Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities

European Journal of Medicinal Chemistry

Volumn 42, Issue 3, 2007, Pages 380-385

  Ashok, Mithun ^a   Holla, Bantwal Shivarama ^a   Kumari, Nalilu Suchetha ^b  

^a MANGALORE UNIVERSITY   (India)

^b NITTE DEEMED TO BE UNIVERSITY   (India)

Author keywords

4 Methylthiophenyl; Antibacterial; Antifungal; Thiazolo 2,3 b dihydropyrimidinones

Indexed keywords

ACETIC ACID DERIVATIVE; ALDEHYDE DERIVATIVE; CICLOPIROXOLAMINE; PYRIMIDINONE DERIVATIVE; THIAZOLE DERIVATIVE; THIAZOLO[2,3 B]DIHYDROPYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; FUNGUS GROWTH; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; CHROMATOGRAPHY, THIN LAYER; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; PYRIMIDINONES; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THIAZOLES;

EID: 33847753903     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.09.003     Document Type: Article

References (27)

1. Domling A. Curr. Opin. Chem. Biol. 4 (2000) 318
2. Weber L. Drug Discov. Today 7 (2002) 143
3. Domling A. Curr. Opin. Chem. Biol. 6 (2002) 306
4. Dolle R.E., and Nelson K.H. J. Comb. Chem. 1 (1999) 235
5. Thompson L.A., and Ellman J.A. Chem. Rev. 96 (1996) 555
6. Gordon E.M., Gallop M.A., and Patel D.V. Acc. Chem. Res. 29 (1996) 144
7. Lee D., Sello J.K., and Schreiber S.L. Org. Lett. 2 (2000) 709
8. Kappe C.O. Eur. J. Med. Chem. 35 (2000) 1043
9. Hurst E.W., and Hull R. J. Med. Pharm. Chem. 3 (1961) 215
10. Mayer T.U., Kapoor T.M., Haggarty S.J., King R.W., Schreiber S.I., and Mitchison T.J. Science 286 (1999) 971
11. T. Kato, Japanese Kokai Tokkyo Koho 59 190, 1984, 974.
12. Atwal K.S., Swanson B.N., Unger S.E., Floyd D.M., Moreland S., Hedberg A., and O'Reilly B.C. J. Med. Chem. 34 (1991) 806
13. Rovnyak G.C., Atwal K.S., Hedberg A., Kimball S.D., Moreland S., Gougoutas J.Z., O'Reilly B.C., Schwartz J., and Malley M.F. J. Med. Chem. 35 (1992) 3254
14. Kappe C.O. Molecules 3 (1998) 1
15. Jauk B., Pernat T., and Kappe C.O. Molecules 5 (2000) 227
16. Patil A.D., Kumar N.V., Kokke W.C., Bean M.F., Freyer A.J., Debrossi C., Mai S., Trunch A., Faulkner D.J., Carte B., Breen A.L., Hertzberg R.P., Johnson R.K., Westley J.W., and Potts B.C.M. J. Org. Chem. 60 (1995) 1182
17. N. Hans, Swiss Patent 592103, 1997;
18. Chem. Abstr. 88 (1978) 22886
19. Wilson K.J., Utig C.R., Subhasinghe N., Hoffmann J.B., Rudolph N.J., Soll R., Molloy C.J., Bone R., and Green D. Bioorg. Med. Chem. Lett. 11 (2001) 915
20. Berlin K.D., and Herd M.D. Proc. Okla. Acad. Sci. 71 (1991) 29
21. Holla B.S., Malini K.V., Rao B.S., Sarojini B.K., and Kumari N.S. Eur. J. Med. Chem. 38 (2003) 313
22. Holla B.S., Mahalinga M., Ashok M., and Karegoudar P. Phosphorus, Sulfur Silicon Relat. Elem. 181 (2006) 1427
23. Russowsky D., Lopes F.A., da Silva V.S.S., Canto K.F.S., D'Oca M.G.M., and Godoi M.N. J. Braz. Chem. Soc. 15 (2004) 165
24. Cruickshank R., Duguid J.P., Marion B.P., and Swain R.H.A. Medicinal Microbiology. twelfth ed. vol. 11 (1975), Churchill Livingstone, London p. 196
25. Collins A.H. Microbiological Methods. second ed. vol. 11 (1976), Butterworth, London
26. Z.K. Khan, In vitro and vivo screening techniques for bioactivity screening and evaluation, in: Proceedings of International Workshop, UNIDO-CDRI, 1997, p. 210.
27. Antifungal agents. In: Verma R.S. (Ed). Past, Present and Future Prospects (1998), National Academy of Chemistry and Biology, India, Lucknow