Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

New England Journal of Medicine

Volumn 341, Issue 4, 1999, Pages 240-246

  Cline, Gary W ^a   Petersen, Kitt Falk ^a   Krssak, Martin ^a   Shen, Jun ^a   Hundal, Ripudaman S ^a   Trajanoski, Zlatko ^a   Inzucchi, Silvio ^a   Dresner, Alan ^a   Rothman, Douglas L ^a   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HUMAN; INSULIN METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; AGED; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EXTRACELLULAR SPACE; FEMALE; GLUCOSE; GLUCOSE-6-PHOSPHATE; GLYCOGEN; HEXOKINASE; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUSCLE, SKELETAL;

EID: 0033595120     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199907223410404     Document Type: Article

References (30)

1. National Diabetes Data Group. Diabetes in America. Bethesda, Md.: National Institute of Diabetes and Digestive and Kidney Diseases, 1995. (NIH publication no. 95-1468.)
2. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 1990; 113:909-15.
3. Lillioja S, Mott DM, Howard BV, et al. Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross-sectional studies in Pima Indians. N Engl J Med 1988;318:1217-25.
4. Haffner SM, Stern MP, Dunn J, Mobley M, Blackwell J, Bergman RN. Diminished insulin sensitivity and increased insulin response in nonobese, nondiabetic Mexican Americans. Metabolism 1990;39:842-7.
5. Reaven GM, Bernstein R, Davis B, Olefsky JM. Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med 1976;60:80-8.
6. DeFronzo RA. Lilly Lecture 1987: the triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 1988;37:667-87.
7. Cahill GF Jr. Beta-cell deficiency, insulin resistance, or both? N Engl J Med 1988;318:1268-70.
8. Lillioja S, Mott DM, Zawadzki JK, Young AA, Abbott WG, Bogardus C. Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. J Clin Endocrinol Metab 1986;62: 922-7.
9. 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990;322:223-8.
10. Bogardus C, Lillioja S, Stone K, Mott D. Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 1984;73:1185-99.
11. Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991;34:239-45
12. Wright KS, Beck-Nielsen H, Kolterman OG, Mandarino LJ. Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM. Diabetes 1988;37:436-40.
13. Kelley DE, Mintun MA, Watkins SC, et al. The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J Clin Invest 1996;97:2705-13.
14. Braithwaite SS, Palazuk B, Colca JR, Edwards CW III, Hofmann C. Reduced expression of hexokinase II in insulin-resistant diabetes. Diabetes 1995;44:43-8.
15. Kruszynska YT, Mulford MI, Baloga J, Yu JG, Olefsky JM. Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects. Diabetes 1998;47:1107-13.
16. Rothman DL, Shulman RG, Shulman GI. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest 1992;89:1069-75.
17. Bonadonna RC, Del Prato S, Bonora E, et al. Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes 1996;45:915-25.
18. Zierath JR, He L, Guma A, Odegoard Wahlstrom E, Klip A, Wallberg-Henriksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 1996;39:1180-9.
19. Dohm GL, Tapscott EB, Pories WJ, et al. An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 1988;82:486-94.
20. Yang YJ, Hope ID, Ader M, Bergman RN. Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest 1989;84:1620-8.
21. Shen J. Use of amplitude and frequency transformations to generate adiabatic pulses of wide bandwidth and low RF power deposition. J Magn Reson B 1996;112:131-40.
22. Trajanoski Z, Brunner GA, Schaupp L, et al. Open-flow microperfusion of subcutaneous adipose tissue for on-line continuous ex vivo measurement of glucose concentration. Diabetes Care 1997;20:1114-21.
23. Moberg E, Hagstrom-Toft E, Arner P, Bolinder J. Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle compared with blood during insulin-induced hypoglycaemia. Diabctologia 1997;40:1320-6.
24. Cline GW, Jucker BM, Trajanoski Z, Rennings AJ, Shulman GI. A novel 13C NMR method to assess intracellular glucose concentration in muscle in vivo. Am J Physiol 1998;274:E381-E389.
25. Kasanicki MA, Pilch PF. Regulation of glucose-transporter function. Diabetes Care 1990;13:219-27.
26. Cline GW, Ren J, Cadman KS, Marshall B. Redistribution of rate control for insulin stimulated muscle glycogen synthesis in Glut1 transgenic mice. Diabetes 1999;48:Suppl 1:A273, abstract.
27. Dresner A, Laurent D, Marcucci M, et al. Effect of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 1999;103:253-9.
28. Shulman RG, Bloch G, Rothman DL. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proc Natl Acad Sci U S A 1995;92:8535-42.
29. Saccomani MP, Bonadonna RC, Bier DM, DeFronzo RA, Cobelli C. A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study. Am J Physiol 1996;270:E170-E185.
30. Nolan JJ, Ludvik B, Baloga J, Reichart D, Olefsky JM. Mechanisms of the kinetic defect in insulin action in obesity and NIDDM. Diabetes 1997; 46:994-1000.