Decreased responsiveness of gluconeogenesis to the modulation by sulfonylureas in hepatocytes isolated from obese (fa/fa) zucker rats

Life Sciences

Volumn 68, Issue 14, 2001, Pages 1617-1628

  Lechuga, Carmen G ^a   Carrillo, Juan J ^a   Sánchez Gutiérrez, Julio C ^a   Felíu, Juan E ^a,b  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Gluconeogenesis; Obese (fa fa) Zucker rat; Sulfonylurea

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATE; FRUCTOSE 6 PHOSPHATE; GLIPIZIDE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN PHOSPHORYLASE; LACTIC ACID; PYRUVATE KINASE; SULFONYLUREA;

ANIMAL CELL; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GLUCONEOGENESIS; LEAN BODY WEIGHT; LIVER CELL; NONHUMAN; OBESITY; RAT;

ANIMALS; CELL SEPARATION; GLIPIZIDE; GLUCONEOGENESIS; HEPATOCYTES; HYPOGLYCEMIC AGENTS; MALE; PHOSPHOFRUCTOKINASE-1; PHOSPHORYLASES; PYRUVATE KINASE; RATS; RATS, ZUCKER; SULFONYLUREA COMPOUNDS;

ANIMALIA;

EID: 0035936724     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)00965-1     Document Type: Article

References (52)

1. Oral hypoglycemic agents
2. Oral antidiabetic drugs: An overview
3. Pancreatic actions of the sulfonylureas
4. Appraisal of the extrapancreatic actions of sulfonylureas
5. The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects
6. Mechanism of action of sulfonylureas with special reference to the extrapancreatic effect: An overview
7. Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals
8. Effects of glyburide on carbohydrate metabolism and insulin action in the liver
9. Effect of glyburide on hepatic glucose metabolism
10. Effect of hypoglycemic sulfonylureas on hepatic fructose metabolism in the rat
11. Hepatic effects of chlorpropamide: Inhibition of glucagon-stimulated gluconeogenesis in perfused livers of fasted rats
12. Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver
13. Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes
14. Effect of glipizide on hepatic fructose 2,6-bisphosphate concentration and glucose metabolism
15. Glipentide and glucose metabolism in isolated rat hepatocytes
16. Tolbutamide stimulated fructose 2,6-bisphosphate formation in perfused rat liver
17. Sulfonylurea stimulates liver fructose 2,6-bisphosphate formation in proportion to its hypoglycemic action
18. Effect of tolbutamide on fructose 6-phosphate 2-kinase and fructose 2,6-bisphosphatase in rat liver
19. Modulation of glucose metabolism by sulfonylureas in primary cultures of adult rat hepatocytes
20. Hepatic gluconeogenesis/glycolysis: Regulation and structure/function relationships of substrate cycle enzymes
21. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
22. The Zucker-fatty rat: A review
23. Animal models of non-insulin-dependent diabetes
24. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats
25. Severe hepatic and peripheral insulin resistance as evidenced by euglycemic clamps in genetically obese fa/fa rats
26. Mechanism of abnormal oral glucose tolerance of genetically obese (fa/fa) rats
27. Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats
28. Impairment of the modulation by glucose of hepatic gluconeogenesis in the genetically obese (fa/fa) Zucker rat
29. Hormonal control of pyruvate kinase and gluconeogenesis in isolated rat hepatocytes
30. A kinetic study of pyrophosphate fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate
31. Determination of D-glucose 6-phosphate and fructose 6-phosphate
32. The stimulation of liver phosphorylase b by AMP, fluoride and sulfate. A technical note on the specific determination of a and b forms of liver glycogen phosphorylase
33. Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes
34. Protein measurement with the Folin fenol reagent
35. Effect of sulfonylureas on hepatic glycogen metabolism: Activation of glycogen phosphorylase
36. 2+ levels in isolated rat hepatocytes
37. Modulation of glycogen phosphorylase activity and fructosa 2,6-bisphosphate levels by glibenclamide and meglitinide in isolated rat hepatocytes: A comparative study
38. Fasting enhances glycogen synthase activation in hepatocytes from insulin-resistant genetically obese (fa/fa) rats
39. Insulin response in skeletal muscle and fat cells of the genetically obese Zucker rat
40. Insulin resistance in soleus muscle from the obese Zucker rats
41. The sulfonylurea receptor
42. 2+ concentration in isolated rat adipocytes
43. Effect of tolbutamide on myocardial energy metabolism
44. Difference in glucose sensitivity of liver glycolysis and glycogen synthesis
45. Impaired calcium metabolism associated with hypertension in Zucker obese rats
46. Cytosolic calcium: A new factor in insulin resistance
47. On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase
48. Altered liver glycogen metabolism in fed genetically obese mice
49. The onset of liver glycogen synthesis in fasted-refed lean and genetically obese (fa/fa) rats
50. 3H]glibenclamide in rat liver membranes
51. Binding of hypoglycemic sulfonylureas to an artificial bilayer
52. Insulinotropic effects of hypoglycemic sulphonamides: The ionophoretic hypothesis