Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

Diabetes

Volumn 52, Issue 3, 2003, Pages 588-595

  Ring, David B ^a   Johnson, Kirk W ^a,c   Henriksen, Erik J ^b   Nuss, John M ^a,d   Goff, Dane ^a,e   Kinnick, Tyson R ^b   Ma, Sylvia T ^a   Reeder, John W ^a   Samuels, Isa ^a,f   Slabiak, Trina ^a   Wagman, Allan S ^a   Hammond, Mary Ellen Wernette ^a   Harrison, Stephen D ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c GeneSoft Inc   (United States)

^d EXELIXIS INC   (United States)

^e RIGEL PHARMACEUTICALS INC   (United States)

^f BAYER CORPORATION   (United States)

Author keywords

GS, glycogen synthase; GSK 3, glycogen synthase kinase 3; GTT, glucose tolerance test; IpGTT, intraperitoneal glucose tolerance test; IRS 1, insulin receptor substrate 1; OGTT, oral glucose tolerance test; PI, phosphatidylinositol; PKC, protein kinase C

Indexed keywords

CHIR 98030; CHIR 99014; CHIR 99021; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; INSULIN; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HORMONE ACTION; HYPOGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT; RAT STRAIN; SKELETAL MUSCLE;

AMINOPYRIDINES; ANIMALS; BIOLOGICAL TRANSPORT; CHO CELLS; CRICETINAE; DIABETES MELLITUS; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION; GLUCOSE; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; HEPATOCYTES; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PYRIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RECEPTOR, INSULIN; TRANSFECTION;

EID: 0037339766     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.588     Document Type: Article

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