Glutamine:Fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells. Relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin

Journal of Clinical Investigation

Volumn 97, Issue 5, 1996, Pages 1235-1241

  Daniels, Marc C ^a   Ciaraldi, Theodore P ^b   Nikoulina, Svetlana ^b   Henry, Robert R ^b   McClain, Donald A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Glucose; Glutamine:fructose 6 phosphate amidotransferase; Hexosamine biosynthesis; Human skeletal muscle culture; Non insulin dependent diabetes mellitus

Indexed keywords

GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE; INSULIN;

ADULT; ARTICLE; BODY MASS; CHROMOSOME 2; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RESISTANCE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SKELETAL MUSCLE;

ADULT; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCOSE; HEXOSAMINES; HUMANS; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; TRANSAMINASES;

EID: 0029928108     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118538     Document Type: Article

References (28)

1. The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329:977-986.
2. Yki-Jarvinen, H. 1992. Glucose toxicity. Endocr Rev. 13:415-431.
3. Unger, R.H. 1991. Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. Science (Wash. DC). 251:1200-1205.
4. Marshall, S , V. Bacote, and R R. Traxinger. 1991. Discovery of a metabolic pathway mediating glucose induced desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance. J. Biol. Chem. 266:4706-4712
5. Daniels, M C., T Smith, P. Kansal, A.J. Paterson, J. Kudlow, and D A. McClain. 1993. Glucose regulation of transforming growth factor alpha expression is mediated by products of the hexosamine biosynthesis pathway. Mol. Endocrinol. 7:1041-1048.
6. McClain, D.A , A.J. Paterson, M.D. Roos, X. Wei, and J.E Kudlow. 1992. Glucose and glucosamine regulate growth factor expression in vascular smooth muscle cells. Proc Natl Acad. Sci. USA. 89:8150-8154.
7. Crook, E.D., M.C. Daniels, T. Smith, and D.A. McClain. 1993. Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts Diabetes. 42 1289-1296.
8. Crook, E.D., J Zhou, M.C. Daniels, J L. Neidigh, and D.A. McClain. 1995. Regulation of glycogen synthase by glucose, glucosamine, and glutamine: fructose-6-phosphate amidotransferase. Diabetes. 44:314-320
9. Robinson, A.R., D.A. Sens, and M.G. Buse. 1993. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Diabetes. 42:1333-1346.
10. Balkan, B., and B.E. Dunning. 1994. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes. 43:1173-1179.
11. Traxinger, R.R., and S. Marshall. 1992. Insulin regulation of pyruvate kinase activity in isolated adipocytes J. Biol. Chem. 267:9718-9723.
12. Traxinger, R.R , and S. Marshall. 1991. Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. J. Biol. Chem. 266:10148-10154.
13. McKnight, G.L., S.L. Mudri, S.L. Mathewes, R.R. Traxinger, S. Marshall, P.O. Sheppard, and P J. O'Hara. 1992. Molecular cloning, cDNA sequence, and bacterial expression of human glutamine: fructose-6-phosphate amidotransferase. J. Biol. Chem. 267:25208-25212.
14. Zhou, J., J.L. Neidigh, R Espinoza, M.M LeBeau, and D.A. McClain. 1995. Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. Hum. Genet 96.99-101.
15. Henry, R.R., L. Abrams, S. Nikoulina, and T P. Ciaraldi. 1995. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: comparison using human skeletal muscle cell cultures. Diabetes. 44:936-946.
16. Ciaraldi, T P., L. Abrams, S. Nikoulina, S. Mudaliar, and R R. Henry. 1995. Glucose transport in cultured human skeletal muscle cells. J. Clin Invest. 96:2820-2827.
17. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
18. Thornburn, A.W., B. Gumbiner, F Bulacan, P. Wallace, and R.R. Henry 1990. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (Type II) diabetes independent of impaired glucose uptake. J. Clin. Invest. 85:522-529
19. Hebert, L., and D.A. McClain. 1995. Overexpression of glutamine: fructose-6-phosphate amidotransferase in skeletal muscle of transgenic mice results in insulin resistance. Diabetes. 44(Suppl 1):47a (Abstr.)
20. Mueckler, M. 1994. Facultative glucose transporters Eur. J. Biochem 219:713-725.
21. Sarabia, V., T. Ramlal, and A. Klip. 1990. Glucose uptake in human and animal muscle cells in culture Biochem. Cell Biol. 68:536-542.
22. Yki-Jarvinen, H., M.C Daniels, A Virkamaki, S. Makimattila, R.A DeFronzo, and D.A. McClain. 1995. Increased glutamine-fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with non-insulin-dependent diabetes. Diabetes. In press.
23. Adler, A.J 1984 Glutamine fructose-6-phosphate aminotransferase and glycoprotein synthesis in the developing chick eye. Curr Eye Res. 3:351-362.
24. Richards, T.C., and O Greengard. 1973. Distribution of glutamine hexosephosphate aminotransferase in rat tissues: changes with state of differentiation. Biochim. Biophys. Acta. 304:842-850.
25. Tsuiki, S., and T. Miyagi. 1976. Neoplastic alterations of glucosamine 6-phosphate synthetase in rat liver. Adv. Enzyme Regul. 15:35-52.
26. Cryer, A. 1987. Comparative biochemistry of hpoprotein lipase. In Lipoprotein Lipase J. Borensztajn, editor. Evenr, Chicago. 277-327
27. Winterburn, P J., and C.F. Phelps. 1971. Purification and some kinetic properties of rat liver glucosamine synthetase. Biochem. J 121:701-709
28. Kornfeld, R. 1967. Studies on L-glutamine D-fructose 6-phosphate amidotransferase. J. Biol Chem 242:3135-3141