Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 11, 1996, Pages 4059-4067

  Cusi, Kenneth ^a,c   Consoli, Agostino ^a,d   Defronzo, Ralph A ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A; INSULIN; LACTIC ACID; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; FEMALE; GLUCONEOGENESIS; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; LACTIC ACID; LIPIDS; LIVER; MALE; METFORMIN; MIDDLE AGED; OXIDATION-REDUCTION;

EID: 0029819936     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.11.4059     Document Type: Article

References (53)

1. Hermann L. 1979 Metformin: a review of its pharmacological properties and therapeutic use. Diabetes Metab. 5:233-245.
2. Bailey CJ. 1992 Biguanides and NIDDM. Diabetes Care. 15:755-772.
3. DeFronzo RA, Goodman A, Multicenter Metformin Study Group. 1995 Efficacy of metformin in NIDDM patients poorly controlled on diet alone or diet plus sulfonylurea. N Engl J Med. 333:541-549.
4. Stumvoll M, Nurjahan N, Perriello G, Dailey G, Gerich JE. 1995 Metabolic effects of metformin in non-insulin dependent diabetes mellitus. N Engl J Med. 333:550-554.
5. DeFronzo RA, Bonadonna RC, Ferrannini E. 1992 Pathogenesis of NIDDM: a balanced overview. Diabetes Care. 15:318-366.
6. DeFronzo R, Ferrannini E, Simonson D. 1989 Fasting hyperglycemia in non-insulin dependent diabetes mellitus; contribution of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism. 38:387-395.
7. Ferrannini E, Simonson D, Katz I, et al. 1988 The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism 47:79-85.
8. Saad F, Knowler C, Pettitt J, Nelson G, Mott M, Bennett PH. 1989 Sequential changes in serum insulin concentration during development of non-insulin dependent diabetes. Lancet. 1:1356-1359.
9. Porte Jr D. 1991 Beta-cells in type II diabetes mellitus. Diabetes. 40:166-180.
10. Hother-Nielsen O, Schmitz O, Andersen PH, Beck-Nielsen H, Pedersen O. 1989 Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes. Acta Endocrinol (Copenh). 120:257-265.
11. Johnson AB, Webster JM, Sum C-F, et al. 1993 The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients. Metabolism 42:1217-1222.
12. Nosadini R, Avogaro A, Trevisan R, et al. 1987 Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes. Diabetes Care. 10:62-67.
13. Wu M-S, Johnston P, Sheu WH-H, et al. 1990 Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients. Diabetes Care. 13:1-8.
14. DeFronzo RA, Barzilai N, Simonson DC. 1991 Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab. 73:1294-1301.
15. Reaven G-M, Johnston P, Hollenbeck CB, Skowronski R, Zhang J, Chen Y-DI. 1992 Combined metformin-sulfonylurea treatment of patients with non-insulin-dependent diabetes in fair to poor glycemic control. J Clin Endocrinol Metab. 74:1020-1026.
16. Giugliano D, De Rosa N, Di Maro G, et al. 1993 Metformin improves glucose and lipid metabolism, and reduces blood pressure in hypertensive, obese women. Diabetes Care. 16:1387-1390.
17. Jackson RA, Hawa MI, Jaspan JV, et al. 1987 Mechanisms of metformin action in non-insulin dependent diabetes. Diabetes. 36:632-640.
18. Shepherd M, Kushwaha R. 1994 Effect of metformin on basal and postprandial lipid and carbohydrate metabolism in NIDDM subjects. Diabetes. 43(Suppl 1):76A.
19. Marena S, Tagliaferro V, Montegrosso G, Pagano A, Scaglione L, Pagano G. 1994 Metabolic effects of metformin addition to chronic gibenclamide treatment in type 2 diabetes. Diabetes Metab. 20:15-19.
20. Perriello G, Misericordia P, Volpi E, et al. 1994 Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes. 43:920-928.
21. Wollen N, Bailey CJ. 1988 Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin. Biochem Pharmacol. 37:4353-4358.
22. Argaud D, Roth H, Wiernsperger N, Leverve XM. 1993 Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes. Eur J Biochem. 213:1341-1348.
23. Consoli A, Nurjhan N, Capani F, Gerich J. 1989 Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38:550-557.
24. National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1051.
25. DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 6:E214-E223.
26. Layman DK, Wolfe RR. 1987 Sample site selection for tracer studies applying a unidirectional circulatory approach. Am J Physiol. 253:E173-E178.
27. Kubicek WG, Kottke IJ, Ramos MU, et al. 1974 The Minnesota impedance cardiograph: theory and applications. Biomed Engin. 9:410-416.
28. Koon-Kang T, Hetherington MD, Haennel RG, Greenwood PV, Rossall RE, Kappagoda T. 1985 Cardiac output measured by impedance cardiography during maximal exercise tests. Cardiovas Res. 19:737-743.
29. Lipid Research Clinics Program. 1974 Manual of laboratory operations. Bethesda: NIH; DHEW publication (NIH) 75-628.
30. Friedewald WT, Levy RI, Fredrickson DS. 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative centrifuge. Clin Chem. 18:499-502.
31. Consoli A, Nurjhan N, Reilly JJ, Bier D, Gerich J. 1990 Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans. Am J Physiol. 259:E677-E684.
32. Miles JR, Glassock J, Aikens J, Gerich J, Haymond M. 1983 A microfluorimetric method of free fatty acid in plasma. J Lipid Res. 24:96-99.
33. Passoneau J. 1972 Lactate. In: Bergmeyer H, eds. Methods of enzymatic analysis. New York: Academic Press; 1468-1472.
34. Steele R, Wall JS, DeBodo RC, Altszuler N. 1956 Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol. 187:15-25.
35. 14C glucose. Recent Prog Horm Res. 19:445-558.
36. Cowan JS, Hetenyi G. 1971 Glucoregulatory responses in normal, and diabetic dogs recorded by a new tracer method. Metabolism. 20:360-372.
37. Simonson DC, DeFronzo RA. 1990 Indirect calorimetry: methodological and interpretive problems. Am J Physiol. 258:E399-E412.
38. 13C nuclear magnetic resonance spectroscopy. N Engl J Med. 322:223-228.
39. Searle G, Cavalieri R. 1972 Determination of lactate kinetics in human analysis of data from single injection vs. continuous infusion methods. Proc Soc Exp Biol Med. 139:1002-1006.
40. Landau BR. 1993 Estimating gluconeogenic rates in NIDDM. Adv Exp Med Biol. 334:209-220.
41. 14C-labeled substrates. Am J Physiol. 248:R391-R399.
42. Consoli A, Nurjhan N, Reilly JJ, Bier D, Gerich JE. 1990 Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus: role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest. 86:2038-2045.
43. Rossetti I, Giaccari A, DeFronzo RA. 1990 Glucose toxicity. Diabetes Care Rev. 13:610-630.
44. Misbin RI. 1977 Phenformin-associated lactic acidosis: pathogenesis and treatment. Ann Intern Med. 87:591-595.
45. Fulop M, Hoberman HD. 1976 Phenformin-associated lactic acidosis. Diabetes. 25:292-296.
46. Hetenyi G, Perez G, Vranic M. 1983 Turnover and precursor production relationships of nonlipid metabolites. Physiol Rev. 63:606-667.
47. Kreisberg RA, Pennington LF, Boshell BR. 1970 Lactate turnover and gluconeogenesis in normal and obese humans. Diabetes. 19:53-63.
48. Consoli A, Nurjhan N, Reilly JJ, Bier D, Gerich JE. 1990 Contribution of liver and skeletal muscle to alanine and lactate metabolism in man. Am J Physiol. 259:E677-E685.
49. Nurjhan N, Consoli A, Gerich JE. 1992 Increased lipolysis and its consequences on gluconeogenesis in non-insulin dependent diabetes mellitus. J Clin Invest. 89:169-175.
50. Puhakainene I, Koivisto VA, Yki-Jarvinen H. 1992 Lipolysis and gluconeogenesis from glycerol are increased in patients with non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab. 75:789-7941.
51. Henry RR, Scheaffer L, Olefsky JM. 1985 Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin dependent diabetes mellitus. J Clin Endocrinol Metab. 61:917-925.
52. Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M. 1993 Relative effects of caloric restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 77:1287-1293.
53. Laasko M, Uusitupa M, Takala J, Majander H, Reijonen T, Penttila I. 1988 Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects. Metabolism. 37:1092-1100.