Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line

Journal of Endocrinology

Volumn 164, Issue 3, 2000, Pages 307-314

  Iizuka, K ^a   Nakajima, H ^a   Ono, A ^a   Okita, K ^a   Miyazaki, J I ^a   Miyagawa, J I ^a   Namba, M ^a   Hanafusa, T ^a   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME SUBUNIT; ENZYME SYNTHESIS; GENE OVEREXPRESSION; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0034067256     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1640307     Document Type: Article

References (23)

1. Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM & Hutton JC 1999 Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes 48 531-542.
2. Argaud D, Kirby TL, Newgard CB & Lange AJ 1997 Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphatase. Journal of Biological Chemistry 272 12854-12861.
3. Ashcroft SJ & Randle PJ 1968 Glucose-6-phosphatase activity of mouse pancreatic islets. Nature 219 857-858.
4. Balaban RS 1990 Regulation of oxidative phosphorylation in the mammalian cell. American Journal of Physiology 258 C377-C389.
5. Duchen MR, Smith PA & Ashcroft FM 1993 Substrate-dependent changes in mitochondrial fuction, intracellular free calcium concentrations and membrane channels in pancreatic beta-cells. Biochemical Journal 294 35-42.
6. Efendic S, Wajngot A & Vranic M 1985 Increased activity of the glucose cycle in the liver; early characteristics of type 2 diabetes. Proceedings of the National Academy of Sciences of the USA 82 2965-2969.
7. Khan A, Chandramouli V, Ostenson CG, Ahren B, Schumann WC, Low H, Landau BR & Efendic S 1989 Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse. Journal of Biological Chemistry 264 9732-9733.
8. Khan A, Chandramouli V, Ostenson CG, Low H, Landau BR & Efendic S 1990 Glucose cycling in islets from healthy and diabetic rats. Diabetes 39 456-459.
9. Liang Y, Najafi H & Matschinsky FM 1990 Glucose regulates glucokinase activity in cultured islets from rat pancreas. Journal of Biological Chemistry 265 16863-16866.
10. Malaisse WJ, Malaisse-Lagae F, Davies DR & Van Schaftingen E 1989 Presence of fructokinase in pancreatic islets. FEBS Letters 255 175-178.
11. Meglasson MD & Matschinsky FM 1984 Purification of the putative islet cell glucose sensor. In Methods in Diabetic Research, vol 1, pp 213-226. Eds J Larner & S Pohl. New York: John Wiley & Sons Inc.
12. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y & Yamamura K 1990 Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127 126-132.
13. Niwa H, Yamamura K & Miyazaki J 1991 Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 193-200.
14. Nordlie RC, Foster JD & Lange AJ 1999 Regulation of glucose production by the liver. Annual Review of Nutrition 19 379-406.
15. Sakuma N, Ishikawa S, Okada K, Miyazaki J & Saito J 1995 Glucose induces calcium-dependent and calcium-independent insulin secretion from the pancreatic beta cell line MIN6. European Journal of Endocrinology 133 227-234.
16. Seoane J. Trinh K, O'Doherty RM, Gomez-Foix AM, Lange AJ, Newgard CB & Guinovart JJ 1997 Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. Journal of Biological Chemistry 272 26972-26977.
17. Shingu R, Nakajima H, Horikawa Y, Hamaguchi T, Yamasaki T, Miyagawa J, Namba M, Hanafusa T & Matsuzawa Y 1996 Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Research Communications in Molecular Pathology and Pharmacology 931 13-24.
18. Sweet IR, Najafi H, Li G, Grodberg J & Matschinsky FM 1997 Measurement and modeling of glucose-6-phosphatase in pancreatic islets. American Journal of Physiology 272 E696-E711.
19. Taljedal I-B 1969 Presence, induction and possible role of glucose-6-phosphatase in mammalian pancreatic cells. Biochemical Journal 114 387-394.
20. Tokuyama Y, Sturis J, DePaol AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS & Bell GI 1995 Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44 1447-1457.
21. Trinh K, Minassian C, Lange AJ, Doherty RM & Newgard CB 1997 Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Journal of Biological Chemistry 272 24837-24842.
22. Waddell ID & Burchell A 1988 The microsomal glucose-6-phosphatase enzyme of pancreatic islets. Biochemical Journal 255 471-476.
23. Wang H & Iynedjian PB 1997 Modulation of glucose responsiveness of insulinoma β-cells by graded overexpression of glucokinase. Proceedings of the National Academy of Sciences of the USA 94 4372-4377.