. 625-648
    • Eichelbaum, M.1    Gross, S.2
  • 6
    • 0029979414 scopus 로고    scopus 로고
    • Polymorphic drug oxidation: Relevance to the treatment of psychiatric disorders
    • Bertilsson L, Dahl ML. Polymorphic drug oxidation: relevance to the treatment of psychiatric disorders. CNS Drugs 1996;5:200-23.
    • (1996) CNS Drugs , vol.5 , pp. 200-223
    • Bertilsson, L.1    Dahl, M.L.2
  • 7
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alván G, Bechtel P, Iselius L, Gundert-Remy U. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 1990;39:533-7.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alván, G.1    Bechtel, P.2    Iselius, L.3    Gundert-Remy, U.4
  • 8
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans DA, Mahgoub A, Sloan TP, Idle JR, Smith RL. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 1980;17:102-5.
    • (1980) J Med Genet , vol.17 , pp. 102-105
    • Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 9
    • 0022179340 scopus 로고
    • A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin
    • Steiner E, Iselius L, Alván G, Lindsten J, Sjöqvist F. A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin. Clin Pharmacol Ther 1985;38:394-401.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 394-401
    • Steiner, E.1    Iselius, L.2    Alván, G.3    Lindsten, J.4    Sjöqvist, F.5
  • 10
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
    • [erratum appears in Clin Pharmacol Ther 1994;55:648].
    • Bertilsson L, Lou YQ, Du YL, Liu Y, Kuang TY, Liao XM, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin [erratum appears in Clin Pharmacol Ther 1994;55:648]. Clin Pharmacol Ther 1992;51:388-97.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Du, Y.L.3    Liu, Y.4    Kuang, T.Y.5    Liao, X.M.6
  • 11
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson L, Åberg-Wistedt A, Gustafsson LL, Nordin C. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit 1985;7:478-80.
    • (1985) Ther Drug Monit , vol.7 , pp. 478-480
    • Bertilsson, L.1    Åberg-Wistedt, A.2    Gustafsson, L.L.3    Nordin, C.4
  • 13
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjöqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993;90:11825-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 14
  • 15
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population: Analysis of the molecular genetic basis
    • Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjöqvist F. Ultrarapid hydroxylation of debrisoquine in a Swedish population: analysis of the molecular genetic basis. J Pharmacol Exp Ther 1995;274:516-20.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 516-520
    • Dahl, M.L.1    Johansson, I.2    Bertilsson, L.3    Ingelman-Sundberg, M.4    Sjöqvist, F.5
  • 16
    • 0028942981 scopus 로고
    • Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
    • Agúndez JA, Ledesma MC, Ladero JM, Benítez J. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population. Clin Pharmacol Ther 1995;57:265-9.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 265-269
    • Agúndez, J.A.1    Ledesma, M.C.2    Ladero, J.M.3    Benítez, J.4
  • 17
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, Johansson I, Rodrigues F, Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996;278:441-6.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodrigues, F.5    Ingelman-Sundberg, M.6
  • 18
    • 0031405796 scopus 로고    scopus 로고
    • Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine
    • Dalén P, Frengell C, Dahl ML, Sjöqvist F. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. Ther Drug Monit 1997; 19:543-4.
    • (1997) Ther Drug Monit , vol.19 , pp. 543-544
    • Dalén, P.1    Frengell, C.2    Dahl, M.L.3    Sjöqvist, F.4
  • 20
    • 0025950370 scopus 로고
    • Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
    • Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA. Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol 1991;10:545-58.
    • (1991) DNA Cell Biol , vol.10 , pp. 545-558
    • Broly, F.1    Gaedigk, A.2    Heim, M.3    Eichelbaum, M.4    Morike, K.5    Meyer, U.A.6
  • 21
    • 0000165070 scopus 로고
    • Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses
    • Alexanderson B, Borgå O. Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses. Eur J Clin Pharmacol 1973; 5:174-80.
    • (1973) Eur J Clin Pharmacol , vol.5 , pp. 174-180
    • Alexanderson, B.1    Borgå, O.2
  • 22
    • 0001140482 scopus 로고
    • Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level
    • Bertilsson L, Alexanderson B. Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level. Eur J Clin Pharmacol 1972;4:201-5.
    • (1972) Eur J Clin Pharmacol , vol.4 , pp. 201-205
    • Bertilsson, L.1    Alexanderson, B.2
  • 23
    • 0019449455 scopus 로고
    • E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation
    • Mellström B, Bertilsson L, Säwe J, Schulz HU, Sjöqvist F. E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation. Clin Pharmacol Ther 1981;30:189-93.
    • (1981) Clin Pharmacol Ther , vol.30 , pp. 189-193
    • Mellström, B.1    Bertilsson, L.2    Säwe, J.3    Schulz, H.U.4    Sjöqvist, F.5
  • 24
    • 0021933958 scopus 로고
    • Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients: Relationship to the debrisoquine hydroxylation metabolic ratio
    • Nordin C, Siwers B, Benitez J, Bertilsson L. Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients: relationship to the debrisoquine hydroxylation metabolic ratio. Br J Clin Pharmacol 1985;19:832-5.
    • (1985) Br J Clin Pharmacol , vol.19 , pp. 832-835
    • Nordin, C.1    Siwers, B.2    Benitez, J.3    Bertilsson, L.4
  • 25
    • 0026001359 scopus 로고
    • Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline
    • Dahl ML, Nordin C, Bertilsson L. Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline. Ther Drug Monit 1991;13:189-94.
    • (1991) Ther Drug Monit , vol.13 , pp. 189-194
    • Dahl, M.L.1    Nordin, C.2    Bertilsson, L.3
  • 26
    • 0018574466 scopus 로고
    • Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline
    • Bertilsson L, Mellström B, Sjöqvist F. Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline. Life Sci 1979;25:1285-92.
    • (1979) Life Sci , vol.25 , pp. 1285-1292
    • Bertilsson, L.1    Mellström, B.2    Sjöqvist, F.3
  • 27
    • 0021267727 scopus 로고
    • Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors
    • Wagner A, Ekqvist B, Bertilsson L, Sjöqvist F. Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors. Life Sci 1984;35:1379-83.
    • (1984) Life Sci , vol.35 , pp. 1379-1383
    • Wagner, A.1    Ekqvist, B.2    Bertilsson, L.3    Sjöqvist, F.4
  • 28
    • 0023137711 scopus 로고
    • Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects
    • Nordin C, Bertilsson L, Otani K, Widmark A. Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects. Clin Pharmacol Ther 1987;41:97-102.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 97-102
    • Nordin, C.1    Bertilsson, L.2    Otani, K.3    Widmark, A.4
  • 29
    • 0025080352 scopus 로고
    • Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
    • Heim M, Meyer UA. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification. Lancet 1990;336:529-32.
    • (1990) Lancet , vol.336 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 31
    • 0022550959 scopus 로고
    • Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects
    • Bertilsson L, Nordin C, Otani K, Resul B, Scheinin M, Siwers B, et al. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clin Pharmacol Ther 1986;40:261-7.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 261-267
    • Bertilsson, L.1    Nordin, C.2    Otani, K.3    Resul, B.4    Scheinin, M.5    Siwers, B.6
  • 33
    • 2642629405 scopus 로고
    • Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug
    • Freyschuss U, Sjöqvist F, Tuck D, Åsberg M. Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug. Pharmacol Clin 1970;2:68-71.
    • (1970) Pharmacol Clin , vol.2 , pp. 68-71
    • Freyschuss, U.1    Sjöqvist, F.2    Tuck, D.3    Åsberg, M.4
  • 35
    • 0026051597 scopus 로고
    • Assessment of the relationship between plasma nortriptyline concentration and inhibition of salivation: Single-dose study
    • Jang I, Shin J, Shin S, Kim JJ, Woo JI, Lee YS, et al. Assessment of the relationship between plasma nortriptyline concentration and inhibition of salivation: single-dose study. Asia Pac J Pharmacol 1991;6:249-54.
    • (1991) Asia Pac J Pharmacol , vol.6 , pp. 249-254
    • Jang, I.1    Shin, J.2    Shin, S.3    Kim, J.J.4    Woo, J.I.5    Lee, Y.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.