Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

Circulation

Volumn 106, Issue 4, 2002, Pages 466-472

  Federici, Massimo ^a   Menghini, Rossella ^a   Mauriello, Alessandro ^a   Hribal, Marta Letizia ^a   Ferrelli, Francesca ^a   Lauro, Davide ^a   Sbraccia, Paolo ^a   Spagnoli, Luigi Giusto ^a   Sesti, Giorgio ^a   Lauro, Renato ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Atherosclerosis; Diabetes mellitus; Endothelium; Insulin; Metalloproteinases

Indexed keywords

GELATINASE A; GELATINASE B; HEXOSAMINE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ACYLATION; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME MODIFICATION; HORMONE ACTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ARTERIOSCLEROSIS; CELLS, CULTURED; CORONARY VESSELS; DIABETES COMPLICATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GLUCOSAMINE; GLUCOSE; GLYCOSYLATION; HUMANS; INSULIN; INSULIN ANTAGONISTS; MATRIX METALLOPROTEINASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 0037162342     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000023043.02648.51     Document Type: Article

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