Design and synthesis of novel α(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Journal of Medicinal Chemistry

Volumn 42, Issue 23, 1999, Pages 4778-4793

  Dhar, T G Murali ^a,c   Nagarathnam, Dhanapalan ^a   Marzabadi, Mohammad R ^a   Lagu, Bharat ^a   Wong, Wai C ^a   Chiu, George ^a   Tyagarajan, Sriram ^a   Miao, Shou Wu ^a   Zhang, Fengqi ^a   Sun, Wanying ^a   Tian, Dake ^a   Shen, Quanrong ^a   Zhang, Jack ^a   Wetzel, John M ^a   Forray, Carlos ^a   Chang, Raymond S L ^b   Broten, Theodore P ^b   Schorn, Terry W ^b   Chen, Tsing Bao ^b   O'Malley, Stacy ^b   Ransom, Richard ^b   Schneck, Kathryn ^b   Bendesky, Robert ^b   Harrell, Charles M ^b   Vyas, Kamlesh P ^b   Zhang, Kanyin ^b   Gilbert, John ^b   Pettibone, Douglas J ^b   Patane, Michael A ^b   Bock, Mark G ^b   Freidinger, Roger M ^b   Gluchowski, Charles ^a   more..

^a H LUNDBECK A S   (Denmark)

^b MERCK RESEARCH LABORATORIES   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N [3 (4 METHYL 4 PHENYLPIPERIDIN 1 YL)PROPYL]CARBOXAMIDO] 6 (3,4 DIFLUOROPHENYL) 5 METHOXYCARBONYL 4 METHOXYMETHYL 2 OXO 1,2,3,6 TETRAHYDROPYRIMIDINE; 5 CARBOXAMIDO 1 [N [3 (4 CYANO 4 PHENYLPIPERIDIN 1 YL)PROPYL]CARBOXAMIDO] 6 (2,4 DIFLUOROPHENYL) 4 ETHYL 2 OXO 1,2,3,6 TETRAHYDROPYRIMIDINE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DIHYDROPYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOG; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PROSTATE HYPERTROPHY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; DOGS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GTP-BINDING PROTEINS; HALF-LIFE; HUMANS; MALE; MICROSOMES; PIPERIDINES; PROSTATE; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, OPIOID, MU; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URETHRA;

EID: 0032749430     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990201h     Document Type: Article

References (27)

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