Design and synthesis of novel α(1a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains

Journal of Medicinal Chemistry

Volumn 42, Issue 23, 1999, Pages 4794-4803

  Lagu, Bharat ^a   Tian, Dake ^a   Nagarathnam, Dhanapalan ^a   Marzabadi, Mohammad R ^a   Wong, Wai C ^a   Miao, Shou W ^a   Zhang, Fengqi ^a   Sun, Wanying ^a   Chiu, George ^a   Fang, James ^a   Forray, Carlos ^a   Chang, Raymond S L ^b   Ransom, Richard W ^b   Chen, Tsing B ^b   O'Malley, Stacey ^b   Zhang, Kanyin ^b   Vyas, Kamlesh P ^b   Gluchowski, Charles ^a  

^a H LUNDBECK A S   (Denmark)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 [N [[4 (2 CARBOXAMIDOPHENYL)PIPERAZIN 1 YL]PROPYL]CARBOXAMIDO] 4 METHYL 6 (3,4 DIFLUOROPHENYL) 2 OXOPYRIMIDINE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DIHYDROPYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOG; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PROSTATE HYPERTROPHY; RAT; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; DOGS; DRUG DESIGN; GTP-BINDING PROTEINS; HALF-LIFE; HUMANS; MALE; PIPERAZINES; PROSTATE; PYRIMIDINONES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, OPIOID, MU; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032752508     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990202+     Document Type: Article

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