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Volumn 25, Issue 5, 2004, Pages 807-830

The cellular fate of glucose and its relevance in type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; HEXOKINASE; HEXOSAMINE; HEXOSE PHOSPHATE; INSULIN;

EID: 5444269110     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2003-0026     Document Type: Review
Times cited : (271)

References (312)
  • 1
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA 1988 Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 2
    • 0027953703 scopus 로고
    • Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR 1994 Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 3
    • 0026110135 scopus 로고
    • Banting lecture 1990. β-cells in type II diabetes mellitus
    • Porte Jr D 1991 Banting lecture 1990. β-cells in type II diabetes mellitus. Diabetes 40:166-180
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 4
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer C, Bogardus C, Mott DM, Pratley RE 1999 The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794
    • (1999) J Clin Invest , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 5
    • 0030671249 scopus 로고    scopus 로고
    • Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus
    • Ludvik B, Nolan JJ, Roberts A, Baloga J, Joyce M, Bell JM, Olefsky JM 1997 Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus. J Clin Invest 100:2354-2361
    • (1997) J Clin Invest , vol.100 , pp. 2354-2361
    • Ludvik, B.1    Nolan, J.J.2    Roberts, A.3    Baloga, J.4    Joyce, M.5    Bell, J.M.6    Olefsky, J.M.7
  • 6
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J 1985 Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76:149-155
    • (1985) J Clin Invest , vol.76 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3    Olsson, M.4    Wahren, J.5
  • 7
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI 2000 Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 8
    • 0025763663 scopus 로고
    • Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy
    • Baron AD, Laakso M, Brechtel G, Edelman SV 1991 Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy. J Clin Invest 87:1186-1194
    • (1991) J Clin Invest , vol.87 , pp. 1186-1194
    • Baron, A.D.1    Laakso, M.2    Brechtel, G.3    Edelman, S.V.4
  • 9
    • 0025980368 scopus 로고
    • Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models
    • Reaven GM 1991 Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models. Diabetes Care 14:195-202
    • (1991) Diabetes Care , vol.14 , pp. 195-202
    • Reaven, G.M.1
  • 10
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR 1992 Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340:925-929
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.S.5    Kahn, C.R.6
  • 11
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR 2001 Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 12
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR 1999 Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 14
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity
    • Poitout V, Robertson RP 2002 Minireview: secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342
    • (2002) Endocrinology , vol.143 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 15
    • 0035122488 scopus 로고    scopus 로고
    • Endocrine pancreas plasticity under physiological and pathological conditions
    • Bernard-Kargar C, Ktorza A 2001 Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes 50(Suppl 1): S30-S35
    • (2001) Diabetes , vol.50 , Issue.1 SUPPL.
    • Bernard-Kargar, C.1    Ktorza, A.2
  • 17
    • 0030067124 scopus 로고    scopus 로고
    • Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM 1996 Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 18
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR 1999 Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96:329-339
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 19
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through a and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
    • Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO 2001 Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol Cell 7:559-570
    • (2001) Mol Cell , vol.7 , pp. 559-570
    • Leibiger, B.1    Leibiger, I.B.2    Moede, T.3    Kemper, S.4    Kulkarni, R.N.5    Kahn, C.R.6    De Vargas, L.M.7    Berggren, P.O.8
  • 20
    • 0017871767 scopus 로고
    • Relationship between the plasma glucose level and glucose uptake in the conscious dog
    • Cherrington AD, Williams PE, Harris MS 1978 Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism 27:787-791
    • (1978) Metabolism , vol.27 , pp. 787-791
    • Cherrington, A.D.1    Williams, P.E.2    Harris, M.S.3
  • 21
    • 0024834748 scopus 로고
    • Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach
    • Bergman RN 1989 Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38:1512-1527
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 22
    • 0030901308 scopus 로고    scopus 로고
    • Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components
    • Ader M, Ni TC, Bergman RN 1997 Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J Clin Invest 99:1187-1199
    • (1997) J Clin Invest , vol.99 , pp. 1187-1199
    • Ader, M.1    Ni, T.C.2    Bergman, R.N.3
  • 24
    • 0038015693 scopus 로고    scopus 로고
    • Glucose autoregulates its uptake in skeletal muscle: Involvement of AMP-activated protein kinase
    • Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB 2003 Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes 52:1635-1640
    • (2003) Diabetes , vol.52 , pp. 1635-1640
    • Itani, S.I.1    Saha, A.K.2    Kurowski, T.G.3    Coffin, H.R.4    Tornheim, K.5    Ruderman, N.B.6
  • 26
    • 0022388944 scopus 로고
    • Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements
    • Ader M, Pacini G, Yang YJ, Bergman RN 1985 Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes 34:1092-1103
    • (1985) Diabetes , vol.34 , pp. 1092-1103
    • Ader, M.1    Pacini, G.2    Yang, Y.J.3    Bergman, R.N.4
  • 28
    • 0028304581 scopus 로고
    • Non-insulin-mediated glucose disappearance in subjects with IDDM. Discordance between experimental results and minimal model analysis
    • Quon MJ, Cochran C, Taylor SI, Eastman RC 1994 Non-insulin-mediated glucose disappearance in subjects with IDDM. Discordance between experimental results and minimal model analysis. Diabetes 43:890-896
    • (1994) Diabetes , vol.43 , pp. 890-896
    • Quon, M.J.1    Cochran, C.2    Taylor, S.I.3    Eastman, R.C.4
  • 29
    • 0029823503 scopus 로고    scopus 로고
    • Reduced glucose effectiveness associated with reduced insulin release: An artifact of the minimal-model method
    • Finegood DT, Tzur D 1996 Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal-model method. Am J Physiol 271:E485-E495
    • (1996) Am J Physiol , vol.271
    • Finegood, D.T.1    Tzur, D.2
  • 30
    • 0031054198 scopus 로고    scopus 로고
    • Impaired basal glucose effectiveness in NIDDM: Contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol
    • Basu A, Caumo A, Bettini F, Gelisio A, Alzaid A, Cobelli C, Rizza RA 1997 Impaired basal glucose effectiveness in NIDDM: contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol. Diabetes 46:421-432
    • (1997) Diabetes , vol.46 , pp. 421-432
    • Basu, A.1    Caumo, A.2    Bettini, F.3    Gelisio, A.4    Alzaid, A.5    Cobelli, C.6    Rizza, R.A.7
  • 31
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM 1995 Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 32
    • 0242696221 scopus 로고    scopus 로고
    • Lipid overload and overflow: Metabolic trauma and the metabolic syndrome
    • Unger RH 2003 Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol Metab 14:398-403
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 398-403
    • Unger, R.H.1
  • 33
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH 2003 Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144:5159-5165
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 34
    • 0027166231 scopus 로고
    • Structure and function of mammalian facilitative sugar transporters
    • Bell GI, Burant CF, Takeda J, Gould GW 1993 Structure and function of mammalian facilitative sugar transporters. J Biol Chem 268:19161-19164
    • (1993) J Biol Chem , vol.268 , pp. 19161-19164
    • Bell, G.I.1    Burant, C.F.2    Takeda, J.3    Gould, G.W.4
  • 37
    • 0034791165 scopus 로고    scopus 로고
    • Stimulation of GLUT-1 glucose transporter expression in response to hyperosmolarity
    • Hwang DY, Ismail-Beigi F 2001 Stimulation of GLUT-1 glucose transporter expression in response to hyperosmolarity. Am J Physiol Cell Physiol 281:C1365-C1372
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Hwang, D.Y.1    Ismail-Beigi, F.2
  • 38
    • 0028260280 scopus 로고
    • Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin
    • Clarke JF, Young PW, Yonezawa K, Kasuga M, Holman GD 1994 Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J 300(Pt 3):631-635
    • (1994) Biochem J , vol.300 , Issue.3 PART , pp. 631-635
    • Clarke, J.F.1    Young, P.W.2    Yonezawa, K.3    Kasuga, M.4    Holman, G.D.5
  • 39
    • 0029098476 scopus 로고
    • Modulation of GLUT1 intrinsic activity in clone 9 cells by inhibition of oxidative phosphorylation
    • Shi Y, Liu H, Vanderburg G, Samuel SJ, Ismail-Beigi F, Jung CY 1995 Modulation of GLUT1 intrinsic activity in clone 9 cells by inhibition of oxidative phosphorylation. J Biol Chem 270:21772-21778
    • (1995) J Biol Chem , vol.270 , pp. 21772-21778
    • Shi, Y.1    Liu, H.2    Vanderburg, G.3    Samuel, S.J.4    Ismail-Beigi, F.5    Jung, C.Y.6
  • 41
    • 0030798401 scopus 로고    scopus 로고
    • Thrombin stimulates glucose transport in human platelets via the translocation of the glucose transporter GLUT-3 from α-granules to the cell surface
    • Heijnen HF, Oorschot V, Sixma JJ, Slot JW, James DE 1997 Thrombin stimulates glucose transport in human platelets via the translocation of the glucose transporter GLUT-3 from α-granules to the cell surface. J Cell Biol 138:323-330
    • (1997) J Cell Biol , vol.138 , pp. 323-330
    • Heijnen, H.F.1    Oorschot, V.2    Sixma, J.J.3    Slot, J.W.4    James, D.E.5
  • 43
    • 0026661997 scopus 로고
    • Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling
    • Jhun BH, Rampal AL, Liu H, Lachaal M, Jung CY 1992 Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling. J Biol Chem 267:17710-17715
    • (1992) J Biol Chem , vol.267 , pp. 17710-17715
    • Jhun, B.H.1    Rampal, A.L.2    Liu, H.3    Lachaal, M.4    Jung, C.Y.5
  • 44
    • 11944271997 scopus 로고
    • Interaction of insulin and exercise on glucose transport in muscle
    • Rodnick KJ, Piper RC, Slot JW, James DE 1992 Interaction of insulin and exercise on glucose transport in muscle. Diabetes Care 15:1679-1689
    • (1992) Diabetes Care , vol.15 , pp. 1679-1689
    • Rodnick, K.J.1    Piper, R.C.2    Slot, J.W.3    James, D.E.4
  • 45
    • 0030048269 scopus 로고    scopus 로고
    • Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle
    • Leturque A, Loizeau M, Vaulont S, Salminen M, Girard J 1996 Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle. Diabetes 45:23-27
    • (1996) Diabetes , vol.45 , pp. 23-27
    • Leturque, A.1    Loizeau, M.2    Vaulont, S.3    Salminen, M.4    Girard, J.5
  • 46
    • 0030069588 scopus 로고    scopus 로고
    • Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle
    • Tsao TS, Burcelin R, Katz EB, Huang L, Charron MJ 1996 Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. Diabetes 45:28-36
    • (1996) Diabetes , vol.45 , pp. 28-36
    • Tsao, T.S.1    Burcelin, R.2    Katz, E.B.3    Huang, L.4    Charron, M.J.5
  • 47
    • 0027453501 scopus 로고
    • Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
    • Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB 1993 Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 268:22243-22246
    • (1993) J Biol Chem , vol.268 , pp. 22243-22246
    • Shepherd, P.R.1    Gnudi, L.2    Tozzo, E.3    Yang, H.4    Leach, F.5    Kahn, B.B.6
  • 49
    • 0029148426 scopus 로고
    • Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
    • Katz EB, Stenbit AE, Hatton K, DePinho R, Charron MJ 1995 Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377:151-155
    • (1995) Nature , vol.377 , pp. 151-155
    • Katz, E.B.1    Stenbit, A.E.2    Hatton, K.3    DePinho, R.4    Charron, M.J.5
  • 52
    • 0028119381 scopus 로고
    • GLUT-1 and GLUT-2 mRNA, protein, and glucose transporter activity in cultured fetal and adult hepatocytes
    • Levitsky LL, Zheng Q, Mink K, Rhoads DB 1994 GLUT-1 and GLUT-2 mRNA, protein, and glucose transporter activity in cultured fetal and adult hepatocytes. Am J Physiol 267:E88-E94
    • (1994) Am J Physiol , vol.267
    • Levitsky, L.L.1    Zheng, Q.2    Mink, K.3    Rhoads, D.B.4
  • 53
    • 0030991329 scopus 로고    scopus 로고
    • Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: Studies with GLUT-1/GLUT-2 chimeras
    • Noel LE, Newgard CB 1997 Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. Biochemistry 36:5465-5475
    • (1997) Biochemistry , vol.36 , pp. 5465-5475
    • Noel, L.E.1    Newgard, C.B.2
  • 54
    • 0026009264 scopus 로고
    • Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic β-cells
    • Tiedge M, Lenzen S 1991 Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic β-cells. Biochem J 279(Pt 3):899-901
    • (1991) Biochem J , vol.279 , Issue.3 PART , pp. 899-901
    • Tiedge, M.1    Lenzen, S.2
  • 55
    • 0026788504 scopus 로고
    • Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets
    • Tal M, Liang Y, Najafi H, Lodish HF, Matschinsky FM 1992 Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J Biol Chem 267:17241-17247
    • (1992) J Biol Chem , vol.267 , pp. 17241-17247
    • Tal, M.1    Liang, Y.2    Najafi, H.3    Lodish, H.F.4    Matschinsky, F.M.5
  • 56
    • 0026454282 scopus 로고
    • Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats
    • Burcelin R, Eddouks M, Kande J, Assan R, Girard J 1992 Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats. Biochem J 288(Pt 2):675-679
    • (1992) Biochem J , vol.288 , Issue.2 PART , pp. 675-679
    • Burcelin, R.1    Eddouks, M.2    Kande, J.3    Assan, R.4    Girard, J.5
  • 58
    • 0030667885 scopus 로고    scopus 로고
    • Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome
    • Santer R, Schneppenheim R, Dombrowski A, Gotze H, Steinmann B, Schaub J 1997 Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Nat Genet 17:324-326
    • (1997) Nat Genet , vol.17 , pp. 324-326
    • Santer, R.1    Schneppenheim, R.2    Dombrowski, A.3    Gotze, H.4    Steinmann, B.5    Schaub, J.6
  • 63
    • 0035887217 scopus 로고    scopus 로고
    • Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle
    • Doege H, Bocianski A, Scheepers A, Axer H, Eckel J, Joost HG, Schurmann A 2001 Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem J 359:443-449
    • (2001) Biochem J , vol.359 , pp. 443-449
    • Doege, H.1    Bocianski, A.2    Scheepers, A.3    Axer, H.4    Eckel, J.5    Joost, H.G.6    Schurmann, A.7
  • 65
    • 0034681328 scopus 로고    scopus 로고
    • GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues
    • Ibberson M, Uldry M, Thorens B 2000 GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem 275:4607-4612
    • (2000) J Biol Chem , vol.275 , pp. 4607-4612
    • Ibberson, M.1    Uldry, M.2    Thorens, B.3
  • 66
    • 0034797683 scopus 로고    scopus 로고
    • Sequence and functional analysis of GLUT10: A glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1
    • Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW 2001 Sequence and functional analysis of GLUT10: a glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab 74:186-199
    • (2001) Mol Genet Metab , vol.74 , pp. 186-199
    • Dawson, P.A.1    Mychaleckyj, J.C.2    Fossey, S.C.3    Mihic, S.J.4    Craddock, A.L.5    Bowden, D.W.6
  • 69
    • 0030070055 scopus 로고    scopus 로고
    • Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption
    • Martin MG, Turk E, Lostao MP, Kerner C, Wright EM 1996 Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. Nat Genet 12:216-220
    • (1996) Nat Genet , vol.12 , pp. 216-220
    • Martin, M.G.1    Turk, E.2    Lostao, M.P.3    Kerner, C.4    Wright, E.M.5
  • 71
    • 0036937335 scopus 로고    scopus 로고
    • Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    • van den Heuvel LP, Assink K, Willemsen M, Monnens L 2002 Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). Hum Genet 111:544-547
    • (2002) Hum Genet , vol.111 , pp. 544-547
    • Van Den Heuvel, L.P.1    Assink, K.2    Willemsen, M.3    Monnens, L.4
  • 72
    • 0026764502 scopus 로고
    • Evidence that glucose transport is rate-limiting for in vivo glucose uptake
    • Fink RI, Wallace P, Brechtel G, Olefsky JM 1992 Evidence that glucose transport is rate-limiting for in vivo glucose uptake. Metabolism 41:897-902
    • (1992) Metabolism , vol.41 , pp. 897-902
    • Fink, R.I.1    Wallace, P.2    Brechtel, G.3    Olefsky, J.M.4
  • 73
    • 0023278013 scopus 로고
    • Kinetics of glucose disposal in whole body and across the forearm in man
    • Yki-Jarvinen H, Young AA, Lamkin C, Foley JE 1987 Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79:1713-1719
    • (1987) J Clin Invest , vol.79 , pp. 1713-1719
    • Yki-Jarvinen, H.1    Young, A.A.2    Lamkin, C.3    Foley, J.E.4
  • 75
    • 0025175753 scopus 로고
    • Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM. Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation
    • Butler PC, Kryshak EJ, Marsh M, Rizza RA 1990 Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM. Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation. Diabetes 39:1373-1380
    • (1990) Diabetes , vol.39 , pp. 1373-1380
    • Butler, P.C.1    Kryshak, E.J.2    Marsh, M.3    Rizza, R.A.4
  • 77
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/ phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI 1995 Decreased muscle glucose transport/ phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 92:983-987
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3    Gerard, D.4    Kahn, C.R.5    Shulman, R.G.6    Shulman, G.I.7
  • 78
    • 0029775874 scopus 로고    scopus 로고
    • Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
    • Zierath JR, He L, Guma A, Odegoard Wahlstrom E, Klip A, Wallberg-Henriksson H 1996 Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39:1180-1189
    • (1996) Diabetologia , vol.39 , pp. 1180-1189
    • Zierath, J.R.1    He, L.2    Guma, A.3    Odegoard Wahlstrom, E.4    Klip, A.5    Wallberg-Henriksson, H.6
  • 79
    • 0032104120 scopus 로고    scopus 로고
    • Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    • Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD 1998 Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 101:2377-2386
    • (1998) J Clin Invest , vol.101 , pp. 2377-2386
    • Garvey, W.T.1    Maianu, L.2    Zhu, J.H.3    Brechtel-Hook, G.4    Wallace, P.5    Baron, A.D.6
  • 80
    • 0025302915 scopus 로고
    • Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM
    • Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS, Kahn BB 1990 Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 39:865-870
    • (1990) Diabetes , vol.39 , pp. 865-870
    • Pedersen, O.1    Bak, J.F.2    Andersen, P.H.3    Lund, S.4    Moller, D.E.5    Flier, J.S.6    Kahn, B.B.7
  • 81
    • 0035191192 scopus 로고    scopus 로고
    • Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: Implications regarding defects in vesicle trafficking
    • Maianu L, Keller SR, Garvey WT 2001 Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. J Clin Endocrinol Metab 86:5450-5456
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5450-5456
    • Maianu, L.1    Keller, S.R.2    Garvey, W.T.3
  • 82
    • 0025910841 scopus 로고
    • Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
    • Garvey WT, Maianu L, Huecksteadt TP, Birnbaum MJ, Molina JM, Ciaraldi TP 1991 Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest 87:1072-1081
    • (1991) J Clin Invest , vol.87 , pp. 1072-1081
    • Garvey, W.T.1    Maianu, L.2    Huecksteadt, T.P.3    Birnbaum, M.J.4    Molina, J.M.5    Ciaraldi, T.P.6
  • 84
    • 0031978984 scopus 로고    scopus 로고
    • Exercise, glucose transport, and insulin sensitivity
    • Goodyear LJ, Kahn BB 1998 Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49:235-261
    • (1998) Annu Rev Med , vol.49 , pp. 235-261
    • Goodyear, L.J.1    Kahn, B.B.2
  • 86
    • 0018424392 scopus 로고
    • Exercise and diabetes mellitus
    • Vranic M, Berger M 1979 Exercise and diabetes mellitus. Diabetes 28:147-163
    • (1979) Diabetes , vol.28 , pp. 147-163
    • Vranic, M.1    Berger, M.2
  • 87
    • 0035864965 scopus 로고    scopus 로고
    • Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: A candidate gene for NIDDM susceptibility
    • McVie-Wylie AJ, Lamson DR, Chen YT 2001 Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics 72:113-117
    • (2001) Genomics , vol.72 , pp. 113-117
    • McVie-Wylie, A.J.1    Lamson, D.R.2    Chen, Y.T.3
  • 88
    • 0036235790 scopus 로고    scopus 로고
    • Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity
    • Cha JY, Kim HS, Kim HI, Im SS, Kim SY, Kim JW, Yeh BI, Ahn YH 2002 Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. Ann Clin Lab Sci 32:114-122
    • (2002) Ann Clin Lab Sci , vol.32 , pp. 114-122
    • Cha, J.Y.1    Kim, H.S.2    Kim, H.I.3    Im, S.S.4    Kim, S.Y.5    Kim, J.W.6    Yeh, B.I.7    Ahn, Y.H.8
  • 89
    • 0027449203 scopus 로고
    • The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro
    • Muller G, Wied S 1993 The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro. Diabetes 42:1852-1867
    • (1993) Diabetes , vol.42 , pp. 1852-1867
    • Muller, G.1    Wied, S.2
  • 90
    • 0029062006 scopus 로고
    • Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide
    • Tsiani E, Ramlal T, Leiter LA, Klip A, Fantus IG 1995 Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide. Endocrinology 136:2505-2512
    • (1995) Endocrinology , vol.136 , pp. 2505-2512
    • Tsiani, E.1    Ramlal, T.2    Leiter, L.A.3    Klip, A.4    Fantus, I.G.5
  • 91
    • 0025860839 scopus 로고
    • Association of metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes
    • Matthaei S, Hamann A, Klein HH, Benecke H, Kreymann G, Flier JS, Greten H 1991 Association of metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes. Diabetes 40:850-857
    • (1991) Diabetes , vol.40 , pp. 850-857
    • Matthaei, S.1    Hamann, A.2    Klein, H.H.3    Benecke, H.4    Kreymann, G.5    Flier, J.S.6    Greten, H.7
  • 92
    • 0028129862 scopus 로고
    • Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM
    • Galuska D, Nolte LA, Zierath JR, Wallberg-Henriksson H 1994 Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia 37:826-832
    • (1994) Diabetologia , vol.37 , pp. 826-832
    • Galuska, D.1    Nolte, L.A.2    Zierath, J.R.3    Wallberg-Henriksson, H.4
  • 93
    • 0036895990 scopus 로고    scopus 로고
    • Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes
    • Hallsten K, Virtanen KA, Lonnqvist F, Sipila H, Oksanen A, Viljanen T, Ronnemaa T, Viikari J, Knuuti J, Nuutila P 2002 Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes 51:3479-3485
    • (2002) Diabetes , vol.51 , pp. 3479-3485
    • Hallsten, K.1    Virtanen, K.A.2    Lonnqvist, F.3    Sipila, H.4    Oksanen, A.5    Viljanen, T.6    Ronnemaa, T.7    Viikari, J.8    Knuuti, J.9    Nuutila, P.10
  • 97
    • 0034018619 scopus 로고    scopus 로고
    • Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells
    • Asano T, Wakisaka M, Yoshinari M, Nakamura S, Doi Y, Fujishima M 2000 Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells. Metabolism 49:308-313
    • (2000) Metabolism , vol.49 , pp. 308-313
    • Asano, T.1    Wakisaka, M.2    Yoshinari, M.3    Nakamura, S.4    Doi, Y.5    Fujishima, M.6
  • 99
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, Carling D 2002 The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277:25226-25232
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 104
    • 0034785085 scopus 로고    scopus 로고
    • Interaction of hexokinase with the outer mitochondrial membrane and a hydrophobic matrix
    • Ehsani-Zonouz A, Golestani A, Nemat-Gorgani M 2001 Interaction of hexokinase with the outer mitochondrial membrane and a hydrophobic matrix. Mol Cell Biochem 223:81-87
    • (2001) Mol Cell Biochem , vol.223 , pp. 81-87
    • Ehsani-Zonouz, A.1    Golestani, A.2    Nemat-Gorgani, M.3
  • 105
    • 0039137541 scopus 로고    scopus 로고
    • Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase
    • Liu X, Kim CS, Kurbanov FT, Honzatko RB, Fromm HJ 1999 Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase. J Biol Chem 274:31155-31159
    • (1999) J Biol Chem , vol.274 , pp. 31155-31159
    • Liu, X.1    Kim, C.S.2    Kurbanov, F.T.3    Honzatko, R.B.4    Fromm, H.J.5
  • 106
    • 0027166197 scopus 로고
    • Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functiong for the N- and C-terminal halves of the enzyme
    • Arora KK, Filburn CR, Pedersen PL 1993 Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functiong for the N- and C-terminal halves of the enzyme. J Biol Chem 268:18259-18266
    • (1993) J Biol Chem , vol.268 , pp. 18259-18266
    • Arora, K.K.1    Filburn, C.R.2    Pedersen, P.L.3
  • 108
    • 17544383235 scopus 로고    scopus 로고
    • Overexpression of hexokinase II in transgenic mice. Evidence that increased phosphorylation augments muscle glucose uptake
    • Chang PY, Jensen J, Printz RL, Granner DK, Ivy JL, Moller DE 1996 Overexpression of hexokinase II in transgenic mice. Evidence that increased phosphorylation augments muscle glucose uptake. J Biol Chem 271:14834-14839
    • (1996) J Biol Chem , vol.271 , pp. 14834-14839
    • Chang, P.Y.1    Jensen, J.2    Printz, R.L.3    Granner, D.K.4    Ivy, J.L.5    Moller, D.E.6
  • 109
    • 0034988197 scopus 로고    scopus 로고
    • Hexokinase isozyme distribution in human skeletal muscle
    • Ritov VB, Kelley DE 2001 Hexokinase isozyme distribution in human skeletal muscle. Diabetes 50:1253-1262
    • (2001) Diabetes , vol.50 , pp. 1253-1262
    • Ritov, V.B.1    Kelley, D.E.2
  • 111
    • 0030657562 scopus 로고    scopus 로고
    • Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine
    • Jones JP, Dohm GL 1997 Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine. Am J Physiol 273:E682-E687
    • (1997) Am J Physiol , vol.273
    • Jones, J.P.1    Dohm, G.L.2
  • 113
    • 0030001414 scopus 로고    scopus 로고
    • Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin
    • Osawa H, Sutherland C, Robey RB, Printz RL, Granner DK 1996 Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin. J Biol Chem 271:16690-16694
    • (1996) J Biol Chem , vol.271 , pp. 16690-16694
    • Osawa, H.1    Sutherland, C.2    Robey, R.B.3    Printz, R.L.4    Granner, D.K.5
  • 114
    • 0037177802 scopus 로고    scopus 로고
    • Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: Epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activated protein kinase pathway activation and induction of hexokinase II expression
    • Robey RB, Ma J, Santos AV, Noboa OA, Coy PE, Bryson JM 2002 Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activated protein kinase pathway activation and induction of hexokinase II expression. J Biol Chem 277:14370-14378
    • (2002) J Biol Chem , vol.277 , pp. 14370-14378
    • Robey, R.B.1    Ma, J.2    Santos, A.V.3    Noboa, O.A.4    Coy, P.E.5    Bryson, J.M.6
  • 115
    • 0033529642 scopus 로고    scopus 로고
    • Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes
    • Heikkinen S, Pietila M, Halmekyto M, Suppola S, Pirinen E, Deeb SS, Janne J, Laakso M 1999 Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes. J Biol Chem 274:22517-22523
    • (1999) J Biol Chem , vol.274 , pp. 22517-22523
    • Heikkinen, S.1    Pietila, M.2    Halmekyto, M.3    Suppola, S.4    Pirinen, E.5    Deeb, S.S.6    Janne, J.7    Laakso, M.8
  • 116
    • 0032942652 scopus 로고    scopus 로고
    • Overexpression of hexokinase II increases insulin and exercise-stimulated muscle glucose uptake in vivo
    • Halseth AE, Bracy DP, Wasserman DH 1999 Overexpression of hexokinase II increases insulin and exercise-stimulated muscle glucose uptake in vivo. Am J Physiol 276:E70-E77
    • (1999) Am J Physiol , vol.276
    • Halseth, A.E.1    Bracy, D.P.2    Wasserman, D.H.3
  • 117
    • 0026680847 scopus 로고
    • Localization of the type III isozyme of hexokinase at the nuclear periphery
    • Preller A, Wilson JE 1992 Localization of the type III isozyme of hexokinase at the nuclear periphery. Arch Biochem Biophys 294:482-492
    • (1992) Arch Biochem Biophys , vol.294 , pp. 482-492
    • Preller, A.1    Wilson, J.E.2
  • 118
    • 0031892853 scopus 로고    scopus 로고
    • Pancreatic β-cell glucokinase: Closing the gap between theoretical concepts and experimental realities
    • Matschinsky FM, Glaser B, Magnuson MA 1998 Pancreatic β-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes 47:307-315
    • (1998) Diabetes , vol.47 , pp. 307-315
    • Matschinsky, F.M.1    Glaser, B.2    Magnuson, M.A.3
  • 119
    • 0022975389 scopus 로고
    • Differential regulation of glucokinase activity in pancreatic islets and liver of the rat
    • Bedoya FJ, Matschinsky FM, Shimizu T, O'Neil JJ, Appel MC 1986 Differential regulation of glucokinase activity in pancreatic islets and liver of the rat. J Biol Chem 261:10760-10764
    • (1986) J Biol Chem , vol.261 , pp. 10760-10764
    • Bedoya, F.J.1    Matschinsky, F.M.2    Shimizu, T.3    O'Neil, J.J.4    Appel, M.C.5
  • 120
    • 0025297993 scopus 로고
    • Glucokinase gene structure. Functional implications of molecular genetic studies
    • Magnuson MA 1990 Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes 39:523-527
    • (1990) Diabetes , vol.39 , pp. 523-527
    • Magnuson, M.A.1
  • 121
    • 0030953106 scopus 로고    scopus 로고
    • Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus
    • Brown KS, Kalinowski SS, Megill JR, Durham SK, Mookhtiar KA 1997 Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus. Diabetes 46:179-186
    • (1997) Diabetes , vol.46 , pp. 179-186
    • Brown, K.S.1    Kalinowski, S.S.2    Megill, J.R.3    Durham, S.K.4    Mookhtiar, K.A.5
  • 123
    • 0022523260 scopus 로고
    • Antagonistic regulation of the glucose/glucose 6-phosphate cycle by insulin and glucagon in cultured hepatocytes
    • Christ B, Probst I, Jungermann K 1986 Antagonistic regulation of the glucose/glucose 6-phosphate cycle by insulin and glucagon in cultured hepatocytes. Biochem J 238:185-191
    • (1986) Biochem J , vol.238 , pp. 185-191
    • Christ, B.1    Probst, I.2    Jungermann, K.3
  • 124
    • 0028287877 scopus 로고
    • Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP
    • Lange AJ, Argaud D, el-Maghrabi MR, Pan W, Maitra SR, Pilkis SJ 1994 Isolation of a cDNA for the catalytic subunit of rat liver glucose-6- phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem Biophys Res Commun 201:302-309
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 302-309
    • Lange, A.J.1    Argaud, D.2    El-Maghrabi, M.R.3    Pan, W.4    Maitra, S.R.5    Pilkis, S.J.6
  • 125
    • 0035296492 scopus 로고    scopus 로고
    • The molecular basis of type 1 glycogen storage diseases
    • Chou JY 2001 The molecular basis of type 1 glycogen storage diseases. Curr Mol Med 1:25-44
    • (2001) Curr Mol Med , vol.1 , pp. 25-44
    • Chou, J.Y.1
  • 126
    • 0032553323 scopus 로고    scopus 로고
    • Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
    • Trinh KY, O'Doherty RM, Anderson P, Lange AJ, Newgard CB 1998 Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem 273:31615-31620
    • (1998) J Biol Chem , vol.273 , pp. 31615-31620
    • Trinh, K.Y.1    O'Doherty, R.M.2    Anderson, P.3    Lange, A.J.4    Newgard, C.B.5
  • 127
    • 0034067256 scopus 로고    scopus 로고
    • Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic β-cell line
    • Iizuka K, Nakajima H, Ono A, Okita K, Miyazaki J, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y 2000 Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic β-cell line. J Endocrinol 164:307-314
    • (2000) J Endocrinol , vol.164 , pp. 307-314
    • Iizuka, K.1    Nakajima, H.2    Ono, A.3    Okita, K.4    Miyazaki, J.5    Miyagawa, J.6    Namba, M.7    Hanafusa, T.8    Matsuzawa, Y.9
  • 128
    • 0028842531 scopus 로고
    • Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients
    • Vestergaard H, Bjorbaek C, Hansen T, Larsen FS, Granner DK, Pedersen O 1995 Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J Clin Invest 96:2639-2645
    • (1995) J Clin Invest , vol.96 , pp. 2639-2645
    • Vestergaard, H.1    Bjorbaek, C.2    Hansen, T.3    Larsen, F.S.4    Granner, D.K.5    Pedersen, O.6
  • 129
    • 0035029812 scopus 로고    scopus 로고
    • Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes
    • Ducluzeau PH, Perretti N, Laville M, Andreelli F, Vega N, Riou JP, Vidal H 2001 Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50:1134-1142
    • (2001) Diabetes , vol.50 , pp. 1134-1142
    • Ducluzeau, P.H.1    Perretti, N.2    Laville, M.3    Andreelli, F.4    Vega, N.5    Riou, J.P.6    Vidal, H.7
  • 131
    • 0028898329 scopus 로고
    • Polymorphisms of the human hexokinase II gene: Lack of association with NIDDM and insulin resistance
    • Laakso M, Malkki M, Kekalainen P, Kuusisto J, Deeb SS 1995 Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance. Diabetologia 38:617-622
    • (1995) Diabetologia , vol.38 , pp. 617-622
    • Laakso, M.1    Malkki, M.2    Kekalainen, P.3    Kuusisto, J.4    Deeb, S.S.5
  • 132
    • 0030007158 scopus 로고    scopus 로고
    • A novel (TA)n polymorphism in the hexokinase II gene: Application to noninsulin-dependent diabetes mellitus in the Pima Indians
    • Ardehali H, Tiller GE, Printz RL, Mochizuki H, Prochazka M, Granner DK 1996 A novel (TA)n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians. Hum Genet 97:482-485
    • (1996) Hum Genet , vol.97 , pp. 482-485
    • Ardehali, H.1    Tiller, G.E.2    Printz, R.L.3    Mochizuki, H.4    Prochazka, M.5    Granner, D.K.6
  • 137
    • 0033985724 scopus 로고    scopus 로고
    • Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: Evidence for a defect in hepatic glucokinase activity
    • Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA 2000 Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 49:272-283
    • (2000) Diabetes , vol.49 , pp. 272-283
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Nair, K.S.6    Jensen, M.D.7    Schwenk, W.F.8    Rizza, R.A.9
  • 142
    • 0032529147 scopus 로고    scopus 로고
    • Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus
    • Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L 1998 Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 102:744-753
    • (1998) J Clin Invest , vol.102 , pp. 744-753
    • Mevorach, M.1    Giacca, A.2    Aharon, Y.3    Hawkins, M.4    Shamoon, H.5    Rossetti, L.6
  • 143
    • 0034034229 scopus 로고    scopus 로고
    • Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
    • Clore JN, Stillman J, Sugerman H 2000 Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Diabetes 49:969-974
    • (2000) Diabetes , vol.49 , pp. 969-974
    • Clore, J.N.1    Stillman, J.2    Sugerman, H.3
  • 144
    • 0036097775 scopus 로고    scopus 로고
    • Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet
    • Mithieux G, Guignot L, Bordet JC, Wiernsperger N 2002 Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet. Diabetes 51:139-143
    • (2002) Diabetes , vol.51 , pp. 139-143
    • Mithieux, G.1    Guignot, L.2    Bordet, J.C.3    Wiernsperger, N.4
  • 146
    • 0032856254 scopus 로고    scopus 로고
    • Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism
    • Davies GF, Khandelwal RL, Roesler WJ 1999 Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism. Biochim Biophys Acta 1451:122-131
    • (1999) Biochim Biophys Acta , vol.1451 , pp. 122-131
    • Davies, G.F.1    Khandelwal, R.L.2    Roesler, W.J.3
  • 147
    • 0027994544 scopus 로고
    • Mechanisms modifying glucose oxidation in diabetes mellitus
    • Randle PJ, Priestman DA, Mistry S, Halsall A 1994 Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 37(Suppl 2):S155-S161
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Randle, P.J.1    Priestman, D.A.2    Mistry, S.3    Halsall, A.4
  • 148
    • 0034653968 scopus 로고    scopus 로고
    • Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression
    • Sugden MC, Kraus A, Harris RA, Holness MJ 2000 Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Biochem J 346(Pt 3):651-657
    • (2000) Biochem J , vol.346 , Issue.3 PART , pp. 651-657
    • Sugden, M.C.1    Kraus, A.2    Harris, R.A.3    Holness, M.J.4
  • 149
    • 0035656127 scopus 로고    scopus 로고
    • Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-α: Implications for glucose-stimulated insulin secretion
    • Sugden MC, Bulmer K, Augustine D, Holness MJ 2001 Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-α: implications for glucose-stimulated insulin secretion. Diabetes 50:2729-2736
    • (2001) Diabetes , vol.50 , pp. 2729-2736
    • Sugden, M.C.1    Bulmer, K.2    Augustine, D.3    Holness, M.J.4
  • 150
  • 151
    • 0025721905 scopus 로고
    • Genetic regulation of malic enzyme activity in the mouse
    • Coleman DL, Kuzava JE 1991 Genetic regulation of malic enzyme activity in the mouse. J Biol Chem 266:21997-22002
    • (1991) J Biol Chem , vol.266 , pp. 21997-22002
    • Coleman, D.L.1    Kuzava, J.E.2
  • 152
    • 0036808680 scopus 로고    scopus 로고
    • Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats
    • Nakai N, Miyazaki Y, Sato Y, Oshida Y, Nagasaki M, Tanaka M, Nakashima K, Shimomura Y 2002 Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats. Endocr J 49:547-554
    • (2002) Endocr J , vol.49 , pp. 547-554
    • Nakai, N.1    Miyazaki, Y.2    Sato, Y.3    Oshida, Y.4    Nagasaki, M.5    Tanaka, M.6    Nakashima, K.7    Shimomura, Y.8
  • 155
    • 0038714272 scopus 로고    scopus 로고
    • Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
    • Wilson JE 2003 Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol 206:2049-2057
    • (2003) J Exp Biol , vol.206 , pp. 2049-2057
    • Wilson, J.E.1
  • 156
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA 1963 The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 157
    • 0017341862 scopus 로고
    • Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat
    • Maizels EZ, Ruderman NB, Goodman MN, Lau D 1977 Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J 162:557-568
    • (1977) Biochem J , vol.162 , pp. 557-568
    • Maizels, E.Z.1    Ruderman, N.B.2    Goodman, M.N.3    Lau, D.4
  • 158
    • 0028343190 scopus 로고
    • Glucose fatty acid interactions and the regulation of glucose disposal
    • Randle PJ, Priestman DA, Mistry SC, Halsall A 1994 Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 55 Suppl:1-11
    • (1994) J Cell Biochem , vol.55 , Issue.SUPPL. , pp. 1-11
    • Randle, P.J.1    Priestman, D.A.2    Mistry, S.C.3    Halsall, A.4
  • 160
    • 0345374578 scopus 로고    scopus 로고
    • Minireview: Malonyl CoA, AMP-activated protein kinase, and adiposity
    • Ruderman NB, Saha AK, Kraegen EW 2003 Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology 144:5166-5171
    • (2003) Endocrinology , vol.144 , pp. 5166-5171
    • Ruderman, N.B.1    Saha, A.K.2    Kraegen, E.W.3
  • 161
  • 162
    • 0004854859 scopus 로고
    • Regulation of the citric acid cycle in mammalian systems
    • Williamson JR, Cooper RH 1980 Regulation of the citric acid cycle in mammalian systems. FEBS Lett 117 Suppl:K73-K85
    • (1980) FEBS Lett , vol.117 , Issue.SUPPL.
    • Williamson, J.R.1    Cooper, R.H.2
  • 164
    • 0036634105 scopus 로고    scopus 로고
    • Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia
    • Sugden MC, Holness MJ 2002 Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr Drug Targets Immune Endocr Metabol Disord 2:151-165
    • (2002) Curr Drug Targets Immune Endocr Metabol Disord , vol.2 , pp. 151-165
    • Sugden, M.C.1    Holness, M.J.2
  • 165
    • 0036066319 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-α ligands, glucocorticoids, and insulin
    • Huang B, Wu P, Bowker-Kinley MM, Harris RA 2002 Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-α ligands, glucocorticoids, and insulin. Diabetes 51:276-283
    • (2002) Diabetes , vol.51 , pp. 276-283
    • Huang, B.1    Wu, P.2    Bowker-Kinley, M.M.3    Harris, R.A.4
  • 168
    • 0032832729 scopus 로고    scopus 로고
    • Dysoxia and lactate
    • Duke T 1999 Dysoxia and lactate. Arch Dis Child 81:343-350
    • (1999) Arch Dis Child , vol.81 , pp. 343-350
    • Duke, T.1
  • 169
    • 0018676274 scopus 로고
    • Glycogen synthesis from lactate in the three types of skeletal muscle
    • McLane JA, Holloszy JO 1979 Glycogen synthesis from lactate in the three types of skeletal muscle. J Biol Chem 254:6548-6553
    • (1979) J Biol Chem , vol.254 , pp. 6548-6553
    • McLane, J.A.1    Holloszy, J.O.2
  • 170
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel A, Schmoll D 2003 Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 285:E685-E692
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 171
  • 173
    • 0025695163 scopus 로고
    • Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus
    • Kelley DE, Mandarino LJ 1990 Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus. J Clin Invest 86:1999-2007
    • (1990) J Clin Invest , vol.86 , pp. 1999-2007
    • Kelley, D.E.1    Mandarino, L.J.2
  • 174
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC 2000 Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751-1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 175
    • 0031442028 scopus 로고    scopus 로고
    • Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance
    • Ristow M, Vorgerd M, Mohlig M, Schatz H, Pfeiffer A 1997 Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance. J Clin Invest 100:2833-2841
    • (1997) J Clin Invest , vol.100 , pp. 2833-2841
    • Ristow, M.1    Vorgerd, M.2    Mohlig, M.3    Schatz, H.4    Pfeiffer, A.5
  • 176
    • 0025666756 scopus 로고
    • Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus
    • Mandarino LJ, Consoli A, Kelley DE, Reilly JJ, Nurjhan N 1990 Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 71:1544-1551
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1544-1551
    • Mandarino, L.J.1    Consoli, A.2    Kelley, D.E.3    Reilly, J.J.4    Nurjhan, N.5
  • 177
    • 0032192401 scopus 로고    scopus 로고
    • Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects
    • Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M 1998 Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab 65:181-186
    • (1998) Mol Genet Metab , vol.65 , pp. 181-186
    • Majer, M.1    Popov, K.M.2    Harris, R.A.3    Bogardus, C.4    Prochazka, M.5
  • 178
    • 0030046495 scopus 로고    scopus 로고
    • Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit
    • Gerbitz KD, Gempel K, Brdiczka D 1996 Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 45:113-126
    • (1996) Diabetes , vol.45 , pp. 113-126
    • Gerbitz, K.D.1    Gempel, K.2    Brdiczka, D.3
  • 181
    • 0032429843 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus
    • Lee HK, Song JH, Shin CS, Park DJ, Park KS, Lee KU, Koh CS 1998 Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 42:161-167
    • (1998) Diabetes Res Clin Pract , vol.42 , pp. 161-167
    • Lee, H.K.1    Song, J.H.2    Shin, C.S.3    Park, D.J.4    Park, K.S.5    Lee, K.U.6    Koh, C.S.7
  • 182
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB 2002 Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51:2944-2950
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 184
    • 0036435899 scopus 로고    scopus 로고
    • Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
    • Yang X, Pratley RE, Tokraks S, Bogardus C, Permana PA 2002 Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians. Diabetologia 45:1584-1593
    • (2002) Diabetologia , vol.45 , pp. 1584-1593
    • Yang, X.1    Pratley, R.E.2    Tokraks, S.3    Bogardus, C.4    Permana, P.A.5
  • 187
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 188
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1 α): Transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1 α): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 190
    • 0035676129 scopus 로고    scopus 로고
    • Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus
    • Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O 2001 Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus. Diabetologia 44:2220-2226
    • (2001) Diabetologia , vol.44 , pp. 2220-2226
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3    Gaede, P.H.4    Drivsholm, T.5    Borch-Johnsen, K.6    Hansen, T.7    Pedersen, O.8
  • 191
    • 0036094896 scopus 로고    scopus 로고
    • No association between the G482S polymorphism of the proliferator- activated receptor-γ coactivator-1 (PGC-1) gene and type II diabetes in French Caucasias
    • author reply, 604
    • Lacquemant C, Chikri M, Boutin P, Samson C, Froguel P 2002 No association between the G482S polymorphism of the proliferator-activated receptor-γ coactivator-1 (PGC-1) gene and type II diabetes in French Caucasias. Diabetologia 45:602-603; author reply, 604
    • (2002) Diabetologia , vol.45 , pp. 602-603
    • Lacquemant, C.1    Chikri, M.2    Boutin, P.3    Samson, C.4    Froguel, P.5
  • 192
    • 0030746213 scopus 로고    scopus 로고
    • Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology
    • Sirover MA 1997 Role of the glycolytic protein, glyceraldehyde-3- phosphate dehydrogenase, in normal cell function and in cell pathology. J Cell Biochem 66:133-140
    • (1997) J Cell Biochem , vol.66 , pp. 133-140
    • Sirover, M.A.1
  • 193
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, Brownlee M 2003 Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112:1049-1057
    • (2003) J Clin Invest , vol.112 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengeller, Z.5    Szabo, C.6    Brownlee, M.7
  • 196
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman RN, Ader M 2000 Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11:351-356
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 199
  • 200
    • 0030749042 scopus 로고    scopus 로고
    • Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver
    • Radziuk J, Zhang Z, Wiernsperger N, Pye S 1997 Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver. Diabetes 46:1406-1413
    • (1997) Diabetes , vol.46 , pp. 1406-1413
    • Radziuk, J.1    Zhang, Z.2    Wiernsperger, N.3    Pye, S.4
  • 201
    • 0027235394 scopus 로고
    • Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes
    • Argaud D, Roth H, Wiernsperger N, Leverve XM 1993 Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes. Eur J Biochem 213:1341-1348
    • (1993) Eur J Biochem , vol.213 , pp. 1341-1348
    • Argaud, D.1    Roth, H.2    Wiernsperger, N.3    Leverve, X.M.4
  • 202
    • 0344417048 scopus 로고    scopus 로고
    • Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin
    • Large V, Beylot M 1999 Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin. Diabetes 48:1251-1257
    • (1999) Diabetes , vol.48 , pp. 1251-1257
    • Large, V.1    Beylot, M.2
  • 204
    • 0028937422 scopus 로고
    • Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice
    • Fujiwara T, Okuno A, Yoshioka S, Horikoshi H 1995 Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice. Metabolism 44:486-490
    • (1995) Metabolism , vol.44 , pp. 486-490
    • Fujiwara, T.1    Okuno, A.2    Yoshioka, S.3    Horikoshi, H.4
  • 205
    • 0034560189 scopus 로고    scopus 로고
    • Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis
    • Raman P, Judd RL 2000 Role of glucose and insulin in thiazolidinedione- induced alterations in hepatic gluconeogenesis. Eur J Pharmacol 409:19-29
    • (2000) Eur J Pharmacol , vol.409 , pp. 19-29
    • Raman, P.1    Judd, R.L.2
  • 209
    • 0035936724 scopus 로고    scopus 로고
    • Decreased responsiveness of gluconeogenesis to the modulation by sulfonylureas in hepatocytes isolated from obese (fa/fa) Zucker rats
    • Lechuga CG, Carrillo JJ, Sanchez-Gutierrez JC, Feliu JE 2001 Decreased responsiveness of gluconeogenesis to the modulation by sulfonylureas in hepatocytes isolated from obese (fa/fa) Zucker rats. Life Sci 68:1617-1628
    • (2001) Life Sci , vol.68 , pp. 1617-1628
    • Lechuga, C.G.1    Carrillo, J.J.2    Sanchez-Gutierrez, J.C.3    Feliu, J.E.4
  • 210
    • 0024265487 scopus 로고
    • Risk factors for type 2 (non-insulin-dependent) diabetes mellitus. Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913
    • Ohlson LO, Larsson B, Bjorntorp P, Eriksson H, Svardsudd K, Welin L, Tibblin G, Wilhelmsen L 1988 Risk factors for type 2 (non-insulin-dependent) diabetes mellitus. Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913. Diabetologia 31:798-805
    • (1988) Diabetologia , vol.31 , pp. 798-805
    • Ohlson, L.O.1    Larsson, B.2    Bjorntorp, P.3    Eriksson, H.4    Svardsudd, K.5    Welin, L.6    Tibblin, G.7    Wilhelmsen, L.8
  • 211
    • 0035491322 scopus 로고    scopus 로고
    • Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes
    • Sandqvist MM, Eriksson JW, Jansson PA 2001 Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes. Diabetes 50:2344-2348
    • (2001) Diabetes , vol.50 , pp. 2344-2348
    • Sandqvist, M.M.1    Eriksson, J.W.2    Jansson, P.A.3
  • 212
    • 0030035651 scopus 로고    scopus 로고
    • Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals
    • Avogaro A, Toffolo G, Miola M, Valerio A, Tiengo A, Cobelli C, Del Prato S 1996 Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. J Clin Invest 98:108-115
    • (1996) J Clin Invest , vol.98 , pp. 108-115
    • Avogaro, A.1    Toffolo, G.2    Miola, M.3    Valerio, A.4    Tiengo, A.5    Cobelli, C.6    Del Prato, S.7
  • 213
    • 0026770646 scopus 로고
    • Lactate production in adipose tissue: A regulated function with extra-adipose implications
    • DiGirolamo M, Newby FD, Lovejoy J 1992 Lactate production in adipose tissue: a regulated function with extra-adipose implications. FASEB J 6:2405-2412
    • (1992) FASEB J , vol.6 , pp. 2405-2412
    • DiGirolamo, M.1    Newby, F.D.2    Lovejoy, J.3
  • 217
    • 0025630056 scopus 로고
    • Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism
    • Consoli A, Nurjhan N, Reilly Jr JJ, Bier DM, Gerich JE 1990 Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest 86:2038-2045
    • (1990) J Clin Invest , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly Jr., J.J.3    Bier, D.M.4    Gerich, J.E.5
  • 220
    • 0037369302 scopus 로고    scopus 로고
    • Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase
    • Stellingwerff T, Watt MJ, Heigenhauser GJ, Spriet LL 2003 Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase. Am J Physiol Endocrinol Metab 284:E589-E596
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Stellingwerff, T.1    Watt, M.J.2    Heigenhauser, G.J.3    Spriet, L.L.4
  • 221
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP 1981 The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 222
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron AD, Brechtel G, Wallace P, Edelman SV 1988 Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 255:E769-E774
    • (1988) Am J Physiol , vol.255
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 224
    • 0025202408 scopus 로고
    • Control of glycogen synthase by hierarchal protein phosphorylation
    • Roach PJ 1990 Control of glycogen synthase by hierarchal protein phosphorylation. FASEB J 4:2961-2968
    • (1990) FASEB J , vol.4 , pp. 2961-2968
    • Roach, P.J.1
  • 225
    • 0030984321 scopus 로고    scopus 로고
    • New insights into the role and mechanism of glycogen synthase activation by insulin
    • Lawrence Jr JC, Roach PJ 1997 New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes 46:541-547
    • (1997) Diabetes , vol.46 , pp. 541-547
    • Lawrence Jr., J.C.1    Roach, P.J.2
  • 227
    • 0029744440 scopus 로고    scopus 로고
    • Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle
    • Manchester J, Skurat AV, Roach P, Hauschka SD, Lawrence Jr JC 1996 Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle. Proc Natl Acad Sci USA 93:10707-10711
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10707-10711
    • Manchester, J.1    Skurat, A.V.2    Roach, P.3    Hauschka, S.D.4    Lawrence Jr., J.C.5
  • 229
    • 0037219253 scopus 로고    scopus 로고
    • Regulation of glycogen synthase by glucose and glycogen: A possible role for AMP-activated protein kinase
    • Halse R, Fryer LG, McCormack JG, Carling D, Yeaman SJ 2003 Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase. Diabetes 52:9-15
    • (2003) Diabetes , vol.52 , pp. 9-15
    • Halse, R.1    Fryer, L.G.2    McCormack, J.G.3    Carling, D.4    Yeaman, S.J.5
  • 230
    • 0029075837 scopus 로고
    • In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis
    • Shulman RG, Bloch G, Rothman DL 1995 In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proc Natl Acad Sci USA 92:8535-8542
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8535-8542
    • Shulman, R.G.1    Bloch, G.2    Rothman, D.L.3
  • 231
    • 0029888220 scopus 로고    scopus 로고
    • Translocation and aggregation of hepatic glycogen synthase during the fasted-to-refed transition in rats
    • Fernandez-Novell JM, Roca A, Bellido D, Vilaro S, Guinovart JJ 1996 Translocation and aggregation of hepatic glycogen synthase during the fasted-to-refed transition in rats. Eur J Biochem 238:570-575
    • (1996) Eur J Biochem , vol.238 , pp. 570-575
    • Fernandez-Novell, J.M.1    Roca, A.2    Bellido, D.3    Vilaro, S.4    Guinovart, J.J.5
  • 232
    • 0030853642 scopus 로고    scopus 로고
    • Muscle glycogen synthase translocates from the cell nucleus to the cystosol in response to glucose
    • Ferrer JC, Baque S, Guinovart JJ 1997 Muscle glycogen synthase translocates from the cell nucleus to the cystosol in response to glucose. FEBS Lett 415:249-252
    • (1997) FEBS Lett , vol.415 , pp. 249-252
    • Ferrer, J.C.1    Baque, S.2    Guinovart, J.J.3
  • 233
    • 0025522071 scopus 로고
    • The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
    • Dent P, Lavoinne A, Nakielny S, Caudwell FB, Watt P, Cohen P 1990 The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348:302-308
    • (1990) Nature , vol.348 , pp. 302-308
    • Dent, P.1    Lavoinne, A.2    Nakielny, S.3    Caudwell, F.B.4    Watt, P.5    Cohen, P.6
  • 234
    • 0024592297 scopus 로고
    • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
    • Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG 1989 Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337:78-81
    • (1989) Nature , vol.337 , pp. 78-81
    • Haystead, T.A.1    Sim, A.T.2    Carling, D.3    Honnor, R.C.4    Tsukitani, Y.5    Cohen, P.6    Hardie, D.G.7
  • 235
    • 0037081563 scopus 로고    scopus 로고
    • Protein phosphatase 1-targeted in many directions
    • Cohen PT 2002 Protein phosphatase 1-targeted in many directions. J Cell Sci 115:241-256
    • (2002) J Cell Sci , vol.115 , pp. 241-256
    • Cohen, P.T.1
  • 236
    • 0037341143 scopus 로고    scopus 로고
    • Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    • Delibegovic M, Armstrong CG, Dobbie L, Watt PW, Smith AJ, Cohen PT 2003 Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. Diabetes 52:596-604
    • (2003) Diabetes , vol.52 , pp. 596-604
    • Delibegovic, M.1    Armstrong, C.G.2    Dobbie, L.3    Watt, P.W.4    Smith, A.J.5    Cohen, P.T.6
  • 237
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 238
    • 0036120653 scopus 로고    scopus 로고
    • Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
    • Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB 2002 Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol 22:2099-2110
    • (2002) Mol Cell Biol , vol.22 , pp. 2099-2110
    • Fang, X.1    Yu, S.2    Tanyi, J.L.3    Lu, Y.4    Woodgett, J.R.5    Mills, G.B.6
  • 239
    • 0036136897 scopus 로고    scopus 로고
    • Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β signaling pathway
    • Pap M, Cooper GM 2002 Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β signaling pathway. Mol Cell Biol 22:578-586
    • (2002) Mol Cell Biol , vol.22 , pp. 578-586
    • Pap, M.1    Cooper, G.M.2
  • 240
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J 2002 Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416:548-552
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 241
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
    • Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR 2000 Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation. Nature 406:86-90
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.S.4    Jin, O.5    Woodgett, J.R.6
  • 243
    • 0032567331 scopus 로고    scopus 로고
    • Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism
    • Mu J, Roach PJ 1998 Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism. J Biol Chem 273:34850-34856
    • (1998) J Biol Chem , vol.273 , pp. 34850-34856
    • Mu, J.1    Roach, P.J.2
  • 244
    • 0033102577 scopus 로고    scopus 로고
    • Self-glucosylation of glycogenin, the initiator of glycogen biosynthesis, involves an intersubunit reaction
    • Lin A, Mu J, Yang J, Roach PJ 1999 Self-glucosylation of glycogenin, the initiator of glycogen biosynthesis, involves an intersubunit reaction. Arch Biochem Biophys 363:163-170
    • (1999) Arch Biochem Biophys , vol.363 , pp. 163-170
    • Lin, A.1    Mu, J.2    Yang, J.3    Roach, P.J.4
  • 245
    • 0023765635 scopus 로고
    • Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle
    • Pitcher J, Smythe C, Cohen P 1988 Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle. Eur J Biochem 176:391-395
    • (1988) Eur J Biochem , vol.176 , pp. 391-395
    • Pitcher, J.1    Smythe, C.2    Cohen, P.3
  • 246
    • 0030727857 scopus 로고    scopus 로고
    • Glycogenin, the primer of glycogen synthesis, binds to actin
    • Baque S, Guinovart JJ, Ferrer JC 1997 Glycogenin, the primer of glycogen synthesis, binds to actin. FEBS Lett 417:355-359
    • (1997) FEBS Lett , vol.417 , pp. 355-359
    • Baque, S.1    Guinovart, J.J.2    Ferrer, J.C.3
  • 247
    • 0037205413 scopus 로고    scopus 로고
    • GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis
    • Skurat AV, Dietrich AD, Zhai L, Roach PJ 2002 GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis. J Biol Chem 277:19331-19338
    • (2002) J Biol Chem , vol.277 , pp. 19331-19338
    • Skurat, A.V.1    Dietrich, A.D.2    Zhai, L.3    Roach, P.J.4
  • 248
    • 0035339849 scopus 로고    scopus 로고
    • The amino-terminal tail of glycogen phosphorylase is a switch for controlling phosphorylase conformation, activation, and response to ligands
    • Biorn AC, Graves DJ 2001 The amino-terminal tail of glycogen phosphorylase is a switch for controlling phosphorylase conformation, activation, and response to ligands. Biochemistry 40:5181-5189
    • (2001) Biochemistry , vol.40 , pp. 5181-5189
    • Biorn, A.C.1    Graves, D.J.2
  • 249
    • 0029878143 scopus 로고    scopus 로고
    • Genetic deficiencies of the glycogen phosphorylase system
    • Hendrickx J, Willems PJ 1996 Genetic deficiencies of the glycogen phosphorylase system. Hum Genet 97:551-556
    • (1996) Hum Genet , vol.97 , pp. 551-556
    • Hendrickx, J.1    Willems, P.J.2
  • 252
    • 0033952199 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in two frequent mutations and mutation update in type III glycogen storage disease
    • Shaiu WL, Kishnani PS, Shen J, Liu HM, Chen YT 2000 Genotype-phenotype correlation in two frequent mutations and mutation update in type III glycogen storage disease. Mol Genet Metab 69:16-23
    • (2000) Mol Genet Metab , vol.69 , pp. 16-23
    • Shaiu, W.L.1    Kishnani, P.S.2    Shen, J.3    Liu, H.M.4    Chen, Y.T.5
  • 253
    • 0036068886 scopus 로고    scopus 로고
    • Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes
    • Pratipanawatr T, Cusi K, Ngo P, Pratipanawatr W, Mandarino LJ, DeFronzo RA 2002 Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes. Diabetes 51:462-468
    • (2002) Diabetes , vol.51 , pp. 462-468
    • Pratipanawatr, T.1    Cusi, K.2    Ngo, P.3    Pratipanawatr, W.4    Mandarino, L.J.5    DeFronzo, R.A.6
  • 254
    • 0028559799 scopus 로고
    • Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM
    • Fery F, Balasse EO 1994 Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes 43:1418-1425
    • (1994) Diabetes , vol.43 , pp. 1418-1425
    • Fery, F.1    Balasse, E.O.2
  • 255
    • 0034457043 scopus 로고    scopus 로고
    • Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited
    • Huang X, Vaag A, Hansson M, Weng J, Laurila E, Groop L 2000 Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited. J Clin Endocrinol Metab 85:1584-1590
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1584-1590
    • Huang, X.1    Vaag, A.2    Hansson, M.3    Weng, J.4    Laurila, E.5    Groop, L.6
  • 256
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
    • Schalin-Jantti C, Harkonen M, Groop LC 1992 Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 41:598-604
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin-Jantti, C.1    Harkonen, M.2    Groop, L.C.3
  • 257
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck-Nielsen H 1992 Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89:782-788
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck-Nielsen, H.3
  • 258
    • 0025117502 scopus 로고
    • Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle
    • Kida Y, Esposito-Del Puente A, Bogardus C, Mott DM 1990 Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 85:476-481
    • (1990) J Clin Invest , vol.85 , pp. 476-481
    • Kida, Y.1    Esposito-Del Puente, A.2    Bogardus, C.3    Mott, D.M.4
  • 260
    • 0029857775 scopus 로고    scopus 로고
    • UKPDS 19: Heterogeneity in NIDDM: Separate contributions of IRS-1 and β 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study
    • Zhang Y, Wat N, Stratton IM, Warren-Perry MG, Orho M, Groop L, Turner RC 1996 UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and β 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. Diabetologia 39:1505-1511
    • (1996) Diabetologia , vol.39 , pp. 1505-1511
    • Zhang, Y.1    Wat, N.2    Stratton, I.M.3    Warren-Perry, M.G.4    Orho, M.5    Groop, L.6    Turner, R.C.7
  • 262
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
    • Cusi K, Consoli A, DeFronzo RA 1996 Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:4059-4067
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4059-4067
    • Cusi, K.1    Consoli, A.2    DeFronzo, R.A.3
  • 263
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-activated protein kinase cascade - The key sensor of cellular energy status
    • Hardie DG 2003 Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144:5179-5183
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 264
    • 0024556390 scopus 로고
    • Effect of sulfonylureas on hepatic glycogen metabolism: Activation of glycogen phosphorylase
    • Mojena M, Marcos ML, Monge L, Feliu JE 1989 Effect of sulfonylureas on hepatic glycogen metabolism: activation of glycogen phosphorylase. Metabolism 38:466-470
    • (1989) Metabolism , vol.38 , pp. 466-470
    • Mojena, M.1    Marcos, M.L.2    Monge, L.3    Feliu, J.E.4
  • 265
    • 0033958644 scopus 로고    scopus 로고
    • Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR 2000 Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes 49:263-271
    • (2000) Diabetes , vol.49 , pp. 263-271
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Mohideen, P.4    Carter, L.5    Henry, R.R.6
  • 267
    • 0036302960 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, Henry RR 2002 Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 51:2190-2198
    • (2002) Diabetes , vol.51 , pp. 2190-2198
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Carter, L.4    Johnson, K.5    Henry, R.R.6
  • 268
    • 0038408484 scopus 로고    scopus 로고
    • Novel targets and therapeutic strategies for type 2 diabetes
    • Morral N 2003 Novel targets and therapeutic strategies for type 2 diabetes. Trends Endocrinol Metab 14:169-175
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 169-175
    • Morral, N.1
  • 270
    • 0029126604 scopus 로고
    • A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
    • Hansen L, Hansen T, Vestergaard H, Bjorbaek C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PT, Pedersen O 1995 A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet 4:1313-1320
    • (1995) Hum Mol Genet , vol.4 , pp. 1313-1320
    • Hansen, L.1    Hansen, T.2    Vestergaard, H.3    Bjorbaek, C.4    Echwald, S.M.5    Clausen, J.O.6    Chen, Y.H.7    Chen, M.X.8    Cohen, P.T.9    Pedersen, O.10
  • 274
    • 0031763878 scopus 로고    scopus 로고
    • Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
    • Hegele RA, Harris SB, Zinman B, Wang J, Cao H, Hanley AJ, Tsui LC, Scherer SW 1998 Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. J Clin Endocrinol Metab 83:3980-3983
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3980-3983
    • Hegele, R.A.1    Harris, S.B.2    Zinman, B.3    Wang, J.4    Cao, H.5    Hanley, A.J.6    Tsui, L.C.7    Scherer, S.W.8
  • 276
    • 0033956880 scopus 로고    scopus 로고
    • Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity
    • Hansen L, Reneland R, Berglund L, Rasmussen SK, Hansen T, Lithell H, Pedersen O 2000 Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Diabetes 49:298-301
    • (2000) Diabetes , vol.49 , pp. 298-301
    • Hansen, L.1    Reneland, R.2    Berglund, L.3    Rasmussen, S.K.4    Hansen, T.5    Lithell, H.6    Pedersen, O.7
  • 277
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA 2000 Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 85:4053-4059
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 278
    • 0033810933 scopus 로고    scopus 로고
    • Effect of dietary energy restriction on glucose production and substrate utilization in type 2 diabetes
    • Christiansen MP, Linfoot PA, Neese RA, Hellerstein MK 2000 Effect of dietary energy restriction on glucose production and substrate utilization in type 2 diabetes. Diabetes 49:1691-1699
    • (2000) Diabetes , vol.49 , pp. 1691-1699
    • Christiansen, M.P.1    Linfoot, P.A.2    Neese, R.A.3    Hellerstein, M.K.4
  • 280
    • 0035968302 scopus 로고    scopus 로고
    • Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: Evidence from metabolic control analysis
    • Aiston S, Hampson L, Gomez-Foix AM, Guinovart JJ, Agius L 2001 Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis. J Biol Chem 276:23858-23866
    • (2001) J Biol Chem , vol.276 , pp. 23858-23866
    • Aiston, S.1    Hampson, L.2    Gomez-Foix, A.M.3    Guinovart, J.J.4    Agius, L.5
  • 281
    • 0033994409 scopus 로고    scopus 로고
    • Radicals and oxidative stress in diabetes
    • West IC 2000 Radicals and oxidative stress in diabetes. Diabet Med 17:171-180
    • (2000) Diabet Med , vol.17 , pp. 171-180
    • West, I.C.1
  • 283
    • 0031722646 scopus 로고    scopus 로고
    • Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency
    • Kugler W, Breme K, Laspe P, Muirhead H, Davies C, Winkler H, Schroter W, Lakomek M 1998 Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. Hum Genet 103:450-454
    • (1998) Hum Genet , vol.103 , pp. 450-454
    • Kugler, W.1    Breme, K.2    Laspe, P.3    Muirhead, H.4    Davies, C.5    Winkler, H.6    Schroter, W.7    Lakomek, M.8
  • 284
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S, Bacote V, Traxinger RR 1991 Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266:4706-4712
    • (1991) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 285
    • 0037013983 scopus 로고    scopus 로고
    • Glucosamine-6-phosphate synthase-the multi-facets enzyme
    • Milewski S 2002 Glucosamine-6-phosphate synthase-the multi-facets enzyme. Biochim Biophys Acta 1597:173-192
    • (2002) Biochim Biophys Acta , vol.1597 , pp. 173-192
    • Milewski, S.1
  • 286
    • 0035937586 scopus 로고    scopus 로고
    • Glycosylation of nucleocytoplasmic proteins: Signal transduction and O-GlcNAc
    • Wells L, Vosseller K, Hart GW 2001 Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc. Science 291:2376-2378
    • (2001) Science , vol.291 , pp. 2376-2378
    • Wells, L.1    Vosseller, K.2    Hart, G.W.3
  • 287
    • 0029742775 scopus 로고    scopus 로고
    • Hexosamines and insulin resistance
    • McClain DA, Crook ED 1996 Hexosamines and insulin resistance. Diabetes 45:1003-1009
    • (1996) Diabetes , vol.45 , pp. 1003-1009
    • McClain, D.A.1    Crook, E.D.2
  • 288
    • 0025781289 scopus 로고
    • Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation
    • Traxinger RR, Marshall S 1991 Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. J Biol Chem 266:10148-10154
    • (1991) J Biol Chem , vol.266 , pp. 10148-10154
    • Traxinger, R.R.1    Marshall, S.2
  • 289
    • 0032543680 scopus 로고    scopus 로고
    • A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
    • Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L 1998 A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393:684-688
    • (1998) Nature , vol.393 , pp. 684-688
    • Wang, J.1    Liu, R.2    Hawkins, M.3    Barzilai, N.4    Rossetti, L.5
  • 291
    • 0028784442 scopus 로고
    • Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity
    • Baron AD, Zhu JS, Zhu JH, Weldon H, Maianu L, Garvey WT 1995 Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. J Clin Invest 96:2792-2801
    • (1995) J Clin Invest , vol.96 , pp. 2792-2801
    • Baron, A.D.1    Zhu, J.S.2    Zhu, J.H.3    Weldon, H.4    Maianu, L.5    Garvey, W.T.6
  • 292
  • 293
    • 0027275367 scopus 로고
    • Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor
    • Robinson KA, Sens DA, Buse MG 1993 Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor. Diabetes 42:1333-1346
    • (1993) Diabetes , vol.42 , pp. 1333-1346
    • Robinson, K.A.1    Sens, D.A.2    Buse, M.G.3
  • 294
    • 0028951518 scopus 로고
    • Regulation of glycogen synthase by glucose, glucosamine, and glutamine:fructose-6-phosphate amidotransferase
    • Crook ED, Zhou J, Daniels M, Neidigh JL, McClain DA 1995 Regulation of glycogen synthase by glucose, glucosamine, and glutamine:fructose-6-phosphate amidotransferase. Diabetes 44:314-320
    • (1995) Diabetes , vol.44 , pp. 314-320
    • Crook, E.D.1    Zhou, J.2    Daniels, M.3    Neidigh, J.L.4    McClain, D.A.5
  • 295
    • 0034457570 scopus 로고    scopus 로고
    • Overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts enhances glucose-mediated glycogen accumulation via suppression of glycogen phosphorylase activity
    • Crook ED, Crenshaw G, Veerababu G, Singh LP 2000 Overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts enhances glucose-mediated glycogen accumulation via suppression of glycogen phosphorylase activity. Endocrinology 141:1962-1970
    • (2000) Endocrinology , vol.141 , pp. 1962-1970
    • Crook, E.D.1    Crenshaw, G.2    Veerababu, G.3    Singh, L.P.4
  • 296
    • 0029785315 scopus 로고    scopus 로고
    • Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production
    • Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L 1996 Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes 45:1329-1335
    • (1996) Diabetes , vol.45 , pp. 1329-1335
    • Barzilai, N.1    Hawkins, M.2    Angelov, I.3    Hu, M.4    Rossetti, L.5
  • 297
    • 0027962608 scopus 로고
    • Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats
    • Balkan B, Dunning BE 1994 Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 43:1173-1179
    • (1994) Diabetes , vol.43 , pp. 1173-1179
    • Balkan, B.1    Dunning, B.E.2
  • 298
    • 0026713285 scopus 로고
    • Insulin regulation of pyruvate kinase activity in isolated adipocytes. Crucial role of glucose and the hexosamine biosynthesis pathway in the expression of insulin action
    • Traxinger RR, Marshall S 1992 Insulin regulation of pyruvate kinase activity in isolated adipocytes. Crucial role of glucose and the hexosamine biosynthesis pathway in the expression of insulin action. J Biol Chem 267:9718-9723
    • (1992) J Biol Chem , vol.267 , pp. 9718-9723
    • Traxinger, R.R.1    Marshall, S.2
  • 301
    • 0033865106 scopus 로고    scopus 로고
    • Transgenic mice with increased hexosamine flux specifically targeted to β-cells exhibit hyperinsulinemia and peripheral insulin resistance
    • Tang J, Neidigh JL, Cooksey RC, McClain DA 2000 Transgenic mice with increased hexosamine flux specifically targeted to β-cells exhibit hyperinsulinemia and peripheral insulin resistance. Diabetes 49:1492-1499
    • (2000) Diabetes , vol.49 , pp. 1492-1499
    • Tang, J.1    Neidigh, J.L.2    Cooksey, R.C.3    McClain, D.A.4
  • 302
    • 0030042488 scopus 로고    scopus 로고
    • Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM
    • Yki-Jarvinen H, Daniels MC, Virkamaki A, Makimattila S, De-Fronzo RA, McClain D 1996 Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM. Diabetes 45:302-307
    • (1996) Diabetes , vol.45 , pp. 302-307
    • Yki-Jarvinen, H.1    Daniels, M.C.2    Virkamaki, A.3    Makimattila, S.4    De-Fronzo, R.A.5    McClain, D.6
  • 303
    • 0029928108 scopus 로고    scopus 로고
    • Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: Relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin
    • Daniels MC, Ciaraldi TP, Nikoulina S, Henry RR, McClain DA 1996 Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin. J Clin Invest 97:1235-1241
    • (1996) J Clin Invest , vol.97 , pp. 1235-1241
    • Daniels, M.C.1    Ciaraldi, T.P.2    Nikoulina, S.3    Henry, R.R.4    McClain, D.A.5
  • 306
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M 2001 Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 307
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M 2001 Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108:1341-1348
    • (2001) J Clin Invest , vol.108 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 308
    • 0034083716 scopus 로고    scopus 로고
    • Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells
    • Goldberg HJ, Scholey J, Fantus IG 2000 Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells. Diabetes 49:863-871
    • (2000) Diabetes , vol.49 , pp. 863-871
    • Goldberg, H.J.1    Scholey, J.2    Fantus, I.G.3
  • 309
    • 0035490104 scopus 로고    scopus 로고
    • Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: The involvement of protein kinases A and C
    • Singh LP, Andy J, Anyamale V, Greene K, Alexander M, Crook ED 2001 Hexosamine-induced fibronectin protein synthesis in mesangial cells is
    • (2001) Diabetes , vol.50 , pp. 2355-2362
    • Singh, L.P.1    Andy, J.2    Anyamale, V.3    Greene, K.4    Alexander, M.5    Crook, E.D.6
  • 310
    • 0037162342 scopus 로고    scopus 로고
    • Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
    • Federici M, Menghini R, Mauriello A, Hribal ML, Ferrelli F, Lauro D, Sbraccia P, Spagnoli LG, Sesti G, Lauro R 2002 Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. Circulation 106:466-472
    • (2002) Circulation , vol.106 , pp. 466-472
    • Federici, M.1    Menghini, R.2    Mauriello, A.3    Hribal, M.L.4    Ferrelli, F.5    Lauro, D.6    Sbraccia, P.7    Spagnoli, L.G.8    Sesti, G.9    Lauro, R.10
  • 311
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M 2000 Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA 97:12222-12226
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3    Fantus, I.G.4    Goldberg, H.5    Ziyadeh, F.6    Wu, J.7    Brownlee, M.8
  • 312
    • 0031938518 scopus 로고    scopus 로고
    • Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: Evidence for high variability and distinct regulation in diabetes
    • Nerlich AG, Sauer U, Kolm-Litty V, Wagner E, Koch M, Schleicher ED 1998 Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. Diabetes 47:170-178
    • (1998) Diabetes , vol.47 , pp. 170-178
    • Nerlich, A.G.1    Sauer, U.2    Kolm-Litty, V.3    Wagner, E.4    Koch, M.5    Schleicher, E.D.6


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