Impaired basal glucose effectiveness in NIDDS: Contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol

Diabetes

Volumn 46, Issue 3, 1997, Pages 421-432

  Basu, Ananda ^a   Caumo, Andrea ^b   Bettini, Francesca ^c   Gelisio, Anna ^c   Alzaid, Aus ^a   Cobelli, Claudio ^c   Rizza, Robert A ^a  

^a MAYO CLINIC   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN; SOMATOSTATIN; TRITIUM;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HUMAN; INSULIN INFUSION; INSULIN RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; LIPID OXIDATION; MALE; METABOLIC REGULATION; MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0031054198     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.3.421     Document Type: Article

References (51)

1. Dinneen S, Gerich J, Rizza R: Carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engt J Med 327:707-713, 1992
2. Hansen IL, Cryer PE, Rizza RA: Comparison of insulin-mediated and glucose-mediated glucose disposal in patients with insulin-dependent diabetes mellitus and in nondiabetic subjects. Diabetes 34:751-755, 1985
3. Best JD, Taborsky GJ Jr, Halter JB, Porte D Jr: Glucose disposal is not proportional to plasma glucose level in man. Diabetes 30:847-850, 1981
4. Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA: Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 77:1525-1532, 1986
5. Ferrannini E, Simonson DC, Katz LD, Reichard G Jr, Bevilacqua S, Barrett EJ, Olsson M, DeFronzo RA: The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism 37:79-85, 1988
6. Welch S, Gebhart SSP, Bergman RN, Phillips LS: Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518, 1990
7. Saad MF, Anderson RL, Laws A, Watanabe RM, Kades WW, Chen Y-DI, Sands RE, Pei D, Savage PJ, Bergman RN: A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes 43:1114-1121, 1994
8. Taniguchi A, Nakai Y, Fukushima M, Kawamura H, Imura H, Naga I, Tokuyama K: Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 41:1540-1546, 1992
9. Davis SN, Monti L, Piatti PM, Moller N, Ng L, Coppack S, Brown MD, Orskov H, Alberti KG: Estimates of insulin action in normal, obese and NIDDM man: comparison of insulin and glucose infusion test, CIGMA, minimal model and glucose clamp techniques. Diabetes Res 23:1-18, 1993
10. Bergman RN, Ider YZ, Bowden CR, Cobelli C: Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677, 1979
11. Quon MJ, Cochran C, Taylor SI, Eastman RC: Non-insulin-mediated glucose disappearance in subjects with IDDM. Diabetes 43:890-896, 1994
12. Finegood DT, Tzur D: Estimation of glucose effectiveness by the minimal-model is dependent on the endogenous insulin secretory response (Abstract). Diabetes 44 (Suppl. 1):192A, 1995
13. Caumo A, Giacca A, Morgese M, Pozza G, Micossi P, Cobelli C: Minimal models of glucose disappearance: lessons from the labelled IVGTT. Diabetic Med 8:822-832, 1991
14. Caumo A, Vicini P, Cobelli C: Is the minimal model too minimal? Diabetologia 39:997-1000, 1996
15. Alzaid AA, Dinneen SF, Turk DJ, Caumo A, Cobelli C, Rizza RA: Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest 94:2341-2348, 1994
16. White NH, Skor D, Santiago JV: Practical closed-loop insulin delivery: a system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics. Ann Intern Med 97:210-213, 1982
17. Butler PC, Caumo A, Zerman A, O'Brien PC, Cobelli C, Rizza RA: Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 264:E548-E569, 1993
18. McMahon M, Marsh HM, Rizza RA: Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM. Diabetes 38:291-303, 1989
19. 14C labeled substrates. Am J Physiol 17:391-399, 1985
20. Brosnan JT: Pathways of carbon flux in gluconeogenesis. Fed Proc 41:91-94, 1982
21. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
22. Ciaraldi TP, Molina JM, Olefsky JM: Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport. J Clin Endocrinol Metab 72:876-882, 1991
23. Steele R, Wall JS, De Bodo RC, Altszuler N, Kiang SP, Bjerknes C: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
24. Bradley DC, Steil GM, Bergman RN: Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am J Physiol 264:E902-E911, 1993
25. Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634, 1983
26. Cobelli C, Pacini G, Toffolo G, Sacca L: Estimation of insulin senstivity and glucose clearance from minimal model: new insights from labeled IVGTT. Am J Physiol 250:E591-E598, 1986
27. Avogaro A, Bristow JD, Bier DM, Cobelli C, Toffolo G: Stable-label intravenous glucose tolerance test minimal model. Diabetes 38:1048-1055, 1989
28. Cobelli C, Vicini P, Toffolo G, Caumo A: The hot IVGTT minimal models: simultaneous assessment of glucose disposal indices and hepatic glucose release. In MinMod 94. Lovejoy J, Bergman RN, Eds. Baton Rouge, LA, Louisiana Press. In press
29. Wajchenberg BL, Santomauro ATMG, Porrelli RN: Effect of a sulfonylurea (gliclazide) treatment on insulin sensitivity and glucose-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Res Clin Pract 20:147-154, 1993
30. Verdonk CA, Rizza RA, Gerich JE: Effects of plasma glucose concentration on glucose utilization and glucose clearance in normal man. Diabetes 30:535-537, 1981
31. Dwyer MS, Melton LJ III, Ballard DJ, Palumbo PJ, Trautmann JC, Chu C: Incidence of diabetic retinopathy and blindness: a population-based study in Rochester, Minnesota. Diabetes Care 8:316-322, 1985
32. Avogaro A, Vicini P, Valerio A, Caumo A, Cobelli C: The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects. Am J Physiol 270:E532-E540, 1996
33. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983
34. Rizza RA, Cryer PE, Haymond MW, Gerich JE: Adrenergic mechanisms of the effects of epinephrine on glucose production and clearance in man. J Clin Invest 65:682-689, 1980
35. Pehling G, Tessari P, Gerich JE, Haymond MW, Service FJ, Rizza RA: Abnormal meal carbohydrate disposition is insulin-dependent diabetes. J Clin Invest 74:985-991, 1984
36. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M: Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 92:1126-1134, 1993
37. Sacca L, Hendler R, Sherwin RS: Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J Clin Endocrinol Metab 47:1160-1161, 1978
38. Hother-Nielsen O, Vaag A, Skott P, Beck-Nielsen H: Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes. Metabolism 42:86-93, 1993
39. Giaccari A, Rossetti L: Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J Clin Invest 89:36-45, 1992
40. Gould GW, Holman GD: The glucose transporter family: structure, function and tissue-specific expression. Biochem J 295:329-341, 1993
41. Bonadonna RC, Del Prato S, Bonora E, Saccomani MP, Gulli G, Natali A, Frascerra S, Pecori N, Ferrannini E, Bier D, Cobelli C, DeFronzo RA: Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes 45:915-925, 1996
42. Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS, Kahn BB: Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 39:865-870, 1990
43. 12 myotubes and rat skeletal muscle. Diabetes 44:646-651, 1995
44. 2+ dependent mechanism. Diabetes 44:1345-1348, 1995
45. Kelley DE, Mokan M, Simoneau J, Mandarino LJ: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92:91-98, 1993
46. Saloranta C, Koivisto V, Widen E, Falholt K, DeFronzo RA, Harkonen M, Groop L: Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol 264:E599-E605, 1993
47. Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
48. Piatti PM, Monti LD, Pacchioni M, Pontiroli AE, Pozza G: Forearm insulin- and non-insulin-mediated glucose uptake and muscle metabolism in man: role of free fatty acids and blood glucose levels. Metabolism 40:926-933, 1991
49. Monti LD, Caumo A, Piatti P, Cucchi E, Orena C, Conti M, Guazzini B, Librenti MC, Pozza G, Pontiroli AE: Differential effects of free fatty acid (FFA) levels on insulin sensitivity and glucose effectiveness in visceral and subcutaneous obesity (Abstract). Diabetes 44 (Suppl. 1):203A, 1995
50. Katz H, Homan M, Jensen M, Caumo A, Cobelli C, Rizza R: Assessment of insulin action in NIDDM in the presence of dynamic changes in insulin and glucose concentration. Diabetes 43:289-296, 1994
51. Rebrin K, Steil GM, Mittelman SD, Bergman RN: Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98:741-749, 1996