Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes

Journal of Biological Chemistry

Volumn 278, Issue 22, 2003, Pages 20303-20312

  Furuta, Takahisa ^a   Takemura, Haruyuki ^a   Liao, Zhi Yong ^a   Aune, Gregory J ^a   Redon, Christophe ^a   Sedelnikova, Olga A ^a   Pilch, Duane R ^a   Rogakou, Emmy P ^a   Celeste, Arkady ^a   Chen, Hua Tang ^a   Nussenzweig, Andre ^a   Aladjem, Mirit I ^a   Bonner, William M ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IONIZING RADIATION; PROTEINS;

REPLICATION;

CELLS;

7 HYDROXYSTAUROSPORINE; APHIDICOLIN; CAMPTOTHECIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE RAD3; DNA DEPENDENT PROTEIN KINASE; DNA TOPOISOMERASE; HISTONE H2A; HISTONE H2AX; MRE11 PROTEIN; NIBRIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAD50 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN; DNA BINDING PROTEIN; ENZYME INHIBITOR; HISTONE; MRE11A PROTEIN, HUMAN; MRE11A PROTEIN, MOUSE; NBS1 PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD50 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CANCER CELL CULTURE; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA STRAND BREAKAGE; EMBRYO; EUKARYOTIC CELL; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; CONFOCAL MICROSCOPY; DNA DAMAGE; DRUG ANTAGONISM; HYDROLYSIS; METABOLISM; MOUSE MUTANT; WESTERN BLOTTING;

ANIMALIA; ATAXIA; ATAXIA TELANGIECTASIA; EUKARYOTA; MAMMALIA;

ANIMALS; BLOTTING, WESTERN; CAMPTOTHECIN; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR ENZYMES; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HISTONES; HUMANS; HYDROLYSIS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE PROTEINS; TUMOR CELLS, CULTURED;

EID: 0038820065     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300198200     Document Type: Article

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