BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 41399-41406

  Brzovic, Peter S ^b   Meza, Jose E ^a,c   King, Mary Claire ^a   Klevit, Rachel E ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESORPTION; DIMERIZATION; IONIZATION; LASER APPLICATIONS; MUTAGENESIS; TUMORS;

LOCAL STRUCTURAL PERTURBATION;

PROTEINS;

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; DIMER; PROTEIN SUBUNIT; RNA BINDING PROTEIN; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; CANCER SUSCEPTIBILITY; COMPLEX FORMATION; DIMERIZATION; GENE MUTATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENETIC PREDISPOSITION; GENETICS; HUMAN; HYDROLYSIS; MASS SPECTROMETRY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

BRCA1 PROTEIN; DIMERIZATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ZINC;

EID: 0035798565     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106551200     Document Type: Article

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