A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis

Molecular Diversity

Volumn 13, Issue 1, 2009, Pages 5-25

  Kolosov, Maksim A ^a   Orlov, Valeriy D ^a   Beloborodov, Dmitriy A ^a   Dotsenko, Victor V ^b,c  

^a V N KARAZIN KHARKIV NATIONAL UNIVERSITY   (Ukraine)

^b Physico chemical Department   (Ukraine)

^c VOLODYMYR DAHL EAST UKRAINIAN NATIONAL UNIVERSITY   (Ukraine)

Author keywords

Biginelli reaction; Condensation; Cyclization; Heterocycles; Sodium chloride

Indexed keywords

3,4 DIHYDROPYRIMIDIN 2 (1H)ONE DERIVATIVE; 3,4 DIHYDROPYRIMIDIN 2 (1H)THIONE DERIVATIVE; 5 ACETYL 4 (2 FURYL) 6 METHYL 3,4 DIHYDROPYRIMIDINE 2 (1H)ONE; 5 ACETYL 4 (4 BROMOPHENYL) 6 METHYL 3,4 DIHYDROPYRIMIDINE 2 (1H)ONE; 5 ACETYL 4 (4 CHLOROPHENYL) 6 METHYL 3,4 DIHYDROPYRIMIDINE 2 (1H)ONE; 5 ACETYL 4 (4 METHOXYPHENYL) 6 METHYL 3,4 DIHYDROPYRIMIDINE 2 (1H)ONE; 5 ACETYL 4 (4 METHOXYPHENYL) 6 METHYL 4 PHENYL 3,4 DIHYDROPYRIMIDINE 2 (1H)THIONE; 5 ACETYL 6 METHYL 4 PHENYL 3,4 DIHYDROPYRIMIDINE 2 (1H)ONE; 5 ACETYL 6 METHYL 4 PHENYL 3,4 DIHYDROPYRIMIDINE 2 (1H)THIONE; ETHYL 6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; N(4 CHLOROPHENYL) 4 ETHYL 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; PYRIMIDINE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

BIGINELLI REACTION; CATALYST; DRUG SYNTHESIS; PRIORITY JOURNAL; REVIEW;

CATALYSIS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PYRIMIDINES; SODIUM CHLORIDE; STEREOISOMERISM;

EID: 58849138719     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-008-9094-8     Document Type: Review

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242. 2/MeCN: Venkat Narsaiah A, Basak AK, Nagaiah K (2004) Cadmium chloride: an efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Synthesis 2004: 1253-1256
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245. 2/PhMe: Bhosale RS, Bhosale SV, Bhosale SV, Wang T, Zubaidha PK (2004) An efficient, high yield protocol for the one-pot synthesis of dihydropyrimidin-2(1H)-ones catalyzed by iodine. Tetrahedron Lett 45:9111-9113
246. 3/100°C/sf: De SK, Gibbs RA (2005) Ruthenium(III) chloride-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions. Synthesis 2005:1748-1750
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250. 2O. Synth Commun 34:1551-1557
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252. 4S(O)OH: Shutalev AD, Sivova NV (1998) Synthesis of 4-Alkyl-substituted 1,2,3,4-tetrahydropyrimidin-2-ones by the Biginelli reaction. Chem Heterocycl Comp 34:848-851
253. 4 in water. Bioorg Med Chem Lett 16:4479-4482
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255. 4/AcOH: Folkers K, Johnson TB (1933) Researches on pyrimidines. CXXXIV. The reaction of phenylacetaldehyde and acetophenone with urea. J Am Chem Soc 55:3361-3368
256. 2O-LiCl as an inexpensive catalyst system. Synth Commun 34:1559-1564
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259. 3/MeCN: De SK, Gibbs RA (2005) Scandium(III) triflate as an efficient and reusable catalyst for synthesis of 3,4-dihydropyrimidin- 2(1H)-ones. Synth Commun 35:2645-2651
260. 2O/80°C/sf: Zhang GL, Cai XH (2005) Magnesium chloride hexahydrate catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions. Synth Commun 35:829-833
261. 2O/MeCN or sf: Romanelli GP, Sathicq AG, Autino JC, Baronetti G, Thomas HJ (2007) Solvent-free approach to 3,4-dihydropyrimidin-2(1H)-(thio)ones: Biginelli reaction catalyzed by a Wells-Dawson reusable heteropolyacid. Synth Commun 37:3907-3916
262. 3/MeCN: Reddy YT, Rajitha B, Reddy PN, Kumar BS, Rao VPG (2004) Bismuth subnitrate catalyzed efficient synthesis of 3,4-dihydropyrimidin- 2(1H)-ones: an improved protocol for the Biginelli reaction. Synth Commun 34:3821-3825
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266. 2/LiCl/EtOH: Manjula A, Rao BV, Neelakantan P (2005) An inexpensive protocol for Biginelli reaction. Synth Commun 34:2665-2671
267. 2 as catalyst. Prep Biochem Biotechnol 36:375-381
268. 2/sf: Yu Y, Liu D, Liu C, Jiang H, Luo G (2007) An efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions. Prep Biochem Biotechnol 37(4):381-387
269. 3H as catalyst for 3,4-dihydropyrimidones via Biginelli reaction under microwave and solvent-free conditions. Synth Commun 36:451-456
270. CAN or Oxone/MeOH/sonication: Yadav JS, Reddy BVS, Reddy KB, Raj KS, Prasad AR (2001) Ultrasound-accelerated synthesis of 3,4-dihydropyrimidin-2(1H)- ones with ceric ammonium nitrate. J Chem Soc Perkin Trans 1:1939-1941
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273. PPE/MWI: Foroughifar N, Mobinikhaledi A, Fathinejad Jirandehi H, Memar S (2003) Microwave-assisted synthesis of some Bi- and Tricyclic pyrimidine derivatives. Phosphorus Sulfur Silicon Relat Elem 178:1269-1276
274. PPE/MWI: Kappe CO, Kumar D, Varma RS (1999) Microwave-assisted high-speed parallel synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones using a solventless Biginelli condensation protocol. Synthesis 1999:1799-1803
275. h ν/THF: Foroughifar N, Mobinikhaledi A, Fathinejad Jirandehi H (2003) Synthesis of some Biginelli compounds in solvent medium using a photochemistry method. Phosphorus Sulfur Silicon Relat Elem 178:495-500
276. 2O or sf: Bose DS, Fatima L, Mereyala HB (2003) Green chemistry approaches to the synthesis of 5-alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones by a three-component coupling of one-pot condensation reaction: comparison of ethanol, water, and solvent-free conditions. J Org Chem 68:587-590
277. 3/EtOH: Fu NY, Yuan YF, Cao Z, Wang SW, Wang JT, Peppe C (2002) Indium (III) bromide-catalyzed preparation of dihydropyrimidinones: improved protocol conditions for the Biginelli reaction. Tetrahedron 58:4801-4807
278. 2O/EtOH: Fu NY, Yuan YF, Pang ML, Wang JT, Peppe C (2003) Indium(III) halides-catalyzed preparation of ferrocenedihydropyrimidinones. J Organomet Chem 672:52-57
279. 4/EtOH: Venkateshwar Reddy C, Mahesh M, Raju PVK, Ramesh Babu T, Narayana Reddy VV (2002) Zirconium(IV) chloride catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron Lett 43:2657-2659
280. 2 under neat conditions: optimized green alternatives for the Biginelli reaction. Tetrahedron Lett 48:5777-5780
281. 2O-mediated three-component, one-pot, condensation reaction: an efficient synthesis of 4-aryl-substituted 3,4-dihydropyrimidin-2-ones. Tetrahedron Lett 42:7873-7875
282. Ytterbium(III)-resin: Dondoni A, Massi A (2001) Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under
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285. 2: a reusable catalyst for high-yield synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron Lett 44: 3305-3308
286. -/sf/100°C: Reddy KR, Reddy CV, Mahesh M, Raju PVK, Reddy VVN (2003) New environmentally friendly solvent free synthesis of dihydropyrimidinones catalysed by N-butyl-N,N- dimethyl-α-phenylethylammonium bromide. Tetrahedron Lett 44:8173-8175
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288. 4Cl/ultrasound irradiation/MeOH: Stefani HA, Oliveira CB, Almeida RB, Pereira CMP, Braga RC, Cella R, Borges VC, Savegnago L, Nogueira CW (2006) Dihydropyrimidin-2(1H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents. Eur J Med Chem 41:513-518
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290. 2O/MWI: Gohain M, Prajapati D, Sandhu JS (2004) A novel Cu-catalysed three-component one-pot synthesis of dihydropyrimidin-2(1H)-ones using microwaves under solvent-free conditions. Synlett 2004:235-238
291. Ion exchange resins (Amberlyst-15, Nafion H)/AcOH/MWI: Yadav JS, Reddy BVS, Reddy EJ, Ramalingam T (2000) Microwave-assisted efficient synthesis of dihydropyrimidines: improved high yielding protocol for the Biginelli reaction. J Chem Res Synop 7:354-355
292. 4/MeCN: Adharvana Chari M, Syamasundar K (2004) Silicagel supported sodium hydrogensulfate as a heterogenous catalyst for high yield synthesis of 3,4-dihydropyrimidin-2(1H)-ones. J Mol Catal A Chem 221:137-139
293. Silica/Fe (Ferrihydrite silica aerogels)/EtOH: Martínez S, Meseguer M, Casas L, Rodríguez E, Molins E, Moreno-Manas M, Roig A, Sabastián RM, Vallribera A (2003) Silica aerogel-iron oxide nanocomposites: recoverable catalysts in conjugate additions and in the Biginelli reaction. Tetrahedron 59:1553-1556
294. 2O)/HCl/EtOH: Lannou M-L, Hélion F, Namy J-L (2008) Applications of lanthanide trichloride hydrates, prepared from mischmetall, in the Biginelli reaction. Synlett 2008:105-107
295. 3/graphite/HCl/MWI/sf: Khabazzadeh H, Saidi K, Sheibani H (2008) Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst. Bioorg Med Chem Lett 18:278-280
296. 2H/sf/90°C: Yu Y, Liu D, Liu C, Luo G (2007) One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst. Bioorg Med Chem Lett 17:3508-3510
297. Aluminia-sulfuric acid: Besoluk S, Kucukislamoglu M, Nebioglu N, Zengin M, Arslan M (2008) Solvent-free synthesis of dihydropyrimidinones catalyzed by alumina sulfuric acid at room temperature. J Iran Chem Soc 5:62-66
298. 3 as an efficient catalyst for the preparation of 3,4-dihydropyrimidin-2(1H)-ones in solution and under solvent-free conditions. J Iran Chem Soc 5:96-99
299. 2O: Xu F, Wang JJ, Tian YP (2008) New procedure for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by Biginelli reaction. Synth Commun 38:1299-1310
300. Pyrazolidine dihydrochloride: Suzuki I, Iwata Y, Takeda K (2008) Biginelli reactions catalyzed by hydrazine type organocatalyst. Tetrahedron Lett 49:3238-3241
301. 2/AcOH: Liu CJ, Wang JD, Li YP (2006) One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)ones using strontium(II) nitrate as a catalyst. J Mol Catal A Chem 258: 367-370
302. 2O, MeCN or sf: Kalita HR, Phukan P (2007) CuI as reusable catalyst for the Biginelli reaction. Catal Commun 8:179-182
303. Uronium hydrogen sulfates/sf: Salehi P, Dabiri M, Zolfigol MA, Baghbanzadeh M (2005) A green approach to the synthesis of 2,3-dihydropyrimidin- 2(1H)-ones by uronium hydrogansulfate under solvent-free conditions. Heterocycles 65:1177-1181
304. 4/AcOH: Heravi MM, Bakhtiari K, Bamoharram FF (2006) 12-Molybdophosphoric acid: a recyclable catalyst for the synthesis of Biginelli-type 3,4-dihydropyrimidine-2(1H)-ones. Catal Commun 7:373-376
305. 4/sf: Valizadeh H, Gholipur H, Zarrebin R, Amiri M, Sabzi MR (2008) Titanium(IV) Chloride catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions via three-component Biginelli reaction. Phosphorus Sulfur Silicon Relat Elem 183:1552-1555
306. 4/EtOH/80°C: Nagawade RR, Kotharkar SA, Shinde DB (2005) Titanium(IV) chloride catalyzed one-pot synthesis of 3,4- dihydropyrimidin-2(1H)-ones and thiones. Mendeleev Commun 15:150-151
307. 40/MeCN: Fazaeli R, Tangestaninejad S, Aliyan H, Moghadam M (2006) One-pot synthesis of dihydropyrimidinones using facile and reusable polyoxometalate catalysts for the Biginelli reaction. Appl Catal A Gen 309:44-51
308. 40/MeCN: Rafiee E, Jafari H (2006) A practical and green approach towards synthesis of dihydropyrimidinones: using heteropoly acids as efficient catalysts. Bioorg Med Chem Lett 16:2463-2466
309. 40 catalyzed expeditious synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions. Catal Commun 7:457-459
310. 40): an efficient and eco-friendly catalyst for the one-pot synthesis of dihydropyrimidin-2(1H)-ones. Catal Commun 7:843-847
311. 4- catalyzed Biginelli reaction: one-pot synthesis of dihydropyrimidin-2(1H)-ones under solvent-free conditions. Catal Commun 8:123-126
312. Trichloroisocyanuric acid/EtOH: Bigdeli MA, Jafari S, Mahdavinia GH, Hazarkhani H (2007) Trichloroisocyanuric acid, a new and efficient catalyst for the synthesis of dihydropyrimidinones. Catal Commun 8:1641-1644
313. 2O/neat: Kamal A, Krishnaji T, Azhar MA (2007) Copper(II) tetrafluoroborate as a mild and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions. Catal Commun 8:1929-1933
314. 3/sf: Adibi H, Samimi HA, Beygzadeh M (2007) Iron(III) trifluoroacetate and trifluoromethanesulfonate: recyclable lewis acid catalysts for one-pot synthesis of 3,4-dihydropyrimidinones or their sulfur analogues and 1,4-dihydropyridines via solvent-free Biginelli and Hantzsch condensation protocols. Catal Commun 8:2119-2124
315. 3: An efficient and reusable heterogeneous catalyst for synthesis of 3,4-dihydropyridine-2(1H)-ones under solvent free conditions. Catal Commun 9: 499-503
316. n as catalyst under solvent-free conditions. Chin J Catal 28:591-595
317. 2H/sf/MWI: Jiang C, You QD (2007) An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation. Chin Chem Lett 18:647-650
318. 2O)/AcOH: Tajbakhsh M, Mohajerani B, Heravi MM, Ahmadi AN (2005) Natural HEU type zeolite catalyzed Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives. J Mol Catal A Chem 236:216-219
319. Ion exchange resin Nafion NR-50/MeCN: Joseph JK, Jain SL, Sain B (2006) Ion exchange resins as recyclable and heterogeneous solid acid catalysts for the Biginelli condensation: an improved protocol for the synthesis of 3,4-dihydropyrimidin-2-ones. J Mol Catal A Chem 247:99-102
320. 2/MeCN: Rafiee E, Shahbazi F (2006) One-pot synthesis of dihydropyrimidones using silica-supported heteropoly acid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli reaction. J Mol Catal A Chem 250:57-61
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322. 2 under ultrasound irradiation. J Mol Catal A Chem 253:207-211
323. 3H/MeCN: Gupta R, Paul S, Gupta K (2007) Covalently anchored sulfonic acid onto silica as an efficient and recoverable interphase catalyst for the synthesis of 3,4-dihydropyrimidinones/thiones. J Mol Catal A Chem 266:50-54
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325. Nafion-H resin/EtOH: Lin H, Zhao Q, Xu B, Wang X (2007) Nafion-H catalyzed cyclocondensation reaction for the synthesis of octahydroquinazolinone derivatives. J Mol Catal A Chem 268:221-226
326. 2O: A novel and reusable catalyst for one pot synthesis of 3,4-dihydropyrimidin-2(1H)- ones under solvent-free conditions. J Mol Catal A Chem 271: 14-17
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328. 4/DMF/MeCN/rt: Ramalingan C, Kwak YW (2008) Tetrachlorosilane catalyzed multicomponent one-step fusion of biopertinent pyrimidine heterocycles. Tetrahedron 64: 5023-5031
329. 2/sf: Su W, Li J, Zheng Z, Shen Y (2005) One-pot synthesis of dihydropyrimidiones catalyzed by strontium(II) triflate under solvent-free conditions. Tetrahedron Lett 46:6037-6040
330. 2O/20°C: Karimullah EA (1967) Pakistan J Sci Ind Res 10:83;
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340. 3OH)/sf: Kumar A, Maurya RA (2007) Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones using Ziegler-Natta catalyst system under solvent free conditions. J Mol Catal A Chem 272:53-56
341. 3/MWI/sf: Saxena I, Borah DC, Sarma JC (2005) Three component condensations catalyzed by iodine-alumina for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones under microwave irradiation and solvent-free conditions. Tetrahedron Lett 46:1159-1160
342. 2O: Sabitha G, Reddy KB, Yadav JS, Shailaja D, Sivudu KS (2005) Ceria/vinylpyridine polymer nanocomposite: an ecofriendly catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron Lett 46:8221-8224
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344. 4/MeOH: Yarapathi RV, Kurva S, Tammishetti S (2004) Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using reusable poly (4-vinylpyridine-co-divinylbenzene)-Cu(II)complex. Catal Commun 5:511-513
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348. 3 catalyst. Catal Commun 4:449-453
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353. 2/EtOH: Wang CF, Jiang H, Gong H, Wang M, Wang ZC (2006) Biginelli condensation of aliphatic aldehydes catalyzed by inorganic zinc compounds. Chin J Org Chem 26:333-336
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