Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity

Annals of Clinical and Laboratory Science

Volumn 32, Issue 2, 2002, Pages 114-122

  Cha, Ji Young ^a   Kim, Hyon Suk ^a   Kim, Ha Il ^a   Im, Seung Soon ^a   Kim, So Youn ^a   Kim, Jae Woo ^a   Yeh, Byung Il ^a   Ahn, Yong Ho ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Gene polymorphisms; Glucose transporter type 2; Noninsulin dependent diabetes mellitus

Indexed keywords

BETA GALACTOSIDASE; GLUCOKINASE; GLUCOSE TRANSPORTER 2; INSULIN;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ELECTROPHORESIS; GENETIC TRANSFECTION; HUMAN; INSULIN RELEASE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OLIGONUCLEOTIDE PROBE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

CELL LINE; DIABETES MELLITUS, TYPE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLUCOSE TRANSPORTER TYPE 2; HUMANS; ISLETS OF LANGERHANS; MONOSACCHARIDE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0036235790     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene
2. Glucokinase and NIDDM. A candidate gene that paid off
3. Lessons learned from molecular biology of insulin-gene mutations
4. Mutations in the insulin receptor gene
5. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
6. Mammalian glucose transporters: Structure and molecular regulation
7. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein
8. Facilitative glucose transporters: An expanding family
9. The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence
10. Facilitative glucose transporters
11. Diabetic hyperglycemia: Link to impaired glucose transport in pancreatic beta cells
12. Underexpression of cell high Km glucose transporters in noninsulin-dependent diabetes
13. Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia
14. Reduced beta-cell glucose transporter in new onset diabetic BB rats
15. The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
16. Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus
17. Multiple restriction fragment length polymorphisms at the GLUT2 locus: GLUT2 haplotypes for genetic analysis of type 2 (non-insulin-dependent) diabetes mellitus
18. Linkage analysis of GLUT1 (HepG2) and GLUT2 (liver/islet) genes in familial NIDDM
19. A mutation in the GLUT2 glucose transporter gene of a diabetic patient abolishes transport activity
20. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus
21. Strategies for cloning in plasmid vectors
22. DNA sequencing with chain-terminating inhibitors
23. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
24. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
25. Identification of transacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors lalpha and 3beta
26. Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects
27. Beta-cell GLUT-2 loss and non-insulin-dependent diabetes mellitus: Current status of the hypothesis
28. Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
29. CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells
30. Recent advances in the genetics of maturity-onset diabetes of the young and other forms of autosomal dominant diabetes