메뉴 건너뛰기




Volumn 59, Issue 6, 1999, Pages 298-309

Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes

Author keywords

Citalopram; Cytochrome P450; Metabolism; Stereoselectivity

Indexed keywords

CITALOPRAM; COMPLEMENTARY DNA; CYTOCHROME P450; SEROTONIN UPTAKE INHIBITOR;

EID: 0032706936     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028333     Document Type: Article
Times cited : (101)

References (31)
  • 1
    • 0025976411 scopus 로고
    • Citalopram: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness
    • Milne RJ, Goa KL: Citalopram: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 1991;41:450-477.
    • (1991) Drugs , vol.41 , pp. 450-477
    • Milne, R.J.1    Goa, K.L.2
  • 2
    • 0028294525 scopus 로고
    • Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
    • Hyttel J: Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int Clin Psychopharmacol 1994;9:19-26.
    • (1994) Int Clin Psychopharmacol , vol.9 , pp. 19-26
    • Hyttel, J.1
  • 3
  • 5
    • 0021253024 scopus 로고
    • High-performance liquid chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients
    • Oyehaug E, Ostensen ET, Salvesen B: High-performance liquid Chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients. J Chromatogr 1984;308:199-208.
    • (1984) J Chromatogr , vol.308 , pp. 199-208
    • Oyehaug, E.1    Ostensen, E.T.2    Salvesen, B.3
  • 8
    • 0030957623 scopus 로고    scopus 로고
    • Identification of three cytochrome P450 isozymes involves in N-demethylation of citalopram enantiomers in human liver microsomes
    • Rochat B, Amey M, Gillet M, Meyer UA, Baumann P: Identification of three cytochrome P450 isozymes involves in N-demethylation of citalopram enantiomers in human liver microsomes. Pharmacogenetics 1997;7:1-10.
    • (1997) Pharmacogenetics , vol.7 , pp. 1-10
    • Rochat, B.1    Amey, M.2    Gillet, M.3    Meyer, U.A.4    Baumann, P.5
  • 9
    • 0031751079 scopus 로고    scopus 로고
    • Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver
    • Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P: Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver. Biochem Pharmacol 1998;56:15-23.
    • (1998) Biochem Pharmacol , vol.56 , pp. 15-23
    • Rochat, B.1    Kosel, M.2    Boss, G.3    Testa, B.4    Gillet, M.5    Baumann, P.6
  • 10
    • 0031434742 scopus 로고    scopus 로고
    • Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes
    • Linnet K, Olesen OV: Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos 1997;25:1379-1382.
    • (1997) Drug Metab Dispos , vol.25 , pp. 1379-1382
    • Linnet, K.1    Olesen, O.V.2
  • 11
    • 0026537062 scopus 로고
    • Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
    • Fuhr U, Doehmer J, Battula N, Wolfel C, Kudla C, Keita Y, Staib AH: Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Biochem Pharmacol 1992; 43:225-235.
    • (1992) Biochem Pharmacol , vol.43 , pp. 225-235
    • Fuhr, U.1    Doehmer, J.2    Battula, N.3    Wolfel, C.4    Kudla, C.5    Keita, Y.6    Staib, A.H.7
  • 12
    • 0030735733 scopus 로고    scopus 로고
    • Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes
    • Olesen OV, Linnet K: Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes. Pharmacology 1997;55:235-243.
    • (1997) Pharmacology , vol.55 , pp. 235-243
    • Olesen, O.V.1    Linnet, K.2
  • 13
    • 0027264432 scopus 로고
    • Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver
    • Leemann T, Transon C, Dayer P: Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver. Life Sci 1993;52:29-34.
    • (1993) Life Sci , vol.52 , pp. 29-34
    • Leemann, T.1    Transon, C.2    Dayer, P.3
  • 14
    • 0023136337 scopus 로고
    • Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes
    • Hall SD, Guengerich FP, Branch RAm, Wilkinson GR: Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. J Pharmacol Exp Ther 1987;240:216-222.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 216-222
    • Hall, S.D.1    Guengerich, F.P.2    Branch, R.Am.3    Wilkinson, G.R.4
  • 15
    • 0026001359 scopus 로고
    • Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline
    • Dahl ML, Nordin C, Bertilsson L: Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline. Ther Drug Monit 1991;13:189-194.
    • (1991) Ther Drug Monit , vol.13 , pp. 189-194
    • Dahl, M.L.1    Nordin, C.2    Bertilsson, L.3
  • 16
    • 0029035739 scopus 로고
    • Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYPE2E1 genetic polymorphisms
    • Kim RB, O'Shea D: Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYPE2E1 genetic polymorphisms. Clin Pharmacol Ther 1995;67:645-655.
    • (1995) Clin Pharmacol Ther , vol.67 , pp. 645-655
    • Kim, R.B.1    O'Shea, D.2
  • 17
    • 0030028816 scopus 로고    scopus 로고
    • Simplified high-performance liquid chromatographic method for the determination of citalopram and desmethylcitalopram in serum without interference from commonly used psychotropic drugs and their metabolites
    • Olesen OV, Linnet K: Simplified high-performance liquid chromatographic method for the determination of citalopram and desmethylcitalopram in serum without interference from commonly used psychotropic drugs and their metabolites. J Chromatogr [B] 1996;675:83-88.
    • (1996) J Chromatogr [B] , vol.675 , pp. 83-88
    • Olesen, O.V.1    Linnet, K.2
  • 18
    • 0004119676 scopus 로고
    • London, Oxford University Press
    • Motulsky H: Intuitive Biostatistics. London, Oxford University Press, 1995, pp 279-282.
    • (1995) Intuitive Biostatistics , pp. 279-282
    • Motulsky, H.1
  • 19
    • 5844225066 scopus 로고
    • m in enzyme reactions
    • m in enzyme reactions. Science 1952;116:329-331.
    • (1952) Science , vol.116 , pp. 329-331
    • Hofstee, B.H.J.1
  • 20
    • 0029035234 scopus 로고
    • Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography
    • Rochat B, Amey M, Baumann P: Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography. Ther Drug Monit 1995;17:273-279.
    • (1995) Ther Drug Monit , vol.17 , pp. 273-279
    • Rochat, B.1    Amey, M.2    Baumann, P.3
  • 21
    • 0030682236 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans
    • Sidhu J, Priskorn M, Poulsen M, Segonzac A, Grollier G, Larsen F: Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans. Chirality 1997;9:686-692.
    • (1997) Chirality , vol.9 , pp. 686-692
    • Sidhu, J.1    Priskorn, M.2    Poulsen, M.3    Segonzac, A.4    Grollier, G.5    Larsen, F.6
  • 22
    • 0029738965 scopus 로고    scopus 로고
    • Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
    • Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K: Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 1996;51:73-78.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 73-78
    • Jeppesen, U.1    Gram, L.F.2    Vistisen, K.3    Loft, S.4    Poulsen, H.E.5    Brosen, K.6
  • 24
    • 0345632734 scopus 로고    scopus 로고
    • Fluvoxamine-clozapine drug interaction: Inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism
    • in press
    • Olesen OV, Linnet K: Fluvoxamine-clozapine drug interaction: Inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. J Clin Psychopharmacol 1999;in press.
    • (1999) J Clin Psychopharmacol
    • Olesen, O.V.1    Linnet, K.2
  • 25
  • 27
    • 0021739994 scopus 로고
    • Effect of phenothiazines on citalopram steady-state kinetics in psychiatric patients
    • Øyehaug E, Eide E, Salvesen B: Effect of phenothiazines on citalopram steady-state kinetics in psychiatric patients. Nord Pharm Acta 1984;46: 37-46.
    • (1984) Nord Pharm Acta , vol.46 , pp. 37-46
    • Øyehaug, E.1    Eide, E.2    Salvesen, B.3
  • 29
    • 0030018415 scopus 로고    scopus 로고
    • Substituting carbamazepine with oxcarbazepine increases citalopram levels: A report on two cases
    • Leinonen E, Lepola U, Koponen H: Substituting carbamazepine with oxcarbazepine increases citalopram levels: A report on two cases. Pharmacopsychiatry 1996;29:156-158.
    • (1996) Pharmacopsychiatry , vol.29 , pp. 156-158
    • Leinonen, E.1    Lepola, U.2    Koponen, H.3
  • 30
    • 0031010982 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects
    • Priskorn M, Larsen F, Segonzac A, Moulin M: Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects. Eur J Clin Pharmacol 1997;52:241-242.
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 241-242
    • Priskorn, M.1    Larsen, F.2    Segonzac, A.3    Moulin, M.4
  • 31
    • 0029903801 scopus 로고    scopus 로고
    • Non-response to citalopram in depressive patients: Pharmacokinetic and clinical consequences of a fluvoxamine augmentation
    • Berl
    • Bondolfi G, Chautems C, Rochat B, Bertschy G, Baumann P: Non-response to citalopram in depressive patients: Pharmacokinetic and clinical consequences of a fluvoxamine augmentation. Psychopharmacology(Berl) 1996;128:421-425.
    • (1996) Psychopharmacology , vol.128 , pp. 421-425
    • Bondolfi, G.1    Chautems, C.2    Rochat, B.3    Bertschy, G.4    Baumann, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.