Identification of a biochemical link between energy intake and energy expenditure

Journal of Clinical Investigation

Volumn 109, Issue 12, 2002, Pages 1599-1605

  Obici, Silvana ^a   Wang, Jiali ^a   Chowdury, Rahena ^a   Feng, Zhaohui ^a   Siddhanta, Uma ^a   Morgan, Kimyata ^a   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; HEXOSAMINE; SYNAPSIN I;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA MICROARRAY; ENERGY EXPENDITURE; GENETIC TRANSCRIPTION; MALE; METABOLISM; MITOCHONDRION; NONHUMAN; NORTHERN BLOTTING; NUTRIENT; OBESITY; OVERNUTRITION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0036081060     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215258     Document Type: Article

References (29)

1. Role of nonexercise activity thermogenesis in resistance to fat gain in humans
2. The response to long-term overfeeding in identical twins
3. Reduced rate of energy expenditure as a risk factor for body-weight gain
4. Changes in energy expenditure resulting from altered body weight
5. Central nervous system control of food intake
6. The "thrifty genotype" in 1998
7. Discovery of a metabolic pathway mediating desensitization of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance
8. Hexosamines stimulate leptin production in transgenic mice
9. Glycosylation of nucleocytoplasmic proteins: Signal transduction and O-GlcNAc
10. Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-alpha gene transcription
11. Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: Post-translational regulation of turnover and transactivation activity
12. O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins
13. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
14. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
15. Overexpression of glutamine: Fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
16. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
17. The effects of leptin on Lep expression is tissue-specific and nutritionally regulated
18. Overfeeding rapidly induces leptin and insulin resistance
19. Making and reading microarray
20. DNA arrays for analysis of gene expression
21. Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine
22. Towards a molecular understanding of adaptive thermogenesis
23. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proreins
24. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
25. O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability
26. On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes
27. Sp1 acts as a repressor of the human adenine nucleotide translocase-2 (ANT2) promoter
28. Nuclear control of respiratory chain expression in mammalian cells
29. A role for brown adipose tissue in diet-induced thermogenesis