메뉴 건너뛰기




Volumn 104, Issue 6, 1999, Pages 787-794

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

EID: 0032742992     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7231     Document Type: Article
Times cited : (1610)

References (65)
  • 1
    • 0002678511 scopus 로고
    • Pathogensis of non-insulin-dependent (type II) diabetes mellitus
    • C.R. Kahn and G.E. Weir, editors. Lea & Febiger. Philadelphia, PA.
    • Weir, G.C., and Leahy, J.L. 1994. Pathogensis of non-insulin-dependent (type II) diabetes mellitus. In Joslin's diabetes mellitus. 13th edition. C.R. Kahn and G.E. Weir, editors. Lea & Febiger. Philadelphia, PA. 240-264.
    • (1994) Joslin's Diabetes Mellitus. 13th Edition , pp. 240-264
    • Weir, G.C.1    Leahy, J.L.2
  • 2
    • 0002027472 scopus 로고    scopus 로고
    • Metabolic abnormalities in the development of non-insulin-dependent diabetes mellitus
    • D. LeRoith, S.I. Taylor, and J.M. Olefski, editors. Lippincot-Raven Publishers. Philadelphia, PA. 459 pp.
    • Bogardus, C. 1996. Metabolic abnormalities in the development of non-insulin-dependent diabetes mellitus. In Diabetes mellitus. D. LeRoith, S.I. Taylor, and J.M. Olefski, editors. Lippincot-Raven Publishers. Philadelphia, PA. 459 pp.
    • (1996) Diabetes Mellitus
    • Bogardus, C.1
  • 3
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: B-cell, muscle, liver. A collision responsible for NIDDM
    • DeFronzo, R.A. 1988. Lilly Lecture 1987. The triumvirate: B-cell, muscle, liver. A collision responsible for NIDDM. Diabetes. 37:667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 4
    • 0018602014 scopus 로고
    • Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
    • National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
    • (1979) Diabetes , vol.28 , pp. 1039-1057
  • 5
    • 0003512785 scopus 로고
    • World Health Organization Technical Report Series, 45 pp.
    • World Health Organization. 1985. Diabetes mellitus: report of a WHO study group. World Health Organization Technical Report Series, Volume 17, 45 pp.
    • (1985) Diabetes Mellitus: Report of a WHO Study Group , vol.17
  • 6
    • 0031965201 scopus 로고    scopus 로고
    • Report of an expert committee on the diagnosis and classification of diabetes mellitus
    • American Diabetes Association. 1998. Report of an expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 21(Suppl. 1):S5-S19.
    • (1998) Diabetes Care , vol.21 , Issue.SUPPL. 1
  • 7
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven, G.M. 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 8
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • DeFronzo, R.A. 1997. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Reviews. 5:177-269.
    • (1997) Diabetes Reviews , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 10
    • 0027458051 scopus 로고
    • Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: Errors of metabolism or of methods?
    • Groop, L.C., Widen, E., and Ferrannini, E. 1993. Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: errors of metabolism or of methods? Diabetologia. 36:1326-1331.
    • (1993) Diabetologia , vol.36 , pp. 1326-1331
    • Groop, L.C.1    Widen, E.2    Ferrannini, E.3
  • 11
    • 0028229508 scopus 로고
    • Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?
    • Taylor, S.I., Accili, D., and Imai, Y. 1994. Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes. 43:735-740.
    • (1994) Diabetes , vol.43 , pp. 735-740
    • Taylor, S.I.1    Accili, D.2    Imai, Y.3
  • 12
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance vs. insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini, E. 1998. Insulin resistance vs. insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr. Rev. 19:477-490.
    • (1998) Endocr. Rev. , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 13
    • 0017686869 scopus 로고
    • Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes
    • Reaven, G.M., and Olefsky, J.M. 1977. Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes. Diabetologia. 13:201-206.
    • (1977) Diabetologia , vol.13 , pp. 201-206
    • Reaven, G.M.1    Olefsky, J.M.2
  • 14
    • 0024590095 scopus 로고
    • Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance
    • Reaven, G.M., Hollenbeck, C.B., and Chen, Y.D.I. 1989. Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance. Diabetologia. 32:52-55.
    • (1989) Diabetologia , vol.32 , pp. 52-55
    • Reaven, G.M.1    Hollenbeck, C.B.2    Chen, Y.D.I.3
  • 15
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
    • Bogardus, C., Lillioja, S., Howard, B.V., Reaven, G., and Mott, D.M. 1984. Relationships between insulin secretion, insulin action and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J. Clin. Invest. 74:1238-1246.
    • (1984) J. Clin. Invest. , vol.74 , pp. 1238-1246
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3    Reaven, G.4    Mott, D.M.5
  • 16
    • 0015324585 scopus 로고
    • Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study
    • Cerasi, E., Luft, R., and Efendic, S. 1972. Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study. Diabetes. 21:224-234.
    • (1972) Diabetes , vol.21 , pp. 224-234
    • Cerasi, E.1    Luft, R.2    Efendic, S.3
  • 17
    • 0024348996 scopus 로고
    • Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus
    • Eriksson, J., et al. 1989. Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus. N. Engl. J. Med. 321:337-343.
    • (1989) N. Engl. J. Med. , vol.321 , pp. 337-343
    • Eriksson, J.1
  • 18
    • 0029791090 scopus 로고    scopus 로고
    • Insulin secretion and insulin deficiency in people with impaired glucose tolerance
    • Pimenta, W., et al. 1996. Insulin secretion and insulin deficiency in people with impaired glucose tolerance. Diabet. Med. 13:S33-S36.
    • (1996) Diabet. Med. , vol.13
    • Pimenta, W.1
  • 19
    • 0026793272 scopus 로고
    • Analysis of early-phase insulin responses in non-obese subjects with mild glucose intolerance
    • Yoneda, H., et al. 1992. Analysis of early-phase insulin responses in non-obese subjects with mild glucose intolerance. Diabetes Care. 15:1517-1521.
    • (1992) Diabetes Care , vol.15 , pp. 1517-1521
    • Yoneda, H.1
  • 20
    • 0022450553 scopus 로고
    • Beta-cell dysfunction, rather than insulin in sensitivity, is the primary defect in familial type 2 diabetes
    • O'Rahilly, S.P., et al. 1986. Beta-cell dysfunction, rather than insulin in sensitivity, is the primary defect in familial type 2 diabetes. Lancet. 2:360-364.
    • (1986) Lancet , vol.2 , pp. 360-364
    • O'Rahilly, S.P.1
  • 21
    • 0029841180 scopus 로고    scopus 로고
    • Insulin response to oral glucose load is consistently decreased in established non-insulin dependent diabetes mellitus: The usefulness of decreased early insulin response as a predictor of diabetes mellitus
    • Kosaka, K., Kuzuya, T., Hagura, R., and Yoshinaga, H. 1996. Insulin response to oral glucose load is consistently decreased in established non-insulin dependent diabetes mellitus: the usefulness of decreased early insulin response as a predictor of diabetes mellitus. Diabet. Med. 13:S109-S119.
    • (1996) Diabet. Med. , vol.13
    • Kosaka, K.1    Kuzuya, T.2    Hagura, R.3    Yoshinaga, H.4
  • 22
    • 0029022819 scopus 로고
    • Pancreeatic beta-cell dycfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
    • Pimenta, W., et al, 1995. Pancreeatic beta-cell dycfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA. 273:1855-1861.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1
  • 23
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM parents. A cross-sectional study
    • Perseghin, G., Ghosh, S., Gerow, K., and Shulman, G.I. 1997. Metabolic defects in lean nondiabetic offspring of NIDDM parents. A cross-sectional study. Diabetes. 46:1001-1009.
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 24
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
    • Gulli, G., Ferrannini, E., Stern, M., Haffner, S., and DeFronzo, R.A. 1992. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 41:1575-1586.
    • (1992) Diabetes , vol.41 , pp. 1575-1586
    • Gulli, G.1    Ferrannini, E.2    Stern, M.3    Haffner, S.4    DeFronzo, R.A.5
  • 25
    • 0017805857 scopus 로고
    • The relationship of insulin response to a glucose stimulus over a wide range of glucose tolerance
    • Zimmet, P., Whitehouse, S., Alford, F., and Chisholm, D. 1978. The relationship of insulin response to a glucose stimulus over a wide range of glucose tolerance. Diabetologia. 15:23-27.
    • (1978) Diabetologia , vol.15 , pp. 23-27
    • Zimmet, P.1    Whitehouse, S.2    Alford, F.3    Chisholm, D.4
  • 26
    • 0029777556 scopus 로고    scopus 로고
    • Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance
    • Haffner, S.M., Miettinen, H., Gaskill, S.P., and Stern, M.P. 1996. Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance. Diabetologia. 39:1201-1207.
    • (1996) Diabetologia , vol.39 , pp. 1201-1207
    • Haffner, S.M.1    Miettinen, H.2    Gaskill, S.P.3    Stern, M.P.4
  • 27
    • 0019814499 scopus 로고
    • Obesity, very low density lipoproteins, and glucose intolerance over 14years. The Framingham study
    • Wilson, P.W., McGee, D.L., and Kannel, W.B. 1981. Obesity, very low density lipoproteins, and glucose intolerance over 14years. The Framingham study. Am. J. Epidemiol. 114:697-704.
    • (1981) Am. J. Epidemiol. , vol.114 , pp. 697-704
    • Wilson, P.W.1    McGee, D.L.2    Kannel, W.B.3
  • 28
    • 0025000188 scopus 로고
    • Diabetes mellitus in the Pima Indians: Incidence, risk factors and pathogenesis
    • Knowler, W.C., Pettitt, D.J., Saad, M.F., and Bennett, P.H. 1990. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab. Rev. 6:1-27.
    • (1990) Diabetes Metab. Rev. , vol.6 , pp. 1-27
    • Knowler, W.C.1    Pettitt, D.J.2    Saad, M.F.3    Bennett, P.H.4
  • 29
    • 0022408652 scopus 로고
    • The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913
    • Ohlson, L.D., et al. 1985. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 34:1055-1058.
    • (1985) Diabetes , vol.34 , pp. 1055-1058
    • Ohlson, L.D.1
  • 30
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja, S., et al. 1993. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin dependent diabetes mellitus. Prospective studies of Pima Indians. N. Engl. J. Med. 329:1988-1992.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1988-1992
    • Lillioja, S.1
  • 31
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes. Results of a 25-year follow-up study
    • Martin, B.C., et al. 1992. Role of glucose and insulin resistance in development of type 2 diabetes. Results of a 25-year follow-up study. Lancet. 340:925-929.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1
  • 32
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type 2 diabetes in the offspring of diabetic parents
    • Warram, J.H., Martin, B.C., Krolewski, A.S., Soeldner, J.S., and Kahn, C.R. 1990. Slow glucose removal rate and hyperinsulinemia precede the development of type 2 diabetes in the offspring of diabetic parents. Ann. Intern. Med. 113:909-915.
    • (1990) Ann. Intern. Med. , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 33
    • 0025854677 scopus 로고
    • A two-step model for development of non-insulin dependent diabetes mellitus
    • Saad, M.F., et al. 1991. A two-step model for development of non-insulin dependent diabetes mellitus. Am. J. Med. 90:229-235.
    • (1991) Am. J. Med. , vol.90 , pp. 229-235
    • Saad, M.F.1
  • 34
    • 0025893266 scopus 로고
    • Risk factors for NIDDM in white population: Paris prospective study
    • Charles, M.A., et al. 1991. Risk factors for NIDDM in white population: Paris prospective study. Diabetes. 40:796-799.
    • (1991) Diabetes , vol.40 , pp. 796-799
    • Charles, M.A.1
  • 35
    • 0029035963 scopus 로고
    • Earlier appearance of impaired insulin secretion than of visceral adipocity in the pathogenesis of NIDDM
    • Chen, K.W., et al. 1995. Earlier appearance of impaired insulin secretion than of visceral adipocity in the pathogenesis of NIDDM. Diabetes Care. 18:747-753.
    • (1995) Diabetes Care , vol.18 , pp. 747-753
    • Chen, K.W.1
  • 36
    • 0028873402 scopus 로고
    • Early and late insulin response as predictors of NIDDM in Pima Indians with impaired glucose tolerance
    • Nagi, D.K., et al. 1995. Early and late insulin response as predictors of NIDDM in Pima Indians with impaired glucose tolerance. Diabetologia. 38:187-192.
    • (1995) Diabetologia , vol.38 , pp. 187-192
    • Nagi, D.K.1
  • 38
    • 0021440736 scopus 로고
    • Aspects of the pathogenesis of type 2 diabetes
    • Efendic, S., Luft, R., and Wajngot, A. 1984. Aspects of the pathogenesis of type 2 diabetes. Endocr. Rev. 5:395-410.
    • (1984) Endocr. Rev. , vol.5 , pp. 395-410
    • Efendic, S.1    Luft, R.2    Wajngot, A.3
  • 39
    • 0025341763 scopus 로고
    • Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes
    • Lundgren, H., Bengtsson, C., Blohme, G., Lapidus, L., and Waldenstroem, J. 1990. Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes. Diabet. Med. 7:407-413.
    • (1990) Diabet. Med. , vol.7 , pp. 407-413
    • Lundgren, H.1    Bengtsson, C.2    Blohme, G.3    Lapidus, L.4    Waldenstroem, J.5
  • 40
    • 0021359902 scopus 로고
    • Risk factors for worsening to diabetes in subjects with impaired glucose tolerance
    • Kadowaki, T., et al. 1984. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia. 26:44-49.
    • (1984) Diabetologia , vol.26 , pp. 44-49
    • Kadowaki, T.1
  • 41
    • 0025142898 scopus 로고
    • Natutal history of β-cell dysfunction in NIDDM
    • Leahy, J.L. 1990. Natutal history of β-cell dysfunction in NIDDM. Diabetes Care. 13:992-1010.
    • (1990) Diabetes Care , vol.13 , pp. 992-1010
    • Leahy, J.L.1
  • 42
    • 0023811760 scopus 로고
    • Obesity and insulin resistance: Lessons learned from the Pima Indians
    • Lillioja, S., and Bogardus, C. 1988. Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab. Rev. 4:517-540.
    • (1988) Diabetes Metab. Rev. , vol.4 , pp. 517-540
    • Lillioja, S.1    Bogardus, C.2
  • 43
    • 0025208270 scopus 로고
    • Energy expenditure in humans: Effects of dietary fat and carbohydrate
    • Abbott, W.G.H., Howard, B.V., Ruoloto, G., and Ravussin, E. 1990. Energy expenditure in humans: effects of dietary fat and carbohydrate. Am. J. Physiol. 258:E347-E351.
    • (1990) Am. J. Physiol. , vol.258
    • Abbott, W.G.H.1    Howard, B.V.2    Ruoloto, G.3    Ravussin, E.4
  • 44
    • 0002991241 scopus 로고
    • A method for underwater weighing and the determination of body density
    • J. Brozek and A. Herschel, editors. National Research Council. Washington, DC
    • Goldman, R.F., and Buskirk, E.R. 1961. A method for underwater weighing and the determination of body density. In Techniques for measuring body composition. J. Brozek and A. Herschel, editors. National Research Council. Washington, DC. 78-106.
    • (1961) Techniques for Measuring Body Composition , pp. 78-106
    • Goldman, R.F.1    Buskirk, E.R.2
  • 45
    • 0003129614 scopus 로고
    • Body composition from fluid spaces and density: Analysis of methods
    • J. Brozek and A. Herschel, editors. National Research Council. Washington, DC.
    • Siri, W.E. 1961. Body composition from fluid spaces and density: analysis of methods. In Techniques for measuring body composition. J. Brozek and A. Herschel, editors. National Research Council. Washington, DC. 223-244.
    • (1961) Techniques for Measuring Body Composition , pp. 223-244
    • Siri, W.E.1
  • 46
    • 0028062006 scopus 로고
    • Body fat distribution and energy metabolism in obese men and women
    • Tataranni, P.A., Larson, D.E., and Ravussin, E. 1994. Body fat distribution and energy metabolism in obese men and women. J. Am. Coll. Nutr. 13:569-574.
    • (1994) J. Am. Coll. Nutr. , vol.13 , pp. 569-574
    • Tataranni, P.A.1    Larson, D.E.2    Ravussin, E.3
  • 47
    • 0345383110 scopus 로고
    • Relationship between obesity and maximal stimulated glucose uptake in vivo and in vitro in Pima Indians
    • Bogardus, C., et al. 1984. Relationship between obesity and maximal stimulated glucose uptake in vivo and in vitro in Pima Indians. J. Clin. Invest. 78:1568-1578.
    • (1984) J. Clin. Invest. , vol.78 , pp. 1568-1578
    • Bogardus, C.1
  • 48
    • 0022592847 scopus 로고
    • Familial dependence of the resting metabolic rate
    • Bogardus, C., Lillioja, S., and Ravussin, E. 1986. Familial dependence of the resting metabolic rate. N. Engl. J. Med. 315:96-100.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 96-100
    • Bogardus, C.1    Lillioja, S.2    Ravussin, E.3
  • 49
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich, J.E. 1998. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr. Rev. 19:491-503.
    • (1998) Endocr. Rev. , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 51
    • 0019810028 scopus 로고
    • Physiological evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and beta cell glucose sensitivity from the response to intravenous glucose
    • Bergman, R.N., Phillips, L.S., and Cobelli, C. 1981. Physiological evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta cell glucose sensitivity from the response to intravenous glucose. J. Clin. Invest. 68:1456-1467.
    • (1981) J. Clin. Invest. , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, L.S.2    Cobelli, C.3
  • 52
    • 0024834748 scopus 로고
    • Toward physiological understanding of glucose tolerance: Minimal model approach
    • Bergman, R.N. 1989. Toward physiological understanding of glucose tolerance: minimal model approach. Diabetes. 38:1512-1527.
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 54
    • 0000380542 scopus 로고
    • Immunoassay of endogenous plasma insulin in man
    • Yalow, R.S., and Berson, S.A. 1960. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39:1157-1167.
    • (1960) J. Clin. Invest. , vol.39 , pp. 1157-1167
    • Yalow, R.S.1    Berson, S.A.2
  • 56
    • 0032523817 scopus 로고    scopus 로고
    • Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in non-diabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts
    • Mott, D., Pratley, R.E., and Bogardus, C. 1998. Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in non-diabetic Pima Indians are related to glycogen synthase fractional activity in cultured myoblasts. J. Clin. Invest. 101:2251-2256.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2251-2256
    • Mott, D.1    Pratley, R.E.2    Bogardus, C.3
  • 57
    • 0026654879 scopus 로고
    • Intracellular defects in glucose metabolism in obese patients with NIDDM
    • Kelley, D.E., Mokan, M., and Mandarino, L.J. 1992. Intracellular defects in glucose metabolism in obese patients with NIDDM. Diabetes. 41:698-706.
    • (1992) Diabetes , vol.41 , pp. 698-706
    • Kelley, D.E.1    Mokan, M.2    Mandarino, L.J.3
  • 58
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin dependent diabetes by 13 C nuclear magnetic resonance spectroscopy
    • Shulman, G.I., et al. 1990. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin dependent diabetes by 13 C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322:223-228.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 223-228
    • Shulman, G.I.1
  • 59
    • 0023924773 scopus 로고
    • Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians
    • Lillioja, S., et al. 1988. Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N. Engl. J. Med. 318:1217-1225.
    • (1988) N. Engl. J. Med. , vol.318 , pp. 1217-1225
    • Lillioja, S.1
  • 60
    • 0023264686 scopus 로고
    • Loss of early phase insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose
    • Calles-Escandon, J., and Robbins, D.C. 1987. Loss of early phase insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes. 36:1167-1172.
    • (1987) Diabetes , vol.36 , pp. 1167-1172
    • Calles-Escandon, J.1    Robbins, D.C.2
  • 61
    • 0024422762 scopus 로고
    • Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans
    • Luzi, L., and DeFronzo, R.A. 1989. Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am. J. Physiol. 257:E241-E246.
    • (1989) Am. J. Physiol. , vol.257
    • Luzi, L.1    DeFronzo, R.A.2
  • 62
    • 0024216182 scopus 로고
    • Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes
    • Bruce, D.G., Chisholm, D.J., Storlien, L.H., and Kraegen, E.W. 1988. Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes. Diabetes. 37:736-744.
    • (1988) Diabetes , vol.37 , pp. 736-744
    • Bruce, D.G.1    Chisholm, D.J.2    Storlien, L.H.3    Kraegen, E.W.4
  • 63
    • 0017236889 scopus 로고
    • Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
    • Brunzell, J.D., et al. 1976. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J. Clin. Endocrinol. Metab. 42:222-229.
    • (1976) J. Clin. Endocrinol. Metab. , vol.42 , pp. 222-229
    • Brunzell, J.D.1
  • 64
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
    • Unger, R. 1995. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes. 44:863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.1
  • 65
    • 0031753344 scopus 로고    scopus 로고
    • Lowering fatty acids potentiates acute insulin response in first-degree relatives of people with type 2 diabetes
    • Paolisso, G., et al. 1998. Lowering fatty acids potentiates acute insulin response in first-degree relatives of people with type 2 diabetes. Diabetologia. 41:1127-1132.
    • (1998) Diabetologia , vol.41 , pp. 1127-1132
    • Paolisso, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.