Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle

Diabetes

Volumn 51, Issue 7, 2002, Pages 2190-2198

  Nikoulina, Svetlana E ^a,b   Ciaraldi, Theodore P ^a,b   Mudaliar, Sunder ^a,b   Carter, Leslie ^a,b   Johnson, Kirk ^c   Henry, Robert R ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHIR 98014; CHIR 98023; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LITHIUM CHLORIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN SENSITIVITY; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0036302960     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.7.2190     Document Type: Article

References (56)

1. Glycogen synthase kinase-3 from rabbit skeletal muscle: Separation from cAMP-dependent protein kinase and phosphorylase kinase
2. Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM
3. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
4. Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue
5. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
6. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B
7. Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells: Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms
8. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue
9. Control of glycogen synthesis in cultured human muscle cells
10. Glycogen synthase from rabbit skeletal muscle: Effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo
11. Covalent phosphorylation in the regulation of glycogen synthase activity
12. New insights into the role and mechanism of glycogen synthase activation by insulin
13. Expression and characterization of glycogen synthase kinase- 3 mutants and their effect on glycogen synthase activity in intact cells
14. Rabbit skeletal muscle glycogen synthase expressed in COS cells: Identification of regulatory phosphorylation sites
15. The role of glycogen synthase kinase 3 b in insulin-stimulated glucose metabolism
16. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action
17. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
18. A molecular mechanism for the effect of lithium on development
19. Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression
20. Lithium's effects on rat liver glucose metabolism in vivo
21. The protein kinase C inhibitors bisindoly-maleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
22. Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes
23. Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: Role of chronic hyperinsulinemia and hyperglycemia
24. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: Comparison using human skeletal muscle cell cultures
25. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: Biochemical and molecular mechanisms
26. Selective inhibitors of glycogen synthase kinase 3 with effects on insulin signaling
27. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
28. Isolation and characterization of human muscle cells
29. Glucose uptake in human and animal muscle cells in culture
30. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake
31. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
32. Glucose transport in cultured human skeletal muscle cells: Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
33. "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein
34. Inhibition of glycogen synthase kinase-3 (GSK3) stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes
35. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
36. Glycogen synthase kinase-3 (GSK3) inhibitors potentiate glucose tolerance and muscle glycogen synthase activity and glucose uptake in the Zucker Diabetic Fatty (ZDF) rat
37. Disease model: Hyperinsulinemia and insulin resistance. Part A. Targeted disruption of insulin signaling or glucose transport
38. Glycogen synthase and phosfructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus
39. More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle
40. Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1
41. Lithium increases susceptibility of muscle glucose transport to stimulation by various agents
42. The role of calcium in stimulation of sugar transport in muscle by lithium
43. Glycogen synthase kinase-3: Functions in oncogenesis and development
44. Regulation and functions of the glycogen synthase kinase-3 subfamily
45. GSK3: A SHAGGY frog story
46. Glycogen synthase-3 is the predominant insulin-regulated eukariotic initiation factor 2B kinase in skeletal muscle
47. A role for glycogen synthase kinase-3 (GSK3) in the desensitization of insulin signaling to glycogen synthase in 3T3-L1 adipocytes
48. Effect of phosphotyrosyl-IRS-1 level and insulin receptor tyrosine kinase activity on insulin-stimulated phosphotyidylinositol 3, MAP and S6 kinase activities
49. The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease
50. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteosome degradation pathway
51. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation
52. GSK3, a master switch regulating cell-fate specification and tumorigenesis
53. Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase
54. Beta-catenin signaling and cancer
55. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
56. Cancer morbidity in psychiatric patients: Influence of lithium carbonate treatment