Allosteric activators of glucokinase: Potential role in diabetes therapy

Science

Volumn 301, Issue 5631, 2003, Pages 370-373

  Grimsby, Joseph ^a   Sarabu, Ramakanth ^a   Corbett, Wendy L ^a   Haynes, Nancy Ellen ^a   Bizzarro, Fred T ^a   Coffey, John W ^a   Guertin, Kevin R ^a   Hilliard, Darryl W ^a,d   Kester, Robert F ^a   Mahaney, Paige E ^a,e   Marcus, Linda ^a   Qi, Lida ^a   Spence, Cheryl L ^a   Tengi, John ^a   Magnuson, Mark A ^b   Chu, Chang An ^a   Dvorozniak, Mark T ^a   Matschinsky, Franz M ^c   Grippo, Joseph F ^a  

^a Hoffman La Roche Department of Metabolic Diseases   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d ELI LILLY AND COMPANY   (United States)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GLUCOSE; INSULIN;

ANTIDIABETIC AGENTS;

DISEASE CONTROL;

2 OXOISOCAPROIC ACID; GLUCOKINASE; GLUCOKINASE ACTIVATOR; GLUCOSE; HEXANOIC ACID; HEXOKINASE; INSULIN; RO 201674; RO 280450; RO 281674; RO 281675; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

DIABETES; GLUCOSE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; DOSE RESPONSE; DRUG MECHANISM; ENZYME BINDING; ENZYME RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIVER CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC REGULATION; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME ACTIVATORS; GLUCOKINASE; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; LIVER; LIVER GLYCOGEN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; PROTEINS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; STEREOISOMERISM; THIAZOLES;

ANIMALIA; RODENTIA;

EID: 0037624071     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1084073     Document Type: Article

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