Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 22, 2000, Pages 12222-12226

  Du, Xue Liang ^a   Edelstein, Diane ^a   Rossetti, Luciano ^a   Fantus, Ivan George ^b   Goldberg, Howard ^b   Ziyadeh, Fuad ^c   Wu, Jie ^a   Brownlee, Michael ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEXOSAMINE; MANGANESE SUPEROXIDE DISMUTASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SUPEROXIDE; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; DIABETES MELLITUS; ENZYME INHIBITION; GLYCOSYLATION; HYPERGLYCEMIA; MITOCHONDRION; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL;

ACETYLGLUCOSAMINE; ANIMALS; CATTLE; CELLS, CULTURED; GLYCOSYLATION; HEXOSAMINES; HYPERGLYCEMIA; MITOCHONDRIA; PHOSPHOSERINE; PHOSPHOTHREONINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; SUPEROXIDES; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; BOVINAE;

EID: 0034710891     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.22.12222     Document Type: Article

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