A novel (TA)n polymorphism in the hexokinase II gene: Application to noninsulin-dependent diabetes mellitus in the Pima Indians

Human Genetics

Volumn 97, Issue 4, 1996, Pages 482-485

  Ardehali, Hossein ^a   Tiller, George E ^a   Printz, Richard L ^a   Mochizuki, Hisayoshi ^b   Prochazka, Michal ^b   Granner, Daryl K ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXOKINASE;

AMERICAN INDIAN; ARTICLE; DNA POLYMORPHISM; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INTRON; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; POPULATION GENETICS; PRIORITY JOURNAL;

BASE SEQUENCE; DIABETES MELLITUS, TYPE 2; HEXOKINASE; HUMANS; INDIANS, NORTH AMERICAN; LINKAGE (GENETICS); MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC;

EID: 0030007158     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02267071     Document Type: Article

References (23)

1. Bogardus C, Lillioja S (1992) Pima Indians as a model to study the genetics of NIDDM. J Cell Biochem 48: 337-343
2. Bogardus C, Lillioja S, Bennett PH (1991) Pathogenesis of NIDDM in Pima Indians. Diabetes Care 14 [Suppl 3]: 685-690
3. DeFronzo RA, Bonadonna RC, Ferrannani E (1992) Pathogenesis of NIDDM: a balanced overview. Diabetes Care 153: 318-368
4. Echwald SM, Bjorbaek C, Hansen T, Clausen JO, Vastergaard H, Zierath JR, Printz RL, Granner DK, Pedersen O (1995) Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM. glucose effectiveness, and insulin sensitivity. Diabetes 44: 347-353
5. Granner DK, O'Brien RM (1992) Molecular physiology and genetics of NIDDM. Diabetes Care 15: 369-395
6. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (1994) The 1993-94 Genethon human genetic linkage map. Nat Genet 7: 246-339
7. Haseman JK, Elston RC (1972) The estimation of linkage between a quantitative trait and a marker locus. Behav Genet 2: 3-19
8. Knowler WC, Pettitt DJ, Saad MF, Bennet PH (1990) Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev 6: 1-27
9. Laakso M, Malkki M, Deeb S (1995) Amino acid substitutions in hexokinase II among patients with NIDDM. Diabetes 44: 330-334
10. Lathrop GM, Lalouel J-M, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81: 3443-3446
11. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennet PH, Bogardus C (1993) Insulin resistance and insulin secretory dysfunction as precursors of noninsulin-dependent diabetes mellitus. N Engl J Med 329: 1988-1992
12. NIH/CEPH CMG (1992) A comprehensive genetic linkage map of the human genome. Science 258: 67-86
13. Printz RL, Ardehali H, Koch S, Granner DK (1995) Human hexokinase II mRNA and gene structure. Diabetes 44: 290-294
14. Printz RL, Koch S, Potter LR, O'Doherty RM, Tiesinga JJ, Moritz S, Granner DK (1993) Hexokinase II mRNA and gene structure, regulation by insulin, and evolution. J Biol Chem 268: 5209-5219
15. Prochazka M, Lillioja S, Tait JF, Knowler WC, Mott DM, Spraul M, Bennet PH, Bogardus C (1993) Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. Diabetes 42: 514-519
16. Prochazka M, Mochizuki H, Baier LJ, Cohen PTW, Bogardus C (1995) Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. Diabetologia 38: 461-466
17. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in noninsulin-dependent diabetes mellitus. J Clin Invest 89: 1069-1075
18. Stoffel M, Froguel P, Takeda J. Zouali H, Vionnet N, Nishi S, Weber IT. Harrison RW, Pilkis SJ, Lesage S, Vaxillaire M, Velho G, Sun F, Iris F, Passa P, Cohen D, Bell GI (1992) Human glucokinase gene: isolation and characterization and identification of two missense mutations linked to early-onset noninsulin-dependent (type 2) diabetes mellitus. Proc Natl Acad Sci USA 89: 7698-7702
19. Ureta T (1982) The comparative isoenzymology of vertebrate hexokinase. Comp Biochem Physiol B 71: 549-555
20. Vadheim CM, Rimoin DL, Rotter JI (1990) Diabetes Mellitus. In: Emery AH, Rimoin DL (eds) Principles and practice of medical genetics. Churchill Livingstone, New York, pp 1521-1558
21. Vaxillaire M, Nathalie V, Corinne V, Fang S, Espinosa R, LeBeau MM, Stoffel M, Lehto M, Beckmann JS, Detheux M, Passa P, Cohen D, Schaftingen EV, Velho G, Bell GI, Froguel P (1994) Search for a third susceptibility gene for maturity-onset diabetes of the young. Diabetes 43: 389-395
22. Vidal-Puig A, Printz RL, Stratton IM, Granner DK, Moller DE (1995) Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln->His substitution. Diabetes 44: 340-346
23. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P, Froguel P, Cohen D (1992) Nonsense mutation in the glucokinase gene causes early-onset noninsulin-dependent diabetes mellitus. Nature 356: 721-722