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Volumn , Issue 2, 2004, Pages 279-282

A Remarkable Rate Acceleration of the One-Pot Three-Component Cyclocondensation Reaction at Room Temperature: An Expedient Synthesis of Mitotic Kinesin Eg5 Inhibitor Monastrol

Author keywords

3,4 dihydropyrimidin 2(1H) ones; Biginelli reaction; Mitotic; Monastrol

Indexed keywords

ALDEHYDE DERIVATIVE; ESTER DERIVATIVE; KINESIN; MONASTROL; PROTEIN INHIBITOR; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG; UREA;

EID: 1242318623     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815416     Document Type: Article
Times cited : (47)

References (30)
  • 1
    • 0034665244 scopus 로고    scopus 로고
    • Passerini three-component and Ugi four-component condensations are the most popular among many other reactions for their wide scope and synthetic utility. For reviews, see: (a) Bienayme, H.; Hulme, C.; Oddon, G.; Schmitt, P. Chem.-Eur. J. 2000, 6, 3321. (b) Domling, A.; Ugi, I. Angew. Chem. Int. Ed. 2000, 39, 3168.
    • (2000) Chem.-Eur. J. , vol.6 , pp. 3321
    • Bienayme, H.1    Hulme, C.2    Oddon, G.3    Schmitt, P.4
  • 2
    • 0034665244 scopus 로고    scopus 로고
    • Passerini three-component and Ugi four-component condensations are the most popular among many other reactions for their wide scope and synthetic utility. For reviews, see: (a) Bienayme, H.; Hulme, C.; Oddon, G.; Schmitt, P. Chem.-Eur. J. 2000, 6, 3321. (b) Domling, A.; Ugi, I. Angew. Chem. Int. Ed. 2000, 39, 3168.
    • (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 3168
    • Domling, A.1    Ugi, I.2
  • 7
    • 0027205552 scopus 로고
    • and references cited therein
    • For a review, see: (a) Kappe, C. O. Tetrahedron 1993, 49, 6937; and references cited therein. (b) Kappe, C. O. Acc. Chem. Res. 2000, 33, 879.
    • (1993) Tetrahedron , vol.49 , pp. 6937
    • Kappe, C.O.1
  • 8
    • 0034518876 scopus 로고    scopus 로고
    • For a review, see: (a) Kappe, C. O. Tetrahedron 1993, 49, 6937; and references cited therein. (b) Kappe, C. O. Acc. Chem. Res. 2000, 33, 879.
    • (2000) Acc. Chem. Res. , vol.33 , pp. 879
    • Kappe, C.O.1
  • 9
    • 1242302999 scopus 로고    scopus 로고
    • note
    • Biginelli stated (ref. 3) that his research was inspired by the earlier work of R. Behrend on the urea-ketoester coupling and U. Schiff on the urea-aldehyde coupling.
  • 27
    • 1242348061 scopus 로고    scopus 로고
    • note
    • +], 247 (81), 229 (97), 203 (71), 183 (100).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.