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Volumn 117, Issue 4, 2008, Pages 305-317

Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; BRCA2 PROTEIN;

EID: 46449130565     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00412-008-0154-8     Document Type: Review
Times cited : (52)

References (132)
  • 2
    • 33646117239 scopus 로고    scopus 로고
    • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    • Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173(2):195-206
    • (2006) J Cell Biol , vol.173 , Issue.2 , pp. 195-206
    • Bekker-Jensen, S.1    Lukas, C.2    Kitagawa, R.3    Melander, F.4    Kastan, M.B.5    Bartek, J.6    Lukas, J.7
  • 3
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich E, Monnat RJ Jr, Kastan MB (2007) Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9(6):683-690
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 683-690
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 4
    • 13944263628 scopus 로고    scopus 로고
    • Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
    • Bradshaw PS, Stavropoulos DJ, Meyn MS (2005) Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat Genet 37(2):193-197
    • (2005) Nat Genet , vol.37 , Issue.2 , pp. 193-197
    • Bradshaw, P.S.1    Stavropoulos, D.J.2    Meyn, M.S.3
  • 5
    • 0035798565 scopus 로고    scopus 로고
    • BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions
    • Brzovic PS, Meza JE, King MC, Klevit RE (2001a) BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions. J Biol Chem 276(44):41399-41406
    • (2001) J Biol Chem , vol.276 , Issue.44 , pp. 41399-41406
    • Brzovic, P.S.1    Meza, J.E.2    King, M.C.3    Klevit, R.E.4
  • 11
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1/CtIP/MRN is important for DNA double-strand break repair
    • Chen L, Nievera C, Lee AY, Wu X (2008) Cell cycle-dependent complex formation of BRCA1/CtIP/MRN is important for DNA double-strand break repair. J Biol Chem 283(12):7713-7720
    • (2008) J Biol Chem , vol.283 , Issue.12 , pp. 7713-7720
    • Chen, L.1    Nievera, C.2    Lee, A.Y.3    Wu, X.4
  • 12
    • 0033523268 scopus 로고    scopus 로고
    • Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium
    • Consortium
    • Consortium (1999) Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst 91(15):1310-1316
    • (1999) J Natl Cancer Inst , vol.91 , Issue.15 , pp. 1310-1316
  • 13
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • (see comments)
    • Cortez D, Wang Y, Qin J, Elledge SJ (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (New York, NY) 286(5442):1162-1166 (see comments)
    • (1999) Science (New York, NY) , vol.286 , Issue.5442 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 16
    • 0036491931 scopus 로고    scopus 로고
    • The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients
    • Elledge SJ, Amon A (2002) The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell 1(2):129-132
    • (2002) Cancer Cell , vol.1 , Issue.2 , pp. 129-132
    • Elledge, S.J.1    Amon, A.2
  • 18
    • 33749007676 scopus 로고    scopus 로고
    • Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
    • Evers B, Jonkers J (2006) Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 25(43):5885-5897
    • (2006) Oncogene , vol.25 , Issue.43 , pp. 5885-5897
    • Evers, B.1    Jonkers, J.2
  • 19
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson SP (2005) Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434(7033):605-611
    • (2005) Nature , vol.434 , Issue.7033 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 21
    • 0036864626 scopus 로고    scopus 로고
    • Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
    • Frank-Vaillant M, Marcand S (2002) Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol Cell 10(5):1189-1199
    • (2002) Mol Cell , vol.10 , Issue.5 , pp. 1189-1199
    • Frank-Vaillant, M.1    Marcand, S.2
  • 26
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Gen 12(2):191-194
    • (1996) Nat Gen , vol.12 , Issue.2 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 27
    • 29944434644 scopus 로고    scopus 로고
    • Multifactorial contributions to an acute DNA damage response by BRCA1/ BARD1-containing complexes
    • Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM (2006) Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev 20(1):34-46
    • (2006) Genes Dev , vol.20 , Issue.1 , pp. 34-46
    • Greenberg, R.A.1    Sobhian, B.2    Pathania, S.3    Cantor, S.B.4    Nakatani, Y.5    Livingston, D.M.6
  • 30
    • 33646064427 scopus 로고    scopus 로고
    • Structural complexity in ubiquitin recognition
    • Harper JW, Schulman BA (2006) Structural complexity in ubiquitin recognition. Cell 124(6):1133-1136
    • (2006) Cell , vol.124 , Issue.6 , pp. 1133-1136
    • Harper, J.W.1    Schulman, B.A.2
  • 31
    • 0037068455 scopus 로고    scopus 로고
    • RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
    • Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419(6903):135-141
    • (2002) Nature , vol.419 , Issue.6903 , pp. 135-141
    • Hoege, C.1    Pfander, B.2    Moldovan, G.L.3    Pyrowolakis, G.4    Jentsch, S.5
  • 32
    • 0035018530 scopus 로고    scopus 로고
    • Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci
    • Huber LJ, Yang TW, Sarkisian CJ, Master SR, Deng CX, Chodosh LA (2001) Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci. Mol Cell Biol 21(12):4005-4015
    • (2001) Mol Cell Biol , vol.21 , Issue.12 , pp. 4005-4015
    • Huber, L.J.1    Yang, T.W.2    Sarkisian, C.J.3    Master, S.R.4    Deng, C.X.5    Chodosh, L.A.6
  • 33
    • 36249031962 scopus 로고    scopus 로고
    • RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
    • Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J (2007) RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131:901-914
    • (2007) Cell , vol.131 , pp. 901-914
    • Huen, M.S.1    Grant, R.2    Manke, I.3    Minn, K.4    Yu, X.5    Yaffe, M.B.6    Chen, J.7
  • 34
    • 0345447604 scopus 로고    scopus 로고
    • Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
    • Ira G, Malkova A, Liberi G, Foiani M, Haber JE (2003) Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115(4):401-411
    • (2003) Cell , vol.115 , Issue.4 , pp. 401-411
    • Ira, G.1    Malkova, A.2    Liberi, G.3    Foiani, M.4    Haber, J.E.5
  • 36
    • 0037115914 scopus 로고    scopus 로고
    • Homologous repair of DNA damage and tumorigenesis: The BRCA connection
    • Jasin M (2002) Homologous repair of DNA damage and tumorigenesis: The BRCA connection. Oncogene 21(58):8981-8993
    • (2002) Oncogene , vol.21 , Issue.58 , pp. 8981-8993
    • Jasin, M.1
  • 37
  • 38
    • 0035833994 scopus 로고    scopus 로고
    • Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development
    • Joukov V, Chen J, Fox EA, Green JB, Livingston DM (2001) Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 98(21):12078-12083
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.21 , pp. 12078-12083
    • Joukov, V.1    Chen, J.2    Fox, E.A.3    Green, J.B.4    Livingston, D.M.5
  • 39
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang J, Bronson RT, Xu Y (2002) Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J 21(6):1447-1455
    • (2002) EMBO J , vol.21 , Issue.6 , pp. 1447-1455
    • Kang, J.1    Bronson, R.T.2    Xu, Y.3
  • 40
    • 33748985129 scopus 로고    scopus 로고
    • Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer
    • Karppinen SM, Erkko H, Reini K, Pospiech H, Heikkinen K, Rapakko K, Syvaoja JE, Winqvist R (2006) Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer. Eur J Cancer 42(15):2647-2652
    • (2006) Eur J Cancer , vol.42 , Issue.15 , pp. 2647-2652
    • Karppinen, S.M.1    Erkko, H.2    Reini, K.3    Pospiech, H.4    Heikkinen, K.5    Rapakko, K.6    Syvaoja, J.E.7    Winqvist, R.8
  • 41
    • 34249950879 scopus 로고    scopus 로고
    • Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
    • Kim H, Chen J, Yu X (2007a) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316(5828):1202-1205
    • (2007) Science , vol.316 , Issue.5828 , pp. 1202-1205
    • Kim, H.1    Chen, J.2    Yu, X.3
  • 42
    • 34547655427 scopus 로고    scopus 로고
    • CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response
    • Kim H, Huang J, Chen J (2007b) CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol 14(8):710-715
    • (2007) Nat Struct Mol Biol , vol.14 , Issue.8 , pp. 710-715
    • Kim, H.1    Huang, J.2    Chen, J.3
  • 43
    • 0142178215 scopus 로고    scopus 로고
    • Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    • King MC, Marks JH, Mandell JB (2003) Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302(5645):643-646
    • (2003) Science , vol.302 , Issue.5645 , pp. 643-646
    • King, M.C.1    Marks, J.H.2    Mandell, J.B.3
  • 44
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB (2004) Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18(12):1423-1438
    • (2004) Genes Dev , vol.18 , Issue.12 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 47
    • 0034624718 scopus 로고    scopus 로고
    • hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee JS, Collins KM, Brown AL, Lee CH, Chung JH (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404(6774):201-204
    • (2000) Nature , vol.404 , Issue.6774 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 48
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber MR, Ma Y, Pannicke U, Schwarz K (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev 4(9):712-720
    • (2003) Nat Rev , vol.4 , Issue.9 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 49
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M, Barlow JH, Burgess RC, Rothstein R (2004) Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins. Cell 118(6):699-713
    • (2004) Cell , vol.118 , Issue.6 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 50
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH (1996) Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev 10(14):1835-1843
    • (1996) Genes Dev , vol.10 , Issue.14 , pp. 1835-1843
    • Liu, C.Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.H.5
  • 51
    • 34547662882 scopus 로고    scopus 로고
    • CCDC98 targets BRCA1 to DNA damage sites
    • Liu Z, Wu J, Yu X (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol 14(8):716-720
    • (2007) Nat Struct Mol Biol , vol.14 , Issue.8 , pp. 716-720
    • Liu, Z.1    Wu, J.2    Yu, X.3
  • 52
    • 0031030223 scopus 로고    scopus 로고
    • An assay for quantifying DNA double-strand break repair that is suitable for small numbers of unlabeled cells
    • Longo JA, Nevaldine B, Longo SL, Winfield JA, Hahn PJ (1997) An assay for quantifying DNA double-strand break repair that is suitable for small numbers of unlabeled cells. Radiat Res 147(1):35-40
    • (1997) Radiat Res , vol.147 , Issue.1 , pp. 35-40
    • Longo, J.A.1    Nevaldine, B.2    Longo, S.L.3    Winfield, J.A.4    Hahn, P.J.5
  • 54
    • 0035872860 scopus 로고    scopus 로고
    • Tumorigenesis in mice carrying a truncating Brca1 mutation
    • Ludwig T, Fisher P, Ganesan S, Efstratiadis A (2001) Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev 15(10):1188-1193
    • (2001) Genes Dev , vol.15 , Issue.10 , pp. 1188-1193
    • Ludwig, T.1    Fisher, P.2    Ganesan, S.3    Efstratiadis, A.4
  • 55
    • 0037341599 scopus 로고    scopus 로고
    • Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    • Lukas C, Falck J, Bartkova J, Bartek J, Lukas J (2003) Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol 5(3):255-260
    • (2003) Nat Cell Biol , vol.5 , Issue.3 , pp. 255-260
    • Lukas, C.1    Falck, J.2    Bartkova, J.3    Bartek, J.4    Lukas, J.5
  • 57
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A, Petrini JH (1999) Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Nat Acad Sci U S A 96(13):7376-7381
    • (1999) Proc Nat Acad Sci U S A , vol.96 , Issue.13 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 58
    • 36248966246 scopus 로고    scopus 로고
    • RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    • Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J (2007) RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131(5):887-900
    • (2007) Cell , vol.131 , Issue.5 , pp. 887-900
    • Mailand, N.1    Bekker-Jensen, S.2    Faustrup, H.3    Melander, F.4    Bartek, J.5    Lukas, C.6    Lukas, J.7
  • 59
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003) BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302(5645):636-639
    • (2003) Science , vol.302 , Issue.5645 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 60
    • 35448968240 scopus 로고    scopus 로고
    • RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors
    • Martin RW, Orelli BJ, Yamazoe M, Minn AJ, Takeda S, Bishop DK (2007) RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res 67(20):9658-9665
    • (2007) Cancer Res , vol.67 , Issue.20 , pp. 9658-9665
    • Martin, R.W.1    Orelli, B.J.2    Yamazoe, M.3    Minn, A.J.4    Takeda, S.5    Bishop, D.K.6
  • 62
    • 0037773540 scopus 로고    scopus 로고
    • Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability
    • McCarthy EE, Celebi JT, Baer R, Ludwig T (2003) Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol 23(14):5056-5063
    • (2003) Mol Cell Biol , vol.23 , Issue.14 , pp. 5056-5063
    • McCarthy, E.E.1    Celebi, J.T.2    Baer, R.3    Ludwig, T.4
  • 64
    • 1942517849 scopus 로고    scopus 로고
    • BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair
    • Morris JR, Solomon E (2004) BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum Mol Genet 13(8):807-817
    • (2004) Hum Mol Genet , vol.13 , Issue.8 , pp. 807-817
    • Morris, J.R.1    Solomon, E.2
  • 65
  • 66
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan ME, Pierce AJ, Jasin M (2001) BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 7(2):263-272
    • (2001) Mol Cell , vol.7 , Issue.2 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 67
    • 0035963338 scopus 로고    scopus 로고
    • Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae
    • Myung K, Chen C, Kolodner RD (2001) Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature 411(6841):1073-1076
    • (2001) Nature , vol.411 , Issue.6841 , pp. 1073-1076
    • Myung, K.1    Chen, C.2    Kolodner, R.D.3
  • 68
    • 0035030368 scopus 로고    scopus 로고
    • Breast cancer genetics: What we know and what we need
    • Nathanson KL, Wooster R, Weber BL (2001) Breast cancer genetics: What we know and what we need. Nat Med 7(5):552-556
    • (2001) Nat Med , vol.7 , Issue.5 , pp. 552-556
    • Nathanson, K.L.1    Wooster, R.2    Weber, B.L.3
  • 69
    • 0030926490 scopus 로고    scopus 로고
    • The scid defect results in much slower repair of DNA double-strand breaks but not high levels of residual breaks
    • Nevaldine B, Longo JA, Hahn PJ (1997) The scid defect results in much slower repair of DNA double-strand breaks but not high levels of residual breaks. Radiat Res 147(5):535-540
    • (1997) Radiat Res , vol.147 , Issue.5 , pp. 535-540
    • Nevaldine, B.1    Longo, J.A.2    Hahn, P.J.3
  • 70
    • 0036849432 scopus 로고    scopus 로고
    • Checking on the fork: The DNA-replication stress-response pathway
    • Osborn AJ, Elledge SJ, Zou L (2002) Checking on the fork: The DNA-replication stress-response pathway. Trends Cell Biol 12(11):509-516
    • (2002) Trends Cell Biol , vol.12 , Issue.11 , pp. 509-516
    • Osborn, A.J.1    Elledge, S.J.2    Zou, L.3
  • 72
    • 34447318130 scopus 로고    scopus 로고
    • The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
    • Peng M, Litman R, Xie J, Sharma S, Brosh RM Jr, Cantor SB (2007) The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J 26(13):3238-3249
    • (2007) EMBO J , vol.26 , Issue.13 , pp. 3238-3249
    • Peng, M.1    Litman, R.2    Xie, J.3    Sharma, S.4    Brosh Jr., R.M.5    Cantor, S.B.6
  • 73
    • 8844237615 scopus 로고    scopus 로고
    • Polyubiquitin chains: Polymeric protein signals
    • Pickart CM, Fushman D (2004) Polyubiquitin chains: Polymeric protein signals. Curr Opin Chem Biol 8(6):610-616
    • (2004) Curr Opin Chem Biol , vol.8 , Issue.6 , pp. 610-616
    • Pickart, C.M.1    Fushman, D.2
  • 74
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • Pierce AJ, Hu P, Han M, Ellis N, Jasin M (2001) Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15(24):3237-3242
    • (2001) Genes Dev , vol.15 , Issue.24 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 75
    • 33646808638 scopus 로고    scopus 로고
    • A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites
    • Polanowska J, Martin JS, Garcia-Muse T, Pcorin MI, Boulton SJ (2006) A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. EMBO J 25(10):2178-2188
    • (2006) EMBO J , vol.25 , Issue.10 , pp. 2178-2188
    • Polanowska, J.1    Martin, J.S.2    Garcia-Muse, T.3    Pcorin, M.I.4    Boulton, S.J.5
  • 76
    • 33746515537 scopus 로고    scopus 로고
    • Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks
    • Potts PR, Porteus MH, Yu H (2006) Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J 25(14):3377-3388
    • (2006) EMBO J , vol.25 , Issue.14 , pp. 3377-3388
    • Potts, P.R.1    Porteus, M.H.2    Yu, H.3
  • 81
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273(10):5858-5868
    • (1998) J Biol Chem , vol.273 , Issue.10 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 82
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146(5):905-916
    • (1999) J Cell Biol , vol.146 , Issue.5 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 84
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully R, Livingston D (2000) In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408:429-432
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.2
  • 85
    • 0030850047 scopus 로고    scopus 로고
    • Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
    • Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM (1997a) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90(3):425-435
    • (1997) Cell , vol.90 , Issue.3 , pp. 425-435
    • Scully, R.1    Chen, J.2    Ochs, R.L.3    Keegan, K.4    Hoekstra, M.5    Feunteun, J.6    Livingston, D.M.7
  • 91
    • 0033590171 scopus 로고    scopus 로고
    • BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
    • Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, Koller BH (1999) BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene 18(55):7900-7907
    • (1999) Oncogene , vol.18 , Issue.55 , pp. 7900-7907
    • Snouwaert, J.N.1    Gowen, L.C.2    Latour, A.M.3    Mohn, A.R.4    Xiao, A.5    DiBiase, L.6    Koller, B.H.7
  • 94
    • 0141831006 scopus 로고    scopus 로고
    • Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
    • Stelter P, Ulrich HD (2003) Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 425(6954):188-191
    • (2003) Nature , vol.425 , Issue.6954 , pp. 188-191
    • Stelter, P.1    Ulrich, H.D.2
  • 95
    • 0037468192 scopus 로고    scopus 로고
    • MDC1 is a mediator of the mammalian DNA damage checkpoint
    • Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421(6926):961-966
    • (2003) Nature , vol.421 , Issue.6926 , pp. 961-966
    • Stewart, G.S.1    Wang, B.2    Bignell, C.R.3    Taylor, A.M.4    Elledge, S.J.5
  • 96
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 64(7):2390-2396
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 97
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123(7):1213-1226
    • (2005) Cell , vol.123 , Issue.7 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 98
    • 33747882412 scopus 로고    scopus 로고
    • Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: New insights and new questions
    • Sung PA, Libura J, Richardson C (2006) Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: New insights and new questions. DNA Repair 5(9-10):1109-1118
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1109-1118
    • Sung, P.A.1    Libura, J.2    Richardson, C.3
  • 101
    • 10944262393 scopus 로고    scopus 로고
    • DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
    • Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, Koshland D (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16(6):991-1002
    • (2004) Mol Cell , vol.16 , Issue.6 , pp. 991-1002
    • Unal, E.1    Arbel-Eden, A.2    Sattler, U.3    Shroff, R.4    Lichten, M.5    Haber, J.E.6    Koshland, D.7
  • 102
    • 0347510576 scopus 로고    scopus 로고
    • End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4
    • van Heemst D, Brugmans L, Verkaik NS, van Gent DC (2004) End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair 3(1):43-50
    • (2004) DNA Repair , vol.3 , Issue.1 , pp. 43-50
    • van Heemst, D.1    Brugmans, L.2    Verkaik, N.S.3    van Gent, D.C.4
  • 103
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman AR (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108(2):171-182
    • (2002) Cell , vol.108 , Issue.2 , pp. 171-182
    • Venkitaraman, A.R.1
  • 104
    • 33846850422 scopus 로고    scopus 로고
    • Ten genes for inherited breast cancer
    • Walsh T, King MC (2007) Ten genes for inherited breast cancer. Cancer Cell 11(2):103-105
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 103-105
    • Walsh, T.1    King, M.C.2
  • 105
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 14(8):927-939
    • (2000) Genes Dev , vol.14 , Issue.8 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 106
  • 107
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward IM, Chen J (2001) Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276(51):47759-47762
    • (2001) J Biol Chem , vol.276 , Issue.51 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 108
    • 33645229532 scopus 로고    scopus 로고
    • Alternative pathways for the repair of RAG-induced DNA breaks
    • Weinstock DM, Jasin M (2006) Alternative pathways for the repair of RAG-induced DNA breaks. Mol Cell Biol 26(1):131-139
    • (2006) Mol Cell Biol , vol.26 , Issue.1 , pp. 131-139
    • Weinstock, D.M.1    Jasin, M.2
  • 109
    • 33747888634 scopus 로고    scopus 로고
    • Modeling oncogenic translocations: Distinct roles for double-strand break repair pathways in translocation formation in mammalian cells
    • Weinstock DM, Richardson CA, Elliott B, Jasin M (2006) Modeling oncogenic translocations: Distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair 5(9-10):1065-1074
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1065-1074
    • Weinstock, D.M.1    Richardson, C.A.2    Elliott, B.3    Jasin, M.4
  • 111
    • 0034809456 scopus 로고    scopus 로고
    • Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1
    • Williams RS, Green R, Glover JN (2001) Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat Struct Biol 8(10):838-842
    • (2001) Nat Struct Biol , vol.8 , Issue.10 , pp. 838-842
    • Williams, R.S.1    Green, R.2    Glover, J.N.3
  • 114
    • 0347987856 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    • Wu L, Hickson ID (2003) The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426(6968):870-874
    • (2003) Nature , vol.426 , Issue.6968 , pp. 870-874
    • Wu, L.1    Hickson, I.D.2
  • 116
    • 0038237514 scopus 로고    scopus 로고
    • Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein
    • Xia Y, Pao GM, Chen HW, Verma IM, Hunter T (2003) Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem 278(7):5255-5263
    • (2003) J Biol Chem , vol.278 , Issue.7 , pp. 5255-5263
    • Xia, Y.1    Pao, G.M.2    Chen, H.W.3    Verma, I.M.4    Hunter, T.5
  • 120
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX (1999) Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 3(3):389-395
    • (1999) Mol Cell , vol.3 , Issue.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.W.6    Harris, C.C.7    Ried, T.8    Deng, C.X.9
  • 121
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B, Kim S, Kastan MB (2001a) Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 21(10):3445-3450
    • (2001) Mol Cell Biol , vol.21 , Issue.10 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 122
    • 0034946638 scopus 로고    scopus 로고
    • Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
    • Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX (2001b) Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28(3):266-271
    • (2001) Nat Genet , vol.28 , Issue.3 , pp. 266-271
    • Xu, X.1    Qiao, W.2    Linke, S.P.3    Cao, L.4    Li, W.M.5    Furth, P.A.6    Harris, C.C.7    Deng, C.X.8
  • 123
    • 0036146085 scopus 로고    scopus 로고
    • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
    • Xu B, Kim ST, Lim DS, Kastan MB (2002) Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22(4):1049-1059
    • (2002) Mol Cell Biol , vol.22 , Issue.4 , pp. 1049-1059
    • Xu, B.1    Kim, S.T.2    Lim, D.S.3    Kastan, M.B.4
  • 125
    • 14144253224 scopus 로고    scopus 로고
    • The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
    • Yang H, Li Q, Fan J, Holloman WK, Pavletich NP (2005) The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature 433(7026):653-657
    • (2005) Nature , vol.433 , Issue.7026 , pp. 653-657
    • Yang, H.1    Li, Q.2    Fan, J.3    Holloman, W.K.4    Pavletich, N.P.5
  • 126
    • 0032566753 scopus 로고    scopus 로고
    • The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
    • Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998) The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem 273(39):25388-25392
    • (1998) J Biol Chem , vol.273 , Issue.39 , pp. 25388-25392
    • Yu, X.1    Wu, L.C.2    Bowcock, A.M.3    Aronheim, A.4    Baer, R.5
  • 127
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • Yu X, Chini CC, He M, Mer G, Chen J (2003) The BRCT domain is a phospho-protein binding domain. Science 302(5645):639-642
    • (2003) Science , vol.302 , Issue.5645 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 128
    • 33745614048 scopus 로고    scopus 로고
    • BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
    • Yu X, Fu S, Lai M, Baer R, Chen J (2006) BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20(13):1721-1726
    • (2006) Genes Dev , vol.20 , Issue.13 , pp. 1721-1726
    • Yu, X.1    Fu, S.2    Lai, M.3    Baer, R.4    Chen, J.5
  • 131
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300(5625):1542-1548
    • (2003) Science , vol.300 , Issue.5625 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 132
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou L, Liu D, Elledge SJ (2003) Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A 100(24):13827-13832
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.24 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3


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