Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance

Diabetes

Volumn 52, Issue 3, 2003, Pages 596-604

  Delibegovic, Mirela ^a   Armstrong, Christopher G ^a,c   Dobbie, Lorraine ^b   Watt, Peter W ^a,d   Smith, Andrew J H ^b   Cohen, Patricia T W ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Upstate Ltd   (United Kingdom)

^d UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

2DOG, 2 deoxy D 1,2 3H glucose; G 6P, glucose 6 phosphate; GS, glycogen synthase; GSK 3, glycogen synthase kinase 3; PP1, protein phosphatase I; WT, wild type

Indexed keywords

GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN PHOSPHATASE 1 R5; PROTEIN SUBUNIT; PROTEIN SUBUNIT PPP1R3A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GENE DISRUPTION; GENETIC CODE; GLUCOSE TOLERANCE; GLYCOGEN MUSCLE LEVEL; HINDLIMB; HOMOZYGOTE; IMMUNOADSORPTION; IMPAIRED GLUCOSE TOLERANCE; INSULIN INFUSION; INSULIN RESISTANCE; LIPID STORAGE; MOUSE; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN TARGETING; SKELETAL MUSCLE; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CARRIER PROTEINS; GLUCOSE INTOLERANCE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; OBESITY; PHOSPHOPROTEIN PHOSPHATASE; WEIGHT GAIN;

EID: 0037341143     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.596     Document Type: Article

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