PEG-assisted solvent and catalyst free synthesis of 3,4-dihydropyrimidinones under mild reaction conditions

Green Chemistry

Volumn 9, Issue 7, 2007, Pages 740-74

  Jain, Suman L ^a   Singhal, Sweety ^a   Sain, Bir ^a  

^a CSIR INDIAN INSTITUTE OF PETROLEUM   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547280363     PISSN: 14639262     EISSN: 14639270     Source Type: Journal    
DOI: 10.1039/b702311a     Document Type: Article

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32. General experimental procedure: a stirred mixture containing the aldehyde (2 mmol), urea/thiourea (2 mmol), β-dicarbonyl compound (2 mmol) and PEG-400 (0.2 g) was heated at 100 °C for 45 min. After completion, the reaction mixture became a solid with a yellow color, which was separated and washed with water. The resulting crude product was recrystallized with ethanol to afford pure 3,4-dihydropyirimidinones. All the products were characterized by comparing their physical and spectral data with those of reported compounds.
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