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Volumn 99, Issue 9, 1997, Pages 2173-2182

Role of the glucosamine pathway in fat-induced insulin resistance

Author keywords

free fatty acids; glucosamine; glucose uptake; insulin resistance; UDP N acetyl glucosamine

Indexed keywords

FAT; FATTY ACID; GLUCOSAMINE; GLUCOSE 6 PHOSPHATE; HEXOSAMINE; INSULIN; LIPID; URIDINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

EID: 0030926433     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119390     Document Type: Article
Times cited : (278)

References (41)
  • 2
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24h in patients with NIDDM
    • Reaven, G.M., C. Hollenbeck, C.-Y. Jeng, M.S. Wu, and Y.-D.I. Chen. 1988. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24h in patients with NIDDM. Diabetes. 37:1020-1024.
    • (1988) Diabetes. , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.-Y.3    Wu, M.S.4    Chen, Y.-D.I.5
  • 3
    • 0028276516 scopus 로고
    • Correlations between fatty acid and glucose metabolism
    • Arslanian, S.A., and S.C. Kahlan. 1994. Correlations between fatty acid and glucose metabolism. Diabetes. 43:908-914.
    • (1994) Diabetes. , vol.43 , pp. 908-914
    • Arslanian, S.A.1    Kahlan, S.C.2
  • 4
    • 0023618126 scopus 로고
    • Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes
    • Felber, J.P., E. Ferrannini, A. Golay, H.U. Meyer, D. Thiebaud, and R.A. Defronzo. 1987. Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes. 36:1341-1350.
    • (1987) Diabetes. , vol.36 , pp. 1341-1350
    • Felber, J.P.1    Ferrannini, E.2    Golay, A.3    Meyer, H.U.4    Thiebaud, D.5    Defronzo, R.A.6
  • 5
    • 50549202600 scopus 로고
    • The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle, P.J., P.B. Garland, C.N. Hales, and E.A. Newsholme. 1963. The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1:785-789.
    • (1963) Lancet. , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 6
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle, P.J., P.B. Garland, E.A. Newsholme, and C.N. Hales. 1965. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann. NY Acad. Sci. 131:324-333.
    • (1965) Ann. NY Acad. Sci. , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 8
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden, G., X. Chen, J. Ruiz, J.V. White, and L. Rossetti. 1994. Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93:2438-2446.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 9
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley, D., M. Mokan, J.-A. Simoneau, and L. Mandarino. 1993. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest. 92:91-98.
    • (1993) J. Clin. Invest. , vol.92 , pp. 91-98
    • Kelley, D.1    Mokan, M.2    Simoneau, J.-A.3    Mandarino, L.4
  • 13
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating desensitization of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall, S., V. Bacote, and R.R. Traxinger. 1991. Discovery of a metabolic pathway mediating desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance. J Biol. Chem. 266:4706-4712.
    • (1991) J Biol. Chem. , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 14
    • 0025781289 scopus 로고
    • Coordinate regulation of glutamine:fructose-6-P amidotransferase activity by insulin, glucose and glutamine
    • Traxinger, R.R., and S. Marshall. 1991. Coordinate regulation of glutamine:fructose-6-P amidotransferase activity by insulin, glucose and glutamine. J. Biol. Chem. 266:10148-10154.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10148-10154
    • Traxinger, R.R.1    Marshall, S.2
  • 15
    • 0029115944 scopus 로고
    • In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
    • Rossetti, L., M. Hawkins, W. Chen, J. Gindi, and N. Barzilai. 1995. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J. Clin. Invest. 96:132-140.
    • (1995) J. Clin. Invest. , vol.96 , pp. 132-140
    • Rossetti, L.1    Hawkins, M.2    Chen, W.3    Gindi, J.4    Barzilai, N.5
  • 16
    • 0028784442 scopus 로고
    • Glucosamine induces insulin resistance in vivo by affecting GLUT4 translocation in skeletal muscle
    • Baron, A., J.-S. Zhu, J.-H. Zhu, H. Weldon, L. Maianu, and W.T. Garvey. 1995. Glucosamine induces insulin resistance in vivo by affecting GLUT4 translocation in skeletal muscle. J. Clin. Invest. 96:2792-2801.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2792-2801
    • Baron, A.1    Zhu, J.-S.2    Zhu, J.-H.3    Weldon, H.4    Maianu, L.5    Garvey, W.T.6
  • 18
    • 0027275367 scopus 로고
    • Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles
    • Robinson, K.A., D.A. Sens, and M.G. Buse. 1993. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Diabetes. 42:1333-1346.
    • (1993) Diabetes. , vol.42 , pp. 1333-1346
    • Robinson, K.A.1    Sens, D.A.2    Buse, M.G.3
  • 19
    • 0028967019 scopus 로고
    • In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: Possible relevance to the maladaptive responses to chronic hyperglycaemia
    • Giaccari, A., L. Morviducci, D. Zorretta, P. Sbraccia, F. Leonetti, S. Caiola, A. Buongiorno, and R.C. Bonadonna. 1995. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia. 38:518-524.
    • (1995) Diabetologia. , vol.38 , pp. 518-524
    • Giaccari, A.1    Morviducci, L.2    Zorretta, D.3    Sbraccia, P.4    Leonetti, F.5    Caiola, S.6    Buongiorno, A.7    Bonadonna, R.C.8
  • 20
    • 0027295399 scopus 로고
    • Regulation of insulin-stimulated glycogen synthase activity by Overexpression of Glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts
    • Crook, E.D., M.C. Daniels, T.M. Smith, and D.A. McClain. 1993. Regulation of insulin-stimulated glycogen synthase activity by Overexpression of Glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts. Diabetes. 42:1289-1296.
    • (1993) Diabetes. , vol.42 , pp. 1289-1296
    • Crook, E.D.1    Daniels, M.C.2    Smith, T.M.3    McClain, D.A.4
  • 21
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti, L., D. Smith, G. Schulman, D. Papachristou, and R. DeFronzo. 1987. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79:1510-1515.
    • (1987) J. Clin. Invest. , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Schulman, G.3    Papachristou, D.4    Defronzo, R.5
  • 22
    • 0029860211 scopus 로고    scopus 로고
    • Increased Hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal
    • Hawkins, M., N. Barzilai, W. Chen, I. Angelov, M. Hu, P. Cohen, and L. Rossetti. 1996. Increased Hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal. Diabetes. 45:1734-1743.
    • (1996) Diabetes. , vol.45 , pp. 1734-1743
    • Hawkins, M.1    Barzilai, N.2    Chen, W.3    Angelov, I.4    Hu, M.5    Cohen, P.6    Rossetti, L.7
  • 23
    • 0031046187 scopus 로고    scopus 로고
    • The tissue concentration of UDP-N-acetyl-glucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake
    • Hawkins, M., I. Angelov, R. Liu, N. Barzilai, and L. Rossetti. 1997. The tissue concentration of UDP-N-acetyl-glucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake. J. Biol. Chem. 272:4889-4895.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4889-4895
    • Hawkins, M.1    Angelov, I.2    Liu, R.3    Barzilai, N.4    Rossetti, L.5
  • 24
    • 0029812859 scopus 로고    scopus 로고
    • Differential effects of GLUT1 or GLUT4 Overexpression on hexosamine biosynthesis by muscles of transgenic mice
    • Buse, M.G., K.A. Robinson, B.A. Marshall, and M.M. Mueckler. 1996. Differential effects of GLUT1 or GLUT4 Overexpression on hexosamine biosynthesis by muscles of transgenic mice. J. Biol. Chem. 271:23197-23202.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23197-23202
    • Buse, M.G.1    Robinson, K.A.2    Marshall, B.A.3    Mueckler, M.M.4
  • 25
    • 0023734690 scopus 로고
    • Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
    • Randle, P.J., A.L. Kerbey, and J. Espinal. 1988. Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes & Metab. Rev. 4:623-638.
    • (1988) Diabetes & Metab. Rev. , vol.4 , pp. 623-638
    • Randle, P.J.1    Kerbey, A.L.2    Espinal, J.3
  • 26
    • 0001090974 scopus 로고    scopus 로고
    • A mechanism for fatty acid inhibition of glucose utilization in liver. Role of xylulose-5-P
    • Liu, Y., and K. Uyeda. 1996. A mechanism for fatty acid inhibition of glucose utilization in liver. Role of xylulose-5-P. J. Biol. Chem. 271:8824-8830.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8824-8830
    • Liu, Y.1    Uyeda, K.2
  • 27
    • 0024467521 scopus 로고
    • Correction of chronic hyperglycemia with vanadate, but not phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle
    • Rossetti, L., and M.R. Laughlin. 1989. Correction of chronic hyperglycemia with vanadate, but not phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle. J. Clin. Invest. 84: 892-899.
    • (1989) J. Clin. Invest. , vol.84 , pp. 892-899
    • Rossetti, L.1    Laughlin, M.R.2
  • 28
    • 0025376250 scopus 로고
    • Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats
    • Rossetti, L., and A. Giaccari. 1990. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J. Clin. Invest. 85:1785-1792.
    • (1990) J. Clin. Invest. , vol.85 , pp. 1785-1792
    • Rossetti, L.1    Giaccari, A.2
  • 29
    • 0027138261 scopus 로고
    • Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. Relation to the insulin-induced inhibition of hepatic glucose production
    • Rossetti, L., and M. Hu. 1993. Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. Relation to the insulin-induced inhibition of hepatic glucose production. J. Clin. Invest. 92: 2963-2974.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2963-2974
    • Rossetti, L.1    Hu, M.2
  • 30
    • 0000190157 scopus 로고
    • D-glucose-6-phosphate
    • N.U. Bergmeyer, editor. VCH Publishers, Weinheim, Germany.
    • Michal, G. 1985. D-glucose-6-phosphate. In Methods of Enzymatic Analysis. Vol. VI. N.U. Bergmeyer, editor. VCH Publishers, Weinheim, Germany. 191-198.
    • (1985) Methods of Enzymatic Analysis , vol.6 , pp. 191-198
    • Michal, G.1
  • 31
    • 0024810673 scopus 로고
    • Isocratic high-performance liquid Chromatographic determination of the concentration and specific activity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts
    • Giaccari, A., and L. Rossetti. 1989. Isocratic high-performance liquid Chromatographic determination of the concentration and specific activity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts. J. Chromatogr. 497:69-78.
    • (1989) J. Chromatogr. , vol.497 , pp. 69-78
    • Giaccari, A.1    Rossetti, L.2
  • 32
    • 0026530891 scopus 로고
    • Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats
    • Giaccari, A., and L. Rossetti. 1992. Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J. Clin. Invest. 89:36-45.
    • (1992) J. Clin. Invest. , vol.89 , pp. 36-45
    • Giaccari, A.1    Rossetti, L.2
  • 33
    • 0025739728 scopus 로고
    • Quantitative determination of phenyl isothiocyanate-derivatized amino sugars and amino sugar alcohols by high-performance liquid chromatography
    • Anumula, K.R., and P.B. Taylor. 1991. Quantitative determination of phenyl isothiocyanate-derivatized amino sugars and amino sugar alcohols by high-performance liquid chromatography. Anal. Biochem. 197:113-120.
    • (1991) Anal. Biochem. , vol.197 , pp. 113-120
    • Anumula, K.R.1    Taylor, P.B.2
  • 35
    • 0023908033 scopus 로고
    • Effect of elevated free fatty acids on glucose oxidation in normal humans
    • Wolfe, B., S. Klein, E. Peters, B. Schmidt, and R. Wolfe. 1988. Effect of elevated free fatty acids on glucose oxidation in normal humans. Metab. Clin. Exp. 37:323-329.
    • (1988) Metab. Clin. Exp. , vol.37 , pp. 323-329
    • Wolfe, B.1    Klein, S.2    Peters, E.3    Schmidt, B.4    Wolfe, R.5
  • 36
    • 0029962286 scopus 로고    scopus 로고
    • Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats
    • Kim, J., J. Wi, and J. Youn. 1996. Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 45:446-453.
    • (1996) Diabetes. , vol.45 , pp. 446-453
    • Kim, J.1    Wi, J.2    Youn, J.3
  • 38
    • 0028817443 scopus 로고
    • A malonyl-CoA fuel-sensing mechanism in muscle: Effects of insulin, glucose and denervation
    • Saha, A., T. Kurowski, and N. Ruderman. 1995. A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose and denervation. Am. J. Physiol. 269:E283-E289.
    • (1995) Am. J. Physiol. , vol.269
    • Saha, A.1    Kurowski, T.2    Ruderman, N.3
  • 39
    • 85036439392 scopus 로고    scopus 로고
    • The malonyl-CoA fuel-sensing and signaling mechanism in skeletal muscle: Its link to cell citrate and the glucose fatty acid cycle
    • Saha, A., D. Vavvas, T. Kurowski, A. Apazidis, L. Witters, E. Shafrir, and N. Ruderman. 1996. The malonyl-CoA fuel-sensing and signaling mechanism in skeletal muscle: its link to cell citrate and the glucose fatty acid cycle. Diabetes. 45(Suppl. 2):12a.
    • (1996) Diabetes. , vol.45 , Issue.2 SUPPL.
    • Saha, A.1    Vavvas, D.2    Kurowski, T.3    Apazidis, A.4    Witters, L.5    Shafrir, E.6    Ruderman, N.7
  • 40
    • 0020465128 scopus 로고
    • Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites fluid cells
    • Ginsberg, B., J. Jabour, and A. Spector. 1982. Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites fluid cells. Biochem. Biophys. Acta. 690:157-164.
    • (1982) Biochem. Biophys. Acta. , vol.690 , pp. 157-164
    • Ginsberg, B.1    Jabour, J.2    Spector, A.3
  • 41
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty-acid composition of skeletal muscle phospholipids
    • Borkman, M., L. Storlien, D. Pan, A. Jenkins, D. Chisholm, and L. Campbell. 1993. The relation between insulin sensitivity and the fatty-acid composition of skeletal muscle phospholipids. N. Engl. J. Med. 328:238-244.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.2    Pan, D.3    Jenkins, A.4    Chisholm, D.5    Campbell, L.6


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