Studies on the Biginelli reaction: A mild and selective route to 3,4-dihydropyrimidin-2(1H)-ones via enamine intermediates

Tetrahedron Letters

Volumn 47, Issue 1, 2006, Pages 55-56

  Mabry, John ^a   Ganem, Bruce ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Biginelli; Dihydropyrimidinones; Enamines

Indexed keywords

ENAMINE; PYRIMIDINE DERIVATIVE;

ARTICLE; BIGINELLI REACTION; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CATALYST; CHEMICAL REACTION; DRUG SYNTHESIS; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 28544451673     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.10.124     Document Type: Article

References (12)

1. Review: C.O. Kappe Acc. Chem. Res. 33 2000 879
2. For a recent compilation of useful catalysts, see: Q. Sun, Y. Wang, Z. Ge, T. Cheng, and R. Li Synthesis 2004 1047
3. B. List, L. Hoang, and H.J. Martin Proc. Natl. Acad. Sci. U.S.A. 101 2004 5839
4. J.S. Yadav, S.P. Kumar, G. Kondaji, R.S. Rao, and K. Nagaiah Chem. Lett. 33 2004 1168
5. -1.
6. J.F. Austin, and D.W.C. MacMillan J. Am. Chem. Soc. 124 2002 1172
7. Prepared as described in R.B. Rao, U.P. Singh, and G.V. Bhide Tetrahedron Lett. 1967 719
8. 4Cl as catalyst has recently been reported, under more forcing conditions: A. Shaabani, A. Basgir, and F. Teimouri Tetrahedron Lett. 44 2003 857
9. J.A. Kloek, and F.L. Leschinsky J. Org. Chem. 43 1978 1460
10. J.S. McManis, and B. Ganem J. Org. Chem. 45 1980 2041
11. O. Munoz-Muniz, and E. Juaristi ARKIVOC 9 2003 16
12. Example: A.S. Franklin, S.K. Ly, G.H. Macklin, L.E. Overman, and A.J. Shaka J. Org. Chem. 64 1999 1612